서방형 Diltiazem제제의 개발을 위한 약동학/약력학적 특성 검토

유경상,배균섭,조주연,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

오스템퍼링한 구상흑연주철(ADI)의 드릴 가공시 경도 및 현미경조직변화에 관한 연구

조규재,장우양,심재기,홍성오,김선진 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.1

This paper was carried out to know the influence of advanced austempered ductile cast iron (ADI) on the tool life and mechanical properties of drilling machinability. For manufactured method of ADI, the spheroidal graphite cast iron were austenized at 900℃ for 1 hour and then austempered for 2 hour at 370℃ in the salt bath. And interrelationship has been investigated between tool life and mechanical characteristics of specimen material on drilling condition when the ordinary and step-feed drilling are carried out to drill holes of specimens. Tensile strength and hardness of ADI decrease and elongation of ADI increases with the increase austempered temperature. It is known that about 2 times of tool life in the case of step-feed decreases compared with ordinary feed due to the high hardness of ADI and hardness ascribed to the fact that retained austenite beame to martensite state due to cutting heat in drilling. Under the constant feed rate 0.1㎜/rev relation between hardness and length of end tip after drilling can be formularized to Hv=788.46L^-0.096 for the cutting speed 6.1m/min.

정신과 문제로 병사용 진단서를 발급받은 환자들의 임상적 특징

장혁진,김학렬,박상학,김상훈,조용래,표경식 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Most Korean young men should take a military physical examination. This study attempted to search the social, economical and psychological features of Korean youths who have psychiatric problems in taking the military physical examination. So this study was intended to help decide whether the youths enter the military service or not. Materials and Methods : This study analyzed diagnostic features that were grouped by 7 categories (antisocial and borderline personality disorder group, the other personality disorders group, psychosis group, organic mental disorder group, neurosis group, pervasive developmental disorders group, the other groups). The study was conducted from 1994 to May 1999 at Chosun University hospital with about 143 patients who were issued the psychiatric certificate for military affairs. Results : According to the results of the psychiatric examination, the antisocial and borderline personality disorder group had increased more year by year than the other groups. Classified by the residential distribution, the residents of agricultural areas belonged to the psychosis group more than others. Classified by the job distribution, the antisocial and borderline personality disorder group had more gangsters than the other groups. Also the pervasive developmental disorders group included those Who were without an occupation. Classified by visiting companion, those who were included in the antisocial and borderline personality disorder group and pervasive developmental disorders group used to come alone as compared with the other groups. In the case of those who have experienced psychiatric treatment in the past and who have been treated psychiatrically after being given the psychiatric certificate, the psychosis group comprised more than 50% statistically. In the case of the existence of a tattoo and self-injured scars, the antisocial and borderline personality disorder group has more than the others statistically. According to psychological examination, by measure of validity scale of MMPI, the antisocial and borderline personality disorder group appeared as the inverted V shape that L, K value was low and F value was high. And the antisocial and borderline personality disorder group measured by the Pd, Pa measure. Pd, Pa measure value got higher points than the organic mental disorder group statistically. Conclusion : The number of the antisocial and borderline personality disorder patients’ visits increased at the psychiatric hospital year by year and there were many gangsters or persons without regular occupation in that kind of patients’group. And there were many visitors who came by themselves to the hospital. Also they tended to have a tattoo or self-injured scars. And most of patients didn’t do commuting psychiatric care after receiving the psychiatric certificate. In the aspect of the psychological examination, they were likely to exaggerate their symptoms or disguise having psychiatric trouble intentionally.

