한우고기의 브랜드 자산이 구전의도 등과의 관계성에 대한 탐색적 연구 - 신뢰와 친밀감의 매개효과를 중심으로 : 한우고기의 브랜드 자산이 구전의도 등과의 관계성에 대한 탐색적 연구

김용만(Kim Yong Man),한일문(Ill Moon Han) 한국마케팅과학회 2006 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

This research is investigated theoretical background of influence the influential factors of components of brand equity that is the quality, advertisement, well-being factors to the components of brand equity that is the perceived quality, the brand association, the brand awareness. This investigation was conducted to see the relationship between the words of mouth attitude, that is, outcome effector and the brand loyalty get through the trust and intimacy that is the mediation factor of Han-Woo beef. So, hereafter the more investigation of the influence the influential factors of components of brand equity to the components of brand equity and the relationship between the influential factors of components of brand equity and mediation factor that is trust and intimacy will be conducted. And, the relationship between the customer"s trust, the intimacy outcome effector that is the words of mouth and brand loyalty will be verified.

영지 (Ganoderma lucidum) 자실체 다당류의 분자량에 따른 생리활성

한만덕;김용현;이현수;권현정;전미애;한국일 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

The study was conducted to investigate the biological activities of an protein-bound polysaccharide (GLP) isolated from the fruit body of Ganoderma lucidum. GLP was extracted by hot water and then it was purified high (GLP-HM) and low (GLP-LM) molecular weight fraction by ethanol precipitation. Both of GLP-HM and GLP-LM at doses of 20 mg/kg in vivo had the ability to inhibit the tumor growth of Sarcoma 180 tumor-bearing mice. Inhibition rates of tumor (%) were inhibited 60.6% and 38.7% by GLP-HM and GLP-LM, respectively. In assay of anti-complementary activity in vitro, the GLP-HM were higher than that of the GLP-LM polysaccharide. And also, the GLP-HM enhanced nitric oxide production of mouse bone marrow cells. When the GLP-HM was injected intraperitoneally in tumor-bearing mouse at doses of 20 mg/kg, the concentration of TNF-α in vivo was 140.9 pg/ml in the serum, 269.6 pg/ml in sarcoma tumor mass and 879.4 pg/ml in liver. This study shows that the high molecular polysaccharide from mushroom can enhance more the bioactivities than that of the low molecular polysaccharide.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

폴록사머 188 및 멘톨에 의한 이부프로펜의 용해도 증가

용철순,정세현,박상만,이종달,최한곤 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.1

To enhance the solubility of poorly water-soluble ibuprofen with poloxamer and menthol, the effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigate. In the absence and presence of additives such as ethanol and poloxamer 188, the solubility of ibuprofen increased until the ratio of menthol to ibuprofen increased from 0:10 to 4:6 followed by and abrupt decrease in solubility above the ratio of 4:6, indicating tat 4 parts of ibuprofen formed eutetic mixture with 6 parts of menthol. In the presence of poloxamer, the solutions with the same ratio showed abrupt increase in the solubility of ibuprofen . Furthermore, in the presence of poloxamer, the solution with ratio of 4:6 showed more than 2.5- and 6-fold increase in the solubility of ibuprofen compared with that without additives and that without menthol, respectively. The solution with menthol/ibuprofen ratio of 1:9 and higher than 15% poloxamer 188 showed the maximum solubility of ibuprofen, 1.2㎎/ml. Thus, menthol gave the greatly enhanced solubility of ibuprofen with poloxamer 188.

터보 차져와 인터쿨러를 장착한 디젤기관의 시뮬레이션 연구

한영출,백두성,류규현,오용석,박만재 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.4

Studies on the turbocharger itself or various aspects generated from turbocharged engine have been made. However, only a few researches have been made on the performance for the natural aspirated engine equipped with the turbocharger and the intercooler. In this study, the performance prediction program based on turbocharger theory is developed for simu-lation which may reduce the cost and the trial-and-error time. The program is verified with the experimental results for 11,000cc diesel engine with the turbocharger and the intercooler. Also, various factors which are invisible in experiment are predicted using this program.

