One-Step Oxidation of Benzene Producing Eight High Value Compounds Using Nitric Acid and Hydrogen Peroxide

Zhen-xue Liu,Zhong-xue Gan,Jun-jie Gu,Qing-feng Song 대전대학교 환경문제연구소 2015 환경문제연구소 논문집 Vol.19 No.-

Benzene was oxidized by binary oxidants composed of nitric acid and hydrogen peroxide at 80℃. The product obtained was analyzed with gas chromatograph-mass spectrometer. Eight high value compounds, 2-nitrophenol, 2-chloro-6-nitrophenol, 4-chloro-2- nitrophenol, 2-chloro-4-nitrophenol, 2,4-dinitrophenol, 4-nitrophenol, 2,6-dinitrophenol and 2-chloro-4,6-dinitro-phenol were found, which they have high contents in the range from 4.28% to 32.52%. These compounds are very widely used in organic synthesis. e.g., synthesizing dye, medicines and chemical reagents, pesticide, explosive, polymer, etc.

Patterns of Failure and Survival Trends in 3,808 Patients with Stage II Nasopharyngeal Carcinoma Diagnosed from 1990 to 2012: A Large-Scale Retrospective Cohort Study

Xue-Song Sun,Di-Han Liu,Sai-Lan Liu,Qiu-Yan Chen,Shan-Shan Guo,Yue-Feng Wen,Li-Ting Liu,Hao-Jun Xie,Qing-Nan Tang,Yu-Jing Liang,Xiao-Yun Li,Jin-Jie Yan,Ming-Huang Hong,Jun Ma,Lin-Quan Tang,Hai-Qiang M 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4

Purpose The purpose of this study was to investigate the survival trends and patterns of failure in patients with stage II nasopharyngeal carcinoma (NPC) treated with radiotherapy (RT) and chemotherapy over the last 20 years. Materials and Methods Thirty-eight hundred and eight patients diagnosed with stage II NPC between January 1990 and December 2012 were involved in this retrospective cohort study. All patients were treated with RT. According to the main imaging techniques and RT technology, we categorized these patients into four calendar periods: 1990-1996, 1997-2002, 2003-2007, and 2008-2012. Overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRFS), and distant metastasis–free survival (DMFS) were served as the clinical outcome. Results After a median follow-up period of 84.7 months, we observed increasing trends in survival and disease control. The 3- and 5-year OS rates increased from 87.1% and 78.7% in the first calendar period to 97.4% and 94.5% in the last calendar period, respectively (p < 0.001). Additionally, significant increasing trends could be seen in the PFS and LRFS during the four calendar periods. In the subgroup analysis, the LRFS in patients older than 50 years at diagnosis showed greater improvement than younger patients. However, the rate of distant metastasis was stable and relatively low, as the 5-year DMFS ranged from 90.5% to 94.7% among the four calendar periods. Conclusion The survival rates in patients with stage II NPC showed increasing trends from 1990 to 2012. The advance of RT provided excellent locoregional control and enhanced OS.

Subdivision of Nasopharyngeal Carcinoma Patients with Bone-Only Metastasis at Diagnosis for Prediction of Survival and Treatment Guidance

Xue-Song Sun,Yu-Jing Liang,Sai-Lan Liu,Qiu-Yan Chen,Shan-Shan Guo,Yue-Feng Wen,Li-Ting Liu,Hao-Jun Xie,Qing-Nan Tang,Xiao-Yun Li,Jin-Jie Yan,Lin-Quan Tang,Hai-Qiang Mai 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4

Purpose The purpose of this study was to subdivide M1 stage nasopharyngeal carcinoma (NPC) patients with bone-only metastases for prognosis prediction while identifying the treatment effect of locoregional radiotherapy (LRRT) and metastasis radiotherapy (MRT) among patients with different risk. Materials and Methods From November 2006 to October 2016, a total of 226 patients with bone-only metastasic NPC were retrospectively enrolled. All patients developed distant lesions before receiving treatment. All potential prognostic factors were considered and the correlation of the M1 subdivisions with overall survival (OS) was determined by Cox regression hazards model. Kaplan-Meier curves were used to appraise survival condition and log-rank testing was used to compare the differences. Results The median follow-up time was 33.9 months (range, 3 to 126 months). According to multivariate Cox proportional hazard analysis, the number of metastatic lesions and Epstein-Barr virus (EBV) DNA status after palliative chemotherapy (PCT) were independent prognostic factors for OS. Thus, we subdivided patients into three risk groups according to these two factors. Systemic chemotherapy combined with LRRT may benefit patients in low- and intermediate-risk groups but not in the high-risk group. Further aggressive MRT based on systemic chemotherapy showed no survival benefit in any risk group. Conclusion The stratification of NPC patients with bone-only metastasis based on EBV DNA after PCT and the number of metastatic lesions provided promising prognostic value and could aid clinicians in person-specific treatment.

