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스테로이드 주입 후 비후성 반흔의 변화에 대한 조직형태계측학적 연구
손영휘,유선열 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6
Hypertrophic scar, occurred from the skin injury or surgical operation causes esthetic, psychologic, and functional problems to both the patients and the surgeon. The drug of choice for the treatment of hypertrophic scar is steroid. The purpose of this study was to evaluate the effects of several kinds of steroid injection on the hypertrophic scar in the rabbit model. Adult male white rabbits, weighing about 2.5kg, were used. After three full-thickness wounding over the ventral surface of each ear, either saline (control group), or triamcinolone(0.8mg), dexamethasone(0.1mg) and prednisolone(0.8mg) was injected on day 16. The rabbits were sacrificed on 1, 2, 3, 4 and 8 weeks after injection, and the specimens were retrieved on bloc. Histologic and histomorphometric examinations of tissue samples were done. The results obtained were as follows : In control group, cartilage proliferation and soft tissue hypertrophy were seen on 1 week and 2 weeks after saline injection. Collagen fibers were thickened in diameter, and arranged in irregular manner. After 3 weeks, cartilage proliferation was markedly decreased. Irregular collagen fibers and soft tissue thickening were also observed. After 4 and 8 weeks, soft tissues were consist of loose connective tissue, and still thickened. In experimental groups, collagen fiber thickness were arranged in somewhat irregular manner, and small amount of blood vessel proliferation were observed in 1,2 and 3 weeks after injection. After 4 weeks, blood vessels and inflammatory cells were decreased, and collagen fibers were arranged in parallel manner. In 8 week-group, small amount of loose connective tissues were observed. After 2 weeks of injection, hypertrophic index of the experimental groups was significantly decreased than the control group. In the experimental group, dexamethasone seemed more potent than triamcinolone and prednisolone. These results suggest that hypertrophic scar was markedly decreased after steroid injection and triamcinolone, dexamethasone, and prednisolone are effective for treatment of hypertrophic scar.
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스테로이드 주입 후 비후성 반흔의 변화에 대한 조직형태계측학적 연구
손영휘,유선열 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1
Hypertrophic scar, occurred from the skin injury or surgical operation causes esthetic, psychologic, and functional problems to the patients and surgeon. The drug of choice for the treatment of hypertrophic scar is steroids. The purpose of this study was to evaluate the effects of several kinds of steroid injection on the hypertrophic scar in the rabbit model. Adult male white rabbits, weighing about 2.5 kg, were used. After three full-thickness wounding over the ventral surface of each ear, either saline (control group), or triamconolone(0.8mg), dexamethasone(0.1mg), and prednisolone(0.8mg) was injected on day 16. Rabbits were sacrificed on 1, 2, 3, 4, and 8 weeks after injection, and the specimens were retrieved en bloc. Histologic and histomorphometric examinations of tissue samples were done. The results obtained were as follows : In control group, cartilage proliferation and soft tissue hypertrophy were seen on 1 week and 2 weeks after saline injection. Collagen fibers were thickened in diameter, and arranged in irregular manner. After 3 weeks, cartilage proliferation was markedly decreased. Irrgular collagen fibers and soft tissue thickening were also observed. After 4 and 8 weeks, soft tissues were consist of loose connective tissue, and still thickened. In experimental groups, collagen fiber thickness were arranged in somewhat irregular manner, and small amount of blood vessel proliferation were observed in 1, 2, and 3 weeks after injections. After 4 weeks, blood vessels and inflammatory cells were decreased, and collagen fibers were arranged in parallel manner. In 8 weeks group, small amount of loose connective tissues were observed. After 2 weeks of injection, hypertrophic index of experimental groups were significantly more decreased than control group. In experimental group, dexamethasone seemed more potent compared with triamcinolone and prednisolone. These results suggest that hypertrophic scar was markedly decreased after steroid injection and triamcinolone, dexamethasone, and prednisolone are effective for treatment of hypertrophic scar.
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박홍주,박세찬,손영휘,윤천주,유선열 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4
Developmental anomalies arising from the branchial apparatus include cysts, external sinuses, internal sinuses, and complete fistulas. Second branchial cleft cysts are by far the most common among these anomalies. It may occur at any age, being most common in the third decade, and more frequent in the male than in the female. It usually presents a smooth, round, nontender fluctuant mass located between the level of the tragus and the clavicle along the anteromedial border of the sternocleidomastoid muscle. It is lined by respiratory or squamous epithelium unless inflammation is present. The considerable amount of lymphoid tissue may be found beneath the epithelium. The treatment of choice of branchial cleft cyst is surgical excision. If the lesion is acutely infected, however, it is essential to relieve the infection prior to the surgery This report deals with two cases of second branchial cleft cyst. In case 1, the cyst had rapidly increased in size over pregnant period. In case 2, the patient presented the swelling in the left neck, and had the history of incision and drainage because of misdiagnosis as submandibular space abscess. The infection was treated by antibiotic therapy in the first place, and then complete surgical excision was made. There was no evidence of any recurrence or complications for these 3∼4 years.
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유선열,박홍주,손영휘,윤천주,박충열,송종운,이용욱 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6
Patients with a cleft lip nasal deformities hope for a pleasing nasal profile, a well-defined angular nasal tip, and symmetry of the nose. The main objective of the correction of cleft lip nasal deformity is to achieve nasal symmetry and an improved nasolabial relationship. The present study was carried out to assess the effect and prognosis of correction of cleft lip nasal deformity with L-shaped iliac bone graft. We performed correction surgery of the severe cleft lip nasal deformity with the autogenous L-shaped iliac bone graft in five patients and described the technique of correction. The columella portion of the L-shaped graft provided stabilization, eliminating the see-saw effect of the bridge on the bony fulcrum of the bony bridge, The disadvantage of this technique was stiffening of the nasal tip, which included the distal end of the grafted bone. However, the nasal tip gradually becomes softer, probably due to resorption of the bony edge several months after the operation. We obtained stable and symmetric reconstruction of the supporting elements of the nose. These results suggest that L-shaped iliac bone graft is stable and esthetic reconstruction method for correction of the severe cleft lip nasal deformity
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