受動的 體位變化에 따른 循環 및 呼吸反應에 미치는 副交感神經 遮斷劑의 影響

全相年,蔡義業 慶北大學校 醫科大學 1979 慶北醫大誌 Vol.20 No.2

Orthostasis에 미치는 부교감신경 차단제의 영향을 추궁하기 위하여 thiopental sodium으로 마취한 실험동물을 경사대에 고정한 후 수동적으로 수평, 기립 및 도립위로 체위를 변화시키면서 각 체위에서 10분간 분시심박수, 평균혈압, 중심정맥압, 분시호흡수, 뇌파 및 혈액의 호흡개스와 pH에 대하여 측정하여 무처치 정상대조군과 atropine 투여군을 비교 관찰하였다. 분시심박수는 atropine투여군에서 비투여군에 비하여 기립시에 증가하는 경향이었다. 도립시에는 양군이 다같이 감소하였으나 atropine 투여군에서는 그 감소의 정도가 적었다. atropine 투여군은 평균혈압이 기립시에 비투여군에 비하여 상승되었고 도립시에는 혈압하강의 정도가 적었다. 기립시에 비투여군의 혈압은 매우 감소하였다. 중심정맥압은 atropine 투여군은 수평위에서 감소하였으며 기립위에서는 양군이 다 같이 감소하였으나 atropine 투여군에서 감소율이 적었다. 도립위에서 양군이 다 같이 증가하였으나 그 증가율이 atropine 투여군에서 더 높았다. 분시호흡수는 atropine 투여군은 비투여군에 비하여 호흡수가 증가하였고 체위변화시의 호흡수 변화는 기립시에는 양군이 다 감소하였으나 atropine 투여군은 감소율이 적었다. 도립시에는 양군이 다 같이 증가하였으나 atropine 투여군은 그 변화가 적었다. 즉 체위변화에 의한 호흡수의 변화는 atropine 투여군이 비투여군에 비하여 변화율이 적었으며 호흡수가 안정되어 있었다. atropine 투여시 혈액의 pH 및 호흡개스분압의 각 체위변화에 따른 결과는 다음과 같다. 혈액 pH는 도립시 약간 증가하였으며 Paco_2는 기립시 증가하고 도립시 감소하였으며 Pvco_2는 기립 및 도립시에 다같이 증가하였다. Pao_2는 기립시 감소하였으며 Pvo_2는 기립 및 도립위에서 감소하였다. 뇌파는 양군이 다 같이 마취의 영향에 의하여 서파(slow wave)가 우세하였으며 atropine 투여군은 체위변화 초기에 속파(β파) 출현이 많았으며 기립 및 도립에서 뇌파의 파고 감소는 atropine 투여군이 적었다. 부교감신경 차단제의 효과는 투여군의 중심정맥압의 대조치가 처음에 감소하는 것을 제외하고는 orthostasis를 방지하는데 효과적이라고 생각된다. To evaluate the effect of atropine on the orthostatic tolerance with blocking of cholinergic cardiac inhibitory fiber of the vasovagal reflex, and the prevention from the stress relaxation of peripheral vessel in gravity dependent region with blocking of cholinergic vasodilator fiber in the skeletal muscle, we injected 30∼60 ㎍m/kg, body weight of atropine sulfate to experimental animals previously, and compared the findings of the atropine injected animal with the control animal by the orthostatic tolerance in the passive tilt. Aneshetized dogs were tilted from supine to 90°upright and 90°head down position. Measurements were made of heart rate (HR), mean blood pressure (BP), central venous pressure(CVP), respiratory rate(RR), EEG, and Po_2, Pco_2 and pH of blood before, during, and after each postural change on 20 dogs after parasympathetic blockade. On atropine, HR increased in supine and increased further in upright. HR decreased in head down in both atropine and the controls. However HR was less affected on atropine. BP increased on atropine in supine. BP was less decreased in upright and head down on atropine while BP markedly decre ased in upright in the controls. CVP decreased on atropine in supine, and CVP decreased in upright in both groups. However CVP was slightly changed on atropine. CVP increased in head down in both groups. However CVP was more increased on atropine. RR increased on atropin in supine, RR decreased in urpight in both groups. However RR was less decreased on atropine. RR increased in head down. On the other hand, RR was less increased on atropine. In addition Pao_2 rose substantially in head down in both groups, but the finding shows that Pao_2 stayed relatively unchanged on atropine. Diminution of amplitude and frequency of EEG in upright and head down is less marked on atropine. It is concluded that atropine has no clear cut effect on cardiorespiratory responses to tilt except for its BP effect.

