Clinical Prognostic Factors in 86 Chinese Patients with Primary Myelodysplastic Syndromes and Trisomy 8: A Single Institution Experience

Xin-Yue Liu,Qing-Fang Yue,Lei Chen,Xiao-Mei She,Bin Hu,Yu Hu,Ping Zou 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.2

Purpose: The objective was to determine the characteristics and prognostic factors of 86 Chinese patients with trisomy 8 aberrationsand compare the prognostic value of International Prognostic System (IPSS) and Revised IPSS (IPSS-R) in this cohort. Materials and Methods: A total of 86 cases diagnosed with primary myelodysplastic syndromes (MDS) with isolated tr8 or with tr8 and other additional cytogenetic aberrations diagnosed and treated at the Union Hospital, Tongji Medical College of Huazhong University of Science and Technology between July 2002 and March 2013 were reviewed. Results: The median survival of the entire group was 23.0 months, and acute myeloid leukemia (AML) developed in 43% (37/86) patients within the follow up time. The univariate analysis revealed that overall survival (OS) was correlated with age, thrombocytopenia,absolute neutrophil count, marrow blasts, cytogenetic status and red blood cell transfusion at diagnosis, and the multivariateanalysis revealed that age, marrow blasts, cytogenetic status and transfusion dependence were independent parameters for the OS. The cytogenetic complexity and marrow blasts had the strongest impact on the AML transformation by multivariate analysis. Comparing the two prognostic systems, both two systems could successfully discriminate risk groups for survival. IPSS-R was more refined than IPSS for predicting OS, but had no advantage in predicting the risk of AML development. Conclusion: This study confirmed the influence of clinical factors on the prognosis of 86 Chinese MDS patients with trisomy 8. In addition, IPSS-R can further refine prognostic discrimination in the IPSS risk categories.

An Improved K-means Algorithm based on Mapreduce and Grid

Li Ma,Lei Gu,Bo Li,Yue Ma,Jin Wang 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.1

The traditional K-means clustering algorithm is difficult to initialize the number of clusters K, and the initial cluster centers are selected randomly, this makes the clustering results very unstable. Meanwhile, algorithms are susceptible to noise points. To solve the problems, the traditional K-means algorithm is improved. The improved method is divided into the same grid in space, according to the size of the data point property value and assigns it to the corresponding grid. And count the number of data points in each grid. Selecting M(M>K) grids, comprising the maximum number of data points, and calculate the central point. These M central points as input data, and then to determine the k value based on the clustering results. In the M points, find K points farthest from each other and those K center points as the initial cluster center of K-means clustering algorithm. At the same time, the maximum value in M must be included in K. If the number of data in the grid less than the threshold, then these points will be considered as noise points and be removed. In order to make the improved algorithm can adapt to handle large data. We will parallel the improved k-mean algorithm and combined with the MapReduce framework. Theoretical analysis and experimental results show that the improved algorithm compared to the traditional K-means clustering algorithm has high quality results, less iteration and has good stability. Parallelized algorithm has a very high efficiency in data processing, and has good scalability and speedup.

Ionic liquid extraction of silkworm pupa protein and its biological characteristics

Zeng Qing-Lei,Zhang Ning,Zhang Yue-Yue,Xin Xiang-Dong,Attaribo Thomas,Shao Ying,Tang Liu-Mei,Zhang Ran,이광식,진병래,Gui Zhongzheng 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1

Silkworm (Bombyx mori) pupa protein (SPP) is a high-quality source of animal protein with substantial nutri tional benefits and health value. To develop an efficient extraction method for SPP that is environmentally friendly, we selected choline hydroxide ionic liquid (CH-IL) as the extraction solvent and performed orthogonal experiments to optimize the extraction conditions. We demonstrated that 3% CH-IL, a solid-to-liquid ratio (g/mL) of 1:30, an extraction temperature of 40 ◦ C, and an extraction time of 1 h facilitated the most efficient extraction. Compared to the conventional alkali solubilization–acid precipitation method, the CH-IL extraction increased protein content by 12.14%. Protein structure analysis showed that the β-sheet content increased by 10.98% and that of disulfide bonds reduced by 16.4%. The processing properties of the CH-IL extracted protein showed that the solubility, emulsification, and foaming capacity were enhanced by 82.87%, 15.44%, and 18.97%, respec tively. The physical properties of SPP remarkably improved relative to the increased stretching of the poly peptide chains. The findings of this study provide technical knowledge that will enhance the processing performance of pupal proteins.

