한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

슬관절 내측 측부인대 파열의 치료에 대한 임상적 고찰

車應南,邊永壽 최신의학사 1989 最新醫學 Vol.32 No.7

만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구

차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

모자형단면 점용접부재의 축압궤특성에 관한 실험적 연구

차천석,김영남,심재기,김기형,양인영 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

차량 전면충돌시 에너지흡수량이 가장 큰 차량전면부 사이드부재의 기본형상인 점용접된 단일모자형 단면부재에 대하여, 정적(0.00017m/sec), 준정적(0.017m/sec) 축방향 압궤실험을 행하였다. 이를 기초로 자체 제작한 수직식 공기압 충격실험장치를 이용하여 실제 차량이 충돌하는 것을 상정하여 충격속도 7.19m/sec(충격에너지 1034J)하에서 형상의 변화 및 폭비와 플랜지 용접간격의 변화에 따른 압궤특성을 고찰하여, 최적의 에너지 흡수성능을 갖는 구조부재에 대하여 검토하였다. The fundamentally and widely used spot welded sections of automobiles(hat and double hat shaped section members) absorb most of the energy in a front-end collision. The sections were tested on axial static(0.00017m/sec) and -quasi-staic(0.017m/sec) loads. Based on these test results, spcimens with various thicknesses, width ratios and spot weld pitches on the flange have been tested with high impact velocity(7.19m/sec 1034J) which imitate a real life car arash Characteristics of collapse have been reviewed and structures of optimal energy absorbing capacity is suggested.

벤토나이트계 廢鑄物砂를 이용한 畜産廢水 處理材에 관한 硏究

차지범,백영남 경희대학교 산학협력기술연구원 2002 산학협력기술연구논문집 Vol.8 No.-

In this research, we try to find the way to recycle waster molding sand to purge the live stock waste which has nitrogen and phosphorus. The established purification systems are expensive, this way needs to spend expensive chemicals, might cause second pollution, and take long time to purge. As a solution to figure out these problems. I suggest a very practical treatment which uses bentonite, zeolite, and TiO_2. I try to find the best way to treat live stoke waste pollution with considering the rate of components, mixing, sintering temperature, and the changing of its grain size.

직장체육지도자의 리이더쉽 유형에 관한 연구

차영남 서원대학교 응용과학연구소 1992 응용과학연구 Vol.1 No.1

The purpose of this study was to examine impact of common constructing factors which represented in the characteristics of leadership and the behavioral characteristics of sportsman on leadership patterns of employee sport leader. Data were collected from one-hundred and fifty six employee leaders who involved in Seminar for Employee Sport Leader held in Jinhae. All subjects was respond to LEAD questionnaire, which was developed by Hersey and Blanchard. The statistics employed the study were x?? test and ANOVA. The conclusions obtained form data analysis were as follow: 1. patterns of leadership among amployee sport leader show the relation-oriented leadership behaviors rather than task-oriented leadership behaviors. 2. Effectiveness score of employee sport leader represent relatively of effective score. 3. Leadership patterns according to age among employee sport leader show that below 35 years old is likely to repressent task-oriented leadership behaviors, while over-36 years old tend to strongly express relation-oriented leadership behavior. And in the effectiveness score, below-35 years old sport leaders exert their leadership in the situation of lower degree of maturation among group members, while over-36 years old sport leaders exert their leadership in the situation of higher degree maturation among group members. 4 Leadership patterns according to career at workplace among employee sport leaders show significantly difference in the situation of lower degree of maturation among group members, less than 10 years in careers represent task-oriented leadership behaviors, while more than 11 years represent relation-oriented leadership behaviors. However, there is no significant difference in effectiveness score between two group, except situation of lower degree of maturation among group members. 5. Leadership patterns according to leader career among employee sport leaders show that there is no significant difference between two groups, except situation of lower degree of maturation among group members. In the effectiveness score, there is no significant difference in the situation of lower degree of maturation among group members, but significantly difference in the situation of higher degree of maturation among group members. 6. Leadership patterns according to prior athletic experience among employee sport leaders show that experienced leaders selected the task-oriented leadership behavior. In the effectiveness score, there is significant difference in the situation of lower degree of maturation among group members. 7. High school graduates represent more task-oriented leadership behavior than university graduates, while university graduates represent more relation-oriented leadership behavior than high school graduates. Sport leader group of university graduates have more effective leadership than that of high school graduates in the situation of higher degree of maturation among group members.

