Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

유아기 자녀를 둔 부모의 자녀교육관 및 양육태도 조사연구

박홍선,박경란 인제대학교 아동ㆍ가족복지연구소 1998 아동ㆍ가족복지연구 Vol.2 No.-

As the nuclear and double income families are increasing resecently, the role of parents for their children is recognized to be very important. In this context, this study examined educational views and child-rearing attitudes of parents with preschool children specially with focuses on : First, general trend of parents' educational views and child-rearing attitudes. Second, parents' educational views and child-rearing attitudes according to their individual background(such as age, education, and family's income level). Third, differences in educational views and child-rearing attitudes between fathers and mothers.

임플랜트를 위한 하악골 측정시 전산화단층사진상의 정확도에 관한 연구: 하악 위치와 gantry각이 미치는 영향

박태원,유동수,최항문,이삼선,박래정,최순철 大韓口腔顎顔面 放射線學會 1998 Imaging Science in Dentistry Vol.28 No.1

We used five adult dog mandibles embedded in resin block and six different cross-sectional planes for each mandible were choosen. According to the angle of mandibular occulsal plane to vertical plane(mandibular angle)and gantry angle of CT machine, we classified 4 experimental groups and 1 control group. The control group images were taken at the mandibular angel 0˚and gantry angle 0˚. The experimental images were taken at the mandibular angle 15˚and gantry angle 0˚(group 1);30˚and 0˚(group 2);15˚and 15˚(group 3);30˚and 30˚(group 4), respectively, Using the reformatted cross-sectional images, the distance from the mandibular canal to the alveolar crest and the distance from the mandibular canal to the buccal cortex and to the lingual cortex was measured and compared. The obtained results were as follows; 1. The distance from the mandibular canal to the alveolar crest of group 1 and 2 was larger than control group, but the distance of group 3 and 4 was smaller. The distance from the mandibular canal to the buccal cortex and to the lingual cortex of all experimental groups was smaller than control group. 2. The distance from the mandibular canal to the alveolar crest showed the largest difference from control group in all experimental groups, especially in group 2 and 4(p<0.05)> 3. In the distance from the mandibular canal to the alveolar crest, the number of deviation value under 1mm was 20 in group 3 and was 11 in group 2 and 4, respectively. 4. The deviation value of the distance from the mandibular canal to the buccal cortex and to the lingual cortex was under 1 mm in most cases.

特性 부가 文法에 依한 類似 標的의 區分

김항준,홍순목,박민호 경북대학교 공과대학 1983 工大硏究誌 Vol.12 No.-

syntactic method is a general tool for pattern recognition but it's not good at distinguishing similar object. In this paper, we use attributed grammar to distinguish long nose plier from diagonal cutter, and good experimental results are obtained.

하악 제1대구치의 치근 만곡에 영향을 주는 요인

최항문,이원진,허민석,이삼선,김정화,최순철,박태원 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To find the cause of root curvature by use of panoramic and lateral cephalometric radiograph. Materials and Methods : Twenty six 1st graders whose mandibular 1st molars just emerged into the mouth were selected. Panoramic and lateral cephalometric radiograph were taken at grade 1 and 6, longitudinally. In cephalometric radio graph, mandibular plane angle, ramus-occlusal plane angle, gonial angle, and gonion-gnathion distance (Go-Gn distance) were measured. In panoramic radio graph, elongated root length and root angle were measured by means of digital subtraction radiography. Occlusal plane-tooth axis angle was measured, too. Pearson correlations were used to evaluate the relationships between root curvature and elongated length and longitudinal variations of all variables. Multiple regression equation using related variables was computed. Results : The Pearson correlation coefficient between curved angle and longitudinal variations of occlusal plane-tooth axis angle and ramus-occlusal plane angle was 0.350 and 0.401, respectively (p<0.05). There was no significant correlation between elongated root length and longitudinal variations of all variables. The resulting regression equation was Y=10.209+0.208X_(1)+0.745X_(2) (Y: root angle, X_(1): variation of occlusal plane-tooth axis angle, X_(2): variation of ramus-occlusal plane angle). Conclusion: It was suspected that the reasons of root curvature were change of tooth axis caused by contact with 2nd deciduous tooth and amount of mesial and superior movement related to change of occlusal plane. (Korean J Oral Maxillofac Radiol 2006; 36 : 55-62)

