Ordered Reverse k Nearest Neighbor Search via On-demand Broadcast

( Li Li ),( Guohui Li ),( Quan Zhou ),( Yanhong Li ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.11

The Reverse k Nearest Neighbor (RkNN) query is valuable for finding objects influenced by a specific object and is widely used in both scientific and commercial systems. However, the influence level of each object is unknown, information that is critical for some applications (e.g. target marketing). In this paper, we propose a new query type, Ordered Reverse k Nearest Neighbor (ORkNN), and make efforts to adapt it in an on-demand scenario. An Order-k Voronoi diagram based approach is used to answer ORkNN queries. In particular, for different values of k, we pre-construct only one Voronoi diagram. Algorithms on both the server and the clients are presented. We also present experimental results that suggest our proposed algorithms may have practical applications.

Centrifugal Infiltration Process of Fibrous Tubular Preform by Al-Cu Alloy

Li, Yanhong,Wang, Kai,Su, Yongkang,Hu, Guoxin The Korean Society for Composite Materials 2009 Advanced composite materials Vol.18 No.4

The kinetics of centrifugal infiltration of fibrous tubular preform is built theoretically, and simulations are conducted to study the effects of various casting conditions on infiltration kinetics and macrosegregation by combining with the energy, mass and kinetic equations. A similarity way is used to simplify the one-dimensional model and the parameter is ascertained by an iterative method. The results indicate that the increase of superheat, initial preform temperature, porosity tends to enlarge the remelting region and decrease copper solute concentration at the infiltration front. Higher angular velocity leads to smaller remelting region and solute concentration at the tip. The pressure in the infiltrated region increase significantly when the angular velocity is much higher, which requires a stronger preform. It is observed that the pressure distribution is mainly determined by the angular velocity, and the macrosegregation in the centrifugal casting is greatly dependent on the superheat of inlet metal matrix, initial temperature and porosity of the preform, and the angular velocity.

Cell Division Cycle 2 Protects Neonatal Rats Against Hyperoxia-Induced Bronchopulmonary Dysplasia

Zhongying Li,Yanhong Chen,Wenrong Li,Fan Yan 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.8

Purpose: Hyperoxia-induced bronchopulmonary dysplasia (BPD) is a lung disease in preterm infants. We aimed to explore therole of cell division cycle 2 (CDC2) on histopathologic changes of lung tissues, as well as the viability, apoptosis, and inflammationof lung cells in rats with hyperoxia-induced BPD. Materials and Methods: Hyperoxia-induced BPD in neonatal rats and hyperoxia-induced A549 cells were constructed. The mRNAexpression of CDC2 was detected by qRT-PCR. The fibrosis score of lung tissues was evaluated by hematoxylin-eosin staining. Theviability and apoptosis of A549 cells were detected by cell counting kit-8 assay and flow cytometry. The protein expressions of bcl-2,bax, and caspase-3 were measured by western blot. The levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β inA549 cells were detected by enzyme-linked immunosorbent assay. The pcDNA3.1-CDC2 was injected into rats to determine therole of CDC2 in hyperoxia-induced BPD in vivo. Results: The expression of CDC2 was decreased in lung tissues of neonatal rats with hyperoxia-induced BPD and hyperoxia-inducedA549 cells. The fibrosis score was increased in the lung tissues of neonatal rats with hyperoxia-induced BPD. Overexpressionof CDC2 increased the viability and protein expression of bcl-2; and inhibited the apoptosis, inflammation, and protein expressionof bax and caspase-3 in hyperoxia-induced A549 cells. Up-regulation of CDC2 alleviated the histopathologic changes in lung tissuesof neonatal rats with hyperoxia-induced BPD. Conclusion: Overexpression of CDC2 promoted the viability and inhibited the apoptosis and inflammation of hyperoxia-inducedcells, and alleviated the histopathologic changes of lung tissues in neonatal rats with hyperoxia-induced BPD.

