Antagonistic properties of Trichoderma species colonizing woods against wood damaging fungi

( Na Yoon Huh ),( Jae Jung Lee ),( Min Ji Kim ),( Gyu Hyeok Kim ),( Jae Jin Kim ) 韓國木材工學會 2010 한국목재공학회 학술발표논문집 Vol.2010 No.-

Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study

Yoon, Hyun Sik,Na, Young Cheon,Choi, Keum Ha,Huh, Woo Hoe,Kim, Ji Min Korean Cleft Palate-Craniofacial Association 2019 Archives of Craniofacial Surgery Vol.20 No.5

Background: Topical hemostatic agents are used when ligation, electrocauterization, or other conventional hemostatic methods are impractical. Because a hemostatic agent is a foreign body, it can cause foreign body reactions, inflammation, and infections that can interfere with the wound healing process. Therefore, we should select hemostatic agents after considering their effects on wound healing. Here, we compared the effects of hemostatic agents on wound healing in a rectus abdominis muscle defect in rats. Methods: Twelve Sprague Dawley rats were subjected to creation of a $6{\times}6mm$ defect in the rectus abdominis muscle and divided into four groups: control group; group A, Tachosil fibrin sealant patch; group B, Surgicel Fibrillar oxidized regenerated cellulose; and group C, Surgicel Snow oxidized regenerated cellulose. For the histologic analysis, biopsies were performed on the 3rd, 7th, and 27th days. Results: The foreign body reaction was the weakest in group A and most significant in group C. The inflammatory cell infiltration was the weakest in group A and similar in groups B and C. Muscle regeneration differed among periods. The rats in group A were the most active initially, while those in group C showed prolonged activity. Conclusion: Tachosil and Surgicel administration increased inflammation via foreign body reactions, but the overall wound healing process was not significantly affected. The increased inflammation in the Surgicel groups was due to a low pH. We recommend using Tachosil, because it results in less intense foreign body reactions than Surgicel and faster wound healing due to the fibrin action.

Rice LIM protein OsPLIM2a is involved in rice seed and tiller development

Na, Jong-Kuk,Huh, Sun-Mi,Yoon, In-Sun,Byun, Myung-Ok,Lee, Yeon-Hee,Lee, Kyun-Oh,Kim, Dool-Yi Springer-Verlag 2014 Molecular breeding Vol.34 No.2

Effect of Underlying Comorbidities on the Infection and Severity of COVID-19 in Korea: a Nationwide Case-Control Study

Ji Wonjun,Huh Kyungmin,Kang Minsun,Hong Jinwook,Bae Gi Hwan,이예린,Na Yewon,Choi Hyoseon,Gong Seon Yeong,Choi Yoon-Hyeong,Ko Kwang-Pil,Im Jeong-Soo,정재훈 대한의학회 2020 Journal of Korean medical science Vol.35 No.25

Background: The coronavirus disease 2019 (COVID-19) pandemic is an emerging threat worldwide. It remains unclear how comorbidities affect the risk of infection and severity of COVID-19. Methods: This is a nationwide retrospective case-control study of 219,961 individuals, aged 18 years or older, whose medical costs for COVID-19 testing were claimed until May 15, 2020. COVID-19 diagnosis and infection severity were identified from reimbursement data using diagnosis codes and on the basis of respiratory support use, respectively. Odds ratios (ORs) were estimated using multiple logistic regression, after adjusting for age, sex, region, healthcare utilization, and insurance status. Results: The COVID-19 group (7,341 of 219,961) was young and had a high proportion of female. Overall, 13.0% (954 of 7,341) of the cases were severe. The severe COVID-19 group had older patients and a proportion of male ratio than did the non-severe group. Diabetes (odds ratio range [ORR], 1.206–1.254), osteoporosis (ORR, 1.128–1.157), rheumatoid arthritis (ORR, 1.207–1.244), substance use (ORR, 1.321–1.381), and schizophrenia (ORR, 1.614–1.721) showed significant association with COVID-19. In terms of severity, diabetes (OR, 1.247; 95% confidential interval, 1.009–1.543), hypertension (ORR, 1.245–1.317), chronic lower respiratory disease (ORR, 1.216–1.233), chronic renal failure, and end-stage renal disease (ORR, 2.052–2.178) were associated with severe COVID-19. Conclusion: We identified several comorbidities associated with COVID-19. Health care workers should be more careful while diagnosing and treating COVID-19 when patients have the abovementioned comorbidities.

