Polymeric Systems for Biohybrid Artificial Organs

배유한 한국고분자학회 1995 한국고분자학회 학술대회 연구논문 초록집 Vol.1995 No.4

생체복합인공췌장을 위한 고분자재료의 설계

배유한 한국공업화학회 1998 한국공업화학회 연구논문 초록집 Vol.1994 No.1

Insulin delivery system

배유한 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1

조직공학기법의 인공장기

배유한 한국고분자학회 1999 고분자 과학과 기술 Vol.10 No.4

Caged Pancreatic Islet for IDDM

배유한 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP

The goals of this research are to improve the functionality (insulin secretion rate and pattern) and to expand the life-span of immunoprotected pancreatic islets. The low functionality (less than 15% of the insulin release rate of native islets in pancreas) required a large number of islets within the implant, which causes complications in surgery and discomfort for patients. The limited life-span of the islets in a biohybrid artificial pancreas (BAP) may require frequent cell reseeding and cause further supply problems in islet transplantation. Improved islet functionality and prolonged life-span will minimize the volume of the BAP by reducing the number of islets needed for diabetic patients to achieve normoglycaemia and reduce problems associated with islet supply. It is hypothesized in this research that 1) by mimicking facilitated oxygen transport in avascular tissues, the immunoprotected islets release a higher amount of insulin, recover their intrinsic biphasic release pattern, and prolong their life-span, and 2) insulinotropic agents further promote insulin secretion from islets. Based on these hypotheses, a new BAP system will be designed which contains the water-soluble polymeric conjugates of oxygen carriers (or oxygen binding vehicles) and islet stimulants of sulfonylurea compounds and glucagon-like insulinotropic peptide-1 with entrapped islets in the BAP. The research examines their effects on islet viability, the amount of insulin secretion, the insulin release profile, and the life-span of immunoprotected pancreatic islets. Especially, the combined synergy effects of both hypotheses will be emphasized. The successful results in improving functionality and life- span of islets entrapped in an immunoprotected membrane can be applied in the delivery of microencapsulated therapeutic cells and to the miniaturization of a BAP. In addition, the approaches proposed in this research will provide a potential solution to the shortage problem of human cell or tissue sources.

피부에 국한된 다발성 Rosai-Dorfman Disease

배유인 ( You In Bae ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),윤숙정 ( Sook Jung Yun ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.4

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is an idiopathic, benign, self-limited, histiocytic proliferative disease confined mainly to cervical lymph nodes. The disease is usually accompanied by massive bilateral lymphadenopathy, fever, elevated erythrocyte sedimentation rate, leukocytosis with neutrophilia, and polyclonal hypergammaglobulinemia. Although cutaneous manifestations are observed in 10% of patients, pure cutaneous RDD without any nodal or systemic involvement is very rare. We report a case of pure cutaneous RDD occurring in a 37-year-old man with asymptomatic erythemaotus to yellowish multiple widespread nodules and tumors on the face and trunk. Histopathologic examination characteristically showed a diffuse infiltrate composed of large histiocytes exhibiting emperiopolesis and mixed inflammatory cells including many plasma cells. Immunohistochemically, these histiocytes were positive for S-100 protein and CD68, but negative for CD1a. During 2 years of follow-up, the patient showed neither nodal nor systemic involvement of the disease and the skin lesions gradually disappeared. The final diagnosis was made by typical cutaneous manifestations without nodal or extranodal involvement and histopathological findings compatible with RDD. (Korean J Dermatol 2010;48(4):300~305)

Imatinib Mesylate (Gleevec(TM))에 의한 건선양 약진

배유인 ( You In Bae ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6

Imatinib mesylate (GleevecTM, formerly known as STI571) is an oral drug that selectively inhibits bcr-abl, c-kit and platelet-derived factor receptor (PDGFR) tyrosine kinase. It has been used for treating chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors. Various adverse cutaneous reactions have been reported, yet the development of psoriasis or a psoriasiform drug eruption by the drug has rarely been reported. We herein report on a case of psoriasiform drug eruption that developed after administering imatinib mesylate to treat CML. (Korean J Dermatol 2009;47(5):722∼725)

