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      • KCI등재

        Caged Pancreatic Islet for IDDM

        배유한 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP

        The goals of this research are to improve the functionality (insulin secretion rate and pattern) and to expand the life-span of immunoprotected pancreatic islets. The low functionality (less than 15% of the insulin release rate of native islets in pancreas) required a large number of islets within the implant, which causes complications in surgery and discomfort for patients. The limited life-span of the islets in a biohybrid artificial pancreas (BAP) may require frequent cell reseeding and cause further supply problems in islet transplantation. Improved islet functionality and prolonged life-span will minimize the volume of the BAP by reducing the number of islets needed for diabetic patients to achieve normoglycaemia and reduce problems associated with islet supply. It is hypothesized in this research that 1) by mimicking facilitated oxygen transport in avascular tissues, the immunoprotected islets release a higher amount of insulin, recover their intrinsic biphasic release pattern, and prolong their life-span, and 2) insulinotropic agents further promote insulin secretion from islets. Based on these hypotheses, a new BAP system will be designed which contains the water-soluble polymeric conjugates of oxygen carriers (or oxygen binding vehicles) and islet stimulants of sulfonylurea compounds and glucagon-like insulinotropic peptide-1 with entrapped islets in the BAP. The research examines their effects on islet viability, the amount of insulin secretion, the insulin release profile, and the life-span of immunoprotected pancreatic islets. Especially, the combined synergy effects of both hypotheses will be emphasized. The successful results in improving functionality and life- span of islets entrapped in an immunoprotected membrane can be applied in the delivery of microencapsulated therapeutic cells and to the miniaturization of a BAP. In addition, the approaches proposed in this research will provide a potential solution to the shortage problem of human cell or tissue sources.

      • A Case of Trauma-Induced Single Xanthelasma Palpebrarum

        배유,심지훈,양정훈,이상훈,박영립 순천향대학교 순천향의학연구소 2011 Journal of Soonchunhyang Medical Science Vol.17 No.2

        A 33-year old Korean man visited our department complaining of single mildly pruritic yellowish flat-topped papule on left upper eyelid. Lipid profile including low density lipoprotein-cholesterol and triglyceride level was above normal range. He remembered that the site was scalded by boiling oil about eight months ago. The patient was diagnosed with xanthelasma palpebrarum (XP)based on the clinical and histopathological findings, including diffuse infiltrate of large, pale-staining cells which have abundant foamy cytoplasm in the dermis. He was treated with CO2 laser ablation followed by application of 70% trichloroacetic acid with wooden stick. After a month, the skin lesion showed moderate improvement with disappearance of yellowish color and flattopped elevation. So far, case of XP developed after minor trauma has not been reported. This case illustrates that minor trauma could be a trigger factor in the development of the disorder.

      • KCI우수등재

        대학의 성평등 증진을 위한 제도적 조건 연구

        배유 한국여성학회 2022 한국여성학 Vol.38 No.3

        Since the 2000s, Korean universities have actively taken measures to accommodate the growing female student population by increasing the number of female faculty, expanding support for female college students in STEM fields, and addressing and providing relief for sexual harassment and violence cases. However, such gender mainstreaming strategies have not worked properly, and there has been no visible agency to promote gender equality. Aware of these problems, the present article investigates theoretical resources useful to explain gender inequality in universities, compares the current level of gender equality in Korean universities with that of academic institutes abroad, and attempts to seek strategies to institutionalize gender equality in universities. It finds that Korean universities continue to have smaller proportions of female students, female faculty, women in STEM fields, and female leaders compared to the universities abroad. The proportion of female deans or presidents proves to be meaningless, with no structural attempt to institutionalize gender in university evaluations. Governmental organizations and universities need to take action to reform the existing gender equality policies by mainstreaming gender in rules and regulations and institutionalizing a culture of non-discrimination in universities. 2000년대 이후 대학은 늘어난 여학생 숫자에 맞게 여성교원 증원 노력이 적극적 조치와 함께 추진되었고, 이공계열의 여대생 지원 확대, 성희롱ㆍ성폭력에 대한 문제제기와 피해 구제 등이 이루어졌다. 하지만 대학에서 성평등 정책은 제대로 자리 잡지 못하면서 주변적인 의제로 남아 있다. 본 논문은 이러한 문제의식을 바탕으로 세 가지 과제를 살펴보았다. 첫째, 그동안 대학의 성불평등 해소 전략으로 어떤 논의들이 이루어졌는지를 알아보았다. 둘째, 현재 한국 대학의 성평등 수준은 해외 대학들과 비교하여 어느 단계에 와 있는가를 주요 성평등 지표를 가지고 비교해 보았다. 마지막으로 대학의 성평등 증진을 위하여 현재의 제도적 조건을 짚어보고 필요한 전략을 찾아보았다. 국내 대학의 성평등 수준은 해외 대학과 비교하여 여학생 비율, 여성교원 비율, 이공계열 여성 비율, 리더십의 대표성 등이 여전히 낮았다. 주요보직, 그중에서도 총/학장의 비율은 비교가 무의미한 수준이며, 제도화 면에서 이렇다 할 추진체계가 갖추어져 있지 않았다. 교육부가 주관하는 대학평가 역시 성인지 관점이 반영되어 있지 않고, 국립대학을 대상으로 별도의 평가가 이루어지는 데 그쳤다. 대학의 성평등 증진을 위해서는 정부의 적극적인 개입, 개별 대학의 추진체계 정비와 규정 마련, 차별금지 제도화와 문화 개선 노력이 시급하다.

