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아스피린 과민성 천식 환자에서 아스피린 기관지유발시험 전후의 혈청 호중구 화학주성능과 myeloperoxidase치의 변화
박해심,김희연,남동호,강경령,정기석,김선신 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.2
Background: There have been few reports suggesting involvement of mast cell and neutrophil to induce bronchoconstriction in aspirin-sensitive asthrna. Objective:To evaluate mast cell and neutrophil activation in pathogenesis of aspirin-sensitive asthma. Material and methods: We observed changes of serum NCA and MPO levels during L-ASA bronchoprovocation test in 14 subjects with aspirin-sensitive asthma. Results: Serum NCA was significantly increased at 30 min(p=0.01) after the inhalation of L-ASA and then, no significant changes were noted at 240 min (p=0.14). NCA was significantly higher in subjects with late asthmatic responses than in those without it (p=0.04). Serum MPO level tended to increase at 30 min with no statistical significance (p=0.08), and then it significantly decreased at 240 min (p=0.05). There was no significant correlation between serum NCA and MPO level (r=0.22, p=0.58). Conclusion: These results support the view that NCA derived from mast cell may contribute to neutrophil recruitment into the airway in aspirin-sensitive asthmatic patients.