Theoretical Analysis and Experimental Study on the Influence of Magnet Structure on Sealing Capacity of Magnetic Fluid Seal

Yanhong Cheng,Zhongzhong Wang,Decai Li 한국자기학회 2019 Journal of Magnetics Vol.24 No.3

The Magnetic fluid is a new type of magnetic material. It is a colloidal liquid made of nanoscale ferromagnetic particles suspended in a carrier fluid. Magnetic fluid sealing is one of the most successful applications of the magnetic fluid. As a new type of seal with the advantages of no leakage, long life and high reliability, magnetic fluid seal has been widely used under vacuum and low pressure differential condition. Two types of permanent magnets, the annular permanent magnets and the cylindrical magnets, are usually used in magnetic fluid seals in engineering. However, the influence of permanent magnet structure on sealing capacity was not clear, hence a new experimental setup was designed in order to study the influence of permanent magnet structure on sealing capacity. The annular permanent magnets and the cylindrical magnets were used as the magnetic source of the experimental setup in a series of tests respectively. The relationship between the sealing capacity of magnetic fluid seal and the end-face area, axial length of the magnet was analyzed by the electromagnetism theories and theoretical derivation. The result of the experiments shows that the sealing capability grows with the end-face area of the magnet, and the growth rate becomes much slower when magnet end-face area attains a certain value; the reluctance of pole pieces and shaft can’t be ignored when magnetic field attains a certain value; the modified theoretical formula had a good match to the measured values when the end-face area of the magnet is small enough to ignore the reluctance of pole pieces and shaft.

Study on Carbon Sequestration Capacity of Typical Crops in Northern China

Tianxin Li,Fang Zhang,Yuanyuan Jiao,Minjie Zhang,Yanhong Chang,Nametso Matomela 한국식물학회 2019 Journal of Plant Biology Vol.62 No.3

The carbon sequestration potential of differentcrops in their mature period in Northern China was analyzedin order to promote the selection of green species. Carbondioxide infrared gas detection, three-dimensional fluorescence,fixed carbon enzyme activity analysis and other methodswere used to test the carbon sequestration capacity of ninerepresentative mature crops in the Beijing area. Results showthat the carbon sequestration capacity of the nine crops was:corn > sorghum > wheat > tomato > cucumber > cabbage >celery > eggplant > pepper. Among them, the carbonsequestration capacity of corn and sorghum which are C4crops was stronger than that of other crops. Meanwhile, thethree-dimensional fluorescence spectra of corn were closer tosorghum, and there were significant differences in thecharacteristics of the three-dimensional fluorescence spectraof C3 crops. Based on the analysis of the activity of the fixedcarbon enzyme—Phosphoenolpyruvate Carboxylase (PEP)carboxylase and Ribulose-1, 5-Bisphosphate (RuBP)Carboxylase of these plants show that the carbon sequestrationcapacity of C4 crops was much larger than C3 crops becauseof its higher PEP carboxylase activity. The carbon sequestrationcapacity of C3 crops was positively correlated with theactivity of RuBP carboxylase in addition to cabbage. Therefore,the carbon sequestration capacity of crops can be measuredby using the portable carbon dioxide infrared analyzer.

'GM-gene-deletor': Fused loxP-FRT Recognition Sequences Dramatically Improve Efficiency of FLP or Cre Recombinase on Transgene Excision from Pollen and Seed of GM Plants

Yi Li,Yan Pei,Keming Luo,Hui Duan,Degang Zhao,Xuelian Zheng,Wei Deng,Yongqin Chen,C. Neal. Stewart Jr.,Richard McAvoy,Yanhong Wu,Xiangning Jiang,Aigong He 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Association between Magnetic Resonance Imaging Findings of the Pelvic Floor and de novo Stress Urinary Incontinence after Vaginal Delivery

Na Li,Can Cui,Yue Cheng,Yanhong Wu,Jianzhong Yin,Wen Shen 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.4

