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국내 건강기능식품의 복수 섭취에 따른 이상사례 신고 내용 분석 및 관리 방안
강권수,이규원,정수한,강대진,고광석 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.5
Extension of life expectancy due to aging has increased interest in health, leading to enlargement of the health function foods (HFF) market. In addition, the factors to contribute to enlargement of the HFF market would be the amounts of purchases, intake, and diversity of HFF depending on customer’s interests. However, it is difficult to obtain clear evidence as to whether or not intakes of multiple specific body function-enhanced products cause harmful effects. In this study, we tracked problematic cases in which consumers took large quantities of functional ingredients in HFF. We classified 10,370 cases of HFF adverse events reported to the Ministry of Food and Drug Safety from 2006 to 2018 based on 85 symptoms and selected five functional materials (Garcinia cambogia, green tea, Aloe vera, saw palmetto, Cynanchum wilfordii), which were suspected to be related to hepatic abnormalities, in order to analyze possible material-material interaction through in vitro study. Furthermore, the domestic and foreign management systems regulating side effects caused by intake of multiple HFF were investigated. When G. cambogia extract and green tea extract were treated together to AML12 cells, viability of the cells was lower than that of the group treated with only G. cambogia extract. We confirmed that combined treatment of G. cambogia extract and green tea extract resulted in clear hepatic toxicity. However, extensive investigation would be necessary to support the interaction possibilities of other combinations. 우리나라 건강기능식품은 지속적인 성장세에 힘입어 2017년 건강기능식품의 판매실적이 2조2,374억 원으로 최근 4년간 연평균 10.6%씩 증가하였다. 이러한 시장의 성장과 함께 건강기능식품 섭취로 인한 이상사례 역시도 꾸준히 증가하고 있는 추세로 2006년부터 2018년 7월까지 건강기능식품 이상사례 신고센터에 5,127건이 신고되었다. 본 연구에서는 이 신고내역의 세부 증상으로 10,370건을 분류하여 이 중 간 기능과 관련된 440건과 관련된 57가지 기능성 원료를 도출하였고, 이상 증상 신고 건수 상위 5가지 원료에 대한 복합 병용 섭취에 대한 학술 문헌과 세포 시험을 진행하였다. 대상으로 선정된 백수오등복합추출물, 가르시니아캄보지아추출물, 녹차추출물, 알로에전잎추출물, 쏘팔메토열매추출물의 간독성과 관련된 학술자료에서는 5가지 원료별로 과량 또는 복합 섭취에 대한 자료들이 보고되고 있고, 세포 손상 실험을 MTT assay를 통해 확인했을 때 녹차추출물과 다른 기능성 원료를 복합 처리한 군(B, E, H, I)의 세포독성이 유의적으로 증가하였고(P<0.05), cell death를 trypan blue assay로 확인한 결과, 녹차추출물에 가르시니아캄보지아추출물이나 백수오등복합추출물 또는 알로에전잎을 복합 처리한 군(B, E, H)의 cell viability가 단독 처리군에 비해 유의적으로 감소한 것으로 나타났다(P<0.05). 세포시험의 한계점은 존재하고 있으나, in vitro 연구를 통해 원료 간 상호작용을 평가할 수 있는 데이터 축적이 필요하고, 고시형 및 개별인정형 기능성 원료의 복합 섭취로 인한 안전성 및 기능성 변화에 관한 평가연구가 지속해서 필요할 것으로 보인다.
Benzethonium chloride에 의한 알레르기성 접촉피부염 1예
강권수,박천욱,이철현 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.4
Benzethonium chloride is quaternary ammonium compounds, which may cross-react with benzalkoniurn chloride. It has been used in the treatment of burns, ulcers, wounds. and infected dermatoses and also present in many cosmetics, deodorants, mouthwashes, dentifrices, lozenges, and ophthalmic preparations. Cetostearyl alcohol is used as emulsifiers and can be considered as preservatives. A 19-year-old female presented with well-demarcated adult-fist sized dark-reddish patch on the left shin. She had applied Senepul® (disinfectant solution) 3 months ago due to scratching wound and applied Travogen®. Patch test with Korean standard series and the ingredients of used topical agents showed positive reactions to benzethonium chloride and cetostearyl alcohol. (Korean J Dermatol 2003;41(4) : 527~529)
강권수,전진곤,한희진,박천욱,이철헌 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7
Shiitake (Lentinus edodes) is nowadays the second most commonly produced edible mushroom in the world. Two patients complained of severe itching and showed widespread disseminated very small erythematous papule and characteristic linear grouped erythematous papules after scratching (Ko¨bner phenomenon). Here we report two cases of mushroom intolerance which developed after ingestion of boiled or cooked shiitake mushrooms. (Korean J Dermatol 2003;41(7) : 974~976)
Minoxidil 외용액에 의한 알레르기성 접촉피부염 1예
강권수,이보현,한희진,박천욱,이철헌 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.4
Minoxidil (2, 6-diamino-4-piperidinopyrimidine 1-oxide) is a systemic antigypertensive agent, the topical application of which has been shown to produce hair growth. Topical minoxidil solution (5% minoxidil, propylene glycol, alcohol, water) has generally been well-tolerated, but allergic contact dermatitis has been reported. When allergic contact dermatitis to minoxidil solution is suspected, evaluation of ingredients of minoxidil solution should be performed because allergic contact dermatitis due to propylene glycol in minoxidil solution has been frequently reported. A 34-year-old male presents with a diffuse erythematous patch on the scalp. He has applied minoxidil solution for 7 days due to androgenic alopecia. A Patch test with Korean standard series and the ingredients of used topical agents showed positive reactions to 1%, 2% and 5% minoxidil solution. (Korean J Dermatol 2004;42(4):500~502)
강권수,김현욱,박천욱,이철헌,안혜경 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.8
We report a 6-year-old male with primary hypercholesterolemia who had tuberous xanthoma. Yellowish nodules first appeared on the knees 3 years ago and gradually increased in size and number and also occurred on the left elbow. The laboratory findings showed markedly increased serum cholesterol and slightly increased triglyceride. Serum lipoprotein electrophoresis showed a marked increase in beta-fraction, suggesting type Ⅱ hyperlipoproteinemia. Histopathology showed many aggregates of foam cells in the dermis and subcutaneous fat. (Korean J Dermatol 2003;41(8) : 1105~1107)