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Paratubal serous borderline tumor
( Hwa Sook Moon ),( Sang Gap Kim ),( Jin Kuk Choi ),( Gun Sik Park ),( Kyung Seo Kim ),( Ja Seong Koo ),( Gyeong Il Nam ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Methods A 60-year-old woman, G0P0A4L0, was referred to our hospital with a pelvic mass. She had history of appendectomy, cholecystectomy and hypertension. Transvaginal ultrasound demonstrated 8.47 x 6.24 cm sized pelvic cyst with heterogenous echo at right adnexal region. MRI findings revealed that cystic mass was 8.3 cm sized and the lesion included about 1cm sized lobular contour mural nodule. Routine laboratory tests including tumor markers were in normal limits. She underwent operative laparoscopy. At the time of surgery, the uterus and both ovaries were atrophic, a cystic mass was detected at right fallopian tube. Exploration of the whole abdomen was performed and there was no additional abnormality. The surface of cyst was clear and well marginated with turbid yellowish fluid inside. Fluid within the peritoneal cavity was collected for cytology. Right salpingo-oophorectomy was performed without rupture of the cyst. Frozen biopsy was reported as a paratubal serous borderline tumor. We performed total laparoscopic hysterectomy and left salpingo-oophorectomy. Results The operative time was 70 minutes with blood loss of about 30mL. The patient recovered well. There was no intraoperative or postoperative complication. The final histological diagnosis was paratubal serous borderline tumor confined to right fallopian tube. The result of the peritoneal washing cytology was negative. No adjuvant chemotherapy or radiotherapy was applied. Until the last follow-up 9 months following surgery, the patient remained disease-free and no local or remote metastasis has been documented. Conclusions Paratubal borderline tumors are extremely rare and little is known about the clinicopathologic characteristics and the optimal treatment of these tumors. Further studies are needed to find the optimal management for paratubal serous borderline tumor.
( Hwa Sook Moon ),( Ja Seong Koo ),( Kyung Seo Kim ),( Byeong Gyu You ),( Hyun Jung Kim ),( Sung Eun Moon ),( Sang Kook Kim ),( Sung Hun Min ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To evaluate the efficacy of ultrasound-guided sclerotherapy with 95% ethanol in the treatment of endometrioma in terms of ovarian reserve. Methods: We retrospectively reviewed the records of 67 patients with ovarian endometrioma, 32 of whom were treated with sclorotherapy and 35 with laparoscopic cystectomy. Results: Clinical characteristics including patient age, duration of infertility, cyst location, and symptoms showed no significant difference between the two groups. Changes in AMH level were smaller in the sclerotherapy group compared to laparoscopic cystectomy group (sclorotherapy group: 1.24 ± 1.4, laparoscopic cystectomy group: 1.96 ± 1.9). However, the difference was not statistically significant. Conclusion: Ultrasound-guided sclerotherapy with 95% ethanol is a safe treatment for ovarian endometriosis, providing relief if related symptom while preserving healthy ovarian tissue and avoiding early menopause.
No Association between PIK3CA Polymorphism and Lung Cancer Risk in the Korean Population
Sung, Jae-Sook,Park, Kyong-Hwa,Kim, Seung-Tae,Seo, Jae-Hong,Shin, Sang-Won,Kim, Jun-Suk,Kim, Yeul-Hong Korea Genome Organization 2010 Genomics & informatics Vol.8 No.4
The PIK3CA gene, oncogenic gene located on human chromosome 3q26.3, is an important regulator of cell proliferation, death, motility and invasion. To evaluate the role of PIK3CA gene in the risk of Korean lung cancer, genotypes of the PIK3CA polymorphisms (rs11709323, rs2699895, rs3729679, rs17849074 and rs1356413) were determined in 423 lung cancer patients and 443 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the PIK3CA gene were not significantly associated with the risk of lung cancer in the Korean population, suggesting that these PIK3CA polymorphisms do not contribute to the genetic susceptibility to lung cancer in the Korean population.
( Sang Hwa Kim ),( Yun Ji Kim ),( Yeon Soo Jung ),( Seung Joo Chon ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Si Hyun Cho ),( Young Sik Choi ),( Byung Seok Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: In order for Korean red ginseng (KRG) to be widely used for alleviating menopausal symptoms, the safety of KRG on breast must be ensured. The purpose of this study was to investigate the effects of KRG on breast cells. Methods: MCF-7 and MCF-10A cells were treated with different concentrations of KRG extracts for 48h. Cell viability was evaluated by MTT assay, and apoptosis was assessed by flow cytometry. The expression of apoptosis-related proteins was determined by western blot analysis. Estrogen receptor(ER) affinity of KRG was examined by ER binding assay. Results: KRG extract inhibited growth and induced apoptosis both MCF-7 and MCF-10A cells in a dose-dependent manner. Treatment with KRG extract increasedthe expression of pro-apoptotic proteins BAX, BAK, and BAD as well as decreased expression of anti-apoptotic proteins Bcl-2 and Bcl-XL in both cells. The expressions of Fas and FasL were increased in lower doses, but soon decreased in higher doses in both cells. Activities of caspase-3, -8 and -9 increased in MCF-10A, but differently expressed in MCF-7. Competition ofKRG to E2 was significant in MCF-7, according to the increased dose of RG, whereas ER binding was hardly shown in MCF-10. Conclusion: KRG induced apoptosis via extrinsic and intrinsic pathway in MCF-7 breast cancer cells and MCF-10A non-malignant cells.KRG may be safely used in postmenopausal women to reduce the vasomotor symptoms.
( Sang Keun Lee ),( Eun Kyoung Jeon ),( Yu Jin Kim ),( Sam Hwa Seo ),( Chang Deok Kim ),( Jong Soon Lim ),( Jeung Hoon Lee ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.3
Background: Psoriasis is a chronic inflammatory skin disease that affects approximately 1~3% of the general population. Objective: We performed cDNA microarray analysis with using the dendrimer labelling method to investigate the gene expression profile in the peripheral blood mononuclear cells (PBMCs) of psoriatic patients. Methods: The peripheral blood mononuclear cells of 5 patients with psoriasis and 8 control subjects were used in the gene expression analyses of psoriasis. Results: We identified 212 differentially expressed genes that showed at least a two-fold induction and/or reduction in psoriatic patients. Among those, 63 genes, including CD44, CD56 and IL7R, were induced, while 139 genes, including the sphingosine kinase 1 and p16-INK genes, were reduced in the psoriatic patients. Conclusion: We can speculate that these genes may have a role for the pathogenesis of psoriasis via their affecting different cellular functions. Our results suggest a possible mechanism by which activated immune cells migrate from the blood to the skin in psoriatic patients, and we provide novel putative targets for developing drugs to treat psoriasis. (Ann Dermatol 21(3) 237~242, 2009)