한국인 강박장애와 Val-158-Met Catechol-O-Methyltransferase 유전자 다형성 간의 상관성 연구

천근아,김세주,김찬형,구민성,남윤영,박성혁,이홍식 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

목적 COMT(Catechol-O-Methyltransferase) 효소는 도파민성과 노어아드레날린성 체계의 조절에서 매우 중요한 작용을 하며 염색제 22q11에 위치해 있다. 일부의 강박장애 환자들은 도파민 차단제에 좋은 치료 반응을 보이며 이런 현상은 COMT가 강박장애의 병인론에 역할을 하고 있을 가능성을 말해준다. Val-158-Met COMT 유전자의 다형성은 효소의 감소를 유도하는 L(저활성) 대림형질, 활성의 증가를 유발하는 H(고활성) 대립형질로 알려져 있으며 L 대립형질 또는 LL 유전형이 강박장애와 연관이 있다는 보고가 있으나, 아직까지 강박장애와 COMT 다형성 사이의 연관성에 대한 연구결과들은 일관되지 않다. 따라서 본 연구에서는 한국인 강박장애 환자들을 대상으로 Val-158-Met COMT 유전자의 다형성과의 연관성을 알아보고자 하였다. 방법 2002년 3월부터 2004년도 2월까지 약 24개월동안 서울지역 일 대학병원과 경기지역 일 대학병원 강박장애 클리닉을 방문하여 강박장애로 진단받은 124명의 환자들을 연구대상으로 하였고 정상 대조군으로는 나이와 성별을 고려하여 자원자 170명이 선별되어 포함되었다. 강박장애군과 정상 대조군의 혈액으로부터 유전자 추출 후 COMT 유전자 형벌 (genotyping)을 시행하였다. 다형성을 H/H 와 H/L, L/L 유전형으로 나눈 뒤 강박장애와 정상대조군 사이의 유전자 빈도를 카이 검정법으로 비교하여 연관성을 관찰하었다. 또한 강박장애 환자들에게 시행한 YBOCS로부터 측정한 강박장애 심각도 및 Hamilton Depression Raing Scale (HDRS) 총점과 COMT 유전자 다형성 사이의 연관성을 비교하였다. 결과 본 연구 결과 한국인 강박장애와 COMT 다형성 간에는 유의한 상관성이 관찰되지 않았다. YBOCS 심각도와 COMT 유전자형과의 유의한 연관성이 관찰되지 않았다. 그러나, 강박장애 환자군들의 COMT 유전자형 세 군 사이의 우울증상 점수에서는 유의한 차이가 관찰되었다. 결론 한국인에서 강박장애와 COMT 유전자 다형성 사이에는 연관성이 없었다. 그러나, COMT의 H 대립형질과 강박장애 군에서 공존하는 우울증상 척도가 유의한 연관성을 보인 현상은 COMT 유전자의 다형성이 강박장애의 공존 우울증상에 영향을 미칠 수 있는 가능성을 시사한다고 생각된다. Objectives : The definite cause of obsessive-compulsive disorder (OCD) is still unknown. Evidences from familial, twin and segregation studies support the role of a genetic factor. There are also growing evidence indicating that OCD has specific neurochemical and neuroanatomical basis. Derived from the effectiveness of treatment with dopamine receptor blocker in certain part of OCD patients (eg. SSRI treatment-resistant OCD), several candidate genes related to dopamine dysregulation have been hypothesized to play an important role in the development of OCD. One of them is the Catechol-O-Methyltransferase (COMT) gene. The aim of this study was to investigate the association between COMT and OCD in Korean population. Methods : 124 OCD patients and 170 normal controls participated in this study. Genomic DNA was extracted from their blood. The genotypes and allele frequencies of the COMT polymorphism between OCD group and control group were compared. We investigated the association between severity of OCD assessed by Yale-Brown obsessive compulsive symptom scale (YBOCS) and Hamilton depression rating scale (HDRS) scores and COMT polymorphism. Results : In this case-control study, we could not find any association between COMT gene polymorphism and development of OCD. In OCD group, patients with H/H genotype had significantly higher scores for the HDRS than those with H/L or L/L genotype. Conclusion : In this study, there was no difference in genotype distributions of COMT between OCD and control groups. However, H/H genotype of COMT gene polymorphism might be related to depressive symptoms in OCD patients.

외측 미칩 갑상선에서 발생하여 다발성 전이로 발현된 유두상 갑상선암 1예

천남일,이창훈,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

유한요소법을 이용한 AGV 구조물의 강도해석

양영수,이세환,이천수 한국공작기계학회 1998 한국생산제조학회지 Vol.7 No.3

The important parts of the developing AGV model are the fabrication of each part and the design technology of body frame. In the present day, design of the body frame depends on the experience of the industrial place. The systematic data need for the optimal design of the frame for the case of model change. In this study, the strength of the early stage AGV(Automatic guided vehicle) is examined with the 3-dimensional finite element method. In order to verify the finite element results, the computed results are compared with the experimental data from the strain-gage output. A New model was designed by removing some parts of the early staged(roughly designed) model and choosing the thickness change of the rectangular-pipes.