Effects of CSN1S2 Genotypes on Economic Traits in Chinese Dairy Goats

Yue, X.P.,Fang, Q.,Zhang, X.,Mao, C.C.,Lan, X.Y.,Chen, H.,Lei, Chuzhao Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.7

The aim of this study was to investigate allele frequencies at the CSN1S2 locus in two Chinese dairy goat breeds and the effects of its variation on dairy goat economic traits. Seven hundred and eight goats from Xinong Saanen (XS, n = 268) and Guanzhong (GZ, N = 440) breeds were selected. The milk samples of 268 XS goats were collected during the middle of lactation, body size parameters (708 goats) and daily milk yield (202 goats) were registered. The RFLP (restriction fragment length polymorphism) and SSCP (single strand conformation polymorphism) were used to detect the polymorphisms in CSN1S2. The Hardy-Weinberg (HW) equilibrium and the associations between body size, milk yield and composition and the genotypes were calculated. The results revealed that only A and F CSN1S2 alleles were found in the two Chinese dairy goat breeds. Allelic frequencies of A and F were 0.795, 0.205 and 0.739, 0.261 in Xinong Saanen and Guanzhong population respectively. Xinong Saanen breed was in Hardy-Weinberg equilibrium, while Guanzhong breed deviated from Hardy-Weinberg equilibrium (p<0.05). The association of polymorphism with economic traits indicated that the goats with FF genotype have higher milk fat and total solid concentration than those with AA and AF genotypes (p<0.05).

Experimental research and molecular dynamics simulation on thermal properties of capric acid/ethylene-vinyl/graphene composite phase change materials

Yue Gu,Linhua Jiang,Weizhun Jin,Zhenhua Wei,Xing Liu,Mingzhi Guo,Kailun Xia,Lei Chen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-

In this paper, a new series of phase change materials (PCMs) composed of capric acid/ethylene-vinylacetate/graphene (CA/EVA/GR) were prepared and thermal properties were investigated using moleculardynamics simulation. The composite PCMs were characterized by Fourier transform infraredspectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanningcalorimetry (DSC) and thermal conductivity measurement. FT-IR, XRD and SEM results manifest that CAcan be successfully wrapped by EVA and GR additives, and there is no chemical reaction between CA, EVAand GR. DSC results indicate that adding GR into CA/EVA can result in composite PCMs maintain the highlatent heat, while too much GR will cause a significant reduction in latent heat. Thermal conductivityobtained from experimental tests reveal that GR can gradually enhance the thermal conductivity of CA/EVA with increasing dosage of GR. The experimental results of thermal conductivity fall close to that ofmolecular dynamics (MD) simulation at GR dosages below 1.8 wt%, but the experimental results present atrend which is contrary to MD simulation at higher GR dosages. The mean square displacement (MSD)results manifest that composite PCMs containing 1.8 wt% GR has the highest diffusion coefficient, whilehigher GR dosage will reduce the diffusion coefficient gradually.

Influence of lining materials on the detonation driving of fragments

Yue Ma,Yong He,Chuan Ting Wang,Yuan He,Cheng Ji,Lei Guo,Peng Chen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3

The shape and strength of prefabricated fragments changes to some extent after detonation loading. In this paper, detonation loading process of prefabricated fragments under two types of lining layers was studied and compared with no lining. By observing the recovered fragments, it was found that the inner part of the material was cracked and the shape of the fragments changed significantly. Comparing the two lining materials, the Kevlar/epoxy was better protective lining than polyurethane. The detonation process was analyzed qualitatively by using shock wave theory. In order to further explore the process, the simulation software LS-DYNA was used to carry out 3D simulation. The simulation results, in good agreement with the experimental results, showed that the Kevlar/Epoxy liner had a great influence on the initial velocity of the fragment. The experimental results and simulation results suggest that spherical fragments are better than cylindrical fragments in detonation drive application.

A Fast-Transient Repetitive Control Strategy for Programmable Harmonic Current Source

Lei, Wanjun,Nie, Cheng,Chen, Mingfeng,Wang, Huajia,Wang, Yue The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.1

The repetitive control (RC) strategy is widely used in AC power systems because of its high performance in tracking period signal and suppressing steady-state error. However, the dynamic response of RC is determined by the fundamental period delay $T_0$ existing in the internal model. In the current study, a ($nk{\pm}i$)-order harmonic RC structure is proposed to improve dynamic performance. The proposed structure has less data memory and can improve the tracking speed by n/2 times. $T_0$ proves the effectiveness of the ($nk{\pm}i$)-order RC strategy. The simulation and experiments of ($6k{\pm}1$)-order and ($4k{\pm}1$)-order RC strategy used in the voltage source inverter is conducted in this study to control the harmonic current source, which shows the validity and advantages of the proposed structure.

