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具然健,黃志煥 홍익대학교 산업기술연구소 2002 産業技術 Vol.12 No.-
This paper presents a waveguide slot 16x16 array antenna with diaphragm for 37.5~38.5 GHz frequency band. At first, the radiation characteristics of longitudinal slots on a broadside of a waveguide have been examined. Diaphragms are used to control the impedance and to minimize the return loss of the structure. A 20 dB Chebyshev array of 16 waveguide slots has been designed by optimizing the positions and sizes of the diaphragms and the slots. Then, a serial feeding system with π-junction power dividers has also designed to get a 20 dB Chebyshev power distribution. We used the HFSS for full-wave analysis and the MW Office for equivalent circuit simulations. The 16x16 slot array antenna, which was designed for a Fixed Wireless Access System at 38 GHz frequency, gives an antenna gain higher than 30 dBi. A slot array antenna was manufactured using a computer controlled milling technique, and measured for the return loss and the antenna pattern.
S-97 The Predictors of Follow up Loss in Patients with Inflammatory Bowel Disease
( Ji Yeon Koo ),( Kyeong Ok Kim ),( Da Eun Jeong ),( Byung Ik Jang ),( Chang Heon Yang ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
There were several studies about the predictors of non-adherence to inflammatory bowel disease (IBD) therapy. However, there were few studies about the predictors of stopping visiting clinics in patients with IBD. Our aims were to evaluate the predictors of follow up loss of visiting clinics in IBD patients. Methods: The medical record of 224 patients with IBD who were followed up between January 2010 and December 2013 were reviewed retrospectively. Follow up loss was defined that patients didn't visit clinics at least 6 months. Results: Among 224 patients with IBD, there were 94 patients with Crohn’s disease and 130 patients with ulcerative colitis. Mean follow up duration was 58.51 months. The follow up loss was noted in 32.1% of patients. The follow up loss rate in patients with CD and UC were 28.7% and 34.6 % respectively. Age, gender and disease severity index at the last visit before being absent the clinics could not show any difference according to the status of follow up. Mean follow up loss duration was 17.72 months. All of the patients who followed up loss revisited clinics and the most common cause of revisit was flare up of the diseas . Lower Education status and C reactive protein also increased the risk for follow up loss by 2.13 and 1.81 times, respectively. By multivariate analysis, risk factors of follow up loss were C reactive protein level below 1.2mg/dL and lower educational status. Conclusions: The follow up loss rate in patient of IBD was 32.1%. Lower educational status and low C reactive protein level increased the risk of follow up loss in IBD patients. Clinician takes an effort to help the patients with lower educational status or low C reactive protein level understand the disease and disease course to prevent follow up loss.
A Study on the Odor Management of Traditional Markets in the Old and New Towns
Yeon-Kyo KOO,Ji-Min YOUN,Jae-Yeon JO,권우택 한국웰빙융합학회 2022 웰빙융합연구 Vol.5 No.4
Purpose: Odor generated in traditional markets causes discomfort, hindering the pleasant life of residents, and complaints of odors are steadily increasing every year. Odor is defined as a smell that stimulates a person's sense of smell by stimulating hydrogen sulfide, mercaptans, amines, and other irritating gaseous substances. Research design, data and methodology: It is not easy to grasp and manage the current status of the odor analysis of living odors such as traditional markets. Seongnam City has an advanced new town of Bundang and Pangyo, while old cities such as Sujeong-gu are relatively underdeveloped. Results: As a result, the gap between the old city center and the new city center widens, so it is urgent to develop a balanced development. Based on this, the market of Seongnam-si is divided into the old city center and the new city center, and the odor complaint in the traditional market is analyzed to find a solution. A survey was conducted to understand the current status of odor management in the Seongnam-si market and the odor felt by users. Moran Market, Seongnam Jungang Market, and Kumho Market and Dolphin Market, located in the new city center, were selected as targets. The items of the survey consisted of the frequency and cause of the odor, the current status of market management, matters that need improvement, and efforts to resolve the odor. Conclusions: Therefore, this study aims to help citizens feel better about odor environment in places where odor standards are exceeded or complaints occur frequently, and to help local governments and market merchants establish more efficient and useful development plans.