Seasonal Variations in PM2.5 Concentrations and Clinical Impact on Chronic Obstructive Pulmonary Disease Patients

( Jin-young Huh ),( Hajeong Kim ),( Geunjoo Na ),( Shinhee Park ),( Seung Won Ra ),( Sung-yoon Kang ),( Ho Cheol Kim ),( Hwan-cheol Kim ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background The high concentration of particulate matter of diameter < 2.5mm (PM2.5) is a known risk factor of COPD. However, there have been few prospective studies that measured ambient PM2.5 of individual COPD patients. We aimed to prospectively evaluate the seasonal individual PM2.5 concentrations and assess their clinical impact. Methods A total of 105 COPD patients were followed-up for one year. Individual PM2.5 concentrations were monitored continuously, indoors by sensors installed at patients’ residence, and outdoors by national observatories. Clinical parameters were evaluated at three months interval. The relationships between PM2.5 concentrations and clinical parameters were evaluated with Pearson correlation and linear regression analysis. Results The mean age of patients was 68.2 ± 7.2 years and 92.4% were male (Table 1). The mean indoor and outdoor PM2.5 concentrations were 16.2 ± 8.4μg/m3 and 17.2 ± 5.0μg/m3 respectively. The season with the highest concentration was winter (indoor: 18.8 ± 11.7μg/m3; outdoor; 22.5 ± 5.0μg/m3). The indoor/outdoor ratio was the lowest in winter (0.837) followed by spring (0.918), fall (1.059) and summer (1.112) (Figure 2). Saint George’s Respiratory Questionnaire for COPD (SGRQ-C) and acute exacerbation (AE) had significant correlation with PM2.5 levels. The correlations were most prominent in winter and absent in summer (Figure 2). In linear regression, changes in SGRQ-C in winter was the largest with duration of PM2.5 ≥ 35μg/ m3, six days before (β: 1.089, 95% confidence interval (CI): 0.216-1.962; p < 0.001) and changes in AE in winter was the largest with duration of PM2.5 ≥ 75μg/m3, four days before (β: 0.246, 95% CI: 0.102-0.390; p < 0.001). Conclusions There were seasonal patterns in ambient PM2.5 concentration, and its impact on clinical parameters of individual COPD patients. SGRQ-C and AE were affected by PM2.5 and the effect was most notable in winter.

Angioimmunoblastic T Cell Lymphomas: Frequent Cutaneous Skin Lesions and Absence of Human Herpes Viruses

( Ghil Suk Yoon ),( Yang Kyu Choi ),( Ha Na Bak ),( Beom Joon Kim ),( Myeung Nam Kim ),( Je Ne Choi ),( Hye Myung Rheu ),( Joo Ryung Huh ),( Jee Ho Choi ),( Sung Eun Chang ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.1

