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( Laura Alonso Guardo ),( Carlos Cano Gala ),( David Sanchez Poveda ),( Pablo Rueda Juan ),( Francisco Jose Sanchez Montero ),( Jose Carlos Garzon Sanchez ),( Juan Ignacio Santos Lamas ),( Miguel Vice 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode (InterStimⓡ, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal. (Korean J Pain 2016; 29: 23-28)
Guardo, Laura Alonso,Gala, Carlos Cano,Poveda, David Sanchez,Juan, Pablo Rueda,Sanchez Montero, Francisco Jose,Garzon Sanchez, Jose Carlos,Lamas, Juan Ignacio Santos,Sanchez Hernandez, Miguel Vicente The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode ($Interstim^{(R)}$, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal.
Silencing the cleavage factor CFIm25 as a new strategy to control Entamoeba histolytica parasite
Juan David Ospina-Villa,Nancy Guillén,Ce´sar Lo´pez-Camarillo,Jacqueline Soto-Sanchez,Esther Ramirez-Moreno,Raul Garcia-Vazquez,Carlos A. Castañon-Sanchez,Abigail Betanzos,Laurence A.Marchat 한국미생물학회 2017 The journal of microbiology Vol.55 No.10
The 25 kDa subunit of the Clevage Factor Im (CFIm25) is an essential factor for messenger RNA polyadenylation in human cells. Therefore, here we investigated whether the homologous protein of Entamoeba histolytica, the protozoan responsible for human amoebiasis, might be considered as a biochemical target for parasite control. Trophozoites were cultured with bacterial double-stranded RNA molecules targeting the EhCFIm25 gene, and inhibition of mRNA and protein expression was confirmed by RT-PCR and Western blot assays, respectively. EhCFIm25 silencing was associated with a significant acceleration of cell proliferation and cell death. Moreover, trophozoites appeared as larger and multinucleated cells. These morphological changes were accompanied by a reduced mobility, and erythrophagocytosis was significantly diminished. Lastly, the knockdown of EhCFIm25 affected the poly(A) site selection in two reporter genes and revealed that EhCFIm25 stimulates the utilization of downstream poly(A) sites in E. histolytica mRNA. Overall, our data confirm that targeting the polyadenylation process represents an interesting strategy for controlling parasites, including E. histolytica. To our best knowledge, the present study is the first to have revealed the relevance of the cleavage factor CFIm25 as a biochemical target in parasites.
Bing Qu,Juan Carlos Sanchez,Hetao Hou,Michael Pollino 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2
This investigation assesses adequacy of the Stiff Rocking Core (SRC) technology for rehabilitating steel Moment Resisting Frames (MRFs) vulnerable to drift concentrations and soft-story failures. The technology installs a single or multiple SRCs pinned to the foundation and connected to a deficient multi-story steel MRF to re-distribute seismic forces along its height and create more uniform inter-story drift and ductility demand distributions. This research team implemented the SRC technology in two archetype steel MRFs including one three-story and one nine-story. Results from nonlinear static analyses show that the SRC technology can reduce inter-story drift concentration in both steel MRFs regardless of the seismic force distributions and drift limits considered in design. Additionally, the SRC extending along the entire height of a steel MRF is more preferable than the one extending over the bottom portion of the system, although these two SRC options can be both valid in many cases.
Escobar-Correa, Natalia,Ramirez-Bustamante, Maria Antonia,Sanchez-Uribe, Luis Alejandro,Upegui-Zea, Juan Carlos,Vergara-Villarreal, Patricia,Ramirez-Ossa, Diana Milena The Korean Association Of Orthodontists 2021 대한치과교정학회지 Vol.51 No.1
Objective: To evaluate the mandibular buccal shelf (MBS) in terms of the angulation and bone depth and thickness according to sex, age, and sagittal and vertical skeletal patterns in a Colombian population using cone-beam computed tomography (CBCT). Accordingly, the optimal site for miniscrew insertion in this area was determined. Methods: This descriptive, retrospective study included 64 hemi-arches of 34 patients. On CBCT images, the angulation, buccal bone depth (4 and 6 mm from the cementoenamel junction [CEJ] of MBS), and buccal bone thickness (6 and 11 mm from the CEJ of MBS) were measured at the mesial and distal roots of the mandibular first and second molars. Results: There were no statistically significant differences in the angulation, depth, and thickness of MBS between male and female patients. The values for the bone around the distal root of the mandibular second molar were significantly greater than the other values. The osseous characteristics were significantly better in participants aged 16-24 years. Class III patients exhibited the best osseous characteristics, with the bone depth at 6 mm being significantly different from that in Class I and Class II patients. Although values tended to be greater in patients with low angles, the difference was not statistically significant. Conclusions: MBS provides an optimal bone surface for miniscrew insertion, with better osseous characteristics at the distal root of the mandibular second molar, 4 mm from CEJ. Adolescent patients, Class III patients, and patients with a low angle exhibit the most favorable osseous characteristics in the MBS area.
( Edoardo Torres-guerrero ),( Elisa Crystal Sanchez-moreno ),( Carlos Enrique Atoche-dieguez ),( Erika Margarita Carrillo-casas ),( Roberto Arenas ),( Juan Xicohtencatl-cortes ),( Rigoberto Hernandez- 대한피부과학회 2018 Annals of Dermatology Vol.30 No.5
Background: The causative agents of leprosy are the well-known Mycobacterium leprae and the newly discovered Mycobacterium lepromatosis. This agent was found in 2008, and it was found to be the cause of diffuse lepromatous leprosy in two Mexican patients. Objective: The objective of this work was to determine if M. leprae and M. lepromatosis were present in formalin-fixed and paraffin- embedded skin samples from cases from different regions in Mexico. Methods: A total of 41 skin samples were obtained from 11 states of Mexico. All patients’ samples were diagnosed by clinical and histopathological analyses. Total DNA was isolated using a Qiagen-DNeasy blood and tissue kit and molecular identification was achieved by two semi-nested polymerase chain reactions. Results: The 41 patient included 33 samples from men and 8 samples from women; 29 samples were polymerase chain reaction (PCR)-positive to Mycobacterium and 12 samples were PCR-negative. From those 29 samples, 13 were PCR-positive to M. leprae, 8 to M. lepromatosis and 8 were positive to both species. The histopathological diagnosis included; Nodular lepromatous leprosy (NLL); Diffuse lepromatous leprosy (DLL); and Borderline leprosy (BL). The 29 PCR-positive samples were classified as follow: 14 NLL, 4 DLL, and 11 BL. In the 12 samples negative to Mycobacterium, 7 showed the NLL, 2 DLL and 3 BL. Conclusion: These findings add evidence to the M. leprae and M. lepromatous distribution, clinical forms and participation of dual infections in Mexico. (Ann Dermatol 30(5) 562∼565, 2018)