Glyco-engineering of Recombinant Expression Systems for Production of Biobetter
Ji-Yeon Kang,Jin Young Gil,Se-Jong Lim,Yeong Hun Kim,Ji-Young Mun,Keun Koo Shin,Doo-Byoung Oh 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07
More than 60% of the currently available therapeutic proteins are glycoproteins attached with glycans, which play important roles in the protein folding, therapeutic efficacy, in vivo half-life, and immune reactions. Our group has focused on N-glycosylation pathway engineering of recombinant expression hosts including yeasts and Chinese hamster ovary (CHO) cells for production of therapeutic glycoproteins with improved potency. Different engineering strategies are required depending on the classes of therapeutic proteins because their optimal glycan structures are different. Many therapeutic enzymes used for treatment of lysosomal storage diseases require high contents of mannose-6- phosphate (M-6-P) glycan, which is essential for cellular uptake and targeting to lysosomes. Although yeasts do not have M-6-P glycans, they have some glycans containing mannosylphosphorylated mannose residues which can be converted to M-6-P structure through removal of the outer capping mannose. Recently, we constructed a glyco-engineered Saccharomyces cerevisiae mnn1Δoch1Δ strain overexpressing YlMPO1 gene, which was shown to have very high content of mannosylphosphorylated glycans [1, 2]. As they were efficiently converted to high content of M-6-P glycans through uncapping process, our engineering strategy showed a promise for production of biobetter enzymes with enhanced lysosomal targeting capabilities. For prolonged in vivo half-life of glycoproteins, sialic acids present on non-reducing terminal of glycan are important. We compared several bacterial α(2,6)-sialyltransferases and found that they have inherent siallidase activities, which decreased the amount of sialylated products [3]. These sialidase activities were inhibited by simple treatment of alkaline phosphatase, which desphosphorylates free cytidine monophosphate (CMP) generated from a donor substrate (CMP-N-acetylneuraminic acid) during the sialyltransferase reaction. It greatly enhanced the efficiency of bacterial α(2,6)- sialyltransferase reaction, which resulted in the increased content of bi-sialylated N-glycan up to ~98% without any decrease in prolonged reactions. Our efforts to construct Chinese hamster ovary (CHO) cells for production of glycoproteins with increased content of sialic acids shall be introduced also.
구정진 ( Jung Jin Koo ),지희준 ( Hee Jun Chi ),김동훈 ( Dong Hoon Kim ),주진영 ( Jin Young Joo ),김지연 ( Ji Yeon Kim ),이지연 ( Ji Yeon Lee ),이윤정 ( Yoon Jung Lee ),장상식 ( Sang Sik Chang ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
목적 : 본 연구는 체외수정시술에 의한 임신성공 1009예의 임상적 분석을 통해 임신율에 영향을 미치는 다양한 요인들을 평가하고자 수행되었다. 연구 방법 : 본 연구는 지난 1994년 9월부터 2001년 12월까지 1823명의 환자를 대상으로 시행된 2604예의 체외수정시술에서 수행하였으며 과배란유도에 대한 난소의 반응, 불임의 원인, 환자의 나이, 채취된 난자의 수, 이식한 배아의 수와 질, 자궁내막의 두께 그리고 체외수정시술의 종류 등이 임신율에 미 Objective : There are various factors affecting the outcome of human in vitro fertilization (IVF) programs. A retrospective study was performed to evaluate the influence of the factors on pregnancy rate of IVF programs. Methods : From September 1994 to De
Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
Koo, Dae Lim,Hwang, Kyoung Jin,Kim, Daeyoung,Kim, You-Jin,Kim, Ji Young,Shin, Wonchul,Kim, Mi Rim,Joo, Eun Yeon,Lee, Jong-Min,Hong, Seung Bong S. Karger AG 2013 European neurology Vol.70 No.1
<P>Abstract</P><P><B><I>Aims:</I></B> To estimate the effect of levetiracetam (LEV) on cognitive function and mood status in newly diagnosed epilepsy patients. <B><I>Methods:</I></B> Fifty-five drug-naïve epilepsy patients (M:F ratio = 31:24; mean age = 30.9 years) were included. All patients underwent two neuropsychological (NP) tests, one before receiving LEV and then another 12.9 ± 5.0 months after starting LEV monotherapy. We evaluated general cognitive function, verbal/visual attention and memory, linguistic and visuospatial functions, frontal lobe function, and mood status. Repeated-measures regression and generalized estimating equation models were applied to assess the effects of all the confounding variables such as seizure control, average LEV dose, duration of epilepsy, inter-test interval, and subtype of epilepsy syndrome. <B><I>Results:</I></B> LEV monotherapy over 1 year revealed significant improvements in the following domains of NP tests with the correction of possible confounding variables: verbal and visual attention, psychomotor speed, mental flexibility, executive function, verbal fluency and word generation. No NP domains showed any significant decrease. <B><I>Conclusion:</I></B> Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-naïve patients with epilepsy.</P><P>Copyright © 2013 S. Karger AG, Basel</P>