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( Hye Jung Yun ),( Ju Young Cheon ),( Narinay Kim ),( In Yang Park ),( Bo Kyung Koo ),( Jiyeon Kim ),( Ji Hyun Kim ),( Ahlm Kwon,),( Myungshin Kim ),( Yonggoo Kim ),( Jong Chul Shin ),( Jong Hoon Kim 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: Adult stem cells are considered as an excellent source for research because they pose few ethical problems and limitations in terms of availability. Although many types of stem cells are available, the sources of the stem cells selected for clinical use should possess the ability to renew, be easily isolated and be pluripotent. These properties can be satisfied with human term placental-derived stromal cells. It is essential to understand the expansion capability and potency of isolated stem cells. 방법: This study focused on the characterization of mesenchymal stromal cells (MSCs) from the chorion of human full term placenta from 15 donors.We characterized the surface markers and multilineage differentiation (adipogenic, osteogenic and chondrogenic induction) ability of cultured chorionic MSCs. We also present our findings regarding their growth rate and gene expressions. 결과: Chorionic MSCs revealed homologous fibroblast-like morphology and expressed CD73, CD29, CD105, and CD90. The hematopoietic stem cell markers including HLA DR, CD11b, CD34, CD79a, and CD45 were not expressed. The growth kinetics of their serial passage was steady at the later passages (passage 10). The multilineage capability of chorionic MSCs was demonstrated by successful adipogenic, osteogenic and chondrogenic differentiation and associated gene expression. Chorionic MSCs expressed genes associated with undifferentiated cells (NANOG, OCT4, REX1) and cardiogenic or neurogenic markers such as SOX2, FGF4, NES, MAP2, and NF. TERT was negative in all the samples. 결론: A low HLA DR expression suggests that chorionic MSCs may serve as a great source of stem cells for transplantation because of their immune- privileged status and their immunosuppressive effect. Based on these unique properties, it is concluded that chorionic MSCs are pluripotent stem cells that are probably less differentiated than BM-MSCs, and they have considerable potential for use in cell-based therapies.
( Narinay Kim ),( Sung Jong Lee ),( Seung Joo Lee ),( Min Jong Song ),( Chung Won Lee ),( Joo Hee Yoon ),( Dong Choon Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
The aim of this study is to investigate the different prevalence of Mycoplasma hominis and Ureaplasma urealyticum infected in the two groups composed of women with symptoms and without symptoms in vagina. Between December 2011 and June 2012, 620 women attending our outpatient clinic were prospectively enrolled in this study. After providing informed consent, vaginal swabs to test for Ureaplasma urealyticum and Mycoplasma hominis were performed on the basis of the reason for the screening test. Women who had been treated with antibiotics or antifungals in the past weeks were excluded. Mycofast (MYCOFASTⓡ Evolution 2, International microbio., France) culture kit was used to detect Ureaplasma urealyticum and Mycoplasma hominis. The test was considered positive when the enumeration of genital microorganisms were up to 104 CCU/mL. The number of symptomatic women and asymptomatic women were 342 and 278, respectively. The age of study population ranges 21 to 85 years. In the population of women with symptoms, the prevalence of Ureaplasma urealyticum, Mycoplasma hominis were 27.0% and 6.3%, respectively. However, the prevalence of Ureaplasma urealyticum, Mycoplasma hominis in asymptomatic women were 4.3% and 1.1%, respectively. The prevalence of Ureaplasma urealyticum, Mycoplasma hominis was high in symptomatic women compared to asymptomatic women (p<0.05). The prevalence of Ureaplasma urealyticum in women > 60 years old was lower, 22.6%, than women < 60 years (p<0.05). The prevalence of Ureaplasma urealyticum, Mycoplasma hominis in symptomatic women were higher than asymptomatic women in Korea. The infection rate of Ureaplasma urealyticum decreased significantly in women > 60 years.
김나리네 ( Narinay Kim ),조윤성 ( Yun Sung Jo ),장동규 ( Dong Gyu Jang ),손현주 ( Hyun Joo Son ),이귀세라 ( Guisera Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.9
Conjoined twins are very rare and the mortality rate of the fetus is extremely high. Early prenatal diagnosis is crucial, as it provides the opportunity for the mother and father to help in recognizing the conjunction of the twins and to help medical team in defining the prognosis of conjoined twins. We present a case of thoraco-omphalopagus conjoined twins diagnosed by two-dimensional and threedimensional transabdominal sonography at 14(+2) weeks of gestation.
( Ju Young Cheon ),( Yonggoo Kim ),( Narinay Kim ),( Hye Jung Yun ),( Se Kyung Choi ),( Hyun Sun Ko ),( Jong Chul Shin ),( In Yang Park ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: We evaluated the effects of fibronectin, collagen, cadherin, and laminin based extracellular matrix (ECM) protein mimetics coated with mussel derived adhesive protein (MAP) on adhesion and proliferation of chorionic mesenchymal stem cells (cMSCs). 방법: Human placental chorionic tissues from term third-trimester pregnancies (n=3) were used. The cMSCs were cultured on rationally designed ECM protein mimetics coated with MAP on plastic surfaces with the addition of reduced fetal bovine serum (0.5%, 1% FBS). Adhesion capabilities were monitored by a real time cell analysis system (RTCA) utilizing an impedance method. Proliferation capabilities were monitored by RTCA and MTS assay. 결과: Of the ECM protein mimetics tested, GRGDSP (FN) coated surfaces exhibited the highest adhesion and proliferation capabilities on RTCA at FBS concentration of 0.5% and 1%. When 0.5% FBS was added to ECM protein mimetics during the MTS assay, GRGDSP (FN), REDV (FN), and collagen mimetics, GPKGAAGEPGKP (ColI) showed higher cMSCs proliferation compared with the control. When 1% FBS was added, GRGDSP(FN) and TAIPSCPEGTVPLYS (ColIV) showed significant cMSCs proliferation capacity. 결론: Fibronectin mimetics, GRGDSP (FN) amino acid sequence showed the highest adhesion and proliferation capabilities. In addition, results from RTCA assessment of cell viability correlated well with the tetrazolium-based MTS assay.
이성종 ( Sung Jong Lee ),정윤지 ( Youn Jee Chung ),이성학 ( Sung Hak Lee ),최윤진 ( Youn Jin Choi ),김나리네 ( Narinay Kim ),손현주 ( Hyun Joo Son ),윤주희 ( Joo Hee Yoon ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.9
Lipomatous variant of angiomyofibroblastoma is a rare tumor of the vulva. Most of cases are usually premenopausal and present with a slowly growing mass without pain. A 46-year-old woman presented with a swelling of the left labium major. The lesion was thought to be a Batholin`s gland cyst or a lipoma preoperatively and a local excision was performed. The tumor was well demarcated and rubbery. On microscopic examination, the alternating hypercellular and edematous hypocellular component with abundant vessels was noted. A large amount of adipose tissue was scattered in the lesion. Stromal cells were positive for vimentin, estrogen receptor, and progesterone receptor and negative for desmin antibody immunostaining. The local excision was enough for complete treatment. No recurrence was noted for 7 months after surgery.