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( Sanghwa Kim ),( Yoen Ju Lee ),( Hye In Kim ),( Heeyon Kim ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Sihyun Cho ),( Young Sik Choi ),( Byung Seok Lee ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: To investigate the impact of laparoscopy assisted methotrexate (MTX) sclerotherapy and laparoscopic cystectomy on the ovarian reserve based on serum anti-Mullerian hormone (AMH) level in ovarian endometrioma patients Methods: From June 2016 to June 2020, 18 patients with ovarian endometrioma underwent laparoscopic cyst aspiration followed by in situ methotrexate injection (Group 1: surgery + MTX sclerotherapy) and 180 patients underwent laparoscopic cystectomy (Group 2: surgery). Using analysis of covariance (ANCOVA), comparing the rate of decline of the serum AMH level between the two groups adjusted for the five covariates (preoperative AMH, age, BMI, Total O SIZE (sum of both ovaries size), cyst laterality) was done. Subgroup analyses controlled for age, Total O SIZE and cyst laterality were done. Results: There is no significant difference in the rate of decline of the serum AMH level between the Group 1 and Group 2 adjusted for the covariates (P =0.7366.). But the postoperative reduction of AMH level was comparatively less in Group 1 than Group 2 (Lsmean -33.1151. VS. -38.4669. ). In all the subgroup analysis, there is no significant difference in the percentage change of AMH between Group1 and Group2. But in the bilateral endometrioma group and the below 30 years old group analysis, decline of AMH level was relatively less in MTX sclerotherapy group. Conclusion: Compared with conventional surgical treatment of ovarian endometrioma having a negatively impact on post-operative ovarian reserve, MTX sclerotherapy showed non-inferiority. Especially the patient of bilateral ovarian endometrioma or age below 30 may expect a more favorable outcome in terms of decreased ovarian reserve. For ovarian endometrioma patient who want to get pregnant, MTX sclerotherapy could be better option.
Multiplexed In Vivo Imaging Using Size-Controlled Quantum Dots in the Second Near-Infrared Window
Jeong, Sanghwa,Jung, Yebin,Bok, Seoyeon,Ryu, Yeon-Mi,Lee, Sumin,Kim, Young-Eun,Song, Jaejung,Kim, Miyeon,Kim, Sang-Yeob,Ahn, G-One,Kim, Sungjee Wiley (John WileySons) 2018 Advanced Healthcare Materials Vol.7 No.24
Delayed postpartum regression of theca lutein cysts with maternal virilization: A case report
Sanghwa Kim,Inha Lee,Eunhyang Park,Yeo Jin Rhee,Kyeongmin Kim,Aminah Ibrahim Aljassim,Joo Hyun Park,Jae Hoon Lee,Bo Hyon Yun,Seok Kyo Seo,Sihyun Cho,Young Sik Choi,Byung Seok Lee 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.4
Theca lutein cysts are rare, benign lesions responsible for gross cystic enlargement of both ovaries during pregnancy. This condition is also termed hyperreactio luteinalis. Elevated human chorionic gonadotropin (hCG) levels or states of hCG hypersensitivity seem to promote these changes, which in up to 30% of patients produce clinical signs of hyperandrogenism. Given the self-limiting course of theca lutein cysts, which are subject to spontaneous postpartum resolution, conservative treatment is the mainstay of patient management. Described herein is a rare case of theca lutein cysts with maternal virilization that failed to regress by 9 months after childbirth. Surgical intervention was eventually undertaken, necessitated by adnexal torsion.
Pancreatic resection for renal cell carcinoma metastasis
Sanghwa Ko,Sungpil Yun,Suk Kim,Tae-nam Kim,Hyung-Il Seo 한국간담췌외과학회 2017 Annals of hepato-biliary-pancreatic surgery Vol.21 No.3
Renal cell carcinoma (RCC) is the most common type of kidney malignancy. The pancreas is an infrequent site of metastasis in relation to any type of malignancy. However, RCC is one of the tumor types that most frequently metastasize to the pancreas. In this study, we report our experiences with two patients who underwent pancreatic resection for metastatic RCC tumors; of these two patients, one patient had a tumor was a metachronous pancreas-only tumor, and the other patient’s tumor was synchronous with hematogenous lung metastasis. Following left-side pancreatic resection, the patients were administered tyrosine kinase inhibitors.
Kim, Sanghwa,Lee, Ah Young,Kim, Hyeon-Jeong,Hong, Seong-Ho,Go, Ryeo-Eun,Choi, Kyung-Chul,Kang, Kyung-Sun,Cho, Myung-Haing Elsevier 2017 Biochemical and biophysical research communication Vol.494 No.3
<P><B>Abstract</B></P> <P>A large amount of fructose intake along with smoking is associated with increased incidence of diseases linked to metabolic syndrome. More research is necessary to understand the complex mechanism that ultimately results in metabolic syndrome and the effect, if any, of high fructose dietary intake and smoking on individual health. In this study, we investigated changes in ER-Golgi network and disturbance to secretion of adipokines induced by cigarette smoking (CS) and excess fructose intake and their contribution to the disruption of metabolic homeostasis. We used high fructose-induced metabolic disorder mice model by feeding them with high fructose diet for 8 weeks. For CS exposure experiment, these mice were exposed to CS for 28 days according to OECD guideline 412. Our results clearly showed that the immune system was suppressed and ER stress was induced in mice with exposure to CS and fed with high fructose. Furthermore, their concentrations of adipokines including leptin and adiponectin were aberrant. Such alteration in secretion of adipokines could cause insulin resistance which may lead to the development of type 2 diabetes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cigarette smoke and fructose excess intake induce disruption to mechanisms involved in ROS generation and ER stress. </LI> <LI> Damage of cellular organelles induced by cigarette smoke and high fructose feeding affects inflammatory response and alters secretion of adipokines. </LI> <LI> Cigarette smoking and fructose excess intake are associated with metabolic syndrome. </LI> </UL> </P>
Characterization of air freshener emission: the potential health effects.
Kim, Sanghwa,Hong, Seong-Ho,Bong, Choon-Keun,Cho, Myung-Haing 日本トキシコロジ-學會 2015 JOURNAL OF TOXICOLOGICAL SCIENCES Vol.40 No.5
<P>Air freshener could be one of the multiple sources that release volatile organic compounds (VOCs) into the indoor environment. The use of these products may be associated with an increase in the measured level of terpene, such as xylene and other volatile air freshener components, including aldehydes, and esters. Air freshener is usually used indoors, and thus some compounds emitted from air freshener may have potentially harmful health impacts, including sensory irritation, respiratory symptoms, and dysfunction of the lungs. The constituents of air fresheners can react with ozone to produce secondary pollutants such as formaldehyde, secondary organic aerosol (SOA), oxidative product, and ultrafine particles. These pollutants then adversely affect human health, in many ways such as damage to the central nervous system, alteration of hormone levels, etc. In particular, the ultrafine particles may induce severe adverse effects on diverse organs, including the pulmonary and cardiovascular systems. Although the indoor use of air freshener is increasing, deleterious effects do not manifest for many years, making it difficult to identify air freshener-associated symptoms. In addition, risk assessment recognizes the association between air fresheners and adverse health effects, but the distinct causal relationship remains unclear. In this review, the emitted components of air freshener, including benzene, phthalate, and limonene, were described. Moreover, we focused on the health effects of these chemicals and secondary pollutants formed by the reaction with ozone. In conclusion, scientific guidelines on emission and exposure as well as risk characterization of air freshener need to be established.</P>