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유원석,이재응,한재영 중앙대학교 기술과학연구소 1996 기술과학연구소 논문집 Vol.26 No.-
본 연구에서는 변위, 속도, 가속도 등의 진동 응답 신호중에서 어느 신호가 비선형 진동계의 비선형 특성을 잘 규명할 수 있는지에 대해서 연구하였다. 진동 응답 신호는 Runge-Kutta법을 사용하여 발생시켰고, 비선형 진동계는 NARMAX(Nonlinear AutoRegressive Moving Average with eXogenous input) 모델로 표현하였다. NARMAX 모델의 계수 추정은 직교 알고리즘을 사용하였다. 모의실험 결과, 비선형 강성을 갖는 계는 규명할 경우는 변위 신호가 가장 적절하였고, 비선형 감쇠를 갖는 계를 규명할 경우는 속도 신호가 가장 적절하였다. 실제 실험을 통해서 진동계의 규명에 가장 많이 쓰이는 가속도 신호는 비선형 진동계의 특성을 규명하는데는 부적절함을 알 수 있었다. 비선형 강성과 비선형 감쇠를 갖는 계는 변위와 속도 신호를 모두 이용해야 할 것으로 앞으로 많은 연구가 필요하다고 사료된다. In this study, identification problems of nonlinear vibrational system has been addressed, and the ability of the various vibration response(i.e. displacement, velocity, and acceleration) signals to identify the nonlinear characteristics of the system has been investigated. Runge-Kutta method has been used to generate the vibration response signals, NARMAX model used to identify the nonlinear vibration system, and the orthogonal algorithm used to identify the parameters of the NARMAX model. The simulation results show that the stiffness nonlinearity can be well identified by using the displacement signals, and the damping nonlinearity well identified by using the velocity signals. The acceleration signals, which is the most widely used vibration signal in real experiments, could not identify the nonlinear characteristics of the system.
다량의 하부위장관출혈이 병발된 Vibrio vulnificus 패혈증 1예
최주연,유진홍,한석원,이대훈,최민호,박순민,김연식,김선우,신완식,강문원,강성구 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2
최근 저자들은 Vibrio vulnificus 감염에 의해 패혈증 및 이차성 피부 병변을 보인 42세의 남자 환자의 치료중 하부 위장관 출혈이 병발된 1예를 경험하였기에 보고하는 바이다. We experienced a case of Vibrop vulnificus septicemia which showed an unusual manifestation such as hematochezia. The patient was a 42-year-old man with chronic liver disease. The blood and wound culture revealed the organism. During intensive care, he suffered from massive hematochezi for several days. Colonoscopy and abdominal CT showed findings suspicious of ischemic colitis. To our knowledge, this is the first unusual case of V.vulnificus infection which showed massive lower gastrointestinal bleeding.
Influence of Vagotomy on Gastric Mucosal Protection of Diallyl disulfide in the Rat
Han, Sok Won,Sun, Hee Sik,Choi, Myung Gyu,Chung, In Sik,Kim, Boo Sung CATHOLIC MEDICAL CENTER 1990 Bulletin of the Clinical Research Institute Vol.18 No.2
Cisplatin has antineoplastic activity, but many side effects including nephrotoxicity and ototoxicity. Several treatments have been used to minimize nephrotoxicity but reports of ototoxicity have been scarce. The purpose of this study was to investigate morphologically the effect of sodium thiosulfate (575) on ototoxicity induced by cisplatin in guinea pig. The results were as follows: 1. Degeneration of the cochlear hair cells in the group treated with Cisplatin alone were observed in the lower turn, particular in the basal turn. The first row of the outer hair cells were severely damaged, but inner hair cells were intact. Comparison of the degree of degeneratin between each row showed decrease of severity in the following order; first second, thired rows of the outer hair cells. 2. Degenerative changes of cochlear hair cells showed to be histopathologically much less severe in the guinea pigs given both cisplatin combined sodium thiosulfate compared with the guinea pigs given cisplatin alone. 3. There was no significant difference in degenerative change of cochlear hair cell between divided dose group and single dose group. 4. Degenerative changes of cochlear hair cells in group 5 were similar to those of single dose group with cisplatin alone.
