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The genome of the extremophile crucifer Thellungiella parvula
Dassanayake, Maheshi,Oh, Dong-Ha,Haas, Jeffrey S,Hernandez, Alvaro,Hong, Hyewon,Ali, Shahjahan,Yun, Dae-Jin,Bressan, Ray A,Zhu, Jian-Kang,Bohnert, Hans J,Cheeseman, John M Nature Publishing Group, a division of Macmillan P 2011 Nature genetics Vol.43 No.9
Thellungiella parvula is related to Arabidopsis thaliana and is endemic to saline, resource-poor habitats, making it a model for the evolution of plant adaptation to extreme environments. Here we present the draft genome for this extremophile species. Exclusively by next generation sequencing, we obtained the de novo assembled genome in 1,496 gap-free contigs, closely approximating the estimated genome size of 140 Mb. We anchored these contigs to seven pseudo chromosomes without the use of maps. We show that short reads can be assembled to a near-complete chromosome level for a eukaryotic species lacking prior genetic information. The sequence identifies a number of tandem duplications that, by the nature of the duplicated genes, suggest a possible basis for T. parvula's extremophile lifestyle. Our results provide essential background for developing genomically influenced testable hypotheses for the evolution of environmental stress tolerance.
Hah, Yung-Chil,Hong, Soon-Woo,Oh, Hee-Bok,Fryer, John L.,Rohovec, John S. The Microbiological Society of Korea 1984 미생물학회지 Vol.22 No.1
아산 양어장에서 양식되고 있는 뱀장어 (Anguilla japonica)로부터 22주의 병원성 세균을 분리하여 그 생화학적 성질, 혈청학적 관계, 금붕어에 대한 감염성 및 여러 항생물질에 대한 감수성을 시험하였다. 22균주중 14주 (64%)는 Edwardsiella tarda 5주 (23%)는 Aeromonas hydrophila, 기타 3균주(14%)는 Vibrio anguillarum으로 동정되었다. 3가지 분리균중에서 E. tarda는 동일한 혈청형으로 그 분리율 및 금붕어에 대한 감염성이 가장 높았다. 이에 따라 E. tarda가 조사된 양어장의 뱀장어에서 발생하는 세균성 질병의 주 병원체로 판명되었다. 세 분리균주의 균액을 수조에 풀어 금붕어에 접촉시켰을 때 그 감염율은 세 균주 모두 상대적으로 낮았다. 10주의 분리균을 택해 12가지 항생물질에 대해 감수성 검사를 한 결과 하나에서 여섯가지 약제에 대해 저항성을 나타냈으며, 그 중 tetracycline 유도체와 sulfisoxazole에 대한 저항성이 현저하였다. Twenty two cultures of pathogenic bacteria were isolated from cultured eels(Anguilla japonica) from Asan Hatchery. The bateria were characterized by their biochemical properties, serological relationships, infectivity to gold fish and susceptibility to various antimicrobial compounds. Fourteen of 22(64%) cultures were identified as Edwardsiella tarda, five (23%) as Aeromonas hydrophila and three (14%) as Vibro anguillarum. Edwardisiella tardo isolates proved to be the main cause of the disease in cultured eels. They were serologically homogeneous and their virulency to gold fish was higher than any of the other groups of bacteria tested. The virulence of 3 isolates were low in gold fish exposed to the bacteria by the waterborn route. Ten strains were tested for their susceptibility to 12 antimicrobial compounds and were resistant to from one to six drugs: in particular, tetracycline derivatives and sulfisoxazole.