Species Classification and Quality Assessment of Chaihu (Radix Bupleuri) Based on High-Performance Liquid Chromatographic Fingerprint and Combined Chemometrics Methods

Xiao-Jie Li,Jie Hu,Zhen-Yu Li,Xue-Mei Qin,Li-Zeng Zhang,Xiao-Qing Guo 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.6

A high-performance liquid chromatographic (HPLC) method was established to analyze 36 Chaihu (Radix Bupleuri) samples collected from three species (Bupleurum chinense DC., B. scorzonerifolium Willd. and B. smithii Wolff.). Addition of trifluoroacetic acid into the mobile phase resulted in fingerprint chromatograms with stable baselines. There were thirty-two characteristic peaks in the standard fingerprint of B. chinense DC. Different recognition pattern methods, including similarity analysis (SA), hierarchical cluster analysis (HCA), principal component analysis (PCA) and partial least squares-discrimination analysis (PLS-DA) were utilized to analyze the 36 samples based on the contents of chemical constituents. Consistent results from SA, HCA and PCA analysis illustrated the rationalisation for why B. smithii Wolff. was not quoted in the Chinese Pharmacopoeia and classified samples were in agreement with their species. PLS-DA loading plots showed the chemical markers which had the most influences on the separation among different species. However, SA, HCA and PCA could not differentiate between wild and cultivated B. chinense DC. as well as between samples from different provinces. HPLC fingerprint in combination with chemometric techniques provided a very flexible and reliable method for homogeneity evaluation and quality assessment of traditional Chinese medicine.

Analysis of thermally induced vibration of cable-beam structures

Han-Qing Deng,Tuan-Jie Li,Bi-Jie Xue,Zuo-Wei Wang 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.3

Cable-beam structures characterized by variable stiffness nonlinearities are widely found in various structural engineering applications, for example in space deployable structures. Space deployablestructures in orbit experience both high temperature caused by sun’s radiation and low temperature by Earth’s umbral shadow. The space temperature difference is above 300K at the moment of exiting or entering Earth’s umbral shadow, which results in structural thermally induced vibration. To understand the thermally induced oscillations, the analytical expression of Boley parameter of cable-beam structures is firstly deduced. Then, the thermally induced vibration of cable-beam structures is analyzed using finite element method to verify the effectiveness of Boley parameter. Finally, by analyzing the obtained numerical results and the corresponding Boley parameters, it can be concluded that the derived expression of Boley parameter is valid to evaluate the occurrence conditions of thermally induced vibration of cable-beam structures and the key parameters influencing structural thermal flutter are the cable stiffness and thickness of beams.

One-Step Oxidation of Benzene Producing Eight High Value Compounds by Using Nitric Acid and Hydrogen Peroxide

Zhen xue Liu,Zhong xue Gan,Jun jie Gu,Qing feng Song 대전대학교 환경문제연구소 2015 환경문제연구소 논문집 Vol.19 No.-

Benzene was oxidized by binary oxidants composed of nitric acid and hydrogen peroxide at 80℃. The product obtained was analyzed with gas chromatograph-mass spectrometer. Eight high value compounds, 2-nitrophenol, 2-chloro-6-nitrophenol, 4-chloro-2- nitrophenol, 2-chloro-4-nitrophenol, 2,4-dinitrophenol, 4-nitrophenol, 2,6-dinitrophenol and 2-chloro-4,6-dinitro-phenol were found, which they have high contents in the range from 4.28% to 32.52%. These compounds are very widely used in organic synthesis. e.g., synthesizing dye, medicines and chemical reagents, pesticide, explosive, polymer, etc.

Clinical Features and Survival Analysis of Very Young (Age<35) Breast Cancer Patients

Wei, Xue-Qing,Li, Xing,Xin, Xiao-Jie,Tong, Zhong-Sheng,Zhang, Sheng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Objectives: To compare the clinicalpathological features and prognosis between premenopausal breast cancer patients aged of <35 and ${\geq}35$ years old. Methods: The clinical data and survival status of 1498 cases premenopausal operable breast cancer treated in our hospital from 2002.1 to 2004. 12 were collected, 118 cases were aged <35. They were divided into 4 groups: Luminal A, Luminal B, HER2-positive, Triple-negative. The disease free survival (DFS) and overall survival (OS) were identified. Results: The 5-year DFS and OS rates were significantly lower in age<35 than in $age{\geq}35$ patients. In the Luminal B, HER2-positive, Triple-negative group, the 5-year recurrence risk was higher in age<35 than in $age{\geq}35$ patients, and age<35 patients' 5-year death risk was higher only in Luminal B, Triple-negative group. Regardless of whether lymph node involved, age<35 patients had a bad prognosis in both DFS and OS. Conclusions: Compared with premenopausal age ${\geq}35$ breast cancer, age<35 patients had a worse outcome.