직장의 체육환경과 생활체육 참가의 관계

차영남 서원대학교 응용과학연구소 1994 응용과학연구 Vol.3 No.1

The purpose of this was to examine the relationships between sport environments such as structural, physical, and psycho-behavioral ones at workplace and participation in mass sport among workers. The sample was drawn from 653 male and female worded at the enterprize located in Seoul, they were selected by the method of systematic stratified cluster random sampling. A set of questionaire was designed to measure effects of sport environments on participation in mass sport, consisting of five areas and twenty-one fixed-alternative and open-ended questions. All of the questioniares were personally delivered to the respondents, who immediately filled them out. Statistics employed in the data analysis were Pearson product-moment correlation and multiple regression analysis. Based on the results of the study, the following conclusions appear warranted: First, structural sport environments such as degree of administrative and financial support to participation in mass sport at the workplace, numbers of workplace's mass sport club, holding a athletic meeting for workers, presence of workplace physical activity program, and degree of co-worker's sport involvement, owner's attitude toward sport have effects on frequency of mass sport participation, structural sport environments such as degree of administrative and financial support to participation in mass sport at the workplace and degree of co-worder's sport involvement have influences on duration of mass sport participation, and structural sport environments such as degree of administrative and financial support to participation in mass sport at the workplace, degree of co-worker's sport involvement, presence of workplace physical activity program, and owner's attitude toward sport have effects of intensity of mass sport participation. Second, opportunity set of workplace sport facilities use as physical sport environment has effects on frequency, duration and intensity of participation in mass sport, and satisfaction with workplace sport facilities and convenience of workplace sport facilities use have effects on mass sport participation among workers. Third, perception of worker's own health is on of the most important psychobehvioral sport environment which effects on frequency, dusration and intensity of mass sport participation among workers, athletic ability has effects on duration and intensity of their mass sport participation, and attitude towards sport has an effect on duration of their mass sport participation.

하지근의 횡단면적과 등척성 근력 및 순발력과의 상관관계

차영남 서원대학교 응용과학연구소 1996 응용과학연구 Vol.5 No.1

The purpose of this study was to examine the relationship among CSA, isometric strength, and power in leg. The subject of this study was 30 college male students, who had not any medical problems. To test CSA, isometric strength, and power, we use martin's anthropometric device, strength dynamometer, ultrasonic vertical jumpmeter respectively. For data analysis, Minimie Wilks' Lambda method was used to verity the corelation among variables. The results was as following; 1.absolute strength was appeared to be highly corelated with relative strength, CSA, and Power. 2.relative strength was appeared to be corelated with CSA. 3.power was appeared to be insignificantly corelated with both relative strength and CSA. With above results, we could conclude that CSA, isometric strength was not significant factor in determining power, rather neuromuscular function and the ratio of muscle enzyme activation would be more important factor.

만성두통환자에게 적용한 비약물적 치료가 통증행동에 미치는 영향

최도영,임사비나,차남현,김건식,이재동,김수영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : This study is a random-controlled post-design for confirmation of headache degree, quality of life, and satisfaction to therapeutical effect on chronic headache adults after management of non-medicinal treatment (acupuncture therapy and stellate ganglion block therapy). Methods : 51 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified in to two groups, acupuncture group (AT group, n=28) and stellate ganglion block group (SGB group, n=23). Treatment was applied 2 times a weeks for 4 weeks. The effects of both groups were analyzed using VAS scores, BPI (Brief Pain Inventory) and the satisfaction degree to the therapy. Results : 1. The recognized score of the headache of AT group and SGB group was reduced indicating the degree of the headache was released. 2. The recognition at damage to the quality of life was reduced post therapy of AT group and SGB group, in which general activity, mood, enjoyment of life, personal relationship, and sleeping showed significant improvement of life quality. 3. The satisfaction degree to the therapy showed lower score than expectation to it in AT group and SGB group, however, it was not significant. Conclusions : The results showed that the four-week non-medicinal treatment (AT and SGB) in chronic headache patients was effective for reducing headache and releasing its damage in daily life, however, no difference in superiority was found. Therefore, non-medicinal treatment (AT therapy and SGB) could be utilized in chronic headache patients.

지치 발거 후 안면부에 발생한 방선균증의 치험례

하지영,김일규,오성섭,최진호,오남식,차상권 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

Actinomycosis is chronic, granulomatous, suppurative and fibrosing disease caused by Actinomyces. Actinomyces are anaerobic, G(+), non-acid-fast, branched, filamentous bacteria. The most commonly found microorganism is Actinomyces israelii. Common site for isolation of actinomyces are dental plaque, dental caries, calculus, and tonsillar crypt. A breach in the integrity of the mucosa by direct trauma or following a fracture, tooth extraction, root canal therapy or some intraoral surgical procedure is thought to be the most likely portal of entry. This is a case report of 23 years old male with cervicofacial actinomycosis developed after extraction and treated with surgical excision and antibiotics.