Novel Buck Mode Three-Level Direct AC Converter with a High Frequency Link

Lei Li,Yue Guan,Kunshan Gong,Guangqiang Li,Jian Guo 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2

A novel family of Buck mode three-level direct ac converters with a high frequency link is proposed. These converters can transfer an unsteady high ac voltage with distortion into a regulated sinusoidal voltage with a low THD at the same frequency. The circuit configuration is constituted of a three-level converter, high frequency transformer, cycloconverter, as well as input and output filters. The topological family includes forward, push-pull, half-bridge, and full-bridge modes. In order to achieve a reliable three-level ac-ac conversion, and to overcome the surge voltage and surge current of the cycloconverter, a phase-shifted control strategy is introduced in this paper. A prototype is presented with experimental results to demonstrate that the proposed converters have five advantages including high frequency electrical isolation, lower voltage stress of the power switches, bi-directional power flow, low THD of the output voltage, and a higher input power factor.

An investigation and forecast on CO₂ emission of China

Lei Wen,Zeyang Ma,Yue Li,Qiao Li 대한환경공학회 2017 Environmental Engineering Research Vol.22 No.4

CO₂ emission is increasingly focused by public. Beijing and Tianjin are conceived to be a new economic point of growth in China. However, both of them are suffering serious environmental stress. In order to seek for the effect of socioeconomic factors on the CO₂ emission of this region, a novel methodology –symbolic regression– is adopted to investigate the relationship between CO₂ emission and influential factors of Beijing and Tianjin. Based on this method, CO₂ emission models of Beijing and Tianjin are built respectively. The models results manifested that Beijing and Tianjin own different CO₂ emission indicators. The RMSE of models in Beijing and Tianjin are 255.39 and 603.99, respectively. Further analysis on indicators and forecast trend shows that CO₂ emission of Beijing expresses an inverted-U shaped curve, whilst Tianjin owns a monotonically increasing trend. From analytical results, it could be argued that the diversity rooted in different development orientation and the mixture of different natural and industrial environment. This research further expands the investigation on CO₂ emission of Beijing and Tianjin region, and can be used for reference in the study of carbon emissions in similar regions. Based on the investigation, several policy suggestions are presented.

Enhanced catalyst activity by decorating of Au on Ag@Cu₂O nanoshell

Chen, Lei,Liu, Maomao,Zhao, Yue,Kou, Qiangwei,Wang, Yaxin,Liu, Yang,Zhang, Yongjun,Yang, Jinghai,Jung, Young Mee Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.435 No.-

<P><B>Abstract</B></P> <P>We successfully synthesized Au-decorated Ag@Cu<SUB>2</SUB>O heterostructures via a simple galvanic replacement method. As the Au precursor concentration increased, the density of the Au nanoparticles (NPs) on the Ag@Cu<SUB>2</SUB>O surface increased, which changed the catalytic activity of the Ag@Cu<SUB>2</SUB>O-Au structure. The combination of Au, Ag, and Cu<SUB>2</SUB>O exhibited excellent catalytic properties, which can further effect on the catalyst activity of the Ag@Cu<SUB>2</SUB>O-Au structure. In addition, the proposed Ag@Cu<SUB>2</SUB>O-Au nanocomposite was used to transform the organic, toxic pollutant, 4-nitrophenol (4-NP), into its nontoxic and medicinally important amino derivative via a catalytic reduction to optimize the material performance. The proposed Au-decorated Ag@Cu<SUB>2</SUB>O exhibited excellent catalytic activity, and the catalytic reduction time greatly decreased (5 min). Thus, three novel properties of Ag@Cu<SUB>2</SUB>O-Au, i.e., charge redistribution and transfer, adsorption, and catalytic reduction of organic pollutants, were ascertained for water remediation. The proposed catalytic properties have potential applications for photocatalysis and localized surface plasmon resonance (LSPR)- and peroxidase-like catalysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Au-decorated Ag@Cu<SUB>2</SUB>O heterostructures via a simple galvanic replacement method were designed. </LI> <LI> We can easily control the density of the Au NPs on Ag@Cu<SUB>2</SUB>O by changing the concentration of the Au precursor. </LI> <LI> Ag@Cu<SUB>2</SUB>O-Au nanomaterials with high absorption exhibited significantly enhanced catalytic activity for 4-NP. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>