근대 이후 한국과 중국의 문화접변에 따른 전통복식 변화에 관한 연구

성희진,유송옥 한국복식학회 2002 춘계 학술대회 Vol.2002 No.-

대학 졸업예정자의 경력개발역량과 경력탐색행동 및 대학경력개발지원의 관계

성희진,나승일 한국농·산업교육학회 2012 농업교육과 인적자원개발 Vol.44 No.1

The purpose of this study was to determine the relationship among career development competency and career exploration behavior of senior student and career development support in universities. The population of this study was 949,477 senior students, considering ratio of metropolitan and provincial students, 200 metropolitan students and 280 provincial students(1:1.4) were sampled for the study. A survey questionnaire, the method of data analysis, consists of demographic items, career development competency scale, career exploration behavior scale and career development support in universities scale; these four scales were subdivided into smaller parts. The results of this study were as follows: First, the career development competency levels of senior students were slightly higher than average. Second, the career exploration behavior levels of senior students were 2.67 and the career development support levels in universities were 3.16. Third, the career development competency of senior students have high positive relationships with the career exploration behavior and have middle positive relationships with the career development support in universities. Fourth, career exploration behavior and support for preparing for a job explained 28.0% of the career development competency. 이 연구의 목적은 대학 졸업예정자의 경력개발역량과 경력탐색행동 및 대학의 경력개발지원 간의 관계를 구명하는데 있었다. 이 연구의 모집단은 우리나라의 4년제 대학에 재학 중인 대학생 중 4학기 이상을 마친 3학년 이상의 대학생으로 2011년 12월 기준 총 949,477명이며, 모집단의 크기에 따른 적정 표집 수는 382명이다. 표집은 수도권과 지방의 학생 비율을 고려하여 비례적 층화 표집하였다. 자료 수집은 우편조사를 통해 이루어졌으며, 최종분석은 389부가 활용되었다. 자료 분석은 기술통계 및 추리통계를 사용하였으며, 통계적 유의수준 0.05를 기준으로 판단하였다. 이 연구의 주요 결과는 다음과 같다. 대학 졸업예정자의 경력개발역량 수준은 평균적으로 보통 이상으로 나타났다. 세부적으로는 자기이해, 전공 및 직업지식, 진로결정 확신도, 의사결정 효능감, 관계활용 효능감은 필요한 정도를 갖추고 있지만 상대적으로 구직기술은 다소 부족하다고 볼 수 있다. 둘째, 대학 졸업예정자의 경력탐색행동 수준은 스스로 결정한 경력목표달성을 목적으로 자기 자신과 직업세계를 이해하기 위한 행위적인 노력에 전반적으로 소홀한 것으로 나타났다. 특히 직업에 대해 탐색하는 노력이 상대적으로 부족하였다. 대학경력개발지원 수준에 대해 대학 졸업예정자는 대학에서 취업준비에 대해서는 어느 정도 지원되고 있지만 현장경험을 쌓을 수 있도록 제공되는 지원은 상대적으로 부족하다고 인식하고 있었다. 셋째, 대학 졸업예정자의 경력개발역량과 경력탐색행동 및 대학경력개발지원은 유의미한 정적관계가 있는 것으로 나타났다. 넷째, 대학 졸업예정자의 경력개발행동과 대학경력개발지원 중 취업준비지원이 경력개발역량에 설명력을 갖는 것으로 나타났다.

Synergistic Effect of Natural Killer Cells and Bee Venom on Inhibition of NCI-H157 Cell Growth

