흰쥐 심장혈관계통에서 3β-hydroxysteroid dehydrogenase/△⁵-△⁴ isomerase의 분포에 관한 연구

오선희,오재민,백용아,박옥규,정연태 대한해부학회 1988 Anatomy & Cell Biology Vol.31 No.3

게리 스나이더(Gary Snyder)의 자연 : 산(Mountain)과 넓적돌(Boulder)의 이미지 Imabes of Mountain and Boulder

박선희 우석대학교 인문사회과학연구소 1998 인문사회과학논총 Vol.1 No.1

The spirit of Gary's poems seems to be derived from the mountains he has climbed up and from the mountains he appreciated in eastern landscape-paintings. 'Mountain' in his poetry connotes a supreme sphere he is aware of his 'mountain' is not a mountain we climb once, but a 'mountain' endlessly, nor a mountain never changed, but a 'mountain' born newly and continually in the course of his life. Gary's 'mountain' reflects his prospect for a hopeful future he has mode true in the course of his life, and is the most precious life he suggests to mankind. The image of boulder in his poems implies a mechanism or a mental process through which a poet may reach to his spiritual awakening in order to live an exalted life he suggests. He makes an overture to take a room for sitting on the boulder to live in harmony with nature, and reminds the readers of the fact that nature and human being are inseparably related. Gary's view of nature presupposes an organic relationship between all the things in the earth and a relationship of reciprocal coexistence and interanimating. He insists that the harmony of nature in the condition of all the variety in nature living brings forth the supreme sphere. Cary inspires that his concern in ecosystem springs from a duty of a poet, and that oneness with nature brings the supreme space to live together.

토당귀 종자의 형태적 특성과 발아와 입모율에 대한 저장방법,생장조절제 및 프라이밍 처리 효과

안희정,안복주,·김도현,·안영섭,·김영국,박춘근,이상원,·박충범·차선우,·송범헌, 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.1

This study was conducted to have basic and applied informations to establish the cultivation method and to improve the cultivation techniques of Angelica gigas Nakai through investigating the rates of germination and seedling establishment with treatment of plant growth regulator and seed priming. The germination rates of round shape seed were about 0.3~12% higher than those of parallel shape. The germination rates with different storage durations were increased at the level of 25oC and 4oC with the storage days, while they were clearly higher at -20oC compared to those at 4oC and 25oC without the storage durations. With the results of germination rates with treating of plant growth regulator and seed priming, their rates with the round shape seeds were comparatively higher about 6% than those with parallel shape seed and they were increased with increasing of the storage durations. The germination rates were generally appeared higher with GA3 than did those with seed priming. The highest germination rate was appeared at 50 ppm GA3 of plant growth regulator and at -0.5 MPa PEG6000 of seed priming. The germination rates?ㅤ ?ㅤ of Angelica gigas were different with different temperature, storage durations and the treatments of plant growth regulator and seed priming. These results could be used according to different cultivating conditions.

해외여행상품구매에 있어서의 라이프스타일과 구매행동유형

윤선희,박정아 문화관광연구학회 2000 문화관광연구 Vol.2 No.4

This paper used psychological variables to understand outbound tourists' purchase behavior on life-style and purchase-style. The purpose of this study is to analyze lifestyle and purchase-style types of outbound tourists. Also it is to see if there is any relationship between life-styles and purchase styles. The research Method includes literary studies and empirical studies. Using 240 questionnaire respondence of outbound tourists, author conducted factor and cluster analysis with one-way ANOVA analysis. The results are as follows. First, the segment-markets according to the life-styles of outbound of tourists turned out to be external/achivemental, indivisualistic and traditional types. Second, purchase-style types of outbound tourists showed advertisement-purchase, safe-purchase, practical-purchase and loyal-purchase. Third, it reveals that there is difference between purchase styles and life styles. In conclusion, purchase-style variable as well as life-style one counts very usefully to be aware of the purchase behavior of outbound tourists.

음주 운동 및 식생활사이의 관련성

박영숙,김희선 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

A survey was performed to investigate the relationship among drinking, exercises and dietary variables of male college students in order to improve their dietary status and habits. The subjects of 199 were asked to answer the questionaires and to visit the students' health center for their anthropometric measurements. Over 81% of the male college students enjoyed drinking and that was as often as once a week mostly. The students usually did exercises by 82.7%, which belonged to moderate strength. Their diet status revealed as moderate by over 60% and as poor by 34.2%. Drinking frequently seemed to be related to reduced nutrition knowledge and to inferior diet status, but not to weight, blood pressure, BIA and various illness. Exercise group showed significantly increased body weight and decreased BIA when compared to no exercise group. But there were no difference in blood pressure, various illness, nutrition knowledges or diet status by exercise.