Steady State Hypoxia의 심맥관계 및 호흡반응

전상년,배성호,김규수 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.1

In order to observe an adaptation process of living body to hypoxia, cardio-pulmonary changes were observed for 50 minutes in moderate hypoxia. Hypoxia was induced by inhalation of a gas mixture with 12% O_2 and 88% N_2 gas. Experimental animals were 18 adult mongrel dogs having average weight of 14 kg. Animals were anesthetized with the thiopental sodium. 10 animals were observed with continuous and simultaneous records of heart rate, blood pressure, central venous pressure and respiration rate, and the other 8 animals were measured for oxygen consumption, tidal volume, minute ventilation, respiration rate at 15 to 20 minutes, 35 to 40 minutes and 45 to 50 minutes after inhalation of low oxygen gas mixture. The measurements in hypoxia was compared with the control data obtained in the room air. Heart rate was maintained higher until 30 minutes after exposure to hypoxia but it returned almost to the normal control at 50 minutes. Blood pressure was gradually decreased. Central venous pressure showed no changes. Respiration rate was maintained higher until 30 minutes but returned to the control value at 50 minutes. Oxygen consumption and tidal volume were gradually decreased. From above results the better compensation to moderate hypoxia as the steady state hypoxia was demonstrated. Despite of minimum changes of respiratory responses, general cardio-pulmonary functions were assumed to be regulated properly except a tendency of decreasing blood pressure that was a specific phenomenon in steady state hypoxia.

Steady State Hypoxia의 심맥관계 및 호흡반응

전상년,배성호,김규수 慶北大學校 醫科大學 1974 慶北醫大雜誌 Vol.15 No.1

子宮內飜症의 1例

李台鎬,全相年,安鍾豪,朴在錫,金元宰 慶北大學校 醫科大學 1969 慶北醫大雜誌 Vol.10 No.2

若年者의 卵巢腫瘍

朴在錫,全相年,洪君植,鄭奇俊,李台鎬 慶北大學校 醫科大學 1970 慶北醫大誌 Vol.11 No.1

Ovarian tumors in children present difficult problems in diagnosis and management. Clinicians has difficult problems in distinguishing the functional varients from the pathologic aberrations which make up ovarian tumors in childhood and in distinguishing benign or malignant neoplasms. The authors undertook this study because of clinical survey of juvenile ovarian tumors as observed 40 cases. The results obtained are as follows: 1) The incidence of ovarian tumors under age of 20(1960-1968) was 5.79% of all ovarian tumors. 2) The incidence of benign ovarian cystadenoma under age of 20 was dermoid cyst 43.5%, mucinous cyst 26%, serous cyst 19.5%. 3) Age distribution of juvenile ovarian tumors was between 9-20 years. The tumors occured frequently between 18-20 years. 4) The incidence of malignant ovarian tumors was about 10%. 5) Among the subjective symtpoms complained of by the patient, about 80% noticed abdominal mass, 15% complained of G-I troubles. 6) As to the objective signs among the patients, about 97% noticed abdominal mass. Abdominal tenderness was observed in 27%. 7) Benign ovarian tumors were observed 44.4% in right ovary, 38.8% in left and 16.6% in bilateral ovaries. We can see the greate roccurence of tumors in right ovary in benign ovarian tumors. 8) The size of benign and malignant ovarian tumors were nearly over adult fist size if the lutein cyst was excluded. The mucinous cysts and serous cysts generally were the largest. 9) The incidence of pedicle torsion of all ovarian tumors was 22.4%. 10) The treatment for benign ovarian tumors of 36 cases was unilateral salpingo-oophorectomy in 30 cases and bilateral salpingo-oophorectomy in 6 cases, and for malignant was surgical primarily and the principle of it was total hysterectomy with bilateral salpingo-oophorectomy with or without omentectomy, Abjuvant treatment, X-ray irradiation was applied to all malignant ovarian tumors.

