Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine for Breast MRI Screening: a Meta-analysis

Yang, Xiao-Ping,Han, Yue-Dong,Ye, Jian-Jun,Chen, Gang,Luo, Ying,Ma, Hong-Xia,Yu, Xue-Wen,Niu, Juan-Qin,Ren, Fang-Yuan,Guo, You-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

Background: As a common and essential contrast medium at present, gadobenate dimeglumine has shown better performance than some other agents when applied to Breast Magnetic Resonance Imaging Screening (Breast MRI Screening). Nevertheless, reports on the diagnostic performance of these two mediums (gadobenate dimeglumine and gadopentetate dimeglumine) are not completely consistent. Objective: To assess the diagnostic value of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MRI Screening in patients suffering from breast cancer and to provide more convinced evidence to guide clinical practice in terms of appropriate contrast agents. Data Sources and Review Methods: Original articles in English and Chinese published before January 2013 were selected from available databases (The Cochrane Library, PUBMED, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, Chinese Journal Full-text). The criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software (Version 1.4) was used for data analysis. Then, the area under curve (AUC) of SROC and the spearman rank correlation of sensitivity against (1-specificity) were calculated. Results: Total of 17 researches involving 1934 patients were included. The pooled sensitivity of gadobenate dimeglumine and gadopentetate dimeglumine were 0.99 (0.97, 1.00) and 0.93 (0.88, 1.00) respectively. The pooled specificity for these two contrast agents were 0.924 (0.902, 0.943) and 0.838 (0.817, 0.858) respectively, and the AUC of SROC curve were 0.9781 and 0.9215 respectively. Conclusions: Gadobenate dimeglumine can be regarded as a more effective and feasible contrast medium for Breast MRI Screening. At least 5% differences in diagnostic performance are usually considered as clinically relevant.

An Artificial Freezing Technique to Facilitate Shield Tail Brush Replacement under High Pore-Water Pressure Using Liquid Nitrogen

Ping Yang,Jiling Zhao,Lin Li 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.4

During tunnelling, with the progression of the shield tunnelling machine, the shield tail brush, which is an important accessory required to seal the shield tail and prevent the tunnel from ground water or grouting fluid discharging, will gradually be worn-out/damaged and inevitably lead to safety problems. As a result, problematic tail brush needs to be replaced to prevent more serious problems from happening before any further tunnelling. The replacement of this shield tail brush can be very risky, especially when the shield tunnelling machine is located at a soil layer under high pore-water pressure. This study introduces an engineering practice to facilitate the shield tail brush replacement under high pore-water pressure through the development of a frozen soil wall with the help of an artificial freezing technique using liquid nitrogen. A case study is adopted to demonstrate the implementation of this technique. For the specific site condition, a numerical simulation is usually performed first to determine the design parameters (e.g., liquid nitrogen temperature, length and spacing of the freezing pipes) required for artificial freezing process. Several holes along the radial direction of the tunnel were then made to monitor the temperature of the soil around the tunnel. Subsequently, the artificial freezing process was performed according to the design. The replacement of the tail brush was initiated when the frozen soil wall developed during freezing met the requirements for tail brush replacement. The artificial freezing technique using liquid nitrogen proved to be a reliable and time-effective option to facilitate the tail brush replacement under high pore-water pressure.

Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population

Yang Sun,Lin Wen,Yi-Yang Luo,Wen-Juan Hu,Hui-Wen Ren,Ye Lv,Cong Zhang,Ping Gao,Li-Na Xuan,Guan-Yu Wang,Cheng-Jie Li,Zhi-Xin Xiang,Zhi-Lin Luan 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12

Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic <i>TEAD1</i> polymorphisms and potential association with schizophrenia.Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of <i>TEAD1</i> were selected and genotyped.Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were significantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correction, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis revealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls.Conclusion The current findings indicated that the human <i>TEAD1</i> gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.

