http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Protective effects of phillyrin against influenza A virus in vivo
Xin-yan Qu,Qing-jun Li,Hui-min Zhang,Xiao-juan Zhang,Peng-hui Shi,Xiu-juan Zhang,Jing Yang,Zhe Zhou,Sheng-qi Wang 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.
Qu, Hong-Hong,Cui, Li-Hong,Wang, Ke,Wang, Peng,Song, Chun-Hua,Wang, Kai-Juan,Zhang, Jian-Ying,Dai, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with 381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFR C677T and A1298C polymorphisms with susceptibility to esophageal cancer (EC) in a Chinese population. Compared with the CC genotype of MTHFR C677T, subjects carrying homozygote TT and variant genotypes (CT+TT) demonstrated reduced risk of EC with adjusted ORs (95% CI) of 0.44 (0.28-0.71) and 0.57 (0.37-0.88), respectively. However, no association was found between the MTHFR A1298C polymorphism and the risk of EC. Comparing to haplotype CA, haplotypes TA and TC could reduce the susceptibility to EC with adjusted ORs (95% CI) of 0.61(0.47-0.79) and 0.06 (0.01-0.43), respectively. In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese.
Bing Qu,Juan Carlos Sanchez,Hetao Hou,Michael Pollino 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2
This investigation assesses adequacy of the Stiff Rocking Core (SRC) technology for rehabilitating steel Moment Resisting Frames (MRFs) vulnerable to drift concentrations and soft-story failures. The technology installs a single or multiple SRCs pinned to the foundation and connected to a deficient multi-story steel MRF to re-distribute seismic forces along its height and create more uniform inter-story drift and ductility demand distributions. This research team implemented the SRC technology in two archetype steel MRFs including one three-story and one nine-story. Results from nonlinear static analyses show that the SRC technology can reduce inter-story drift concentration in both steel MRFs regardless of the seismic force distributions and drift limits considered in design. Additionally, the SRC extending along the entire height of a steel MRF is more preferable than the one extending over the bottom portion of the system, although these two SRC options can be both valid in many cases.
Amentoflavone protects the hematopoietic system of mice against γ‑irradiation
Xin-yan Qu,Qingjun Li,Xiao-juan Zhang,Zhaofen Wang,Shengqi Wang,Zhe Zhou 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.11
Some flavonoids have been shown to exhibitgood antioxidant activity and protect mice from damageinduced by radiation. Amentoflavone (AMF), a biflavonoidderived from the traditional herb-Selaginella tamariscina,has been reported to have antioxidant properties. The protectiveeffects and mechanism of action of AMF against radiationinjury remain unknown. In this study, male C57BL/6mice were subjected to total-body 60Co γ-irradiation at 7.5or 3.0 Gy. The survival rate and mean survival time wereevaluated to determine the radioprotective effect of AMF. Number of peripheral blood cells, frequency of colony formingunit-granulocytes, monocytes and micronuclei weremeasured to assess the protective effects of AMF on thehematopoietic system. Levels of superoxide dismutase andglutathione, and pathological changes in the bone marrowwere determined. Additionally, next-generation sequencingtechnology was used to explore potential targets of AMF. Weobserved that AMF markedly extends average survival time,reduces injury to the hematopoietic system and promotes itsrecovery. Furthermore, treatment with AMF significantlyattenuated radiation-induced oxidative stress. In addition,AMF had a significant effect on gene tumor necrosis factor alpha-induced protein 2. Together, the results of this studysuggest that AMF is a potential protective agent againstradiation injury.
( Xiaoxue Liu ),( Yanping Li ),( Juan Qu ),( Yong Ding ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.2
Telecare Medical Information System (TMIS) helps the patients to gain the health monitoring information at home and access medical services over the mobile Internet. In 2015, Das et al proposed a secure and robust user AKA scheme for hierarchical multi-medical server environment in TMIS, referred to as DAKA protocol, and claimed that their protocol is against all possible attacks. In this paper, we first analyze and show DAKA protocol is vulnerable to internal attacks, impersonation attacks and stolen smart card attack. Furthermore, DAKA protocol also cannot provide confidentiality. We then propose a lightweight pseudonym AKA protocol for multi-medical server architecture in TMIS (short for PAKA). Our PAKA protocol not only keeps good security features declared by DAKA protocol, but also truly provides patient`s anonymity by using pseudonym to protect sensitive information from illegal interception. Besides, our PAKA protocol can realize authentication and key agreement with energy-saving, extremely low computation cost, communication cost and fewer storage resources in smart card, medical servers and physical servers. What`s more, the PAKA protocol is proved secure against known possible attacks by using Burrows-Abadi-Needham (BAN) logic. As a result, these features make PAKA protocol is very suitable for computation-limited mobile device.
