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김시영,고근아,윤휘중,조경삼 대한내과학회 1991 대한내과학회지 Vol.40 No.3
The development of leukemia during pregnancy is uncommon. Since acute leukemia is potentially curable, best available regimen should be used. But management decisions are difficult and data is not so much. One important consideration is the potential effect of chemotherapy on fetus. This, 23 years old female patient was successfully treated for ALL from second trimester of pregnancy and deliverd a 2,500 male infant through normal vaginal delivery at the 36th gestational week.
PCR 을 이용한 인슐린 수용체 β - 소단위의 DNA 측정에 관한 연구
최웅환(Woong Hwan Choi),유계수(Ge Soo Yoo),고근아(Keun Ah Koh),정형진(Hyung Jin Chung),김해엽(Hae Youp Kim),신현호(Hyun Ho Shin),한인권(In Kwon Han),문인걸(In Gul Moon) 대한내과학회 1991 대한내과학회지 Vol.40 No.6
N/A Insulin resistance is one of the most important mechanisms of type II diabetes, which may result from acquired or genetic abnormalities in the pathway of insulin action. As the develoment of cloning method of human insulin receptor precursor cDNA, it has become possible to investigate the insulin receptor at the genetic level. We used the modified PCR technique method that permitted us to employ small amounts of cellular RNA as the initial template to amplify the region that encodes the intracellar β-subunit of the human insulin receptor and C-terminal region of β-subunit. We think that this PCR method will facilitate a definite determination to what degree insulin resistance can be ascribed to genetic alterations in the structure of the insulin receptor molecule in type II diabetes.