Biomechanical Evaluation of 2 Endoscopic Spine Surgery Methods for Treating Lumbar Disc Herniation: A Finite Element Study

Yang Zou,Shuo Ji,Hui Wen Yang,Tao Ma,Yue Kun Fang,Zhi Cheng Wang,Miao Miao Liu,Ping Hui Zhou,Zheng Qi Bao,Chang Chun Zhang,Yu Chen Ye 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: This study aimed to evaluate the effects of 2 endoscopic spine surgeries on the biomechanical properties of normal and osteoporotic spines. Methods: Based on computed tomography images of a healthy adult volunteer, 6 finite element models were created. After validating the normal intact model, a concentrated force of 400 N and a moment of 7.5 Nm were exerted on the upper surface of L3 to simulate 6 physiological activities of the spine. Five types of indices were used to assess the biomechanical properties of the 6 models, range of motion (ROM), maximum displacement value, intervertebral disc stress, maximum stress value, and articular protrusion stress, and by combining them with finite element stress cloud. Results: In normal and osteoporotic spines, there was no meaningful change in ROM or disc stress in the 2 surgical models for the 6 motion states. Model N1 (osteoporotic percutaneous transforaminal endoscopic discectomy model) showed a decrease in maximum displacement value of 20.28% in right lateral bending. Model M2 (unilateral biportal endoscopic model) increased maximum displacement values of 16.88% and 17.82% during left and right lateral bending, respectively. The maximum stress value of L4–5 increased by 11.72% for model M2 during left rotation. In addition, using the same surgical approach, ROM, maximum displacement values, disc stress, and maximum stress values were more significant in the osteoporotic model than in the normal model. Conclusion: In both normal and osteoporotic spines, both surgical approaches were less disruptive to the physiologic structure of the spine. Furthermore, using the same endoscopic spine surgery, normal spine biomechanical properties are superior to osteoporotic spines.

Au/Co3O4/CeO2 heterostructures: Morphology controlling, junction formation and enhanced catalysis performance

Ping Yang,Yunshi Liu 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

Co3O4 nanochain and Co3O4/CeO2 heterostructures were prepared via an electrospinning process and subsequent calcination. The formation and shape evolution from Co3O4 nanochains to Co3O4/CeO2 composite nanobelts were investigated, suggesting that both components and preparation parameters play important roles in resulted morphology and properties. Homogeneous Co3O4/CeO2 junctions in belt samples were formed towards enhanced catalysis performance. Well-dispersed Au nanoparticles were deposited on Co3O4/CeO2 composite nanostructures or doped inside through reduction and direct calcination route method, respectively. The loading of Au nanoparticles significantly enhanced catalytic performance with onset CO conversion at 100 C and resulted in CO conversion over at 127 C.

Metal-organic framework-derived hierarchical ZnO/NiO composites: Morphology, microstructure and electrochemical performance

Ping Yang,Xueling Song,Changchao Jia,Hsueh-Shih Chen 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-

Hierarchical ZnO/NiO microstructures with different morphologies were synthesized employing bimetallic Zn/Ni MOFs as the precursor. The MOFs with rambutan- and seaweed-like morphologies were produced using terephthalic acid and polyvinylpyrrolidone. The molar ratio of Zn/Ni plays an important role for the microstructure and capacitance performance of samples. In particular, hierarchical ZnO/NiO hollow microspheres and seaweed microflowers were obtained when the molar ratio of Zn/Ni was 1:2 and 1:1, respectively. The seaweed microflowers exhibited larger specific capacitance and higher rate capability. The composition and unique microstructure result in improved ionic and electronic conductivity and rich electroactive sites for the electrochemical reactions.

Experimental investigations on the resistance performance of a high-speed partial air cushion supported catamaran

Yang, Jinglei,Lin, Zhuang,Li, Ping,Guo, Zhiqun,Sun, Hanbing,Yang, Dongmei The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.-

The partial air cushion supported catamaran (PACSCAT) is a novel Surface Effect Ship (SES) and possesses distinctive resistance performance due to the presence of planing bottom. In this paper, the design of PACSCAT and air cushion system are described in detail. Model tests were carried out for Froude numbers ranging from 0.1 to 1.11, the focus is on the influence of air cushion system on resistance characteristics. Drag-reducing effect of air cushion system was proved by means of contrast tests in cuhionborne and non-cushionborne mode. Wave-making characteristics reflect that the PACSCAT would eventually enter planing regime, in which the air could just escape under the seals and the hull body could operate in a steady state. To acquire different air cushion pressure, air flow rate and leakage height were adjusted during tests. Experimental results show that the resistance performance in planing regime would decrease evidently as the increased air flow rate, however, the scheme with medium leakage height presents the best resistance performance in the hump region.