일산화탄소 중독시 과산화수소 관장에 의한 혈액가스의 변동

윤경선,고응린,박항배 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

The administration of hydrogen peroxide as the means of correcting tissue hypoxia has been studied by many researchers since early 1920's. The purpose of this study is to investigate the validity of clinical application of H₂O₂ enema for the treatment of carbon monoxide poisoning which, in Korea, is one of the most serious life threatening maladies. Sixty rabbits were exposed to carbon monoxide (7,000 ppm) for fifty minutes and the arterial blood gas pictures before and after the exposure were observed. Immediately after the exposure, half of the animals were given with 10ml of 0.5% H₂O₂ solution per kg plus 1 ml of human whole blood by enema and the other half(control) simply with 10 ml of physiologic saline per kg by the same route. A series of blood sampling and gas analysis in every thirty minutes (up to 2 hours) following the enema were carried out and comparison was made between the two groups. The conclusions were as follows: 1) The arterial blood gas picture after the exposure(poisoning) to carbon monoxide was suggestive of partially compensated metabolic acidosis which is interpreted as the result of lactic acid formation by anaerobic tissue metabolism. 2) Immediately after the exposur, extreme reduction of arterial PaCO₂ was observed. The reduced tissue metabolism through aerobic pathway and hyperventilation to overcome the hypoxic condition, both are considered to be the cause of this drop in arterial CO₂ tension. 3) Arterial PaO₂ of the experimental group at 30 minutes after the enema with 0.5% H₂O₂ solution was 19.5 mmHg higher than that of control group and this difference decreased gradually to 10.3 mmHg at 120 minutes. Even though the result of tissue oxygenation by H₂O₂ enema is far less satisfactory than that of 100% oxygen inhalation, the application of this method may be considered as substitute of (or supplement to) oxygen treatment in some particular situations when oxygen equipment is not available or pulmonary function is significantly inhibited (e.g. burn to the respiratory tract, pneumonia etc).

악하선에 발생한 방선균증

이진호,박인우,최항문,허민석,이삼선 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.2

Actinomycosis is defined as a chronic, specific, suppurative, granulomatous disease caused mainly by the anaerobic, gram positive organism, Actinomyces israelii. Actinomycosis in the salivary gland is a rare disease that is caused by an inhabitant of the normal flora. We report the case of the actinomycosis of submandibular gland. A 53-year old man presented with the swelling on left submandiblar area. The lesion was not painful but had been increasing for about 10 days. In the CT view, the internal portion of the mass showed homogeneous moderate signal. The mass had continuities with the inferior portion of the left enlarged submandibular gland. In the MRI, there was a mass that showed a buldging pattern inferiorly in the left submandibular gland without bony invasion sign. The biopsy shows the colony of special organism. Many filaments are discovered with clubbed ends diffused from center of colony. We diagnosed this disease as actinomycosis in the submandibular gland by the postoperational biopsy. (Korea J Oral Maxillofac radiol 2000; 30: 132-137)

