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( Shinhee Park ),( An-soo Jang ),( Pureun-haneul Lee ),( Ae-rin Baek ),( Jong-sook Park ),( June-hyuk Lee ),( Sung-Woo Park ),( Do-jin Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Objectives The SRY-related high-mobility group box 18 (SOX18) is an angiogenic transcription factor involved in tissue injury, wound healing and development of vessels. The expression of SOX18 is increased in acute lung injury and asthma exacerbation, but the role of SOX18 in chronic obstructive pulmonary disease (COPD) has not been studied. To investigate the relationship between SOX18 and COPD, we evaluated the relationship between SOX18 with the clinical parameters of COPD, including lung functions and exacerbations. Methods We recruited a cohort of 30 patients with COPD and 25 healthy controls, and compared their clinical parameters, including lung function. We measured the plasma SOX18 level of healthy controls and COPD patients who were in stable and exacerbated state. Results The COPD patients were all males, and predominantly smokers; their baseline lung function was lower than the healthy controls. The mean SOX18 plasma level was 0.0272 ± 0.0145 ng/mg in the control group, 0.1574 ± 0.0692 ng/mg in the stable COPD group (COPD-ST) and 0.2336 ± 0.1921 ng/mg in the exacerbated COPD (COPD-EXA) group. The plasma SOX18 level was significantly higher in both COPD-ST and COPD-EXA groups compared to healthy control group. The plasma SOX18 level was inversely correlated with BMI, FVC, and FEV1 of COPD patients (r = -0448, P < 0.001, r = -0.511, P < 0.001, and r = 0.607, P < 0.001, respectively). Conclusions The plasma SOX18 level was increased in COPD patients regardless of exacerbation and negatively correlated with lung function. These findings suggest that SOX18 may play a role in pathogenesis of COPD.
ADAM29 Elevation in Patients with COPD and Its Association with Lung Function
( Shinhee Park ),( Min Hyeok An ),( Pureun-haneul Lee ),( Yun Ha Nam ),( Ae Rin Baek ),( Jong Sook Park ),( Junehyuk Lee ),( Sung-woo Park ),( Do Jin Kim ),( An Soo Jang ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
( Shinhee Park ),( An-soo Jang ),( Pureun-haneul Lee ),( Ae-rin Baek ),( Jong-sook Park ),( June-hyuk Lee ),( Sung-Woo Park ),( Do-jin Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Objectives Chronic obstructive pulmonary disease (COPD) imposes a major healthcare burden. A tight junction protein, claudin-4 (CLDN4), may play a protective role in acute lung injury, but its role in COPD is unclear. To investigate the relationship between CLDN4 and COPD, we evaluated the association of CLDN4 with the clinical parameters of COPD, including exacerbations. Methods We analyzed a cohort of 30 patients with COPD and 25 healthy controls, and evaluated their clinical parameters, including lung function. The plasma CLDN4 level in stable and exacerbated COPD was measured. Results The COPD patients were all males, and predominantly smokers; their initial lung function was poorer than the healthy controls. The mean CLDN4 plasma level was 0.0219 ± 0.0205 ng/mg in the control group, 0.0086 ± 0.0158 ng/mg in the stable COPD group (COPD-ST) and 0.0917 ± 0.0871 ng/mg in the exacerbated COPD (COPD-EXA) group. The plasma CLDN4 level was significantly lower in the COPD-ST than control group, but was significantly elevated in the COPD-EXA group. The plasma CLDN4 level was inversely correlated with FVC and FEV1 in the COPD-EXA group (r = 0.506, P = 0.001 and r = 0.527, P < 0.001, respectively). Conclusions The plasma CLDN4 level is closely correlated with COPD exacerbations and decreased lung function. This suggests that CLDN4 has potential as a severity marker for COPD.
고대 희랍으로부터 중세 Hermannus까지 음계체계 발전의 이론적 필연성
朴信姬 ( Shinhee Park ) 한양대학교 음악연구소 1988 音樂論壇 Vol.4 No.-
By following the evolution of the gamut systems of the ancient Greeks through the Medieval period, this paper presents a theoretical study of tetrachordal structures and their relationship to the modes they create. Analysis of the gamut systems reveals not only the weakness of the system used in Musica Enchiriadis, but also the anomalous construction of the finalis G in contrast with the paralleled three finalis A, B, C with D, E, F in Micrologus. This analysis confirms Hermannus' modal affinity which clarified the confusion around the Hypomixolydian by illustrating a different collection of tetrachords in the range of the Dorian mode. Riemann points out that it was Boethius who conveyed the antique theory to the medieval period by a displacement of a fourth which caused the series of proslambanomeni to appear from A to g, rather than E to d(Ex.2). By following Riemann's understanding of Boethius's theory(Ex.5.1), modes can be constructed with characteristic octaves based on proslambanomeni which do not correspond(Fig.1). Identical mode names should be kept on the same pitches between the original and displaced proslambanomeni(Ex.5.2) in order to correspond modes with their characteristic octaves(Fig.2). However, if the Hypomixolydian is added, the eighth proslambanomenos and its characteristic octave based on the mode no longer correspond with each other in the original proslambanomeni(Fig.3). Only through a fourth transposition as suggested by Boethius does Hypomixolydian finds its correct placement in relation to its proslambanomenos and its characteristic octave(Fig.4). This suggests that Boethius's misinterpretation of Ptolemy's antique scales should be reconsidered as more than a pure error.