급성일산화탄소 중독이 뇌파에 미치는 영향

채의업,이석강,전상년,김병권 慶北大學校 醫科大學 1978 慶北醫大誌 Vol.19 No.1

급성일산화탄소 중독시의 실험동물의 뇌파의 변화와 회복과정의 양상을 추궁하기 위하여 토끼를 0.2% 및 0.5%의 일산호탄소에 폭로하여 급성일산화탄소 중독을 야기시키고 0.2%농도에서는 100분간, 0.5%농도에선ㄴ 30분간 폭로후에 뇌파 및 호흡곡선을 기록하였다. 뇌파의 유도는 토끼두골에 금속전극을 뇌경막외부에 심어서 쌍극유도로 기록하였다. 급성일산화탄소 중독시의 토끼뇌파는 전반적인 파고감소와 주파(主波)의 주파수(周波數)의 감소가 초래되며 일산화탄소중독 회복기중에 일시적으로 빈도가 느리고 파고가 높은 서파를 관찰했다. 이와같은 변화는 양성 및 음성가속도 폭로시의 토끼 뇌파변화와 급격기압강하시 뇌파변화와 매우 유사한 변화이며 일산화탄소중독에 의한 특이한 변화는 아닌 것 같다. 동일한 일산화탄소 농도하에서도 그 회복 과정의 뇌파의 회복시간은 개체에 따라 약간씩 차이가 있음을 보았다. 이것은 개체의 일산화탄소 중독에 대한 내력(耐力)의 차이라고 생각되며 뇌파회복의 시간 차이의 요인으로서는 대뇌의 저산소증을 초래하는 정도에 좌우된다고 할것이며 일산화탄소 폭로후의 일산화탄소의 조속한 체외배출이 가능한가에 연유한다고 사료된다. In order to observe the effects of the acute carbon monoxide poisoning on experimental animals, rabbits were exposed to the 0.2% and 0.5% carbon monoxide gas mixtures with room air. The duration of the exposure in the 0.2% concentration was 100 minutes and that in the 0.5% concentration was 30 minutes. The EEG was recorded with the fronto-occipital bipolar lead. The stainless steel needle electrodes were implanted extradurally through skull bone. The EEG of rabbits in the acute carbon monoxide poisoning showed a generalized diminished voltage in the amplitude and a slightly decsea&ed frequency in the rhythm of the main waves. During the recovery period the relatively high voltage slow wave activity were observed on several occasions. The above EEG abnormalities were similar to the previously reported EEG findings in the rabbits exposed to the positive(+Gz) and negative acceleratron(-Gz), and the rapid decompression. There are individual variations in the length of the recovery period from the acute carbon monoxide posioning at the same concentration of the gas mixture. The individual variation of the recovery period of the EEG seems to be orginated by the tolerance of each animal to the carbon monoxide poisoning and also the tolerance to the gas poisoning will largely depend upon the degree of the resultant brain hypoxia.

分娩中 子宮破裂

李台鎬,洪亨植,高在祐,全相年 大韓産婦人科學會 1968 大韓産婦人科學會雜誌 Vol.11 No.11

난소종양의 임상병리학적 고찰

고재우(JW Koh),전상년(SN Jeun),이웅길(WK LEE),권병일(BI Kwon) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.7

A clinico- pathological as well as statistical survey was made on a series of 117 ovarian tumors operated upon and confirmed with postoperative histo-pathological study at the Department of Obstetrics & Gyneclolgy, Lyung Pook University Hospital, Taegu, Korea, during a period of 3 year from july 1965 to july 1968. The results obtained are as follows; 1. The incidence of benign tumor was 85.5% of all ovarian tumors while that of malignant one 14.5%. 2. The mean age of beingn ovarian tumor was 37years, while that of malignant ones 51.1years. There was a gap of 15 year between benign and malignant tumors. All patient under 20 years old had benign ovarian tumors, which incidence was about 6%. 3. Primary sterility was noted in 9.4% of this study. 4. Menstruation was regular in 56.4%, irregular in 17.0% of all ovarian tumors. 5. Bilateraity of dermoid cysts was in 29.4% of all benign ovarian rumors, that of serous cystomas 19.3%, that of pseudomucinous cystomas 9.3% and that of serous cystomas 19.3%, that of pseudomucinous cystomas 9.3% and that of malignant ovarian tumors in 53% of all malignant ovarian tumors. 6. The incidence of pedicle torsion was 40.6% in Pseudomucinous cystadenoma, 34.7% in dermoid cystadenoma and 19.3% in serous cystadenoma of all benign ovarian tumors. 7. The co-incidence of ovarian tumors with pregnancy was 23.5% in dermoid cyst, 6.4% in serous cystadenoma, 6.2% in pseudomucinous cystadenoma and 5.8% in malignant ovarian tumors. 8. Among the benign tumors, the incidence of pseudomucinous cystadenomas was 32%, that of serous cystadenomas

분만중 자궁파열

이태호(TH Lee),홍형식(HS Hong),고재우(JW Koh),전상년(SN Jeun) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.11

This report consisted of 11 cases of the uterine rupture, both spontaneous and traumatic, from Jan. 1962 to Dec. 1967 in Kyungpook National University Hospital. The results are summarized as follows: 1) The incidence was approximately 1% 2) Most of the rupture occured at the lower uterine segment 3) The distribution of age ranged from 29 to 42 year-old. 4) All cases were multipara. 5) Three out of 11 cases were spontaneous rupture of the uterus and 8 were traumatic. 6) There was no maternal mortality but the fetal mortality was 100%.