酸性降雨에 의한 畓土讓內 金屬物質의 浸出 및 吸着能에 關한 硏究(Ⅰ)

김남천,우세홍,채수권,권우택,유영식 서울保健大學 1992 論文集 Vol.12 No.1

Leaching characteristics and adsorption ability of Fe and Mn in the paddy soil were studied with synthetic acid rain. 1. Leaching quantity of Fe from the paddy soil by acid rain was 8 times as much as by neutral rain, and 6 times for Mn. 2. Leaching quantity was changed with heat treatment methods of sample soil (ignition or air drying), with kind of meta](Fe or Mn) and with acidity of soil (acid or netural). 3. The adsorption ability of Fe on the paddy soil was twice as much as, that of Mn. 4. Langmuir isotherm equation was c/q=20C+10 for Fe(air drying paddy soil) and c/q=160 C - 610 for Mn(ignation paddy soil). 5. Contineous column experiment showed that the adsorption ability of Mn was above 100, and for Fe, it was changed with kinds of sample soil and pouring methods.

光波長이 오이(Cucumis sativus L.) 플러그苗의 生長에 미치는 影響

용영록,전지영,황세진,김일섭,정천순 강릉대학교 동해안지역연구소 2000 東海岸硏究 Vol.11 No.1

This research was carried to find out the optimum artificial light condition for plug seedling production of high quality cucumber through investigating growth response of the seedling by both light wave length and treatment period. The treatment with blue and red fluorescent lamp increased the fresh weight involving hypocotyl and root and controlled the elongation of hypocotyl, compared with other treatments. The 30-day-old seedling treatment with blue and red light for 12 hours showed that vegetative growth including root, stem and leaves was better than that of seedling treated with other lamps. Seedling under blue and red light for 12 hours grew 60.0mm and 0.55g in length and weight of hypocotyl. respectively, Hypocotyl length and weight were 44.9mm and 0.62g when seedling was grown under above light condition for 6 hours. Total chlorophyll contents of hypocotyl were highest in the light mixing treatment, and this accelerated greening. Morphological characteristics by investigating cross and longitudinal section of 30-day-old cucumber seedling treated with the mixing fluorescent lamps indicated that epidrmis tissues were usually single layer and thicker, resulting in small, compact and non-intercellular spaces of cells. On the other hand, epidermis tissues of the control composed of large, longer and round cells and cortex tissues showed large intercellular spaces between cells. Longitudinal section of photo-treated hypocotyl showed that there were more shorter cells and non-intercellular spaces of cells than untreated tissues. As a result, blue and red light mixing treatment controled the cell elongation of seedling hypocotyl, resulting in shortening hypocotyl of cucumber seedling.

立地特性別 Asbestos의 環境濃度

유영식,김종규,민달기,김남천,이형춘,최한영,김을환,우세홍,이상건 서울保健大學 1989 論文集 Vol.9 No.1

보리순의 영양성분 조성

서혜지,최용민,김상천,이준수,이기택,정명근,천지연,황진봉,남진식,서우덕,황영,김행란,김세나 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

비정형 기관지 유암종에 의한 이소성 ACTH 증후군 1례

이창훈,천남일,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 全南大醫大 2001 전남의대학술지 Vol.37 No.2

경부에 발생한 2새열낭종 2례

박홍주,박세찬,손영휘,윤천주,유선열 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Developmental anomalies arising from the branchial apparatus include cysts, external sinuses, internal sinuses, and complete fistulas. Second branchial cleft cysts are by far the most common among these anomalies. It may occur at any age, being most common in the third decade, and more frequent in the male than in the female. It usually presents a smooth, round, nontender fluctuant mass located between the level of the tragus and the clavicle along the anteromedial border of the sternocleidomastoid muscle. It is lined by respiratory or squamous epithelium unless inflammation is present. The considerable amount of lymphoid tissue may be found beneath the epithelium. The treatment of choice of branchial cleft cyst is surgical excision. If the lesion is acutely infected, however, it is essential to relieve the infection prior to the surgery This report deals with two cases of second branchial cleft cyst. In case 1, the cyst had rapidly increased in size over pregnant period. In case 2, the patient presented the swelling in the left neck, and had the history of incision and drainage because of misdiagnosis as submandibular space abscess. The infection was treated by antibiotic therapy in the first place, and then complete surgical excision was made. There was no evidence of any recurrence or complications for these 3∼4 years.

마이크로컴퓨터에 의한 溫熱指數의 自動測定 및 學習

이형춘,우세홍,김을환,최한영,유영식,김남천,이상건 서울保健大學 1991 論文集 Vol.11 No.1