정신병원 간호사의 공정성 지각과 조직몰입이 이직의도에 미치는 영향

정수미,민순,강명근,류소연,박종,김기순 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Objectives: The purpose of this study was to identify the influence of equality perception and organizational commitment on turnover intention of jobs among psychiatric hospital nurses. Method: Data were collected by questionnaire survey among 158 nurses working in 10 psychiatric hospitals from August 1st to September 30th. 2004. Results: The degree of turnover intention of jobs was significantly different by marital status, religion, qualification of psychiatric specialized nursing, monthly income and the location of hospitals. The correlation analysis showed that the turnover intention of jobs decreased as the equality perception and the organizational commitment increased. The hierachical multiple regression analysis showed that significantly related variables with turnover intention of jobs were religion, monthly income, equality perception and organizational commitment. The model explanation power was 53.1%. Conclusion: Because the equality perception explained 53.1% of variance of turnover intention among psychiatric nurses and organizational commitment was related with the turnover intention of nurses at psychiatric hospitals, activation strategy of organization must include the promotion strategy of equality perception and organizational commitment to decrease turnover intention of jobs among nurses.

LT, Others : PE-133 ; A case of hepatic hemangioma appearing atypical finding confirmed by dynamic MRI in patients with high risk of hepatocellular carcinoma

( Dong Won Park1 ),( Soo Hyung Ryu1 ),( Myung Ki Oh ),( Seong Yeon Jeong ),( Kyeong Sam Ok ),( Jae Chan Shim ),( Jin Nam Kim ),( You Sun Kim ),( Jeong Seop Moon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Hemangioma is the most common benign hepatic tumor. Many hepatic hemangiomas tend to be found incidentally, but should be differentiated from malignant tumors. We report an interesting case of hepatic hemangioma in patient who has high risks of hepatocellular carcinoma. Case: A 52-year-old woman, who was a chronic alcoholic abuser and hepatitis C virus carrier with no treatment experience, was admitted due to diarrhea. The patient had suffered from intermittent abdominal pain in the right subcostal area for recent 3 months. Also the patient had easy bruising and frequent epistaxis. She had used oral contraceptives for almost 20 years. Systolic blood pressure was 160 mmHg and diastolic blood pressure was 80 mmHg. Body temperature was normal. Physical examination revealed icteric sclerae and tenderness in right upper quadrant of the abdomen. Laboratory study showed platelet count of 31,000/ul, AST/ALT of 302/127 IU/L, and total bilirubin of 2.7 mg/dl. 3-phased contrast-enhanced abdominal computed tomography (CT) revealed a 4 cm × 4 cm sized hepatic mass involving both segment 5 and 6. Abdominal CT finding suggested hepatic hemangioma, however, typical finding of hemagioma was unclear, therefore, could not rule out the malignancy. Since she had risk factors for hepatocellular carcinoma, abdominal ultrasonography was performed for further evaluation. But abdominal ultrasonography also showed atypical finding. The confirmative diagnosis could be done by dynamic magnetic resonance imaging (MRI) using primovist®, which is an innovative liver cell-specific contrast medium. Dynamic MRI presented peripheral globular enhancement and a centripetal fill-in pattern, confirmatory findings of hepatic hemangioma, on the delayed image. The patient got relief from abdominal pain and diarrhea during admission, now is being followed-up at a general out-patient clinics. Conclusions: Hemangiomas with atypical abdominal CT and ultrasonographic findings in patients with high risks of hepatocellular carcinoma can be easily characterized with primovist-enhanced dynamic MRI.

Effect of Individual's Learning Organization on Knowledge Management and Innovative Behavior - Comparative Analysis on the Employees in Service, Production, and IT -