Diffusion-Weighted Imaging for the Left Hepatic Lobe has Higher Diagnostic Accuracy for Malignant Focal Liver Lesions

Han, Xue,Dong, Yin,Xiu, Jian-Jun,Zhang, Jie,Huang, Zhao-Qin,Cai, Shi-Feng,Yuan, Xian-Shun,Liu, Qing-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: This study was conducted to investigate whether apparent diffusion coefficient (ADC) measurements by dividing the liver into left and right hepatic lobes may be utilized to improve the accuracy of differential diagnosis of benign and malignant focal liver lesions. Materials and Methods: A total of 269 consecutive patients with 429 focal liver lesions were examined by 3-T magnetic resonance imaging that included diffusion-weighted imaging. For 58 patients with focal liver lesions of the same etiology in left and right hepatic lobes, ADCs of normal liver parenchyma and focal liver lesions were calculated and compared using the paired t-test. For all 269 patients, ADC cutoffs for focal liver lesions and diagnostic accuracy in the left hepatic lobe, right hepatic lobe and whole liver were evaluated by receiver operating characteristic curve analysis. Results: For the group of 58 patients, mean ADCs of normal liver parenchyma and focal liver lesions in the left hepatic lobe were significantly higher than those in the right hepatic lobe. For differentiating malignant lesions from benign lesions in all patients, the sensitivity and specificity were 92.6% and 92.0% in the left hepatic lobe, 94.4% and 94.4% in the right hepatic lobe, and 90.4% and 94.7% in the whole liver, respectively. The area under the curve of the right hepatic lobe, but not the left hepatic lobe, was higher than that of the whole liver. Conclusions: ADCs of normal liver parenchyma and focal liver lesions in the left hepatic lobe were significantly higher than those in the right hepatic lobe. Optimal ADC cutoff for focal liver lesions in the right hepatic lobe, but not in the left hepatic lobe, had higher diagnostic accuracy compared with that in the whole liver.

A Role of YlBud8 in the Regulation of Cell Separation in the Yeast Yarrowia lipolytica

( Yun-qing Li ),( Qing-jie Xue ),( Yuan-yuan Yang ),( Hui Wang ),( Xiu-zhen Li ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.1

The spatial landmark protein Bud8 plays a crucial role in bipolar budding in the budding yeast Saccharomyces cerevisiae. The unconventional yeast Yarrowia lipolytica can also bud in a bipolar pattern, but is evolutionarily distant from S. cerevisiae. It encodes the protein YALI0F12738p, which shares the highest amino acid sequence homology with S. cerevisiae Bud8, sharing a conserved transmembrane domain at the C-terminus. Therefore, we named it YlBud8. Deletion of YlBud8 in Y. lipolytica causes cellular separation defects, resulting in budded cells remaining linked with one another as cell chains or multiple buds from a single cell, which suggests that YlBud8 may play an important role in cell separation, which is distinct from the function of Bud8 in S. cerevisiae. We also show that the YlBud8-GFP fusion protein is located at the cell membrane and enriched in the bud cortex, which would be consistent with a role in the regulation of cell separation. The coiled-coil domain at the Nterminus of YlBud8 is important to the correct localization and function of YlBud8, as truncated proteins that do not contain the coiled-coil domain cannot rescue the defects observed in Ylbud8Δ. This finding suggests that a new signaling pathway controlled by YlBud8 via regulation of cell separation may exist in Y. lipolytica.

Influence of Particle Shape on the Density and Compressive Performance of Calcareous Sand

Shuai Wang,Xue-Wen Lei,Qing-Shan Meng,Jie-Li Xu,Ling-Feng Xie,Yu-Jie Li 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.1

Particle shape influence the bearing capacity of calcareous sand foundations in island reef engineering. An improved Computer Image Analysis method that combined with mathematical statistics was proposed to categorize and sort different shapes of calcareous sand particles within the size range of 5 – 10 mm. Three single-shape calcareous sand specimens (granular ﾠ ﾠshape, dendritic shape, long strip shape) were obtained. A new self-developed vibration device was used measuring the maximum density of calcareous, the shape and content as the variables in the orthogonal test. On this basis, the lateral compression tests were carried out to assess the influence of particle shape on the density, compressive performance of calcareous sand. Test results showed that better discriminability was achieved by taking mean flatness (EL/B) as the quantification parameter of the particle shapes. The average flatness EL/B of specimens is approximately normally distributed in the statistical results. The shape and content of sand particles had an obvious influence on the density of calcareous sand. The compressive properties of calcareous sands with different particle shapes have obvious differences. After loaded, the particle size distribution of specimen improved, the average flatness EL/B of the granular-shaped specimens increased, while that of the dendritic-shaped and the long-strip-shaped specimens decreased, the average flatness EL/B of the specimens tended to be uniform. The relative fracture rate Br and the load value Pmax satisfied the exponential function fitting relationship. Therefore, it can be argued that particle shape should be taken into consideration when optimizing the foundation design in island reef engineering to achieve better compressive performance of the foundation.