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AHN, GOOK JUN,YU, JAE YOUNG,CHOI, SEUL MIN,KANG, KYUNG KOO,AHN, BYOUNG OK,KWON, JONG WON,KANG, SUNG KEUN,LEE, BYEONG CHUN,HWANG, WOO SUK Blackwell Science Ltd 2005 International journal of andrology Vol.28 No.5
<P>Summary</P><P>This study was conducted to determine if the long-term administration of the phosphodiesterase type 5 (PDE 5) inhibitor, DA-8159, to diabetic rats can ameliorate the development of erectile dysfunction (ED) and endothelial dysfunction. After inducing diabetes with streptozotocin, DA-8159 was orally administered at a dose of 3 mg/kg or 10 mg/kg for 8 weeks. To examine the effect on erectile response, electrostimulation of the cavernous nerve with the parameters of 3 V, 5 ms, 5 Hz or 10 Hz, was performed to measure the intracavernous pressure (ICP) and mean arterial pressure (MAP). Thoracic aorta relaxation <I>in vitro</I> was evaluated by adding acetycholine (Ach) cumulatively to the bathing medium. In addition, the plasma endothelin-1 (ET-1) levels were measured in order to investigate the effect of DA-8159 on endothelial dysfunction. The area under the curve (AUC) from the ICP/MAP ratio in the 10 Hz stimulation showed a significantly increased AUC after the 10 mg/kg treatment compared with the diabetic group (8891 ± 619 vs. 6316 ± 1016, respectively, <I>p</I> < 0.05). At the 5 Hz frequency, DA-8159 10 mg/kg also induced a significant increase in the AUC compared with the diabetic control. The maximum ICP/MAP ratio (%) of the 10 mg/kg treatment group was significantly higher in both the 10 Hz and 5 Hz frequency groups (<I>p</I> < 0.05). A treatment of 3 mg/kg tended to increase the AUC and peak ICP/MAP but was not statistically significant. The Ach EC<SUB>50</SUB> value of the diabetic group was significantly higher than in the normal control (120.50 ± 22.90 n<SMALL>M</SMALL> vs. 86.80 ± 9.30 n<SMALL>M</SMALL>, respectively), and 10 mg/kg treatment group showed a significantly lower EC<SUB>50</SUB> value (88.38 ± 19.7 n<SMALL>M</SMALL>). The ET-1 level was lower in groups treated with DA-8159, 3 mg/kg and 10 mg/kg treatment induced a statistical difference compared with the diabetic control (1.15 ± 0.34 fmol/mL vs. 2.51 ± 0.55 fmol/mL, respectively, <I>p</I> < 0.05). These results demonstrate that chronic administration of DA-8159 could attenuate the development of the ED in diabetes and its effect is associated with an improvement in the endothelial function.</P>
안성태,이용주,한승태,김준식,김경국 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.4
Acute appendicitis most commonly affects the young adult and the adolescent child. Although symptoms are generally recognized by pediatricians, general practicianers and emergency room physicians, young children and elderly patients are still often overlooked and misdiagnosed. It is true that acute appendicitis in infancy and childhood is very difficult to diagnose and has high incidence of perforation. This retrospective study was carried out on 184 consecutive patients fifteen years of age or younger who underwent operation because of suspicion of acute appendicitis at Inha hospital during the past three years between January 1, 1993 and December 31, 1995. The following results were abtained. There were 129 male (70.2%) and 55 female (29.9%) children. On operation 164 children (89.1%) had acute appendicitis, 20 (10.9%) had no disease in the appendix. Of the 164 children. 38 (23.2%) had perforated appendixes. The highest incidence(31.1%) was in age group between ten and twelve years of age. The incidence was low(6.7%) under the age of 3. It occured most frequently in autumn, however it was not significant. The most common symptoms on initial presentation were abdominal pain. vomiting, nausea, fever, and anorexia in the order of frequency. The most common initial clinical signs were tenderness on right lower abdominal quadrant, rebound tenderness on right lower abdominal quadrant, and abdominal rigidity in the order of frequency. The rate of perforation increased from 6.0% for children who had symptoms for less than 20 hours to 100% for those who had symptoms for longer than 80 hours. The rate of perforation was 22.6% for children who had mean duration (time from patient hospital arrival to operation) less than 6 hours. Leukocytosis (more than 10,000 cells/㎣) was present in 138 children (84.1%) with an average white blood cell count of 14,200 cells/㎣ and with perforation rate 24.6%. The average hospital stay after operation was 5.7 days. The rates of perforation were 14.3% for children who had admitted via emergency department, 46.7% for children who had admitted via any pediatric or general surgery outpatient department, 92.3% for children who had admitted via pediatric outpatient department, 28.1% for children who had admitted via general surgery outpatient department.