Objective: The study aimed to evaluate the contributions of levator ani muscle (LAM) injury, vesical neck movement, urethral length and mobility, and urethral sphincter dysfunction observed on magnetic resonance imaging (MRI) towards stress urinary incontinence (SUI) after vaginal delivery. Materials and Methods: Fifty primiparous women after 6 months of delivery (15 with SUI and 35 without) and 35 nulliparous as continent controls underwent MRI at rest and Valsalva maneuver. A published levator ani scoring system was used to characterize morphological changes of LAM. The severity of the injury was divided into three categories as none, minor, and major. A series of common parameters including levator plate angle, iliococcygeal angle, and levator hiatus were used to describe the functional conditions of LAM. Urethral mobility was defined based on the rotation of the urethra between Valsalva and rest status. Vesical neck movement was evaluated by its distance to the pubococcygeal line. Urethral sphincter dysfunction was defined as the widening of the proximal urethra and/or funneling at the urethrovesical junction during Valsalva. Results: Primiparous incontinent (PI) women had additional major levator ani defects (33.3% vs. 17.1%) while less minor defects (0.7% vs. 31.4%) than primiparous continent (PC) women. Vesical neck downward movement in PI women was more obvious than PC women (28.5 mm vs. 24.2 mm, p = 0.006). Urethral mobility was more active in primiparous women than in nulliparous continent controls (57.4 vs. 52.4), whereas no difference was observed on urethral mobility in the primiparous group (p = 0.25). Urethral sphincter dysfunction and funneling were present in 80% of PI women versus 22.9% in PC women (p < 0.001). Conclusion: The MRI findings revealed that de novo SUI was associated with major LAM injury, vesical neck downward movement as well as urethral sphincter dysfunction. Vesical neck funneling on sagittal images can be treated as a valuable predictor for SUI. The intervention for the PI should focus on the elevation of vesical neck, rehabilitation of LAM as well as recovery of the urethral sphincter muscle.

Structure learning of exponential family graphical model with false discovery rate control

Liu Yanhong,Zhang Yuhao,Li Zhonghua 한국통계학회 2023 Journal of the Korean Statistical Society Vol.52 No.3

Probabilistic graphical models enjoy great popularity in a wide range of domains due to their ability to model the conditional dependency relationships among random variables. This paper explores the structure learning for the exponential family graphical model with false discovery rate (FDR) control. Most existing FDR-con-trolled structure learning procedures have been designed for the Gaussian graphical model (GGM). A systematic approach for more general exponential family graphical models is still lacking. In this paper, we introduce a unified procedure to learn the structure of the exponential family graphical model with FDR control utilizing the symmetrized data aggregation (SDA) technique via sample splitting, data screening, and information pooling. We show that our method controls FDR asymptotically under some mild conditions. Extensive simulation results and two real-data examples validate the effectiveness of our method.

A novel CHD7 variant in a chinese family with CHARGE syndrome

Shan Yanhong,Yao LingFang,Li Linli,Gao Xueping,Jiang Jinghan 한국유전학회 2024 Genes & Genomics Vol.46 No.3

