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고흥선,이우재,마용,Koh, Hung-Sun,Lee, Woo-Jai,Ma, Yong The Korean Society of Systematic Zoology 1996 Animal Systematics, Evolution and Diversity Vol.12 No.3
중국과 한국에 서식하는 흰넓적다리붉은쥐(Apodemus Peninsulae) 3아종의 표본들의 4개 외부형질과 27개 두골형질들을 다변량통계 방법으로 분석하였다. 4개형(form)으로 나뉘 어졌는데, 한국의 월악산과 연천의 아종 peninsulae와 중국의 길림과 흑룡성의 아종 praetor 는 가장 큰 형이며, 중국 내몽고의 아종 praetor와 중국 산서와 산동성의 아종 sowerbyi는 큰형이고, 중국 북경의 아종 sowerbyi는 중간 형이며, 중국 신강성의 아종 sowerbyi는 작은 형이었다. Corbet(1978)는 아시아 대륙내의 흰넓적다리붉은쥐의 분포범위에서는 2아종 (peninsulae and sowerbyi)으로 분류된다고 하였지만, 형태적 형질을 이용한 본 연구에서 아 종 praetor와 peninsulae가 큰 형이었고, 아종 sowerbyi는 3개의 형태로 나뉠 정도로 다양했 으므로, 단지 2아종으로만 분류할 수가 없음이 밝혀졌다. 중국과 러시아의 다른 표본들을 포 함한 계속되는 연구가 본 종의 확실한 분류의 완성을 위해서 필요하다. Four external and 27 cranial characters of Korean field mice (Apodemus peninsulae) from nine regions in China and Korea, representing three subspecies, were analyzed by multivariate methods. Four size-forms were recognized a largest-size form Mt. Weolak and Yeoncheon in Korea (= subspecies peninsulae) and Kirin and Heilung in China (= subspecies praetor), a large-size form from Inner Mongolia in China (= subspecies praetor) and Sanxi and Sandong in China (= subspecies sowerbyi), a middle-size form from Beijing in China (= subspecies sowerbyi), and a small-size form from Xinjiang in China (= subspecies sowerbyi). Although Corbet (1978) recognized only two subspecies in A. peninsulae, subspecies peninsulae and sowerbyi, within its distributional range in the continent of Asia, it was revealed in this study with morphometric characters that A. peninsulae could not be classified simply into two subspecies, because subspecies praetor and subspecies sowerbyi formed the large-size form and because subspecies sowerbyi was so diverse in its morphology as to be composed of three size-forms. Further analyses with the samples from other regions of China and Russia seem to be necessary to clarify the taxonomy of A. peninsulae.
고흥선,장경희,인성택,한의동,조재은,함의정,정선기,이종혁,김광선,권구희 한국동물분류학회 2012 Animal Systematics, Evolution and Diversity Vol.28 No.3
To examine genetic divergences of two endemic Sorex caecutiens subspecies from Korea (S. c. hallamontanus in Korean Jeju Island and S. c. annexus in the mainland Korean Peninsula), we obtained partial cytochrome oxidase I (COI) sequences (429 bp) and complete cytochrome b sequences (1,140 bp) from the two Korean subspecies, and we compared these sequences to the corresponding sequences of S. caecutiens, obtained from GenBank. We found that Jeju S. c. hallamontanus is one of three clades within S. caecutiens, with an average Jukes-Cantor distance of 1.57% in the COI sequences and the distance of 2.07% and 11 fixed site differences in the cytochrome b sequences, indicating that Jeju S. c. hallamontanus is one endemic subspecies with concordant genetic distinctness, although further analyses with nuclear DNA sequences are necessary to confirm these findings. However, S. c. annexus from the mainland Korean Peninsula was not divergent from S. c. macropygmaeus from northeastern China and adjacent Russia, indicating that S. c. annexus from the mainland Korean Peninsula is another endemic subspecies with only morphological differences, although it is necessary to reexamine the subspecies status of S. c. annexus.
