야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

흰쥐 視床下部 神經細胞의 [met]^(G4635)-enkephalin과 Oxytocin 同所存在性에 關한 免疫組織化學的 硏究

李永植,李永基,張家鏞,趙斗英 서울醫大 1990 精神醫學 Vol.15 No.2

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

블리스터 시험법을 이용한 열증착 금박막의 기계적 성질 측정

문호정,함순식,엄윤용,조영호,Moon, Ho-Jeong,Ham, Soon-Sik,Earmme, Yun-Young,Cho, Young-Ho 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.3

Mechanical properties, including Young's modulus, residual stress and rupture strength, of a thermally evaporated gold film have been measured form a blister test. In a theoretical study, the priniple of minimum potential energy and that of virtual work have been applied to the pressurized circular membrane problem, and load-deflection relations have been derived for typical membrane deflection mode of spheroidal shape. In an experimental study, circular gold membranes of 4800 A-thickness and 3.5mm diameter were fabricated by the silicon electropolishing technique. Mecahnical properties of the thin gold films were deduced from the load-deflection curves obtained by the blister test, Young's moduli, obtianed from blister test, have been in the range of 45-70 GPa, while those of bulk gold have been in the range of 78-80 GPa. Residual stresses in the evaporated gold films have been measured as 28-110MPa in tension, The rupture strength of the gold film has turned out to be almost equal to that of dental gold alloy (310-380MPa). It has been demonstrated that the present specimen fabrication method and blister test apparatus have been effective for simultaneous measurement of Young's modulus, residual stress and repture strength of thin solid films. Especially, the electropolishing technique employed here has provided a simple and practical way to fabricate thin membranes in a circular or an arbitrary shape, which could not be obtained by the conventional anisotropic silicon mecromachining technique.

인조 합성 테니스 바닥재의 지면 반력 분석

조승제,정미라,서국웅,박승범,윤양진,이훈식,강영택 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

Some authors suggest that certain types of surfaces are the origin of such injuries. A few years after the first medical concerns about surfaces were voiced, publications of biomechanical measurements apperared, describing accleration, force, and impact measurement on different types of surfaces. In many sport activities, surfaces can be under very high dynamic load. This was the reason for the development of various methods for impact simulation, like the development of various methods for impact simulation, like the artificial athlete. Furthermore, it is important to collect information about the hardness of new and already existing surfaces in sport arenas. The idea on which this measuring system is based Is as follows: The stiffness of the material can be computed from the kinematics measurd at touch down of a rigid body onto a material sample. The results show the following The result for the artifical surfaces(Synpave ace) is surprising. It is known that these surfaces are much harder than synpave rebound classic, synpave spring. This finding suggests that it may be possible that the subjective impression is used as one criterion in the selection of landing(or style) strategies. The number of subjects in this experiment is too small to make statistically significant conclusions. It is shown analytically that when an object a deformable surface, the acceleration it experiences is inversely propotional to its mass. In future, it need to stress that the interaction between shoe and surface is important, and this aspect has now become well accepted. Considering biomechanical aspect in player's injury, it request Korean Standards for synthetic playing surfaces in sport like ASTM(America Society for Testing & Materials) standards of America, DIN 18035 standards of Germany, BSI standards of U.K.

MLE공법을 이용한 고농도 질소 함유 도축폐수의 처리

조영민,이병희,유호식 대한상하수도학회 2002 상하수도학회지 Vol.16 No.3

The objective of this study was to investigate the feasibility of nitrogen removal in the slaughterhouse wastewater by modified Ludzack and Ettinger (MLE) process without external carbon addition at various HRTs and SRTs. In order to remove nitrogen from high nitrogen wastewater using biological methods, estimation for concentration of free ammonia (FA) and free nitrous acid (FNA) has to be carried out. It has been known that FA and FNA can inhibit the biological reaction of nitrificaion. In this study, the inhibition by FA and FNA was investigated by using literature and experimental data such as total ammonia and nitrite concentrations, pH, and temperature. Since denitrification using high organic material in influent had been occurred in front end of anoxic reactor, phosphorus release had been occurred in rear end of anoxic reactor and biological phosphorus removal was observed. In this study, average removal efficiencies of SS, BOD5, COD_cr, T-N and T-P were 94.3, 99.8%, 97%, 89.7% and 95%, respectively. And the average effluent concentrations of SS, BOD_5, COD_cr, T-N and T-P were 13.3mg/L, 3.1mg/L, 120.2mg/L, 48.4mg/L and 1.4mg/L, respectively.

한국형 소아우울척도의 개발

조수철,이영식 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.4

While the previous literature on childhood depression is confusing and contains insufficient and insubstantial research data, recent studies do report that depression in childhood does exist, and the standardized evaluation of children is essential for clinical research. This study I s conducted to develop the Korean form of the "Kovacs' children's Depression Inventory" and carries the following four main purposes : 1) To test the reliability of the CDI by means of test-retest reliability, split-half reliability, item0total correlations and internal consistency. 2) To investigate the factor structure of depression among normal Korean children. 3) To examine the differences of response to self-report questionnaire depending on age and sex. 4) To compare the severity of depression of Korean children with that of foreign children. The results summarized as follows : 1) Two week test-retest(coefficient r=0.71, p<0.001), mean of item-total correlations (coefficient r=0.44, p<0.001) were acceptable, and CDI turned out to be an internally consistent instrument(coefficient r=0.88, p<0.001). 2) Factor analysis using vari-max rotation yielded eight factors. 3) Among school-aged normal children(from 4th to 6th grade), the scores were not(or minimally) related to the respondent's age and sex. 4) The mean scores of CDI of Korean children were higher than those of the foreign children. These results indicate that firstly, "Korean form of the Kovacs' Children's Depression Inventory is a reliable instrument, secondly, the structure of depression in Korean children is multidimensional, hardly, this instrument may be used in different school-aged children, and lastly, the cut-off points to make a diagnosis of childhood depression may be different from those of foreign children. The authors suggest that future research should be directed to get normative data using various populations including clinic population, and concurrent use of "Children's Depression Rating Scale" of Lang and Tisher, "Children's Depression Rating Scale" of Poznanski or "School-age Depression Listed Investory" of Petti and Law will further validate this instrument.

치위생과정 개발에 관한 연구

조영식 남서울대학교 2004 남서울대학교 논문집 Vol.10 No.-

The dental hygiene process of care is a model for providing intergrated dental hygiene care. It was developed in the 1990s. The purpose of the dental hygiene process is to provide a framework of the dental hygiene theory and quality of dental hygiene care. This model enable the dental hygienist to focus on patient need. The process is composed of five components : assessment, dental hygiene diagnosis, planning, implementation, evaluation. The practice of dental hygiene has to move from simple clinical procedure to comprehensive, systemic dental hygiene care. The dental hygiene diagnostic model broadens the biomedical dental model to the behavioral model to include health behavior and health function of individuals. The dental hygiene process will provide a mechanism to develop dental hygienest's role and scope of practice in Korea.