전태국,안혁,Jun, Tae-Gook,Ahn, Hyuk 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.4
Successful emergency pulmonary embolectomy with the cardiopulmonary bypass was performed in a 41 \ulcorneryear old male who suffered massive pulmonary embolism after longterm bed rest due to the injury of left knee. Temporary cardiopulmonary bypass provided 120 minutes of circulatory support while complete removal of bilateral pulmonary emboli accomplished using Forgarty catheter and Gall stone forceps. Also, manual compression of the lungs was necessary to remove distal branching emboli. The patient had smooth and uneventful hospital course without complications and discharged from hospital taking coumadine on the 13th day after the operation.
Kang, Kyung-Koo,Ahn, Gook-Jun,Sohn, Yong-Sung,Ahn, Byoung-Ok,Kim, Won-Bae The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.8
In this study, we evaluated the effects of oral administration of DA-8159, a selective phosphodiesterase-5 inhibitor, on the development of pulmonary hypertension (PH) induced by monocrotaline (MCT). Rats were administered either MCT (60 mg/kg) or saline. MCT-treated rats were divided into three groups and received orally administered vehicle, or 1 mg/kg or 5 mg/kg of DA-8159, twice a day for twenty-one days. The MCT group demonstrated increased right ventricular weights, medial wall thickening in the pulmonary arteries, myocardial fibrosis and the level of plasma cyclic guanosine monophosphate (cGMP), along with decreased body weight gains. However, DA-8159 markedly and dose-dependently reduced the development of right ventricular hypertrophy and medial wall thickening. DA-8159 also amplified the increase in plasma cGMP level and significantly increased the level of lung cGMP, compared with the MCT group. Although the body weight gain was still lower from the saline-treated control group, DA-8159 demonstrated a significant increase in body weight gains, in both 1 mg/kg and 5 mg/kg groups, when compared with the MCT group. In myocardial morphology, MCT-induced myocardial fibrosis was markedly prevented by DA-8159. These results suggest that DA-8159 may be a useful oral treatment option for PH.
Benefits from Utilizing A Conceptual Model of Indoor GIS Based Evacuation Information System
Luo, Wen-Yuan,Ahn, Byung-Ju,Kim, Jae-Jun,Lee, Gwang-Gook,Kim, Whoi-Yul Korea Institute of Construction Engineering and Ma 2009 한국건설관리학회 논문집 Vol.10 No.5
When an emergency situation happens in buildings, the top priority is to ensure the occupant from danger as soon as possible. Achieving that goal is a multifaceted and difficult task. However, current evacuation systems have many deficiencies in dealing with the emergency in multi-level structures. The shortage of abilities to continuously update database, predict the future situation and provide the information to users with contextual information is the limit in current systems. Thus, it is very crucial to introduce Evacuation Information System (EIS), which is able to respond quickly to the emergency, and transfer the information to both the administrator and the occupant. The main purpose of this paper is to build EIS on the basis of the indoor Geographical Information System (GIS). When the emergency happens, EIS gives the instruction to Emergency Response Model (ERM) at once. ERM carries out the order and calculates the optimal evacuation routes, then sends the result to EIS. At last, EIS transmits evacuation messages to the occupant who implements evacuation plan. This paper highlights the benefits of EIS in two aspects. One is that EIS can update the data continuously to support evacuation strategy-making. The other is that it can transmit evacuation messages to both the administrator and the occupant.