지하공동구 화재 실험 및 시뮬레이션에 의한 화재 실험 예측 평가

윤명오,고재선,박형주,박성은 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.1

지하공동구는 최근 통신의 발달로 인해 국가 중추기능으로서의 주요 역할를 하는 시설로, 사고시 신속한 대처가 힘들고 케이블 연소시 발생하는 유독가스에 의한 검은 연기로 공동구 내에 진입하여 소화하기가 힘들다. 따라서 화재발생시 막대한 재산피해 및 통신의 두절 등 국가의 중추신경이 마비됨은 물론 시민 불편사항을 초래시켰다. 본 논문은 지금까지 발생되어온 공동구 화재를 바탕으로 실제 공동구 모형을 제작하여 화재를 재현함으로서, 과학적으로 화재의 성상을 분석하고 지하공동구 내에 소방설비를 갖춘 후에 일정온도에서 각각의 소방설비들이 제대로 작동하는지를 검증하는데 그 목적이 있다. 화재실험은 지하공동구 내에 정온식 감지선형 감지기, 방화문, 연결살수설비 및 환기설비를 설치하고 송 · 배전케이블은 일정구간 내화도료로 도장하며 난방관은 내화피복된 상태에서 실험하였다. 그 결과 최고 온도가 932℃로 측정되었고 일정온도에서 정온식 감지선형 감지기가 작동하여 화재위치를 정확히 수신반에 나타내었다. 그리고 송 · 배선케이블은 일정구간 내화도료로 도장한 것은 내화성능이 없는 것으로 나타났고, 내화피복된 난방관은 약 30분 정도의 내화 성능이 있는 것으로 나타났다. 컴퓨터 화재 시뮬레이션은 실제 화재 시험시의화재하중을 입력하여 실시한 결과 최고 온도가 943℃로 실제 화재시의 최고 온도인 932℃와 거의 일치하였다. 따라서 공동구 화재하중만으로 화재 시뮬레이션을 실시하여 화재의 성상에 대한 예측이 가능한 것으로 판단되며 시뮬레이션으로 얻는 열방출량, 연기층의 높이, 산소, 일산화탄소, 이산화탄소의 농도 등의 결과 값들을 실제 화재 실험시의 값으로 적용시킬 수 있는 것으로 판단된다. The utility tunnels are the important facility as a mainstay of country because of the latest communication developments. However, the utilities tunnel is difficult to deal with in case of a fire accident. When a cable burns, the black smoke containing poisonous gas will be produced. This black smoke goes into the tunnel, and makes it difficult to extinguish the fire, Therefore, when there was fire in the utility tunnel, the central nerves of the country had been paralyzed, such as property damage, communication interruption, in addition to inconvenience for people. This paper is based on the fire occurred in the utilities tunnel in the past, and reenacting the fire by making the real utilities tunnel model. The aim of this paper is the scientific analysis of the character image of the fire, and the verification of each fire protection system whether it works well after process of setting up a fire protection system in the utilities tunnel at a constant temperature. The fire experiment was equipped with the linear heat detector, the linear heat detector, the fire door, the connection water spray system and the ventilation system in the utilities tunnel. Fixed portion of an electric power supply cable was coated with a fire retardant coating, and a heating tube was covered with a fireproof. The result showed that the highest temperature was 932℃ and the liner heat detector was working at the constant temperature, and it pointed at the place of the fire on the receiving board, and Fixed portion of the electric power supply cable coated with the fire retardant coating did not work as the fireproof. The heating tube was covered with the fireproof had the function of the fireproof about 30 minutes.

충청지방에서 발생한 한국형출혈열 54예의 임상적 고찰

이종대,조항복,박붕연,심우익,신영태,김선영 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

In Dae Jeon Eul-Ji General Hospital, activated since 1581, 54 patients with Korean Hemorrhagic Fever Who were all positive for Korea antigen were observed from January, 1981 to December, 1984. Epidemiology, clinical features, laboratory findings, complications and clinical course in Korean Hemorrhagic Fever were analyzed. The results were as follows: 1. The most prevalent area was OK-Chun Kun. 2. The peak incidence of age was fifth decade and male to female ratio was 2:1. 3. The peak incidence was November to December. 4. The most frequent symptomes were epigastric pain, nausea and vomiting and followed by hemsturia. 5. Conservative treatment was done and hemodialysis was performed in 19 patients without death.

디지털공제방사선촬영술을 이용한 치근단 흡수의 평가

허민석,이삼선,이경희,최항문,최순철,박태원 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.1

Purpose : This study was performed to compare the diagnostic ability of conventional intraoral radiographs with that of digital subtraction image and to assess the quantifying ability of digital subtraction image for simulated apical root resorption Materials and Methods : Conventional intraoral radiographs and digital images of ten sound maxillary central incisors and those with simulated apical root resorption were taken with varying horizontal and vertical angulations of the x-ray beam. The diagnostic accuracy to detect the lesion was evaluated on conventional intraoral radiographs and digital subtraction images by ROC analysis. The amount of simulated apical root resorption was also estimated on the reconstruction images by Emago□ and compared with actual amount of tooth loss using paired t-test. Results : The diagnostic accuracy of conventional intraoral radiographs to detect the apical root resorption was low(ROC area = 0.6446), and the sensitivity and the specificity of digital subtraction images were 100%, respectively. The calculated amounts of apical root resorption showed no statistically significant difference with the actual amounts of the lesion (p 〉 0.05). Conclusion : Digital subtraction radiography is powerful tool to detect the small apical root resorption, and quantitative analysis of small amounts of the lesion can be evaluated by digital subtraction radiography.(Korean J Oral Maxillofac Radiol 2001;31:51-5)