Improvement of CF/ABS Composite Properties by Anodic Oxidation of Pitch based C-type Carbon Fiber

Yang, Xiao Ping,Wang, Cheng Zhong,Yu, Yun Hua,Ryu, Seung-Kon Korean Carbon Society 2002 Carbon Letters Vol.3 No.2

The surface treatment of C-type isotropic pitch-based carbon fiber was carried out by anodic oxidation in 5 wt% $NH_4NO_3$ electrolyte. The changes of fiber surface and carbon fiber/ABS resin composites were characterized by SEM, XPS and mechanical properties test. The oxygen functional groups on the surface, such as hydroxyl (-C-OH), carboxyl (-COOH) groups etc., increased after oxidation. Tensile strength, flexural strength and modulus of carbon fiber/ABS composites were also enhanced. However, the impact strength decreased with the improvement of the surface adhesion between CF and matrix.

Two-dimensional multiple-snapshot grid-free compressive beamforming

Yang, Yang,Chu, Zhigang,Ping, Guoli Elsevier 2019 Mechanical systems and signal processing Vol.124 No.-

<P><B>Abstract</B></P> <P>Compressive beamforming with planar microphone arrays can effectively achieve the two-dimensional direction-of-arrival (DOA) estimation and strength quantification of acoustic sources. This paper focuses on developing a multiple-snapshot grid-free method and comparing it against the existing grid-based and single-snapshot grid-free ones. The minimization of the atomic norm of multiple-snapshot microphone pressure induced by acoustic sources and the matrix pencil and pairing method are utilized jointly. The former is utilized to denoise the measured pressure and therefore obtain the pressure from acoustic sources. The latter is utilized to estimate DOAs and quantify strengths. Both simulations and experiments demonstrate the advantages of the developed method. For sources that are active across multiple snapshots, it can overcome the basis mismatch conundrum of the grid-based compressive beamforming. When the sources are uncorrelated or partially correlated in both spatial and temporal dimensions, it outperforms the single-snapshot grid-free compressive beamforming in terms of denoising, DOA estimation and strength quantification accuracy and resolution. These advantages stand up whether a standard uniform rectangular array or a non-uniform array constituted by a small number of microphones is utilized.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A two-dimensional multiple-snapshot grid-free compressive beamforming method is proposed. </LI> <LI> It can overcome the basis mismatch conundrum of the grid-based method. </LI> <LI> It enjoys obvious advantages over the single-snapshot grid-free method. </LI> </UL> </P>

The Cancer/Testis Antigen CT45A1 Promotes Transcription of Oncogenic Sulfatase-2 Gene in Breast Cancer Cells and Is Sensible Targets for Cancer Therapy

Ping Yang,Yingnan Qiao,Huaidong Liao,Yizheng Huang,Mei Meng,Yu Chen,Quansheng Zhou 한국유방암학회 2023 Journal of breast cancer Vol.26 No.2

Purpose: Invasive breast carcinomas (BRCAs) are highly lethal. The molecular mechanisms underlying progression of invasive BRCAs are unclear, and effective therapies are highly desired. The cancer-testis antigen CT45A1 promotes overexpression of pro-metastatic sulfatase-2 (SULF2) and breast cancer metastasis to the lungs, but its mechanisms are largely unknown. In this study, we aimed to elucidate the mechanism of CT45A1-induced SULF2 overexpression and provide evidence for targeting CT45A1 and SULF2 for breast cancer therapy. Methods: The effect of CT45A1 on SULF2 expression was assessed using reverse transcription polymerase chain reaction and western blot. The mechanism of CT45A1-induced SULF2 gene transcription was studied using protein-DNA binding assay and a luciferase activity reporter system. The interaction between CT45A1 and SP1 proteins was assessed using immunoprecipitation and western blot. Additionally, the suppression of breast cancer cell motility by SP1 and SULF2 inhibitors was measured using cell migration and invasion assays. Results: CT45A1 and SULF2 are aberrantly overexpressed in patients with BRCA; importantly, overexpression of CT45A1 is closely associated with poor prognosis. Mechanistically, gene promoter demethylation results in overexpression of both CT45A1 and SULF2. CT45A1 binds directly to the core sequence GCCCCC in the promoter region of SULF2 gene and activates the promoter. Additionally, CT45A1 interacts with the oncogenic master transcription factor SP1 to drive SULF2 gene transcription. Interestingly, SP1 and SULF2 inhibitors suppress breast cancer cell migration, invasion, and tumorigenicity. Conclusion: Overexpression of CT45A1 is associated with poor prognosis in patients with BRCA. CT45A1 promotes SULF2 overexpression by activating the promoter and interacting with SP1. Additionally, SP1 and SULF2 inhibitors suppress breast cancer cell migration, invasion, and tumorigenesis. Our findings provide new insight into the mechanisms of breast cancer metastasis and highlight CT45A1 and SULF2 as sensible targets for developing novel therapeutics against metastatic breast cancer.