DOC의 K-7 Mode에 의한 배기가스 저감에 관한 연구

한영출,백두성,오용석,박만재,박귀열,류규현 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.3

With the significant growth of the number of vehicles, environmental problems is raised. NOx, SOx, and PM emissions in diesel powered vehicles are larger than that in gasoline, because the development of pollutants reduction techniques has no: been yet achieved. So it is need to develop after-treatment or to convert into alternative fuel to satisfy emission regula-tion. Among the after-treatment systems to reduce the diesel emissions, studies with diesel oxidation catalyst(DOC) are done greatly. In this study using DOC, reduction efficiency with the change of temperature and catalyst loading was calculated through measurements of CO, HC, PM, and SOx.

합병기업의 공시 및 규모효과

한만용ㆍ이수욱 충북대학교 국가미래기술경영연구소 2019 기술경영 Vol.4 No.3

본 연구는 2005년부터 2016년까지 한국거래소 KOSPI시장에서 타 기업과의 합병을 공시한 기업 중에서 280건의 표본을 선정하여 합병을 공시한 시점에서 나타날 수 있 는 공시효과와 함께 합병기업에 대한 규모효과를 실증적으로 분석하였다. 본 연구를 실증분석한 결과를 살펴보면 다음과 같다. 첫째, 전체 합병표본(280건)의 공시시점에서 유의적인 양(+)의 누적평균비정상수익률 (CAAR)이 나타나고 있어 합병의 공시효과를 지지해 주는 결과를 얻을 수 있었다. 둘째, 기업규모의 대용변수인 총자산과 자본금을 이용하여 합병표본을 대기업표본과 소기업표본의 하위표본으로 분류하여 분석해 본 결과는 다음과 같다. 먼저 총자산규모 에 따라 분류된 하위표본에서는 소기업표본(137건)이 대기업표본(133건)보다 더 높은 비정상수익률이 관찰되었으며, 두 표본간의 평균의 차이에서도 유의적인 결과가 나타 났다. 또한 자본금규모에 따라 분류된 하위표본에서도 소기업표본(152건)이 대기업표 본(118건)보다 더 높은 비정상수익률이 관찰되었을 뿐만 아니라 두 표본간의 평균의 차이에서도 유의적인 것으로 나타났다. 따라서 총자산규모변수 및 자본금규모변수 모 두 기업규모효과를 지지해 주는 것으로 나타났다. 셋째, 전체 합병표본(280건)의 공시 시점에서 측정된 누적평균비정상수익률(CAAR)인 종속변수에 영향을 미치는 설명변수를 분석해 본 결과에서 총자산규모변수(TA)와는 유의적인 음(-)의 회귀계수가 나타난 반면, 자본금규모변수(CAP)와는 비유의적인 양 (+)의 회귀계수를 관찰할 수 있어, 기업규모의 대용변수는 자본금 규모 변수보다는 총 자산 규모 변수가 기업규모 효과를 더 잘 설명해 주는 것으로 나타났다.

Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.

헬리코박터 파이로리 균 진단용 ^13C-요소 캅셀의 개발

용철순,김용일,김지만,강성훈,권기철,이종달,김종국,사홍기,최한곤 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

The purpose of this study was to develop a new ^13C-urea-containing capsule for diagnosis of H.pylori. The urea-containing capsules were prepared with various diluents such as polyethylene glycol (PEG), microcrystaline cellulose, sodium lauryl sulfate and citric acid. The dissolution test, ^13C-urea breath test and stability test were then performed on the capsules. Microcrystalline cellulose and sodium lauryl sulfate retarded the initial dissolution rates of urea. However, PEG increased the initial dissolution rates of urea. Furthermore, two formulae composed of PEG,[^13C-urea/PEG (38/1.9 mg/cap)] and [^13C-urea/PEG (38/1.9/1.9 mg/cap)] had the maximum DOB value. about 16 at 20 min, while the formula composed of only 38 mg ^13C-urea had the maximum DOB value at 30 min. The results indicated that PEG improved the sensitivity of ^13C-urea in the human volunteers. The capsule [^13C-urea/PEG (38/1.9 mg/cap)] was stable for at least six months in 25 and 37℃. Thus, a PEG-containing capsule, [^13C-urea/PEG (38/1.9 mg/cap)] would be a more economical, sensitive and stable perparation for diagnosis of H. pylori.