Ryu, Yeon Hwa,Song, Kyung Soo 한국인적자원관리학회 2015 인적자원관리연구 Vol.22 No.3

본 연구는 개인의 학습조직활동이 지식경영활동과 혁신행동에 미치는 영향에 대하여 분석한 실증연구 이다. 이를 위한 연구 방법으로서 본 논문은 서비스/제조/IT 대기업 종사자를 대상으로 설문조사를 실시 하였고, 이를 토대로 산업별 변수 간의 관계에 대하여 비교·분석하였다. 본 연구에서 사용한 용어에 대한 정의를 살펴보면, 혁신행동은 새로운 공정 혹은 제품 아이디어를 찾고 개발하며, 아이디어를 실행하기 위해 필요한 자금을 확보하고, 적합한 실행 계획과 일정을 수립하고 스케 줄을 개발하는 행동을 의미한다. 급변하는 경영환경 속에서 기업이 지속적인 경쟁우위를 획득하기 위해 서는 다양한 방법으로 조직의 변화와 혁신을 추구하여야 하며, 이러한 혁신행동의 선행요인으로서 지식 경영활동과 학습조직활동이 중요하게 인지되었다. 이상과 같이 실시된 연구 결과를 종합하여 살펴보면, 서비스업과 제조업, IT업은 개인의 학습조직 활동 이 지식경영활동과 혁신행동에 모두 유의한 영향을 미치는 것으로 나타났다. 또한 지식경영활동도 혁신 행동에 유의한 영향을 미치는 것으로 나타났다. 각 집단 별로 분석해보면, 개인의 학습조직활동이 지식경 영활동에 미치는 영향에서는 제조업이 가장 큰 것으로 나타났다. 또한 지식경영활동이 혁신행동에 미치 는 영향에 있어서는 IT업이 가장 큰 것으로 나타났고, 개인의 학습조직활동이 혁신행동에 미치는 영향에 서는 제조업이 가장 큰 것으로 나타났다. 마지막으로 위와 같은 분석결과를 토대로, 본 연구는 학습조직활 동이 산업별 종사자들에게 미치는 차이점과 변수 간의 관계에 대하여 중점적으로 논의하였고 그 원인을 제시하였다. This is an empirical study analyzing the effects of individual's learning organization activity on knowledge management activity and innovative behavior. In this study, a survey was conducted on the employees of large business organizations in the fields of services, productions, and IT, and relationship between the variables among different industries was compared and analyzed. Among the terminologies used in this study, the innovative behavior indicates the following: seeking and developing new process or product ideas, obtaining necessary budget for executing the ideas, and establishing appropriate execution plan and developing schedule. In order to secure competitive advantage in this quickly advancing business environment, various methods should be used to promote innovations and organizational changes. The important antecedents of these innovative behaviors can be known as knowledge management activity and learning organization activity. As a result of this study, the individual learning organization activity was shown to have a significant effect on knowledge management activity and innovative behavior, in the fields of services, production, and IT. Also, the knowledge management activity had significant effect on the innovative behavior. According to the analysis by each group, the effect of individual learning organization activity on knowledge management activity was shown to be greatest in the field of production. Also, the effect of knowledge management activity on innovative behavior was shown to be greatest in the field of IT. Finally, the effect of individual learning organization activity on innovative behavior was shown to be greatest in the field of production. Based on the above analysis, this study examined the relationship between the differences and the variables of the effects of learning organization activity on employees of each field, and its causes were suggested

Expression of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$ and PPAR-${\gamma}$ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue

Ryu, Seung Lok,Shim, Jae Won,Kim, Duk Soo,Jung, Hye Lim,Park, Moon Soo,Park, Soo-Hee,Lee, Jinmi,Lee, Won-Young,Shim, Jung Yeon The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.4

Purpose: We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$, PPAR-${\gamma}$, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-${\gamma}$ agonist. Methods: We developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and without rosiglitazone. We performed real-time polymerase chain reaction for leptin, leptin receptor, adiponectin, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-${\alpha}$, transforming growth factor (TGF)-${\beta}$, PPAR-${\alpha}$ and PPAR-${\gamma}$ from the lung tissue and determined the cell counts and cytokine levels in the bronchoalveolar lavage fluid. Results: Mice with OVA challenge showed airway hyperresponsiveness. The lung mRNA levels of PPAR${\alpha}$ and PPAR-${\gamma}$ increased significantly in obese mice with OVA challenge compared to that in other types of mice and decreased after rosiglitazone administeration. Leptin and leptin receptor expression increased in obese mice with and without OVA challenge and decreased following rosiglitazone treatment. Adiponectin mRNA level increased in lean mice with OVA challenge. Lung VEGF, TNF-${\alpha}$, and TGF-${\beta}$ mRNA levels increased in obese mice with and without OVA challenge compared to that in the control mice. However, rosiglitazone reduced only TGF-${\beta}$ expression in obese mice, and even augmented VEGF expression in all types of mice. Rosiglitazone treatment did not reduce airway responsiveness, but increased neutrophils and macrophages in the bronchoalveolar lavage fluid. Conclusion: PPAR-${\alpha}$ and PPAR-${\gamma}$ expressions were upregulated in the lung tissue of OVA-challenged obese mice however, rosiglitazone treatment did not downregulate airway inflammation in these mice.

