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An He,Perucho Jose AU,Chiu Keith WH,Hui Edward S,Chu Mandy MY,Ngu Siew Fei,Ngan Hextan YS,Lee Elaine YP 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.5
Objective: To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC). Materials and Methods: This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III–IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm2) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival. Results: Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007–1.560; p = 0.043). Conclusion: A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.
Baryon content of massive galaxy clusters at 0.57 < <i>z</i> < 1.33
Chiu, I.,Mohr, J.,McDonald, M.,Bocquet, S.,Ashby, M. L. N.,Bayliss, M.,Benson, B. A.,Bleem, L. E.,Brodwin, M.,Desai, S.,Dietrich, J. P.,Forman, W. R.,Gangkofner, C.,Gonzalez, A. H.,Hennig, C.,Liu, J. Oxford University Press 2016 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.455 No.1
Non-radiative healing assessment techniques for fractured long bones and osseointegrated implant
S. Lu,B. S. Vien,M. Russ,M. Fitzgerald,W. K. Chiu 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
The paper provides an overview of the fracture healing process of long bones, a review of work that proposed appropriatephysical parameters for the assessment of healing and highlights some recent work that reported on the development ofnon-radiative technique for healing assessment. An overview of the development and monitoring of osseointegration fortrans-femoral osseointegrated implant is also presented. The state of healing of a fractured long bone and the stability ofosseointegrated implants can be seen as engineering structural components where the mechanical properties are restored tofacilitate their desired function. To this end, this paper describes non-radiative techniques that are useful for healing assessmentand the stability assessment of osseointegrated implants. The achievement of non-radiative quantitative assessmentmethodologies to determine the state of healing of fractured long bones and to assess the stability of osseointegrated implantwill shorten the patient’s rehabilitation time, allowing earlier mobility and return to normal activities. Recent work on thedevelopment of assessment techniques supported by the Offi ce of Naval Research as part of the Monitoring of OsseointegratedImplant Prosthesis program is highlighted.
Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers
Goodman, S.B.,Ma, T.,Spanogle, J.,Chiu, R.,Miyanishi, K.,Oh, K.,Plouhar, P.,Wadsworth, S.,Smith, R.L. Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of biomedical materials research. Part A Vol.a81 No.2
<P>The effects of an oral p38 mitogen-activated protein kinase (MAPK) inhibitor and polyethylene particles separately and together on tissue differentiation in the bone harvest chamber (BHC) in rabbits over a 3-week treatment period were investigated. The harvested tissue was analyzed histomorphometrically for markers of bone formation (percentage of bone area), osteoblasts (alkaline phosphatase staining), and osteoclasts (CD51, the α chain of the vitronectin receptor). Polyethylene particles decreased the percentage of bone ingrowth and staining for alkaline phosphatase. The p38 MAPK inhibitor alone decreased alkaline phosphatase staining. When the oral p38 MAPK inhibitor was given and the chamber contained polyethylene particles, there was a suppression of bone ingrowth and alkaline phosphatase staining. In contrast to oral non-steroidal anti-inflammatory drugs (NSAIDs) and local Interleukin-1 receptor antagonist (IL-1ra) administration, the oral p38 MAPK inhibitor alone did not suppress bone formation when given during the initial phase of tissue differentiation. Particle-induced inflammation and the foreign body reaction were not curtailed when the p38 MAPK inhibitor was given simultaneously with particles. Additional experiments are needed to establish the efficacy of p38 MAPK inhibitor administration on mitigating an established inflammatory and foreign body reaction that parallels the clinical situation more closely. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res 2007</P>
Lin, Yuanhsu,Tseng, Ming-Lang,Chiu, Anthony S.F.,Wang, Ray Korean Institute of Industrial Engineers 2014 Industrial Engineeering & Management Systems Vol.13 No.1
Evaluation of the implementation and performance of a firm's green supply chain management (GSCM) is an ongoing process. Balanced scorecard is a multi-criteria evaluation concept that highlights implementation and performance measures. The literature on the framework is abundant literature but scarce on how to build a hierarchical framework under uncertainty with dependence relations. Hence, this study proposes a hybrid approach, which includes applied interpretive structural modeling to build a hierarchical structure and uses the analytic network process to analyze the dependence relations. Additionally, this study applies the fuzzy set theory to determine linguistic preferences. Twenty dependence criteria are evaluated for a GSCM implemented firm in Taiwan. The result shows that the financial aspect and life cycle assessment are the most important performance and weighted criteria.
Vibration isolation system with a compact damping system for power recycling mirrors of KAGRA
Akiyama, Y,Akutsu, T,Ando, M,Arai, K,Arai, Y,Araki, S,Araya, A,Aritomi, N,Asada, H,Aso, Y,Bae, S,Baiotti, L,Barton, M A,Cannon, K,Capocasa, E,Chen, C-S,Chiu, T-W,Cho, K,Chu, Y-K,Craig, K,Dattilo, V,Do Institute of Physics 2019 Classical and quantum gravity Vol.36 No.9
<P>A vibration isolation system called the Type-Bp system used for power recycling mirrors has been developed for KAGRA, the interferometric gravitational-wave observatory in Japan. A suspension of the Type-Bp system passively isolates an optic from seismic vibration using three main pendulum stages equipped with two vertical vibration isolation systems. A compact reaction mass around each of the main stages allows for achieving sufficient damping performance with a simple feedback as well as vibration isolation ratio. Three Type-Bp systems were installed in KAGRA, and were proved to satisfy the requirements on the damping performance, and also on estimated residual displacement of the optics.</P>
Is Adjuvant Transarterial Chemoembolization Useful for Hepatocellular Carcinoma?
( Wong Hoi She ),( Cheung Tan To ),( Simon H. Y. Tsang ),( Wing Chiu Dai ),( Albert C. Y. Chan ),( Kenneth S. H. Chok ),( Kelvin K. C. Ng ),( Chung Mau Lo ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatectomy is the well-established curative treatment for hepatocellular carcinoma (HCC). However, adjuvant therapy is still controversial. This study tried to look into the effect of transarterial chemoembolization (TACE) in patients receiving hepatectomy for HCC. Methods: This is a retrospective study held in a single institution using prospectively maintained database for all the patients who underwent hepatectomy for HCC between January 2000 - December 2015. The perioperative details, pathological data and outcome were studied. Patients were matched at 1:10 ratio with comparable tumor size, number, indocyanine green retention test at 15 minutes, Child’s grading and tumor staging. The Kaplan-Meier method was used for survival analysis. The log-rank test was used for survival comparison. Results: There were total 1316 patients underwent hepatectomy for HCC. 38 patients with TACE were identified, and matched with 380 patients without TACE. The patients’ characteristics including age, sex, comorbidity, Child’s grading, ICG, tumor size and numbers were the same. The median sizes of the tumor were similar (9cm in TACE vs 8cm). There was no difference in terms of intraoperative management, extent of hepatectomy and postoperative complications. There were more patients with margin involvement in TACE group (23.7% vs 7.9%, p=0.004). The staging of the disease showed no significant difference in both groups. The disease free survival was similar (12.6 (TACE) vs 10.1months, p=0.794). There was no difference in overall survival with median survival of 27.8 (TACE) vs 36.9 months (5-year overall survival of 27.9% vs 41.2%, p=0.941). Conclusions: Margin involvement was known to be adverse factor for survival. Adjuvant TACE may benefit high-risk HCC patients with margin involvement as shown to have similar survival for those patients without margin involvement.