고흥선,장경희,오장근,한의동,조재은,함의정,정선기,이종혁,김경선,권구희,인성택 한국동물분류학회 2012 Animal Systematics, Evolution and Diversity Vol.28 No.2
The objective of this study was to determine the degree of mitochondrial DNA (mtDNA) divergence between two subspecies of Mustela sibirica from Korea (M. s. coreanus on the Korean Peninsula and M. s. quelpartis on Jeju Island) and to examine the taxonomic status of M. s. quelpartis. Thus, we obtained complete sequences of mtDNA cytochrome b gene (1,140 bp) from the two subspecies, and these sequences were compared to a corresponding haplotype of M. s. coreanus, downloaded from GenBank. From this analysis, it was observed that the sequences from monogenic M. s. quelpartis on Jeju Island were identical to the sequences of four M. s. coreanus from four locations across the Korean Peninsula, and that the two subspecies formed a single clade;the average nucleotide distance between the two subspecies was 0.26% (range, 0.00 to 0.53%). We found that the subspecies quelpartis is not genetically distinct from the subspecies coreanus, and that this cytochrome b sequencing result does not support the current classification, distinguishing these two subspecies by pelage color. Further systematic analyses using morphometric characters and other DNA markers are necessary to confirm the taxonomic status of M. s. quelpartis.
고흥석,김방수,한병철,김윤석,조진수,박정근,송태의,서상렬,마경란 대한내과학회 1996 대한내과학회지 Vol.50 No.4
Paroxysmal nocturnal hemoglobinuria(PNH) is a rare, nonfamilial disorder of insidious onset and chronic course characterized by abnormal sensitivity of blood cells to the lytic action of complements. This disorder is associated ith a striking predisposition to intravenous thrombosis, of which fatal thrombosis usually involve the brain or portal system. However, arterial thrombosis is rare, and PNH shoud be considered among the unusual causes of ischemic cerebral infarcts in young adults. We experienced a case of cerebral arterial thrombosis associated with PNH in 36-year-old women patient complained of left hemeplegia and easy fatigability for about 17years. Ham's test showed positive reaction of 25% hemolysis. Our patient showed signs of reght middle and anterior cerebral arterial occlusion: this was documented by computed tomographic (CT) scan, magnetic resonance image (MRI) and magnetic resonance(MR) angiography. We present this case with a review of the literature.
Ehrlich 복수암의 피하이식에 대한 능동면역 생쥐의 비장 및 장간막 임파절의 반응
고흥수,박희설,홍재흥 최신의학사 1972 最新醫學 Vol.15 No.9
It is a well known fact that immunotherapy of tumor consists of active immunization, passive immunization, adoptive immunization and treatment with immunogeneic nucleic acids. It has now been firmly established that active immunization of a susceptible animal with live tumor cells given in subliminal dose, with properly killed tumor cells, or with the oncogenic virus establishes immunity and solid resistance to challenge with either the oncogenic virus or with tumor cells. Kown and Kim (1972) observed a high level of immunity was produced in mice against subcutaneously implanted Ehrlich carcinoma by mounting of diffusion chamber containing live tumor cells and suggested the immunity produced by live tumor cell was cell--mediated. It is also a well known fact that in the cell-mediated immune reaction a small thymus-dependent lymphocyte transforms into a large pyroninophilic cell at the thymus-dependent area-paracortical area of the lymph node and periarterial sheath of the spleen, in response to antigen, which will elicit either a delayed hypersensitivity reaction or an allograft rejection response (Parrott et al. , 1966). In this paper we made an attempt to observe the response of thymus-dependent area both of t .e spleen and the lymph node of the survived mice following active immunization with live Ehrlich ascites tumor cell in intraperitoneally mounted diffusion chamber against subcutaneously challenged tumor. The results were as follows: Proliferation of large lymphoid cells in periarterial sheath of the spleen and paracortical area of ! i the mesenteric lymph node and tile development of paraccri.cal area of the nicserteric lymph node was prominent in the survived mice 40 days after subaxiilar challenge. of E arlich ascites tumor, which is inoculated 4 or 5 weeks after mounting or 2 weeks after removal of mounted diffusion chamber for 1 or 2 week duration.
1LM-6 Conformal transfer printing based on ultrathin electronic device
고흥조 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Fabrication of ultrathin electronic devices followed by transfer printing enables ‘stick-and play’ system that provides high performance electronic functionalities to desired surfaces. Regarding the related transfer printing, there are several challenging issues. In relation to picking up a desirable layer and placing it onto a desired surface, perfect transfer yield with no change of position and no crack formation is of great importance. Second, when surface mismatch occurs between printable formats and receiving substrates, development of a means to allow conformal transfer printing is also important. This presentation will address these issues.