The Association between the State of Lipiodol Uptake after TACE and Recurrence of HCC

( Soo Yeon Jo ),( Soo Hyung Ryu ),( Jung Hwa Min ),( Kyung Jin Lee ),( Bo Kyung Lee ),( Won Jae Yoon ),( Jeong Seop Moon ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Transarterial chemoembolization (TACE) has regarded as one of the major therapies for Hepatocellular carcinoma (HCC). However, the frequent recurrence after TACE has been a major limitation of HCC treatment. We evaluated whether compact or incompact lipiodol uptake in tumors after first TACE affects the rates and patterns of recurrence. Methods: We retrospectively analyzed the HCC patients who underwent underwent first TACE at Seoul Paik Hospital from January 2000 to March 2016. Only HCC patients with the size ≤ 5 cm and the number less than 3 who were followed up at least more than 6 months after TACE were included in this study. A total of 36 HCC patients (M:F=26:10; Age: 65.3 ± 9.1 years; 21 HBV, 11 HCV, 2 alcohol, 2 unknown; Child-Pugh Class 29 A, 6 B) were subjected. We analyzed relationship between the state of lipiodol uptake and the rates and patterns of first detected recurrence during follow-up. Results: On an abdominal CT performed one month after first TACE, compact lipiodol uptake was noted in 24 patients and incompact lipiodol uptake was seen in 12 patients. In the compact lipiodol uptake group, regarding recurrence patterns, marginal recurrence, intrahepatic recurrence as new lesion, and both of them were 21.1%, 68.4%, and 10.5%, respectively, while in incompact uptake group, 50.5%, 41.7%, and 8.3%, respectively. The cumulative recurrence rate of HCC at 1, 2, and 3 years after 1st TACE were significantly lower in compact uptake group than in incompact uptake (54.2%, 67.2%, and 67.2% vs. 83.3%, 91.7%, and 91.7%, respectively, P=0.011). The cumulative rates of marginal recurrence of HCC was significantly higher in the incompact uptake group (P=0.008). Conclusions: The patients with incompact lipiodol uptake after TACE showed significant higher rates of recurrence. Therefore, further management for HCC or short term follow up should be considered in these patients.

Secondary adrenal insufficiency caused by sorafenib administration in a patient with hepatocellular carcinoma

( Soo Yeon Jo ),( Soo Hyung Ryu ),( Mi Young Kim ),( Jeong Seop Moon ),( Won Jae Yoon ),( Jin Nam Kim ) 영남대학교 의과대학 2016 Yeungnam University Journal of Medicine Vol.33 No.2

Sorafenib (Nexavar) has been regarded as a treatment for unresectable hepatocellular carcinoma (HCC), with side effects that include hand-foot skin reaction, diarrhea, rash, fatigue, hypertension, nausea, anorexia, weight loss, and alopecia. Thyroid disorder, such as endocrine side effect, has also been reported. However no case involving adrenal insufficiency has been reported. Here, we report a case of adrenal insufficiency which occurred after taking sorafenib in a patient with HCC. A 56-year-old man visited our hospital due to right upper quadrant abdominal pain and he was diagnosed as multiple disseminated and unresectable HCCs with portal vein invasion; therefore transarterial chemoembolization was performed and sorafenib administration was started. Two months later, he was admitted to the hospital complaining of severe fatigue. The laboratory results showed cortisol of <0.2μ g/dL and adrenocorticotropic hormone of <1.00 pg/mL. The patient had no history of taking steroids or herbal medications. Secondary adrenal insufficiency was diagnosed and prednisolone 10 mg per day was started immediately; as a result, fatigue remarkably improved. This may be the first report indicating a possible association between sorafenib and adrenal insufficiency and it implies that the possibility of adrenal insufficiency should be considered in patients taking sorafenib who complain of severe fatigue.

Intracellular Ca^(2+) Mobilization and Beta-hexosaminidase Release Are Not Influenced by 60 Hz-electromagnetic Fields (EMF) in RBL 2H3 Cells

Yeon Hee Hwang,Ho Sun Song,Hee Rae Kim,Myoung Soo Ko,Jae Min Jeong,Yong Ho Kim,Jeong Soo Ryu,Uy Dong Sohn,Yoon-myoung Gimm,Sung-Ho Myung,Sang Soo Sim 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.5

The effects of extremely low frequency electromagnetic fields (EMF) on intracellular Ca^(2+) mobilization and cellular function in RBL 2H3 cells were investigated. Exposure to EMF (60 Hz, 0.1 or 1 mT) for 4 or 16 h did not produce any cytotoxic effects in RBL 2H3 cells. Melittin, ionomycin and thapsigargin each dose-dependently increased the intracellular Ca2+ concentration. The increase of intracellular Ca^(2+) induced by these three agents was not affected by exposure to EMF (60 Hz, 1 mT) for 4 or 16 h in RBL 2H3 cells. To investigate the effect of EMF on exocytosis, we measured beta- hexosaminidase release in RBL 2H3 cells. Basal release of beta-hexosaminidase was 12.3±2.3% in RBL 2H3 cells. Exposure to EMF (60 Hz, 0.1 or 1 mT) for 4 or 16 h did not affect the basal or 1μM melittin-induced beta-hexosaminidase release in RBL 2H3 cells. This study suggests that exposure to EMF (60 Hz, 0.1 or 1 mT), which is the limit of occupational exposure, has no influence on intracellular Ca^(2+) mobilization and cellular function in RBL 2H3 cells.