지방 거버넌스와 제도주의적 시각:이론, 유형 및 비교연구

배유일 고려대학교 정부학연구소 2003 정부학연구 Vol.9 No.2

최근 개념적 혼란을 겪고 있는 거버넌스의 개념은 어떤 전략이나 통치운영의 양식이라기보다는 사회문제 해결과정에서 전통적 정부의 역할이 점차 변화되고 비정부부문 행위자들의 역할이 점차 강화되는 하나의 과정(process)으로 이해되어야 한다. 유럽학자들에 의하여 도입되어 미국에서도 점차 주도적 이론으로 등장하고 있는 거버넌스는 미국적 상황설명에 적합한 성장기구론(growth machine theory)과 레짐이론(regime theory)의 틀에서 벗어나 기존의 지방정치 연구를 통합할 수 있는 기초를 제공한다. 특히, 지방정치 현상은 단지 지방의 현상이 아니고 국가 및 초국가(supranational)의 영향뿐 아니라 공-사부문의 특성의 영향을 크게 받는다는 점에서 지방 거버넌스의 제도적 맥락(institutional context)에 대한 이해가 강조되고 있는데, 방법론적으로도 다층분석(multilevel analysis)이 이루어져야 한다. 본 연구에서는 최근 지방정치 연구의 핵심으로 떠오르는 지방 거버넌스와 신제도주의적 시각에 관한 비판적 분석을 통해 한국 및 비서구국가에 적합한 거버넌스 모형의 가능성을 제시하였다. Recently a growing body of literatures explores the limit of state and government authority and seeks to develop a more diverse view of state-private-nonprofit relationship. Those attempts explaining the changes in societies have been integrated into the scope of ‘governance theory,’ which was initiated by European students, and has become popular in the United States. The most significant development in advanced and newly industrialized economies over the past couple of decades has been the transformation of traditional image of government and political power, and the growth of private and non-profit sector in solving governance issues. Governance is multi-layered and cross-sectoral phenomena at all levels, and in the local societies, urban regime theory and growth machine theory has been predominant among a large set of explanations of local governance. However, the monopoly of two theories is in doubt in terms of the possibilities of crossnational comparison, and thus to improve comparativity of the two theories recent comparativists emphasize institutional analysis of nation- specific local governance. This paper reviews these current debates concerning comparative local governance, and attempts to suggest multilevel analysis of local governance and institutional aspect of non-western settings such as East Asian countries.

환경 변화와 지역 공동체의 관점에서 바라본 토지횡령(land-grabbing) 사안에 대한 고찰 : 말라위 드왕그와(Dwangwa) 지역 사탕수수 산업과 카옹고지(Kaongozi) 공동체 사례를 중심으로

