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Notes : S-Adenosyl-L-Methionine Analogues to Enhance the Production of Actinorhodin
( You Hoon Chong ),( Jung Mo Young ),( Jin Young Kim ),( Yu Kyung Lee ),( Kwang Su Park ),( Jun Ho Cho ),( Hyung Jin Kwon ),( Joo Won Suh ),( Yoong Ho Lim ) 한국미생물 · 생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.7
( Joong Hoon Ahn ),( Bong Gyu Kim ),( You Hoon Chong ),( Byoung Chan Ahn ),( Eun Ji Joe ),( Jun Cheol Park ),( Jung Na Ri ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.10
The attachment of sugar to flavonoids enhances their solubility. Glycosylation is performed primarily by uridine diphosphate-dependent glycosyltransferases (UGTs). The UGT from Bacillus cereus, BcGT-1, transferred three glucose molecules into kaempferol. The structural analysis of BcGT-1 showed that its substrate binding site is wider than that of plant flavonoid monoglucosyltransferases. In order to create monoglucosyltransferase from BcGT-1, the error-prone polymerase chain reaction (PCR) was performed. We analyzed 150 clones. Among them, two mutants generated only kaempferol O-monoglucoside, albeit with reduced reactivity. Unexpectedly, the two mutants harbored mutations in the amino acids located outside of the active sites. Based on the modeled structure of BcGT-1, it was proposed that the local change in the secondary structure of BcGT-1 caused the alteration of triglucosyltransferase into monoglucosyltransferase.
Structure-Activity Relationship Studies of Isoquinolinone Type Anticancer Agent
Cheon, Seung Hoon,Park, Joon Suck,Lee, Joon Yeol,Lee, You Na,Yi, Hyo,Chung, Byung-Ho,Choi, Bo-Gil,Cho, Won-Jea,Choi, Sang-Un,Lee, Chong-Ock 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Substituted isoquinolin-1 -ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
Structure-Activity Relationship Studies of Isoquinolinone Type Anticancer Agent
Cheon, Seung-Hoon,Park, Joon-Suck,Lee, Joon-Yeol,Lee, You-Na,Yi, Hyo,Lee, Chong-Ock The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.4
Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-H-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
Understanding the RNA-Specificity of HCV RdRp: Implications for Anti-HCV Drug Discovery
Kim, Jin-young,Chong, You-hoon Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.1
Unlike other viral polymerases, HCV RNA-dependent RNA polymerase (RdRp) has not been successfully inhibited by nucleoside analogues presumably due to its strong substrate specificity for RNA. Thus, in order to understand the RNA-specificity of HCV RdRp, the structural characteristics of the active site was investigated. The hereto unknown 2-OH binding pocket at the active site of RdRp provides invaluable implication for the development of novel anti-HCV nucleoside analogues.
소관절천공술(Miniarthrotomy)로 시행한 슬관절 전방십자인대재건술 : One - tunnel 술식과 자가 슬개골건을 이용한 16 례의 임상결과 분석
김진영,박종훈,유경호,성진형,김원유 대한슬관절학회 1995 대한슬관절학회지 Vol.7 No.2
Anterior cruciate ligament(ACL) reconstructions using central one-third of bone-patellar tendon-bone aut with mioiarthrotomy and one-tunnel tcchnique were perfonned on 25 consecutive patients between January 1993 and Mareh 1995. 16 patients(11 deonic and 5 aeute cases)of them, followed up more than 12 rnonths were reviewed aad evaluated with Lysholm functional knee scoring system and radio 4ic patellar height. The average follow-up period was 17.5 months ranging from 12 months to 27 months and the avarage age of patients(14 male and 2 female) at operation was 34.8 years ranging froim 18 to S5years old. The average Lysholm functional kmee score was improved to 72(range, 37-90) from 59.4(range, 37-74) in 11 chronic cases aad 77.7(range, 68-89) in 5 acute cases after reconstruetion. To evaluatc the change of patellar tendon length, we meas the average patellar height value by Blackburne and Pcel mcthod. The average value was 0.78(range, 0.53-1.03) to 0.70(range, 0.52-1.09) after operation and there was no significant difference because both were in normal ranges. Minimthmtomy technique for ACL reconstmction using one-tunnel technique and central one-third bone patellar tendon-bone autograft may be a good procedure which is giving short operation time, adeqqate notchplasty, minimal operative smt due to elimination of lateral incision and improvement of clinical results.