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Min-Sup Shin,Bung-Nyun Kim,Minji Cho,Mirae Jang,Hanbyul Shin,Ryemi Do,Hyungseo Park,Narae Yoon,Gahye Noh,Jae-Won Song,Yebin Ahn,Jiyoon Shin,Soomin Jang,Eunjung Noh,Eunhwa Lee 대한소아청소년정신의학회 2021 소아청소년정신의학 Vol.32 No.2
Objectives: This study was conducted to investigate the reliability and validity of the Korean version of the DSM-5 Level 2 Cross-Cutting Symptom Measure–inattention [Swanson, Nolan and Pelham, version IV (SNAP-IV)] and anger [Patient-Reported Outcome Measurement Information System (PROMIS) Anger] for parents and guardians of children aged 6–17 years. Methods: We included 104 children and adolescents diagnosed with attention-deficit/hyperactivity disorder (ADHD), ADHD with anxiety and depression, depressive disorder, anxiety disorder, and tic disorder with somatic symptoms (ADHD=41, depression=9, anxiety=14, ADHD+anxious depression=11, tic+somatic symptoms=29). Their ages ranged from 8 years to 15 years. The participants’ mothers completed the SNAP-IV, PROMIS Anger scale, Korean version of the IOWA Conners Rating Scale (K-IOWA), and Korean ADHD Rating Scale (K-ARS) so that the reliability and validity of the SNAP-IV and PROMIS Anger scales, which are DSM-5 scales for assessing inattention and anger of children and adolescents, could be examined. Results: The reliability coefficient of SNAP-IV (Cronbach’s α) was 0.94. The correlation coefficients between SNAP-IV, K-IOWA inattention, and K-ARS inattention scores ranged from 0.73 to 0.86. The mean SNAP-IV scores of the ADHD and the ADHD+anxious depression groups were significantly higher than those of the anxiety and the tic+somatic symptoms groups. The reliability coefficient of the PROMIS Anger was 0.91. The correlation coefficient between PROMIS Anger and K-IOWA oppositional/defiant scores was 0.75. The PROMIS Anger mean score of the ADHD+anxious depression group tended to be higher than that of the other groups. Conclusion: These results suggest that the Korean version of the DSM-5 Level 2 Cross-Cutting Symptom Measure–inattention and anger for parent and guardian of child age 6–17 might be a reliable and valid test and may be useful for screening children and adolescents with ADHD.
Shin, Sun Ah,Na, Hee Young,Choe, Ji Young,Chung, Doohyun,Park, Mira,Oh, Sohee,Kim, Ji Eun 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.6
<P><B>Background</B></P><P>The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of this study was to examine the expression levels of adipophilin and related hypoxic signaling proteins and to determine their prognostic impacts and associations with the pathologic characteristics of lung adenocarcinoma.</P><P><B>Methods</B></P><P>Expression levels of adipophilin, heat shock protein 27 (HSP27), carbonic anhydrase IX, and hypoxia-inducible factor 1α were examined by immunohistochemical staining using tissue microarray blocks. Correlations between protein expression levels and various clinicopathologic features were analyzed.</P><P><B>Results</B></P><P>A total of 230 cases of primary adenocarcinoma of the lung were enrolled in this study. Adipophilin expression was more frequent in males and with the solid histologic type. It was correlated with HSP27 expression. Patients with adipophilin-positive adenocarcinoma showed a shorter progression-free survival (PFS) (median PFS, 17.2 months vs 18.4 months) in a univariable survival analysis, whereas HSP27 positivity correlated with favorable overall survival (OS) and PFS. In a multivariable analysis, adipophilin and HSP27 were independent prognostic markers of both OS and PFS.</P><P><B>Conclusions</B></P><P>Activated lipid metabolism and the hypoxic signaling pathway might play a major role in the progression of lung adenocarcinoma, especially in the solid histologic type.</P>
Shin, Hye Kyoung,Park, Mira,Kim, Hak-Yong,Park, Soo-Jin Elsevier 2015 Journal of industrial and engineering chemistry Vol.32 No.-
<P><B>Abstract</B></P> <P>This work evaluated the effect of various amounts of tension on polyacrylonitrile (PAN) precursor fibers during electron beam irradiation (EBI) stabilization. X-ray diffraction (XRD), tensile testing, and scanning electron microscopy (SEM) were implemented to determine the effects of tension on the PAN fibers. During the stabilization process, the fibers shrunk due to a loss of molecular alignment, and the addition of tension acting on the PAN fibers during stabilization was proposed to address this issue. In this work, PAN fibers were stabilized by EBI under various loads. It was found from the XRD data that tension led to the development of crystalline structures during EBI stabilization. From the tensile test, it was found that tension led to a small increase in strength due to conversion of disordered structures into ordered structures in the fibers.</P>
Synthesis of Silver-doped Silica-complex Nanoparticles for Antibacterial Materials
Shin, Yu-Shik,Park, Mira,Kim, Hak-Yong,Jin, Fan-Long,Park, Soo-Jin Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10
Silver nanoparticles have been synthesized by liquid-phase and alcohol reduction methods. Silver-doped silica-complex nanoparticles were prepared using a sol-gel process. The formation, structure, morphology, and particle size of the nanoparticles have been studied using several techniques. Silver nanoparticles of size of 30-40 nm were formed successfully by alcohol reduction. TEM images show that both the concentration and the molecular weight of polyvinyl pyrrolidone (PVP) considerably affect the size of the emerging silver nanoparticles. The number of silver-doped silica-complex particles increased by a mercapto-group treatment that showed a narrower size distribution than that of silica treated with amino groups. The silver/polyester and silver-doped silica/polyester masterbatch chips showed excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.
Automated Maskless Photolithography System for Peptide Microarray Synthesis on a Chip
Shin, Dong-Sik,Lee, Kook-Nyung,Yoo, Byung-Wook,Kim, Jaehi,Kim, Mira,Kim, Yong-Kweon,Lee, Yoon-Sik American Chemical Society 2010 Journal of combinatorial chemistry Vol.12 No.4
<P>Maskless photolithographic peptide synthesis was performed on a glass chip using an automated peptide array synthesizer system. The peptide array synthesizer was built in a closed box, which contained optical and fluidic systems. The conditions for peptide synthesis were fully controlled by a computer program. For the peptide synthesis on a glass chip, 20 NVOC-protected amino acids were synthesized. The coupling efficiencies of two model peptide sequences were examined on ACA/APTS and PEG/CHI/GPTS chips. PEG/CHI/GPTS chip gave higher average stepwise yields of GIYWHHY (94%) and YIYGSFK (98%) than those of ACA/APTS chip. To quantify peptide−protein binding affinity, HPQ- or HPM-containing pentapeptides were synthesized on a PEG/CHI/GPTS chip and the binding event of Cy3 labeled-streptavidin was quantified. The peptide sequence of IQHPQ showed highest binding affinity with Cy3 labeled-streptavidin. The results demonstrated that the photolithographic peptide array synthesis method efficiently quantified the binding activities of protein-peptide interactions and it can be used for additional biological assay applications.</P><P>A maskless photolithography system for peptide array synthesis on a chip is presented.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jcchff/2010/jcchff.2010.12.issue-4/cc100009g/production/images/medium/cc-2010-00009g_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100009g'>ACS Electronic Supporting Info</A></P>