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許康茂 전북대학교 법학연구소 2002 法學硏究 Vol.23 No.-
Recently the higher the political·economic importance of a subsidy, the more making a demand an administrative reform such as arrangement and rationalization of subsidy. Nevertheless a statue which is disciplined subsidy is exceedingly scanty , the management which is left to administration's discretion in actual fact don't practical expost facto control in that financial loss grows heavier, whereas the control of a national assembly gradually reduces. In this reality, it is necessary viewpoint that the legal issue of subsidization solves with focusing on legal control with usual discussion - a form of an act of subsidizaton and the existence·nonexistence of the necessity with legal reservation. That is to say, if we grasp the practical affairs of subsidization that is managed on a large scale extraordinarily without legal basis, we need to investgate 'regulative law' and 'the principal of control' which secured impartiality, such as the control of national assembly, administrative process and judical judgment. At this sense of sight, this paper examine the general discussion with subsidization in Chapter 2, I will descirbe the summary contents with legal control and a detaied control system in Chapter 3. In addition to I will argue about, necessities and problems with legal control of subsidization in Chapter 4 shortly.
pH-Sensitive Polymers for Drug Delivery
허강무,배유한,강한창,이영주 한국고분자학회 2012 Macromolecular Research Vol.20 No.3
Various pH-sensitive polymers have been developed for biomedical applications and recently attracted much attention for pH targeting nanomedicine. Recent development of pH-sensitive polymer systems that sharply respond to specific pH environment in solid tumors and cells and demonstrate modulated properties (e.g., triggered drug release at extratumoral pH, ligands or cell penetrating peptides exposure by shielding/deshielding mechanism or by pop-up mechanism, and endosomal pH targeting) have led significant progress in tumor targeting technology. These pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs. This review highlights recent progress of pH-sensitive polymers with special emphasis on pH targeting nanomedicine.