Background: Angioimmunoblastic T-cell lymphoma (AITL) is a complex lymphoproliferative disorder and often mimics a viral infection with frequent skin involvement. Epstein-Barr virus (EBV) and human herpes virus (HHV)-6 are reported to be associated with AITL, but there are conflicting results. Objective: We evaluated the association of EBV and HHV-6 with AITL. Methods: We reviewed the clinical, histological and immunophenotypical features of 19 cases of AITL. Among them, 11 lymph node biopsies of AITL were examined for HHV-6, -7, and -8 by polymerase chain reaction (PCR) using virus-specific primers. In situ hybridization of EBV early region RNA (EBER) was performed and T cell receptor (TCR) gene rearrangement was also investigated in some cases. Results: Among these 19 cases, maculopapular, plaque or nodular skin lesions accompanied AITL in 12 cases. Clonal TCR gene rearrangement was seen in 8/9 cases tested. EBER in situ hybridization was positive in 8 cases (57.1%). Among 7 cases with skin biopsies, five cases were consistent with cutaneous involvement of AITL, 1 case was a drug eruption, and the other case was Kaposi`s sarcoma. Except a HHV-8 (+) case who also had Kaposi`s sarcoma, all of these cases were negative for HHV-6, -7 and -8. Conclusion: Skin manifestation seems to be a cardinal component of AITL, be it in the context of presentation, progression or recurrent disease. Recognition of clinicopathological features of skin lesions in AITL as diagnostic clues should be stressed among dermatologists. The lack of HHV-6, -7 and -8 in lymph node biopsy of AITL argues against a pathogenic role for HHVs in AITL. (Ann Dermatol(Seoul) 21(1) 1∼5, 2009)

포토샵 레이어 기능을 활용한 동양회화 구도수업

박하나(Ha-Na Park),허윤정(Yoon-Jung Huh) 한국콘텐츠학회 2014 한국콘텐츠학회논문지 Vol.14 No.10

동양회화 수업이 소홀히 여겨지는 이유는 교사의 부담과 용구의 준비와 사용의 번거로움 때문이다. 이러한 부담감은 매체의 전환으로 극복될 수 있다. 본 연구는 동양회화 수업의 단점을 극복하고 학생들의 흥미를 높이며 효과적인 구도 수업을 위한 방안으로 포토샵 프로그램의 레이어를 활용한 동양회화 구도 수업을 제시하였다. 포토샵을 활용한 동양회화 구도 수업 안을 개발하고 그 효과를 알아보고자 고등학교 1학년 60명을 대상으로 수업 전과 후에 설문조사를 시행하고 수업 결과물을 분석하였다. 대다수(75%)가 동양회화 구도 수업에 포토샵 수업이 적절하며, 포토샵을 활용한다면 주제에 상관없이 참여하겠다는 의견이 58.3%로 포토샵에 높은 흥미를 나타내었다. 포토샵 프로그램을 활용한 수업의 장점으로 직접 그리지 않아 부담이 적은 점(33.3%), 다양한 표현이 가능한 점(30%), 준비물이 없는 점(26.6%) 등을 답하여 포토샵 활용이 기존 동양회화수업의 단점을 극복할 수 있음을 확인할 수 있었다. Oriental painting lesson is considered neglectedly, because of pressure on teachers and troublesomeness of preparing and using for art supplies. However, change of medium can solve pressure on teachers and students for Oriental painting lesson enough. Therefore this study will present composition of Oriental painting lesson planning using photoshop program as a way of overcoming weak points, increasing students interests and giving effective composition lesson. We developed composition of Oriental painting lesson planning using layer of photoshop program. Then We surveyed 60 students who are two classes of the first grade in G high school to know the effect and possibility of the lesson planning and analyzed the results. The most(75%) of the respondents answered that composition of Oriental painting lesson planning using photoshop program was appropriate. The more than half (58.3%) respondents wanted to participated in lesson regardless of any subjects. That shows highly interest for photoshop program. The respondents answered that the merits of this lesson using photoshop program are less pressure for drawing(33.3%), possibility of variety expression(30%), not requiring art supplies(26.6%). So this study shows using photoshop program for art class can solve weak points of Oriental painting lesson.