Model Organisms in Development and Disease : Regulation of the retinocollicular topography by endocytosis of the Ephephrin signaling complex

( Soo Yeon Ryu ),( Yu Jin Kim ),( Soo Chul Park ) 한국생화학분자생물학회 (구 한국생화학회) 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-

Significance of Anti-HCV Signal-to-Cutoff Ratio in Predicting Hepatitis C Viremia

( Yeon Seok Seo ),( Eun Suk Jung ),( Jeong Han Kim ),( Young Kul Jung ),( Ji Hoon Kim ),( Hyong Gin An ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Chang Duck Kim ),( Ho Sang Ryu ),( Soo 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.4

Background/Aims: Hepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which is more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) for predicting HCV RNA results. Methods: Patients on whom a qualitative HCV RNA test was performed due to a positive anti-HCV enzyme immunoassay were enrolled. Patients were divided into viremia and no-viremia groups according to HCV RNA results. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO for a diagnosis of viremia. Results: In total, 487 patients were enrolled. HCV RNA was positive in 301 subjects (61.8%). Age, serum ALT level, and anti-HCV S/CO ratio were significantly different between the viremia and no-viremia groups. By ROC curve analysis, anti-HCV S/CO ratio (area, 0.989; 95% confidence interval, 0.981 to 0.998) accurately predicted the presence of viremia, with a cutoff value of 10.9 (sensitivity, 94.4%; specificity, 97.3%). Conclusions: Anti-HCV S/CO ratio was found to be highly accurate at predicting HCV viremia. The anti-HCV S/CO ratio can be used to determine whether a quantitative or qualitative HCV RNA test should be used to confirm HCV viremia in patients with a positive anti-HCV by the following criteria: if the anti-HCV S/CO ratio is <10.9, a qualitative HCV RNA test can be used, and if the anti-HCV S/CO ratio is ≥10.9 a quantitative HCV RNA test can be performed. (Korean J Intern Med 2009;24:302-308)

Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by <i>Helicobacter pylori</i> in Human Gastric Carcinogenesis

Ryu, Yeon-Mi,Myung, Seung-Jae,Park, Young Soo,Yang, Dong-Hoon,Song, Ho June,Jeong, Jin-Yong,Lee, Sun Mi,Song, Miyeoun,Kim, Do Hoon,Lee, Hyo-Jeong,Park, Soo-Kyung,Fink, Stephen P.,Markowitz, Sandy D.,J American Association for Cancer Research 2013 Cancer prevention research Vol.6 No.4

<P><I>Helicobacter pylori</I> (<I>H. pylori</I>) infection induces a chronic inflammatory response, which promotes gastric carcinogenesis. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) plays a key role as a tumor suppressor in gastrointestinal cancers. The aim of this study was to elucidate the role of 15-PGDH in gastric carcinogenesis associated with <I>H. pylori</I>. 15-PGDH expression in gastric biopsies from <I>H. pylori</I>–infected (<I>n</I> = 25) and noninfected (<I>n</I> = 15) subjects was analyzed by quantitative real-time PCR, Western blot analysis, and immunohistochemistry. 15-PGDH DNA methylation was evaluated by methylation-specific PCR and pyrosequencing. The expression of 15-PGDH, Snail, extracellular signal–regulated kinase (ERK)1/2, TLR4, and MyD88 in response to <I>H. pylori</I> infection was assessed by immunoblot analysis. Compared with negative specimens, <I>H. pylori</I>–positive specimens had 2-fold lower 15-PGDH mRNA levels and significantly less 15-PGDH protein. In four <I>H. pylori–</I>infected subjects with longitudinal follow-up, the suppression of 15-PGDH expression was reversed by <I>H. pylori</I> eradication therapy. In parallel with suppressing 15-PGDH expression, <I>H. pylori</I> infection activated expression of TLR4 and MyD88 expression, increased levels of phospho-ERK1/2, and increased expression of EGF receptor (EGFR)-Snail. Inhibition of Snail and MyD88 reversed suppression of 15-PGDH expression, and siMyD88 reduced phosphorylated ERK1/2. Similarly, treatment with an ERK1/2 and EGFR inhibitor also restored 15-PGDH expression. <I>H. pylori</I> appeared to promote gastric carcinogenesis by suppressing15-PGDH. This process is mediated by the TLR4/MyD88 pathway via ERK1/2 or EGFR-Snail transcriptional regulation. 15-PGDH may be a useful marker and a potential therapeutic target in <I>H. pylori</I>–induced gastric carcinogenesis. <I>Cancer Prev Res; 6(4); 349–59. ©2013 AACR.</I></P>