하악에 발생한 과잉치의 치험례 : A CASE REPORT

박정아,양규호,,최남기,김선미,장희숙 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

과잉치는 정상치판(dental lamina)의 과도한 증식이 결과로 발생되어, 가족적 성향을 보이며, 쇄골두개이형성(Cleidocranial dysplasia), Gardner 증후군 등의 여러 질환과 관련되어 나타나기도 한다. 그 빈도는 유치열에서 0.3~0.8%, 영구치열에서 1.0~3.5% 이고, 남성에서 호발되며(2:1), 상악에서 더 많이 발생한다(9:1). 상악에서는 mesiodens라고 불리는 중절치 사이의 위치가 가장 흔한 부위이고, 그 다음은 fourth molar와 측절치 부위이다. 하악에서는 소구치 부위가 가장 흔한 부위이고 전치부위에서는 약 2%로 매우 드물게 발생한다. 과잉치의 만기 잔존은 치간 이개, 인접한 치아의 맹출 장애, 치근 흡수 등을 야기하고 과잉치와 관련되어 함치성 낭종이 발생될 수 있으므로 조기진단과 적절한 치료가 중요하다. 본 두 증례는 비교적 드물게 나타나는 하악에 발생한 과잉치로, 하악 전치부와 소구치부에 발생한 과잉치를 발거하고 교정치료를 시행하여 양호한 결과를 얻었기에 보고하는 바이다. Supernumerary tooth was resulted from excessive proliferation of dental lamina and associated with familial tendency and a congenital syndrome such as Cleidocranial dysostosis or Gardner's syndrome. Incidence reports identify a range of 0.3~0.8% in primary dentition. 1.0~3.5% in permanent dentistion with males being affected twice as frequently as females. maxilla nine times as frequently as mandible. The most common supernumeraty tooth is the mesiodens, which located between the maxillary central incisors, and the next common site is the fourth molar and lateral incisors. Supernumerary teeth are uncommon in the mendible, but premolars are the most common supernumerary teeth and occurrence is very rare in the incisor region of the mandible of possibility of diastema and cruption failure displacement. rotation of the associated permanent teeth, root resorption and dentigerous cyst with presence of the supernumerary teeth. In this two case, one supernumerary tooth located in the mandibular incisor region, the other supernumerary tooth located in premolar region. We could get normal alignment of mandibular dentition by extraction and orthodontic treatment.

약물로 인해 유발된 좌불안석증에서 세로토닌 차단제인 Cyproheptadine의 효과

정동선,박인준,권영준,정희연,한선호 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

목 적 : 약물로 인해 유발된 좌불안석증은 항정신병 약물로 치료받은 환자에게서 자주 발생한다. 항세로토닌 제제인 Cyproheptadine은 좌불안석증 환자들을 치료키 위해 사용되어져 왔다. 방 법 : 21명의 항정신병 약물로 치료받은 좌불안석증을 동반한 환자들이 4일간에 걸쳐 하루 16mg의 Cyproheptadine을 투여 받았다. 좌불안석증에 대한 평가는 Barnes' rating scale을 이용하여 이루어졌다. 우울증과 정신병증상의 정도가 Brief psychiatric rating scale(BPRS)와 Hamilton rating scale for depression(HAM-D)에 의해 평가되어졌다. 결 과 :좌불안석증을 보인 대부분의 환자들이(20/21) Cyproheptadine 치료에서 호전을 보여주었다. 치료기간에 정신병이나 우울증의 악화는 없었다. Cyproheptadine 투여가 중단되었을 때 좌불안석증의 증상은 악화되었다. 결 론 : Cyproheptadine은 약물로 인해 유발된 좌불안석증 치료에 유용하다. Objective : Neuroleptic Induced Akathisia(NIA) often occurs in neuroleptic treated patients. Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic induced akathisia. Method : In an open trial 21 neuroleptic-treated patients with akathisia were administrated Cyproheptadine(16mg/day) over 4 days. Assessment of akathisia was evaluated using Barnes' rating scale(BAS) for neuroleptic induced akathisia. The degree of depression and psychosis were assessed by brief psychiatric rating scale(BPRS) and Hamilton rating scale for depression(HAM-D). Result : Most patients(20 of 21) with neuroleptic induced akathsia(NIA) showed improvement under the treatment of cyproheptadine. There was no aggravation of psychosis or depression during the treatment. Symptoms of akathisia aggravated when cyproheptadine was discontinued. Conclusion : Cyproheptadine may be useful in the treatment of neuroleptic induced akathisia(NIA).