Objective CHARGE syndrome is a rare autosomal dominant (AD) multi-system disorder with a broad and variable clinical manifestation and occurs in approximately 1/10,000 newborns in the world. Mutations in the CHD7 gene are the genetic cause of over 90% of patients with typical CHARGE syndrome. The present study reported a novel variant in the CHD7 gene in a Chinese family with an abnormal fetus. Methods Routine prenatal ultrasound screening showed fetal heart abnormality and left foot varus. Chromosomal microarray analysis (CMA) and fetus-parent whole-exome sequencing (trio-WES) were performed to determine the genetic cause of the fetus. The candidate variant was further verified using Sanger sequencing. Results CMA analysis revealed normal results. However, WES analysis identified a de novo heterozygous variant of c.2919_2922del (NM_017780.4) on exon 11 of CHD7 gene, resulting in a premature truncation of the CHD7 protein (p.Gly975*). The variant was classified as Pathogenic (PVS1 + PS2_Moderate + PM2_Supporting) based on the ACMG guidelines. Combined with the clinical phenotype of fetal heart abnormalities, it was confirmed CHARGE syndrome. Conclusion We identified a novel heterozygous variant c.2919_2922del in CHD7 of a Chinese fetus with CHARGE syndrome, enriching the genotype-phenotype spectrum of CHD7. These results suggest that genetic testing could help facilitate prenatal diagnosis of CHARGE syndrome, thus promoting the appropriate genetic counseling. Objective CHARGE syndrome is a rare autosomal dominant (AD) multi-system disorder with a broad and variable clinical manifestation and occurs in approximately 1/10,000 newborns in the world. Mutations in the CHD7 gene are the genetic cause of over 90% of patients with typical CHARGE syndrome. The present study reported a novel variant in the CHD7 gene in a Chinese family with an abnormal fetus. Methods Routine prenatal ultrasound screening showed fetal heart abnormality and left foot varus. Chromosomal microarray analysis (CMA) and fetus-parent whole-exome sequencing (trio-WES) were performed to determine the genetic cause of the fetus. The candidate variant was further verified using Sanger sequencing. Results CMA analysis revealed normal results. However, WES analysis identified a de novo heterozygous variant of c.2919_2922del (NM_017780.4) on exon 11 of CHD7 gene, resulting in a premature truncation of the CHD7 protein (p.Gly975*). The variant was classified as Pathogenic (PVS1 + PS2_Moderate + PM2_Supporting) based on the ACMG guidelines. Combined with the clinical phenotype of fetal heart abnormalities, it was confirmed CHARGE syndrome. Conclusion We identified a novel heterozygous variant c.2919_2922del in CHD7 of a Chinese fetus with CHARGE syndrome, enriching the genotype-phenotype spectrum of CHD7. These results suggest that genetic testing could help facilitate prenatal diagnosis of CHARGE syndrome, thus promoting the appropriate genetic counseling.

Distinct Dose-Dependent Association of Free Fatty Acids with Diabetes Development in Nonalcoholic Fatty Liver Disease Patients

Fuxi Li,Junzhao Ye,Yanhong Sun,Yansong Lin,Tingfeng Wu,Congxiang Shao,Qianqian Ma,Xianhua Liao,Shiting Feng,Bihui Zhong 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.3

Background: Excessive delivery of free fatty acids (FFAs) to the liver promotes steatosis and insulin resistance (IR), with IR defined as reduced glucose uptake, glycogen synthesis and anti-lipolysis stimulated by normal insulin levels. Whether the associations between FFAs and diabetes development differ between patients with and without nonalcoholic fatty liver disease (NAFLD) remains unclear. Methods: Consecutive subjects (2,220 NAFLD subjects and 1,790 non-NAFLD subjects according to ultrasound imaging) were enrolled from the First Affiliated Hospital of Sun Yat-sen University between 2009 and 2019. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Results: There was an approximate J-shaped relationship between FFA levels and HOMA-IR in the NAFLD group. Higher FFA concentration quartiles were associated with higher risks of IR (odds ratio [OR], 9.24; 95% confidence interval [CI], 6.43 to 13.36), prediabetes (OR, 10.48; 95% CI, 5.66 to 19.39), and type 2 diabetes mellitus (T2DM; OR, 19.43; 95% CI, 12.75 to 29.81) in the NAFLD group but not in the non-NAFLD group. The cut-off points for the FFA levels increased in a stepwise manner in discriminating IR, prediabetes and T2DM (573, 697, and 715 μmol/L) in the NAFLD group but not in non-NAFLD individuals. Conclusion: A distinct dose-dependent relationship of FFA levels was found with IR, prediabetes and T2DM in NAFLD patients. Screening serum FFA levels in NAFLD patients would be valuable in preventing diabetes development.