      • KCI등재

        화학용액 증착법으로 제조된 희토류 금속으로 치환한 Bi(Fe0.975Cu0.025)O3-δ 박막의 전기적 특성

        배유,김진원,김상수 한국물리학회 2012 New Physics: Sae Mulli Vol.62 No.8

        Pure 순수한 BiFeO_3(BFO),(Bi_(0.9)Dy_(0.1))(Fe_(0.975)Cu_(0.025))O_(3-δ)(BDFC) and (Bi_(0.9)Eu_(0.1))(Fe_(0.975)Cu_(0.025))O_(3-δ)(BEFC) thin films were prepared on Pt(111)/Ti/SiO_2/Si(100) substrates by using a chemical solution deposition method. The coated thin films were annealed at 550℃C for 30 min under a nitrogen atmosphere by using a conventional annealing process and the changes in the micro-structure and the electrical properties with doping were investigated. The micro-structure of the thin films was characterized by means of X-ray diffraction, Raman scattering spectroscopy and scanning electron microscopy. The BDFC and the BEFC thin films exhibited good hysteresis characteristics. The values of the remnant polarizations (2P_r) and the coercive fields(2E_c)of the BDFC and the BEFC thin films were 52 μ/C㎠ and 849kV/cm and 49 μC/㎠ and 981 kV/cm at an electric field of 935kV/cm, respectively. The leakage current densities of the BFO, BDFC and BEFC thin films were 2.60 × 10^-3 A/㎠, 2.07× 10^-4 A/㎠ and 4.45 × 10^-5 A/㎠ at an electric field of 100 kV/cm, respectively. Also the values of the dielectric constants and the dielectric loss of the BFO, BDFC and BEFC thin films were 121 and 0.049, 140 and 0.037, and 135 and 0.040at a frequency of 1 kHz, respectively. The improved electrical properties could be explained by the reduction of oxygen vacancies due to the substitution of Dy^3+, Eu^3+ and Cu^2+ions into BFO and by a change in the micro-structure. 순수한 BiFeO_3(BFO) 박막과 BiFeO_3의 Bi^(3+)이온 일부를Dy^(3+)또는 Eu^(3+)이온으로 치환하고 Fe^(3+)이온일부를Cu^(2+) 이온으로 동시에 치환한(Bi_(0.9)Dy_(0.1))(Fe_(0.975)Cu_(0.025))O_(3-δ)(BDFC),(Bi_(0.9)Eu_(0.1))(Fe_(0.975)Cu_(0.025))O_(3-δ)(BEFC)박막을 Pt(111)/Ti/SiO_2/Si(100) 기판 위에 화학 용액 증착법으로성장시켰다. 성장시킨 박막들은 550℃의 질소 분위기에서 통상적인방법으로 열처리 하였으며 치환에 따른 박막의 미세구조와 전기적 특성변화를 측정, 비교 분석 하였다. BDFC와 BEFC 박막의 전기적 특성이순수한 BFO 박막에 비해 크게 향상되었는데 외부 전기장이 935 kV/cm 일때 잔류 분극(2P_r)과 항전기장(2E_c) 값은 각각 52 μC/㎠과 849 kV/cm, 49 μC/㎠ 과 981 kV/cm이었다. 또 외부 전기장이100 kV/cm 일 때 BFO와 BDFC, BEFC 박막의 누설 전류 밀도는 각각 2.60× 10^{-3} A/㎠과 2.07× 10^-4 A/㎠, 4.45× 10^-5} A/㎠이었으며, 1 kHz에서 측정한 유전상수와유전 손실 값은 각각 121과 0.049, 140과 0.037, 135와 0.040이었다. 이처럼 동시 치환한 박막들이 좋은 전기적 특성을 보이는 것은 치환에의해 산소 빈자리 수의 감소가 일어났기 때문이라고 보여진다.

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