혈청 감마지티(gamma glutamyl transferase)치와 대사증후군의 연관성

장미,유병욱,조용진,오정은,홍성호,조주연 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

Background: Serum gamma glutamyl transferase(GGT) level has been widely used as an index of liver dysfunction and a marker of alcohol intake. But, recently it is identified that the elevated GGT level was associated with insulin resistance. This study aimed to examine the association between metabolic syndrome and elevated GGT level in the women who had less alcoholic influence generally. Methods: From 585 women who received their annual health check-up, 577 women were selected for analysis except for 28 women who had hepatitis B surface antigen positive or antibody to hepatitis C virus positive, Categories of serum GGT were classified into four groups by quartile and then evaluated. Results: A abnormal GGT level(≥52U/L) was seen in 29(5.2%) of the 557 women. As GGT level increased, the prevalence rate of factors(body mass index≥25kg/m2, hypertension, hemoglobin≥14g/dL, total cholesterol≥220mg/dL, triglyceride≥150mg/dL, fasting plasma glucose≥110mg/dL, HDL-choles tero1<50mg/dL) except for hyperuhcemia was increased. The GGT level was correlated with age, body mass index, thglyceride and uric acid in women with fatty liver, but not in women without fatty liver. Factors independently contributing to elevated GGT level was diabetes, hyperthglycehdemia and obesity. Conclusion: The elevated, albeit normal, GGT level was strongly associated with the factors of metabolic syndrome in Korean women. Because measurement of serum GGT level is easy, reliable, and not expensive, it might have more important implication as predictive factor of metabolic syndrome.

Hollow-Fiber LPME를 이용한 잔류농약 검출

조현우,이상섭,신윤지,장미애 경기대학교 기초과학연구소 2008 기초과학논문집 Vol.21 No.-

A method for the determination of trace amount of pesticides in aqueous samples using hollow fiber-liquid phase microextraction(HF-LPME) and capillary gas chromatograph/micro electron capture detector(GC/μ ECD) has been established. HF-LPME method has been optimized with respect to several experimental parameters including the effects of extraction solvent, extraction time and extraction temperature for the determination of pesticides from aqueous samples. The calibration curves for pesticides showed good linearity (above r²=0.98). The established method is feasible for the determination of trace amounts of pesticides in several aqueous sample. The limit of detection(LOD) and the limit of quantitation(LOQ) have been found to be 0.05~1.0 and 0.5~2.5 ng/mL, respectively. The established HF-LPME method for the analysis of pesticides from aqueous sample can be used for the determination of biological, food and environmental samples.

한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

술후 Morphine과 Butorphanol의 지속적 정주 효과 비교

조상선,안정찬,이상근,한인숙,장사충 日新基督病院 1997 日新基督病院論文集 Vol.12 No.-

가스크로마토그래피를 이용한 요중 마뇨산 측정시 새로운 시료 전처리 방법의 검증

조수현,임용현,김선민,권호장,하미나,한상환 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Urinary hippuric acid was analyzed by gas chromatography/mass spectrometry method. A simple and economical derivatization procedure using excessive methanol in acidic condition was adopted to esterify hippuric acid. Quantitative analysis was performed with two internal standards, heptadecanoic acid and hydrocinnamic acid, to evaluate the derivatization procedure as an analytical method. Using the standard addition method, linear and reproducible calibration curves were obtained for both internal standards. Calibration experiment showed that good quantitative result could also be obtained with the calibration curve obtained without urine matrix. Recovery rates for the urine samples were in the range of 95.6∼111.4%. Using hydrocinnamic acid as internal standard, analysis time could be reduced.

이방성 이종재료 내의 Ⅴ-노치 균열에 대한 응력특이성의 수치해석적 연구

조상봉,양장흥 경남대학교 신소재연구소 1997 論文集 Vol.9 No.-

이방성 이종재료 내의 V-노치 균열에 대한 응력특이성을 구하기 위하여 복소응력함수의 형태를 제안한 바 있다. 제안된 복소응력함수를 이용하여 특성방성식을 만들고 상용 수치해석 프로그램의 하나 인 MATHEMATICA를 이용하여 특성방정식을 풀어 고유치를 구하였다. The form of complex stress function had been proposed t o obtain stress sinlgularities and coefficient vectors for V-notched cracks in anisotropic dissimilar materials. The characteristic equation for V-notched cracks in anisotropic dissimilar materials was obtained using the complex stress function and was solved by a commercial numerical program, MATHEMATICA.

뇌경막내에 위치한 수막성 골종 증례보고

조영도,조준,문창택,장상근,윤상애 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

This case report deals with a 75-year-old female. The patient was admitted for headache due to passenger traffic accident. Plain radiographs of the skull showed the finding of dense calcified lesion in the right parietal bone. In the Brain CT scan, this lesion showed uniformly hyperdense and non-enhancing mass. The clinical examination showed no gross abnormalities. In the operation field, this lesion attached to the inner surface of the dura by the dense fibrous band and protruded into the cerebral cortex. One fragment was about 1cm×1.4cm×1.6cm and the other about 3mm×2mm×3mm. Histologic examination of the surgical specimen(H/E stain) showed a benign osteoma.