朴信姬 ( Shinhee Park ) 漢陽大學校 音樂硏究所 1987 音樂論壇 Vol.3 No.-
"The Guidonian Hand," invented by Guido d'Arezzo for teaching solmization, superbly organizes the core of music theories available throughout the Medieval and Renaissance periods. This article seeks to explain the logical and coherent arrangement of locus, vox, deduction, and clavis which are all 73 different pitch functions in "The Hand," with references to the symbolism of the Trinity, that is, the concept of perfection in that period.
이란 사파비왕조(1501~1722) 청화도기에 보이는 중국 수출자기의 영향
朴信喜(Park Shinhee) 미술사연구회 2013 미술사연구 Vol.- No.27
Following the increase in marine trade in the eighth century, Chinese ceramics emerged as an important product in seafaring trade between East and West. The fragility, weight and volume of ceramics were such that the sea, which offered greater stability and allowed the carrying of heavier loads, provided a more suitable option for transport than land routes. This fact is confirmed by the huge quantities of ceramic shards, dating from the Tang to the Qing dynasties, which had been excavated at the major international marine trading outposts on the way to the West Asia, including the Malay Peninsula, Indonesia, Sri Lanka, India, Iraq and as well as Egypt. Chinese ceramics in the collections of Iran’s Ardebil Shrine and Turkey’s Topkapi Palace Museum, moreover, offer us some idea of the large quantity in which they reached Iran and neighboring countries. Chinese ceramics were unfailingly copied in every region that they reached, offering further proof of the high demand for them. This study explores the influence, divided into four distinct periods, of Chinese export porcelains on blue-and-white wares of the Safavid Dynasty(1701~1722), the most powerful Persian political entity since the Sasanian Empire. This period saw the production of the finest and most advanced pieces in the history of Islamic ceramics; it is also the period that showed the greatest influence from Chinese export porcelains. The study begins by examining the various styles of Chinese export wares that reached Persia at the time, their forms and routes by which they reached West Asia, in order to explain their particular characteristics. Chinese export wares reached the Safavid Dynasty during the late-Ming and early-Qing dynasties by three routes: tributary trade; trade via European East India companies; and through trading by hawkers at major international trading ports in Southwest and Southeast Asia. Safavid blue-and-white wares imitating the Chinese export wares that reached Persia via these three routes can be divided into the following four periods, according to different characteristics. The first period, which spans the 16th century, is that during which blue-and-white wares inherited characteristics from those of the preceding Timurid Dynasty. The second period, in the first half of the 17th century, saw unprecedented support for the arts on the part of the Safavid Dynasty. The third, in the second half of the 17th century, saw a decline in royal authority but an emphasizing of tradition and independence in Persian culture, while the fourth period spans the end of the 17th and beginning of the 18th century and saw the collapse of the Safavid Dynastye amid economic difficulties, religious persecution, chaotic public sentiment and threats from neighbouring countries, accompanied by the influence of new porcelains from the Qing Dynasty. Finally, the study attempts to explain the circumstances that allowed the potters of the Safavid Dynasty to produce ceramics similar to those of China and which were of a higher quality than those in other West Asian countries at the time and of previous eras.
박신희(Shinhee Park),한동철(Donghul Han) 한국자동차공학회 1999 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1999 No.11_2
To reduce computing time and model efforts, The hybrid modeling method of the vehicle component has been developed by using beam element and nonlinear spring element to which axial and bending collapses are applied. A new vehicle is designed using the hybrid modeling scheme along the design process. Crashworthiness analyses of the hybrid vehicle model is executed and the results are compared with those of full car analysis using shell elements. Occupant simulations on impact condition have also been performed on the shell model as well as the hybrid vehicle model. Relatively good agreement is achieved between these analyses, while the computing time is significantly reduced for the proposed method. Finally, the optimization of occupant behavior using genetic algorithms is performed.
Rapidly resolved IgG4-related retroperitoneal fibrosis after steroid pulse therapy
Jeung, Soomin,Kim, Hyosang,Seo, Yuri,Yoon, Hee-Young,Lee, Nah Kyum,Park, Shinhee,Seo, Bomi,Park, Su-Yeon,Park, Su-Kil Yeungnam University College of Medicine 2016 Yeungnam University Journal of Medicine Vol.33 No.1
Retroperitoneal fibrosis (RF) is a disorder characterized by the presence of a retroperitoneal mass and concurrent systemic inflammation. Some cases of RF are recognized as belonging to the spectrum of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoids are highly effective for treatment of retroperitoneal fibrosis, although the optimal dose and duration of therapy have not been established. An initial dose of prednisone (40-60 mg) daily is usually administered with a tapering scheme. We report on a 55-year-old man diagnosed with IgG4-related RF and successfully treated with a 3-day course of daily 250 mg (4 mg/kg) intravenous methylprednisolone, which resulted in the prompt resolution of urinary obstruction and systemic symptoms.