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Keum Jihyun,Ryu Ki-Young,Roh Jaesook 한국독성학회 2023 Toxicological Research Vol.39 No.1
Animal and human studies suggest that thyroid hormone may have critical roles in the development of the ovary. For example, thyroid deficiency disrupts the ovarian microarchitecture and menstrual cycle in neonate and adult women, respectively. Therefore, it is conceivable that thyroid deficiency might disrupt sexual maturation during the peri-pubertal period. To investigate the impact of radioactive iodine-induced thyroid deficiency on reproductive organs throughout puberty, immature female rats were given water containing radioactive iodine (0.37 MBq/g body weight) twice, on postnatal days 22 and 29. Radioactive iodine-induced hypothyroidism was revealed by low free thyroxin levels. Thyroid deficiency delayed the onset of vaginal opening, reduced ovarian weight and the number of medium-sized follicles and led to elongated uteri. However, there was no effect on the estrous cycle or absolute uterus weight. We conclude that radioactive iodine-induced thyroid deficiency delays sexual maturation and alters normal ovarian growth in peri-pubertal rats.
Architecture-Based Software Testing
Lee, Jihyun,Kang, Sungwon,Keum, Changsup World Scientific Publishing Company 2018 INTERNATIONAL JOURNAL OF SOFTWARE ENGINEERING AND Vol.28 No.1
<P>It has been recognized by many researchers that the notion of test architecture should be utilized for software testing to cope with the task of testing complicated software, as it can support test architecture design and test case generation based on test architecture as well as efficient fault detection and error locating. However, in the current software testing theory and practice, the notion of test architecture and how it can be utilized for software testing are not well understood. To redress this situation, this paper provides foundational concepts and principles of architecture-based software testing to help utilize test architecture for software testing. Case study experiments are conducted to show how the concepts and principles of architecture-based software testing work and the effects that can be obtained by using architecture-based software testing.</P>
( Mi Rang Seo ),( Joong Sub Choi ),( Jaeman Bae ),( Won Moo Lee ),( Jeong Min Eom ),( Eunhyun Lee ),( Jihyun Keum ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.5
Objective To analyze the preoperative diagnostic clues to ovarian pregnancy (OP). Methods This study conducted a retrospective chart review of 23 patients with OP and 46 patients with tubal pregnancy (TP) from October 1, 2003 to September 31, 2016 in Hanyang University Hospital. Results There were no significant differences in demographic and clinical characteristics between the two groups. The presence of an ectopic gestational sac and hemoperitoneum was significantly higher in the TP group (13.0% vs. 95.7%, P=0.000; 13.0% vs. 54.3%, P=0.001, respectively) in preoperative ultrasonogram. The OP group had more ruptured ectopic gestational sacs than the TP group (73.9% vs. 45.7%, P=0.039) in surgical findings. Conclusion For the patients in whom a gestational sac is not detected in the uterus or the fallopian tubes, it is important to be aware of the possibility of OP and rupture of an ovarian gestational sac to promote early diagnosis and surgical intervention.
( Hyeon Myeong Hong ),( Joong Sub Choi ),( Jaeman Bae ),( Won Moo Lee ),( Jeong Min Eom ),( Jihyun Keum ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: To analyze the efficacy and safety of the WOMEN CARE(SJ global, bucheon). Methods: This study is conducted by randomized controlled trial of 20 patients with Women care(Tap water) and 22 patients with control group(Dressing with Povidone iodine) from September 1, 2019 to Febrary 28, 2020 in Hanyang University Hospital. Each group patients were visited our center four times. At first visit(VISIT 1), patients were examed of STD 12 and cervical culture. About 7 days later(VISIT 2), they were visited and grouped by Women care or povidone iodine dressing by randomized selection. They were dressing by each method. After 2 days later(VISIT 3) from VISIT2, cervical culture was done. After 2 days later(VISIT4) from VISIT3, cervical culture was done finally. Results: There were no significant differences in demographic and clinical characteristics between the two groups. We compared the results of cervical culture gram positive bacteria at VISIT 1 and VISIT3. The quantitative decrease of bacteria was seen the 6 patients of 20 patients in WOMEN CARE group. In the control group, The quantitative decrease of gram positive bacteria was seen the 5 patients of 22 patients. Conclusion: By this study, there was no significant side effect of WOMEN CARE; Vaginal itching sensation, redness and burning sensation. We confirmed the safety and efficacy of the WOMEN CARE.