비알콜성 지방간 : 임상소견과 초음파소견의 비교

채희복,김미성,박선미,성노현,윤세진 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 : 최근 건강검진이 널리 시행됨에 따라서 지방간 환자가 많이 발견되고 있으며 이에 대한 사람들의 관심이 증대되고 있다. 본 논문에서는 지방간 환자의 임상적인 특징을 살펴보고 위험요인과 예후에 관련된 인자들을 규명해 보고자 하였다. 연구대상 및 방법: 1998년 2월부터 2000년 3월까지 충북대학교 병원에 내원한 환자 중 초음파로 지방간을 진단받은 65명의 환자를 대상으로 하였다. 후향적으로 진료기록을 검토하였으며, 전화로 체중, 키, 음주력, 약물복용력, 관련증상 유무를 확인하였다. 초음파상 지방간의 중증도와 대상환자들의 체질량지수, 혈청 ALT치의 상승, 기저질환, 관련 임상 증상들간에 상관성이 있는지를 비교분석 하였다. 결과: 체질량지수와 초음파상 지방간의 중증도간에는 유의한 상관관계가 관찰되었다. 혈청 ALT치를 80 IU/L를 기준으로 두 군으로 나누어 지방간의 중증도와 비교하여 본 결과 중증도가 심할수록 혈청 ALT치의 이상소견이 더 높은 빈도로 관찰되었다. (P < 0.01) AST/ALT비는 초음파상 중증도와 역의 상관관계를 나타내었다. (P < 0.01) 소량음주군과 비음주군의 두 군으로 나누었을 때 지방간의 중증도가 심한 군에서 소량음주군이 보다 더 많이 포함되는 경향을 보였다 (P = 0.052) 첫 초음파 검사 시행 시점부터 평균 32개월의 기간이 경과한 뒤 추적검사가 가능하였던 9명의 환자 중 6명에서 무변, 3명에서 호전이 관찰되었다. 결론: 본 연구의 결과 초음파상 지방간 중증도가 심한 환자에서 더 자주 혈청 ALT치의 상승이 관찰되었다. 지방간 환자 중에서 간내 지방축적이 심할수록 염증을 동반할 기회가 많아진다고 생각된다. 이러한 간내 염증괴사소견의 동반은 좋지 않는 예후를 시사하므로 간조직검사등의 적극적인 진단과 비 알콜성지방간염에 대한 조기대응이 필요하다고 생각된다 아울러 지방간 이환기간과 간내 염증과의 상관성을 증명하기 위한 후속연구가 더 필요하다고 생각된다. Background/purpose : Nonalcoholic fatty liver disease can be found more frequently than before due to a high fat diet and a sedentary life style. The aim of this study was to compare clinical characteristics and outcomes of patients with different sonographical grade of the nonalcoholic fatty liver. Methods : 65 patients were diagnosed as nonalcoholic fatty limier patients by abdominal solography from Feb. 1998 to Mar. 2000. We reviewed medical records and confirmed the clinical data by phone. We compared the sonographical grade of the fatty liver with such clinical data as BMI, serum ALT level, underlying diseases and associated symptoms. Results: 1) There was a significant correlation between the BMI and the sonographical grade of the fatty liver . 2) The more severe the sonographical grade of the fatty liver, the higher the serum ALT level was. 3) There were significant inverse correlations between the AST/ALT ratio and the sonographical grade of the fatty liver. 4) Out of the 9 patients whose status could be assessed by sonography or biochemical tests after about 3 years, 3 patients improved and the other 6 patients showed no interval change. Conclusion : Both the amount of excessive fat and the duration of the fatty liver are considered to be the risk factors of nonalcoholic steatohepatitis. We confirmed the association between the sonographical grade of the fatty liver and the serum ALT level by this study, but the association between the duration of the fatty liver diesease and the nonalcoholic steatohepatitis needs to be studied more in the future. The nonalcoholic steatohepatitis showing necrosis or a Mallory body may take an aggressive course leading to cirrhosis and liver related death. Therefore, a liver biopsy and active therapeutic intervention is necessary, early and properly

Swivel joint를 이용한 비대칭 발치증례의 교정적 공간폐쇄

고창희,임성훈,김광원,정동기,김도영,박선주,양용근 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1

Extraction therapy is popular treatment protocol in orthodontics. Generally, symmetric premolar extraction is performed. But, in some cases, asymmetric extraction is required to solve asymmetric dental alignment. But asymmetric extraction treatment has side effects and disadvantages like a) collapse of dental arch form. b) canting of occlusal plane, c) extended treatment duration. For a good treatment result, we applied the orthodontic space closing arch wire with swivel joint to allow rotational movement of arch wire segments during space closure, Now we present a case treated with orthodontic space closing arch wire with swivel joint.

인슐린의 세포사멸억제 작용에서 신호전달경로의 특성

허규희,허정식,김선욱,이영기,박덕배 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-

Insulin has a variety of activities like as glucose uptake, inhibition of lipolysis, glycogen biosynthesis in a number of cells and tissues. Recently insulin has known to exert an antiapoptotic activity in different cell systems. However, it is not clear by which insulin can protect apoptosis cells from apoptosis. Thus, CHO cells expressing the human insulin receptors (CHO-IR) were used to evaluate the importances of different signaling steps activated by insulin in this process. The Ras/Raf-1/MEK/ERK cascade and the serine/threonine protein kinase Akt are two survival pathways that may be activated in response to insulin. We tested the hypothesis that inhibition of farnesylated Ras was casually related to manumycin-induced apoptosis and showed that the response to manumycin was found to be independent of K-Ras function. Moreover, blocking Ras/Raf-1/MEK/ERK cascade by the expression of a transdominant inhibitory mSOSI mutant in CHO-IR cells kept cells to sensitive to the antiapoptotic action of insulin. Insulin-dependent activation of Akt was blocked by 4th treatment with manumycin. This study suggest that the deplection of short-lived farnesylated proteins by manumycin suppresses the antiapoptotic action of insulin at least in part by disrupting Akt­activation but not of the K-Ras/Raf-1/MEK/ERK-dependent cascade.