이영석(Young Sok Lee),한남익(Nam Ik Han),박일영(Il Young Park),김욱(Wook Kim),원종만(Jong Man Won),이종호(Jong Ho Lee),한석원(Seok Won Han) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.3
Solitary or multiple pancreatic stones are commonly associated with chronic pancreatitis, however, little is known of their pathogenesis. But they are believed to develop by the calcification of intraductal protein plugs which are composed primarily of calcium carbonate in the form of calcite and pancreatic stone protein. And choledochal cyst is a relatively rare anomaly usually presenting with abdominal pain, jaundice and palpable mass. The follwing is a report of 53 years female patient with intermittent RUQ abdominal pain, palpable mass and large calcification shadow on a abdominal plain radiography who showed no clinical and biochemical evidence of pancreatitis. Investigation revealed a simultaneously developed Type-I choledochal cyst with huge, multiple pancreatic duct stones which were treated by cholecystectomy, excision of choledochal cyst with Roux-en-Y choledochojejunostomy anddirect pancreaticolithotomy.
무증상 B 형 간염 보균자에서 생긴 이형성 간세포 선종 1예
정규원,김부성,이영석,선희식,한남익,한석원,지미경,이해규,김석헌 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2
The hepatocellular adenoma is a rare benign tumor, occupying on non-cirrhotic liver, especially in man. we experienced a case of hepatocellular adenoma from a 34 year-old, HBs Ag positive, man. The hepatocellular adenoma with severe dysplasia was confirmed by histologic examination after operation.
이성원(Sung Won Lee),이영석(Young Sok Lee),한석원(Suk Won Han),한남익(Nam Ik Han),김욱(Wook Kim),원종만(Jong Man Won),장은덕(Eun Deok Chang),이해규(Hae Giu Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Malignant fibrous histiocytoma is the major subset of soft tissue sarcomas which occurs most commonly in the extremities and trunk, but rarely in the visceral organs. This report documents a case of malignant fibrous histiocyoma arising in the omentum in 36 year-old female whose chief complaints were growing non-tender masses. After surgical resection, there are no evidences of recurrencee or metastasis during 4 months follow up period. Electron microscopic study of the tumor showed irregular, spindle-shaped histiocyte with large indented nuclei and prominent nucleoli. The cytoplaem was abundant with microfilament and distended mitochondria. There was no evidence of myofibril in the tumor.
이은정,최규용,정인식,이강문,선희식,이창돈,신제현,한석원,안창혁,김성수,한원희,채현석,손동균,박만원 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6
The prevalcnce of colorectal cancer is increasing now in Korea and the principal strategy of its management is early detection and surgical resection. Current discussion of the topic of colorectal polyps and cancer is largely based on the concept of the adenoma-carcinoma sequence, which is thought to be the most probable pathogenesis for colorectal cancer. But the case reports about colonic adenocarcinoma arising from adenoma in clinical practice between short interval arc rare in Korea. We experienced two cases of colon cancer, which were transformed from small adenoma can not be removed because of patients' refusal, 3 years ago. So we present these cases with a review of relevant litcratures.
PTP1B Inhibitory Effect of Abietane Diterpenes Isolated from <i>Salvia miltiorrhiza</i>
Han, Yu Mi,Oh, Hyuncheol,Na, MinKyun,Kim, Beom Seok,Oh, Won Keun,Kim, Bo Yeon,Jeong, Dae Gwin,Ryu, Seong Eon,Sok, Dai-Eun,Ahn, Jong Seog Pharmaceutical Society of Japan 2005 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.28 No.9
<P>Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of <I>Salvia miltiorrhiza</I> B<SMALL>UNGE</SMALL> (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1—3. Compounds 1—3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1—3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μ<SMALL>M</SMALL>, 22.4±0.6 μ<SMALL>M</SMALL> and 56.1±6.3 μ<SMALL>M</SMALL>, respectively.</P>