Corrigendum : 2019 Seoul Consensus on Esophageal Achalasia Guidelines
( Hye-Kyung Jung ),( Su Jin Hong ),( Oh Young Lee ),( John Pandolfino ),( Hyojin Park ),( Hiroto Miwa ),( Uday C Ghoshal ),( Sanjiv Mahadeva ),( Tadayuki Oshima ),( Minhu Chen ),( Andrew S B Chua ),( 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.3
2019 Seoul Consensus on Esophageal Achalasia Guidelines
( Hye-kyung Jung ),( Su Jin Hong ),( Oh Young Lee ),( John Pandolfino ),( Hyojin Park ),( Hiroto Miwa ),( Uday C Ghoshal ),( Sanjiv Mahadeva ),( Tadayuki Oshima ),( Minhu Chen ),( Andrew S B Chua ),( 대한소화기기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.2
Esophageal achalasia is a primary motility disorder characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis. Achalasia is a chronic disease that causes progressive irreversible loss of esophageal motor function. The recent development of high-resolution manometry has facilitated the diagnosis of achalasia, and determining the achalasia subtypes based on high-resolution manometry can be important when deciding on treatment methods. Peroral endoscopic myotomy is less invasive than surgery with comparable efficacy. The present guidelines (the “2019 Seoul Consensus on Esophageal Achalasia Guidelines”) were developed based on evidence-based medicine; the Asian Neurogastroenterology and Motility Association and Korean Society of Neurogastroenterology and Motility served as the operating and development committees, respectively. The development of the guidelines began in June 2018, and a draft consensus based on the Delphi process was achieved in April 2019. The guidelines consist of 18 recommendations: 2 pertaining to the definition and epidemiology of achalasia, 6 pertaining to diagnoses, and 10 pertaining to treatments. The endoscopic treatment section is based on the latest evidence from meta-analyses. Clinicians (including gastroenterologists, upper gastrointestinal tract surgeons, general physicians, nurses, and other hospital workers) and patients could use these guidelines to make an informed decision on the management of achalasia. (J Neurogastroenterol Motil 2020;26:180-203)
Lambrechts Mark J.,Issa Tariq Z.,Lee Yunsoo,Tran Khoa S.,Heard Jeremy,Purtill Caroline,Fried Tristan B.,Oh Samuel,Kim Erin,Mangan John J.,Canseco Jose A.,Kaye I. David,Rihn Jeffrey A.,Hilibrand Alan S 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.6
Study Design: This study is a retrospective cohort study.Purpose: This study aims to determine whether preoperative neuroforaminal stenosis (FS) severity is associated with motor function patient-reported outcome measures (PROMs) following anterior cervical discectomy and fusion (ACDF).Overview of Literature: Cervical FS can significantly contribute to patient symptoms. While magnetic resonance imaging (MRI) has been used to classify FS, there has been limited research into the impact of FS severity on patient outcomes.Methods: Patients undergoing primary, elective 1–3 level ACDF for radiculopathy at a single academic center between 2015 and 2021 were identified retrospectively. Cervical FS was evaluated using axial T2-weighted MRI images via a validated grading scale. The maximum degree of stenosis was used for multilevel disease. Motor symptoms were classified using encounters at their final preoperative and first postoperative visits, with examinations ≤3/5 indicating weakness. PROMs were obtained preoperatively and at 1-year follow-up. Bivariate analysis was used to compare outcomes based on stenosis severity, followed by multivariable analysis.Results: This study included 354 patients, 157 with moderate stenosis and 197 with severe stenosis. Overall, 58 patients (16.4%) presented with upper extremity weakness ≤3/5. A similar number of patients in both groups presented with baseline motor weakness (13.5% vs. 16.55, <i>p</i> =0.431). Postoperatively, 97.1% and 87.0% of patients with severe and moderate FS, respectively, experienced full motor recovery (<i>p</i> =0.134). At 1-year, patients with severe neuroforaminal stenosis presented with significantly worse 12-item Short Form Survey Physical Component Score (PCS-12) (33.3 vs. 37.3, <i>p</i> =0.049) but demonstrated a greater magnitude of improvement (Δ PCS-12: 5.43 vs. 0.87, <i>p</i> =0.048). Worse stenosis was independently associated with greater ΔPCS-12 at 1-year (β =5.59, <i>p</i> =0.022).Conclusions: Patients with severe FS presented with worse preoperative physical health. While ACDF improved outcomes and conferred similar motor recovery in all patients, those with severe FS reported much better improvement in physical function.