THE LONG-TERM HEMISPHERIC VARIATION OF POLAR FACULAE
Deng, Lin-Hua,Qu, Zhong-Quan,Liu, Ting,Huang, Wen-Juan The Korean Astronomical Society 2011 Journal of The Korean Astronomical Society Vol.44 No.6
In this paper, the long-term hemispheric variation of the polar faculae is investigated. It is found that, (1) both the N-S asymmetry and N-S asynchrony of the polar faculae exhibit a long-term persistence, which suggests that they should not be regarded as a stochastic phenomenon; (2) both the N-S asynchrony and N-S asymmetry of the polar faculae are functions of the latitude, implying that the N-S asynchrony of the polar faculae is related to the N-S asymmetry of the polar faculae; (3) from a long-term view, the dominant hemisphere of the polar faculae seems to have close connection with the phase-leading hemisphere of the polar faculae.
A REBCO Persistent-Current Switch (PCS): Test Results and Switch Heater Performance
Michael, Philip C.,Timing Qu,Voccio, John,Bascunan, Juan,Hahn, Seungyong,Iwasa, Yukikazu Institute of Electrical and Electronics Engineers 2017 IEEE transactions on applied superconductivity Vol.27 No.4
<P>In this paper, we report preliminary results of our on-going effort to develop a superconducting persistent-current switch (PCS) for REBCO pancake coils that will be operated in liquid helium. In the first part of this paper, we briefly describe experimental results of our PCS operated in the temperature range 77-57 K, i.e., liquid-and solid-nitrogen environments. The rest we devote to a new PCS heater design in which we target a heating power of < 1 W in liquid helium.</P>
Liu, Guo-Bing,Qu, Yan-Juan,Liao, Mei-Yan,Hu, Hui-Juan,Yang, Gui-Fang,Zhou, Su-Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Objective: To explore the relationship between computed tomography (CT) manifestations of thymoma and its WHO pathological classification. Methods: One hundred and five histopathologically confirmed cases were collected for their pathological and CT characteristics and results were statistically compared between different pathological types of thymoma. Results: Tumor size, shape, necrosis or cystic change, capsule integrity, invasion to the adjacent tissue, lymphadenopathy, and the presence of pleural effusion were significantly different between different pathological types of thymomas (P<0.05). Type B2, B3 tumors and thymic carcinomas were greater in size than other types. More than 50% of type B3 tumors and thymic carcinomas had a tumor size greater than 10 cm. The shape of types A, AB, and B1 tumors were mostly round or oval, whereas 75% of type B3 tumors and 85% of thymic carcinomas were irregular in shape. Necrosis or cystic change occurred in 67% of type B3 thymomas and 57% of thymic carcinomas, respectively. The respective figures for capsule destruction were 83% and 100%. Increases in the degree of malignancy were associated with increases in the incidence of surrounding tissue invasion: 33%, 75%, and 81% in type B2, type B3, and thymic carcinomas, respectively. Pleural effusion occurred in 48% of thymic carcinomas, while calcification was observed mostly in type B thymomas. Conclusions: Different pathological types of thymic epithelial tumors have different CT manifestations. Distinctive CT features of thymomas may reflect their pathological types.
Zhan, Yun-Hong,Liu, Jing,Qu, Xiu-Juan,Hou, Ke-Zuo,Wang, Ke-Feng,Liu, Yun-Peng,Wu, Bin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Background: Renal-cell carcinoma (RCC) is resistant to almost all chemotherapeutics and radiation therapy. ${\beta}$-Elemene, a promising anticancer drug extracted from a traditional Chinese medicine, has been shown to be effective against various tumors. In the present study, anti-tumor effects on RCC cells and the involved mechanisms were investigated. Methods: Human RCC 786-0 cells were treated with different concentrations of ${\beta}$-elemene, and cell viability and apoptosis were measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and flow cytometry, respectively. Protein expression was assayed by western blotting. Autophagy was evaluated by transmission electron microscopy. Results: ${\beta}$-Elemene inhibited the viability of 786-0 cells in a dose- and time-dependent manner. The anti-tumor effect was associated with induction of apoptosis. Further study showed that ${\beta}$-elemene inhibited the MAPK/ERK as well as PI3K/Akt/mTOR signalling pathways. Moreover, robust autophagy was observed in cells treated with ${\beta}$-elemene. Combined treatment of ${\beta}$-elemene with autophagy inhibitors 3-methyladenine or chlorochine significantly enhanced the anti-tumor effects. Conclusions: Our data provide first evidence that ${\beta}$-elemene can inhibit the proliferation of RCC 786-0 cells by inducing apoptosis as well as protective autophagy. The anti-tumor effect was associated with the inhibition of MAPK/ERK and PI3K/Akt/mTOR signalling pathway. Inhibition of autophagy might be a useful way to enhance the anti-tumor effect of ${\beta}$-elemene on 786-0 cells.
Zhi-Ning Huang,Han Liang,Hong Qiao,Bao-Rui Wang,Ning Qu,Hua Li,Run-Run Zhou,Li-Juan Wang,Shan-Hua Li,Fu-Nan Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13 μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.