평면 고위 결찰술 및 함입 발거술을 이용한 하지 정맥류의 치료 경험

김영욱,허승,나목찬,윤우성 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

Purpose: Flush high ligation of the saphenofemoral or saphenopoplieal junction combined with invaginated stripping of the greater saphenous vein to just below the knee or perforate invaginate stripping of the proximal lesser saphenous vein appears to be the method of choice for good clinical results and low incidence of damage to the saphenous or sural nerve, and is important in the prevention of recurrence. Method: From January 2001 to August 2001, we performed 84 operations for 72 patients with varicose veins. Among them, 77 flush high ligations (62 saphenofemoral and 15 saphenopopliteal) and 64 invaginated strippings (55 greater and 9 lesser saphenous veins) were performed. Result: Seventy seven flush high ligations were successfully performed in all patients, but 2 invaginated strippings were failed due to their large branches of greater saphenous veins. All of 9 proximal invaginated strippings for lesser saphenous veins were completely performed without any complications. As early postoperative complications related with invaginated strippings for greater saphenous veins, 24 (43.6%) cases of ecchymosis and 5 (9.1%) cases of paresthesia were occurred at thigh. One case of wound infection at popliteal fossa and 3 cases of wound inflammation at inguinal area were occurred. But those complications were recovered within 10 days. Conclusion: The results show that the invaginated stripping is very useful for patients with varicose veins, especially in stripping of lesser saphenous veins and the flush high ligation is safe for the treatment of junctional incompetence.

임상신질환 : 혈청빌리루빈이 단백뇨의 유병률에 미치는 영향

박재윤 ( Jea Yoon Park ),허남주 ( Nam Joo Huh ),송영림 ( Young Rim Song ),유선진 ( Sun Jin You ),진호준 ( Ho Jun Chin ),나기영 ( Ki Young Na ),채동완 ( Dong Wan Chae ),김성권 ( Suhng Gwon Kim ),정은숙 ( En Suk Jeong ) 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1

Short-term changes of human acellular dermal matrix (Megaderm) in a mouse model

Kim, Yang Seok,Na, Young Cheon,Yoon, Hyun Sik,Huh, Woo Hoe,Kim, Ji Min Korean Cleft Palate-Craniofacial Association 2019 Archives of Craniofacial Surgery Vol.20 No.1

Background: Physicians tend to overcorrect when applying the acellular dermal matrix for reconstructive option because of volume decrement problem after absorption comparing with initial volume. However, there are no studies on the exact volume decrement and absorption rate with commercial products in South Korea. To figure out absorption rate of acellular dermal matrix product in South Korea (Megaderm), authors designed this experiment. Methods: Nine mice were used and randomly divided into three groups by the time with sacrificing. The implant (Megaderm) was tailored to fit a cuboid form ($1.0cm{\times}1.0cm$ in length and width and 2.0 mm in thickness). A skin incision was made at anterior chest with blade #15 scalpel with exposing the pectoralis major muscle. As hydrated Megaderm was located upon the pectoralis major muscle, the skin was sutured with Ethilon #5-0. After the surgical procedure, each animal group was sacrificed at 4, 8, and 12 weeks, respectively, for biopsies and histological analysis of the implants. All samples were stained with routine hematoxylin and eosin staining and Masson's trichrome staining and the thickness were measured. A measurements were analyzed using Friedman test. Statistically, the correlation between thicknesses of Megaderm before and after implantation was analyzed. Results: After sacrificing the animal groups at postoperative 4, 8, 12 weeks, the mean tissue thickness values were $2.10{\pm}1.03mm$, $2.17{\pm}0.21mm$, and $2.40{\pm}0.20mm$ (p= 0.368), respectively. The remaining ratios after absorption comparing with after initial hydrated Megaderm were 82.7%, 85.4%, and 94.5%, respectively. In histopathological findings, neovascularization and density of collagenous fiber was increased with time. Conclusion: Author's hypothesis was absorption rate of implant would be increased over time. But in this experiment, there is no statistical significance between mean absorption thickness of implant and the time (p= 0.368). Also it can be affected by graft site, blood supply, and animals that were used in the experiment.