배유진(Bae, Yuh Jin) 한국아프리카학회 2019 한국아프리카학회지 Vol.56 No.-

토지횡령(land-grabbing)은 아프리카 내에서 가장 주목받는 사안 중 하나다. 특히, 2008년 급상승한 국제 식량 가격과 원유 가격은 선진국들과 신흥 개발국들로 하여금 그들의 식량 안보 및 에너지 안보 해결을 위한 방안을 빠르게 강구하도록 이끌었고, 아프리카 국가들의 토지를 사용하는 것이 하나의 해결방안으로써 대두되어 토지횡령에 대한 이슈가 더욱 커졌다. 대부분의 기존 토지횡령 연구는 토지횡령자를 규명하는데 집중하고, 공동체의 불만이나 경제적 손실에 대해 간략하게 설명한다. 이는 토지횡령으로 인해 가장 직접적인 영향을 받는 공동체의 목소리가 제대로 반영되지 않는다는 것이며, 토지횡령 연구의 결여점이다. 본 연구는 말라위의 사탕수수 재배 지역인 드왕그와(Dwangwa)에서 설탕 산업으로 인해 강제 이주를 경험한 카옹고지(Kaongozi) 공동체의 시각에서 토지횡령를 해석함으로써 기존 토지횡령 연구의 결여점을 보완하고 앞으로 나아갈 방향을 제시하는데 목적을 둔다. 본 연구는 카옹고지 지역 공동체에 있어 토지횡령이나 이주라는 용어의 중요성이 크지 않고, 이들의 불만과 경제적 고통의 원인이 ‘토질’이나 ‘지형’과 같은 일차적인 환경 차이, 혹은 변화에서 비롯되었다는 것을 규명했다. 토지횡령은 경제적 논리를 넘어 마리팽가(Malipenga), 치오다(chioda) 춤과 같은 전통과 문화의 소멸을 초례하고 있다. 또한, 공동체들에게 있어 토지 횡령자의 규명보다 현재 이들이 처한 상황을 개선해 줄 수 있는 행위자가 더 중요하다. 기존 토지횡령 연구들이 이런 중요한 사안들을 규명하지 못한 이유는 전반적으로 이들이 공동체들이 이주했던 과거의 상황과 횡령자 규명에만 집중하고 있고, 공동체의 시각이나 목소리를 제대로 반영하지 않기 때문이다. 이는 전반적인 토지횡령 연구가 과거의 정치·경제적 시각에서 벗어나 공동체의 사회·문화적 측면에서 해석하는 새로운 단계로 나아가야 한다는 것을 시사한다. 이런 진전이 이루어질 시 전통·문화의 소멸과 변화와 같은 새로운 주제와 융합되어 한 단계 진보한 연구주제로 나아갈 수 있을 것이다. Since 2000, land-grabbing issues in Africa have been receiving increased attention. Most existing studies focus on analyzing the main actors which contributed to land-grabbing. Unfortunately, it is often the case that the communities’ perspectives are not fully analyzed. Accordingly, this quantitative study aims to analyze land-grabbing issue from the perspective of the community. By conducting in-depth interviews with Kaongozi community in Malawi, it endeavoured to discover points that may have been missing(or absent) in previous land-grabbing studies. This study finds that the biggest challenge the Kaongozi community faced since their displacement from the previous settlement(Matiki) was environmental change. Poor soil condition and rocky topography in Kaongozi changed how they identify themselves from ‘Matiki community’ to ‘poor people’. Further, the performance of their traditional dance such as Malipenga and Chioda has also ceased following their forced relocation. In other words, land-grabbing has also influenced the community’s culture. Additionally, the community did not identify a specific actor as the cause of their displacement but a combination of different actors. However, they did not appear to attach great importance to finding the actual land-grabber but rather to an individual or individuals that could provide compensation for the hardship they experienced. From this study it can be concluded that existing studies miss out on many important points as they ignored communities’ perspective on land-grabbing. And the key reason behind it is because researchers still tend to focus on at the time when the displacement occurred. This naturally makes them continue to focus on finding the land-grabber. It is time for researchers to move to the next phase of land-grabbing studies which is to focus on communities’ perspective. This will not only enrich the study but also can bring about new research topic by relating land-grabbing and loss of traditions and culture as found in this study.

진공증착 방법을 이용하여 제작한 크롬 박막의 전기전도 특성

배유리 ( Yuri Bae ),홍기민 ( Kimin Hong ) 충남대학교 기초과학연구원 2021 충남과학연구지 Vol.38 No.1

We made use of a thermal evaporation method to fabricate high purity Cr thin films. The electrical resistivity of the films was measured between 80 and 500 K by using a Hall effect measurement system. The variation of the resistivity strongly depended on the film thickness and species of the substrate. In general, thick Cr films exhibited metallic properties while relatively thin films showed semiconducting behavior.