다발성 뇌동맥류 환자의 수술적 치료 결과에 대한 고찰

이녹영,김재민,백광흠,신형식,김영수,고용,오성훈,오석전,김남규,김광명 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

From January 1990 to January 1996, we analyzed outcome according to the distribution of aneurysms the type of surgical treatment the timing of operation, and the patient's pre-operative status in a total of 54 cases of multiple intracranial aneurysms. The frequency of multiple intracranial aneurysms was 13.4% and the sex ratio was 1 : 2 with female being predominant. The frequency of aneurysmal location was MCA(35.0%), P-comm, artery(25.0%) and A-comm artery (15.0%) in that order. The number of ruptured aneurysms was in the order of MCA aneurysms A-comm aneurysms, and F-comm aneurysms. The size of ruptured aneurysms was 6-10mm if 34 cases(64.2%). The unilateral distribution of aneurysms was 31 cases(57.4%) and the bilateral was f8 cases(42.6%). Depending on how many times the patient had the operation, there were 29(57.4%) cases of complete single operation, 17 cases(31.5%) of complete two-stage operation, and 8 cases(14.8%) of partial operation. Surgical outcome was good(GOS≤4) in 42 cases(77.8%). and six patients(11.1%) expired. Based on the results of the above study we have concluded that initial Hunt-Hess grade has a close relationship with the outcome, but the operation type, the timing of operation, the number and distribution of aneurysms do not significantly effect the outcome.

추체골을 침범한 측두골의 원발성 횡문근육종

이녹영,김영수,백광흠,김재민,고용,오성훈,오석전,김남규,김광명 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

The rhabdomyosarcoma(RMS), a leading malignant soft tissue tumor in the pediatric population, occurs most commonly in the craniocervical region RMS has involved the temporal bone approximately 7% in the literature. Petrous bone invasion was very rare and the overall outcome was always fatal, in spite of the efficacy of multimodality therapy until recent years. The authors report a case of primary RMS in the temporal bone invading petrous bone and the result of multimodality treatment.

대퇴골 간부에 발생한 피로 골절

이재형,김종오,문병철,김철준,강승구,김녹수 대한골절학회 1996 대한골절학회지 Vol.9 No.4

Fatigue fracture art commonly seen in military personnel. especially at basic training c enter. and have been noted in athletes, ballet dancers, laborers, and even pregnant women. This type of injury is usually encountered in the metatasal shaft. however in we cases, fatigue fracture in the femoral shaft was reported. The purpose of this article is to call attention to the importance of early diagnosis of fatigue fracture of the shaft of the femur so that displacement, which may lead to the necessity for surgical intervention, may be prevented. The following clinical results were obtained by analysis of 6 cases of femoral fatigue fractures experienced in the department of orthopedic surgery, Capital Armed Forces General Hospital from January 1993 to April 1996. 1. A series of 6 femoral fatigue fractures are reponed in the military recruits. 2. The average age was 21 years and all patient's sex were male. 3. All the patients were peculiarly army recruits, whose average body heights were 170.3 centimeters and body weights were 61.6 Kilograms. 4. All the patients had previously led a sedentary life style, with very little physical activity of any kind. including walking. 5. The site of predilection in the femoral shaft was distal one-third, occuring .in 5(83 3%) of the cases. The site of other one case was middle one-third of the shaft. 6. The main cause of the fatigue fractures was marching on had roads, and other cause was playing football. 7. Most of femoral fatigue fractures were classified as grade I, showing periosteal reaction on bath cortices. 8. All soldiers were treated by immedinte stoppage of physical activity, with no plaster immobiization except a displaced fatigue fracture.

PLOS : ONE ; Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic potentials

( Thanh Thi Nguyen ),( Somy Yoon ),( Yi Yang ),( Ho Bin Lee ),( Soo Nok Oh ),( Min Hye Jeong ),( Jong Jin Kim ),( Sung Tae Yee ),( Florin Crisan ),( Cheol Moon ),( Kwang Youl Lee ),( Kyung Keun Kim ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-

Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested the cytotoxic activity of 17 lichen species against several human cancer cells and further investigated the molecular mechanisms underlying their anti-cancer activity. We found that among 17 lichens species, F. cucullata exhibited the most potent cytotoxicity in several human cancer cells. High performance liquid chromatography analysis revealed that the acetone extract of F. cucullata contains usnic acid, salazinic acid, Squamatic acid, Baeomycesic acid, d-protolichesterinic acid, and lichesterinic acid as subcomponents. MlT assay showed that cancer cell lines were more vulnerable to the cytotoxic effects of the extract than non-cancer cell lines. Furthermore, among the identified subcomponents, usnic acid treatment had a similar cytotoxic effect on cancer cell lines but with lower potency than the extract. At a lethal dose, treatment with the extract or with usnic acid greatly increased the apoptotic cell population and specifically activated the apoptotic signaling pathway; however, using sub-lethal doses, extract and usnic acid treatment decreased cancer cell motility and inhibited in vitro and in vivo tumorigenic potentials. In these cells, we observed significantly reduced levels of epithelialmesenchymal transition (EMn markers and phosphor-Akt, while phosphor-c-Jun and phosphor-ERK1/2 levels were only marginally affected. Overall, the anti-cancer activity of the extract is more potent than that of usnic acid alone. Taken together, F. cucullata and its subcomponent, usnic acid together with additional component, exert anti-cancer effects on human cancer cells through the induction of apoptosis and the inhibition of EMT.

퇴행성 요추 질환에서 후방경유 추체간 유합술과 360° 고정술의 비교

이녹영,오성훈,이우택,배재성,이형중,김영수,고용,김광명,오석전,Lee, Nok Young,Oh, Seong Hoon,Rhee, Woo Tack,Bae, Jae Seong,Yi, Hyeong Joong,Kim, Young Soo,Ko, Yong,Kim, Kwang Myung,Oh, Suck Jun 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.10

Objectives : The goal of operation for degenerative lumbar diseases is to relieve radiculopathy and low back pain and to prevent further degeneration. The authors analyzed the surgical results of posterior lumbar interbody fusion(PLIF) and $0^{\circ}$ fixation to evaluate the proper treatment policy in spinal stenosis, degenerative spondylolisthesis and low grade isthmic spondylolisthesis. Material and Methods : The authors performed PLIF on 92 patients and $0^{\circ}$ fixation on 138 patients with spinal stenosis, degenerative spondylolisthesis and low grade isthmic spondylolisthesis. We retrospectively studied clinical outcomes and subjective satisfaction of these patients by several criteria such as visual analog scale(VAS), Prolo's economic and functional outcome scale, medication usage after operation and questionaire for overall outcome. Result : Pre- and postoperative VAS on back pain and leg pain showed decrease of pain from 6.5, 6.7 to 2.2, 2.4 in PLIF group and from 7.0, 7.2 to 2.5, 2.7 in $0^{\circ}$ fixation group. Excellent and good outcomes on Prolo's scale were 81.5% in PLIF group and 82.6% in $0^{\circ}$ fixation group. Medication usage after operation was reduced in 79.3% of PLIF group and in 78.3% of $0^{\circ}$ fixation group. Patients' self-reported overall success of their procedure showed 82% in PLIF group and 84% in $0^{\circ}$ fixation group. Conclusion : Both PLIF and $0^{\circ}$ fixation showed good outcomes and provided biomechanically stable fusion in spinal stenosis, degenerative spondylolisthesis and low grade isthmic spondylolisthesis. Therefore, only PLIF seems necessary and considered a proper surgical treatment for these disorders.