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김상대,송석훈,이상진,하태영,Lin, Kuan-Pin 한독경상학회 2002 經商論叢 Vol.20 No.2
The firm’s job-based alcohol policy implied that problem drinking and alcoholism were the treatable health problems, but its chief focus was on correcting the impaired work performance that accompanies problem drinking among employees. The central purpose of this study was to compare the firm’s preventive measures and treatment policy for intoxicated workers among Korean, German and American companies. The results indicated that German and U.S. companie’s formal alcoholism policy and rehabilitation program produced the rate of success for prevention and rehabilitation of problem drinking employees. Supervisors reported that about 80% of intoxicated workers improved in general conduct, and 74% of work performance following program intervention in Germany and U.S.A.A tangible result of the company program on alcoholism was the reduction in absenteeism. With treatment, the absence severity rate was less than four days per year in the rehabilitated cases. We also found that the use of formal discipline was associated with undesirable outcomes in these two countries. Overall, the Step by Step Programs that were conducted by the supervisor with the assistance of company’s medical personnel, alcohol program coordinator and counselor were the most effective measures for problem-drinking employees. These facts would indicated that the company’s alcohol policy was a positive step toward the prevention of disability from chronic problem drinking, but we found that there were no any company’s alcohol policies in Korean firms.
Po-Han Chou,Yen-Feng Lin,Ming-Kuei Lu,Hsin-An Chang,Che-Sheng Chu,Wei Hung Chang,Taishiro Kishimoto,Alexander T. Sack,Kuan-Pin Su 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2
Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety dis-order, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.
Pei-Ju Chen,Keng-Chen Liang,Hui-Chen Lin,Ching-Liang Hsieh,Kuan-Pin Su,Mei-Chu Hung,Lee-Yan Sheen 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
This study adopted the forced-swimming paradigm to induce depressive symptoms in rats and evaluated the effects on learning and memory processing. Furthermore, the effects of the water extract of Gastrodia elata Bl., a well-known Chinese traditional medicine, on amnesia in rats subjected to the forced-swimming procedure were studied. Rats were subjected to the forced-swimming procedure, and the inhibitory avoidance task and Morris water maze were used to assess learning and memory performance. The acquisition of the two tasks was mostly impaired after the 15-minute forced-swimming procedure. Administration of the water extract of G. elata Bl. for 21 consecutive days at a dosage of 0.5 or 1.0 g/kg of body weight significantly improved retention in the inhibitory avoidance test, and the lower dose showed a better effect than the higher one and the antidepressant fluoxetine (18 mg/kg of body weight). In the Morris water maze, the lower dose of the water extract of G. elata Bl. significantly improved retention by shortening escape latency in the first test session and increasing the time in searching the target zone during the probe test. These findings suggest that water extracts of G. elata Bl. ameliorate the learning and memory deficits induced by forced swimming.