성희진,송호섭 대한침구의학회 2016 대한침구의학회지 Vol.29 No.6

Objectives : This study examined the effects of Bee venom on apoptosis in NCI-H157 human lung cancer cells and for promoting the apoptosis effects of Natural killer cell. Methods: Bee venom and Natural killer-92 cells were cultured either separately from or together with NCI-H157 cells for 24 hours. To figure out whether Bee venom enhances the cytotoxic ef- fect of Natural Killer-92 cells, a cell viability assay was conducted. To observe the changes in Death receptors, apoptotic regulatory proteins and Nuclear factor-κB, western blot analysis was conducted. To observe the effect of Bee venom through an extrinsic mechanism, a trans- fection assay was conducted. Results: 1. Natural killer-92 cells and Bee venom significantly inhibited the growth of NCI-H157 cells and co-culture had more inhibitory effect than the separate culture. 2. Expressions of Fas, DR3, DR6, Bax, caspase-3, caspase-8, cleaved caspase-3, cleaved caspase-8 were increased, and expressions of Bcl-2 and cIAP were decreased. More ef- ficacy was observed in co-culture than in separate culture. 3. Nuclear Factor-κB activation was clearly decreased. And co-culture showed much less activation than separate culture. 4. As a result of treatment for DR-siRNA, the reduced cell viability of NCI-H157 cells and the activity of Nuclear factor-κB were increased. With this, it can be seen that Bee venom and Natural killer-92 cells have an effect on the cancer cells through the extrinsic mechanism. Conclusion : Bee venom is effective in inhibiting the growth of human lung cancer cells. Fur- thermore Bee venom effectively enhances the functions of Natural killer cells.

견갑골 내측 부 자침으로 야기된 기흉 1례

성희진,임수지,최현영,이은용,노정두,이참결 대한침구의학회 2016 대한침구의학회지 Vol.33 No.4

A Case Report on Pneumothorax Caused by Interscapular Area Acupuncture Hee Jin Sung1, Su Sie Lim1, Hyun Young Choi2, Eun Yong Lee1, Jung Du Roh2 and Cham Kyul Lee1,* 1Department of acupuncture & moxibustion medicine, chung-ju hospital of oriental medicine, semyung university 2Department of acupuncture & moxibustion medicine, je-cheon hospital of oriental medicine, semyung university Objectives : The purpose of this study was to report the case prognosis and evaluate treatment and prevention of pneumothorax after acupuncture treatment. Methods : A 32-year-old slender male complained of pain in the interscapular area. As a result, acupuncture needling and manual technique were performed to trigger the points of trapezius and rhomboid muscles. After this, chest pain and dyspnea occurred. Pneumothorax was confirmed by chest radiography and symptom progression was observed for 14 days while high pressure oxygen was administered. Results : The chest pain disappeared after 4 days of pneumothorax, and most of the related symptoms disappeared after 14 days. Conclusion : For acupuncture treatment to the interscapular area, the depth and manual technique should be carefully performed.

Acute respiratory alkalosis occurring after endoscopic third ventriculostomy -A case report-

성희진,손주태,김재곽,신일우,옥성호,이헌근,정영균 대한마취통증의학회 2010 Korean Journal of Anesthesiology Vol.59 No.-

An endoscopic third ventriculostomy was performed in a 55-year-old man with an obstructive hydrocephalus due to aqueductal stenosis. The vital signs and laboratory studies upon admission were within the normal limits. Anesthesia was maintained with nitrous oxide in oxygen and 6% desflurane. The patient received irrigation with approximately 3,000 ml normal saline during the procedure. Anesthesia and operation were uneventful. However, he developed postoperative hyperventilation in the recovery room, and arterial blood gas analysis revealed acute respiratory alkalosis. We report a rare respiratory alkalosis that occurred after an endoscopic third ventriculostomy.

특발성 안면마비에서 내외적 요인과 호전시기와의 상관관계

성희진,임수지,최현영,이은용,노정두,이참결 대한침구의학회 2016 대한침구의학회지 Vol.33 No.1

Objectives : The purpose of this study was to investigate the correlation between patients’ characteristics and the beginning period of improvement, as well as contribute to the efficient management of Bell’s palsy patients. Methods : The subjects were 94 patients with Bell’s palsy. This study was carried out through the use of an administrative database that included patients’ characteristics and clinical information. The analysis of the beginning period of improvement by gender, hypertension, diabetes, drinking history, smoking history and facial palsy history was conducted by independent sample t-test. The analysis of the beginning period of improvement by age, House-Brackmann grade, Yanagihara scale and period receiving Korean medical treatment was conducted by Pearson’s correlation analysis. Further analysis of the beginning period of improvement by associated symptoms and seasons was conducted by one-way analysis of variance. Results : 1. Significant correlations were not found between the beginning period of improvement and gender, age, season, smoking history, drinking history, facial palsy history, House-Brackmann grade, Yanagihara scale, hypertension, diabetes or associated symptoms. 2. There was significant correlation between the period of receiving Korean medical treatment and the beginning period of improvement. Conclusion : In this study, the earlier that patients received korean medicine treatment after onset, the earlier that the beginning period of improvement could be seen. Therefore, for the efficient management of facial paralysis patients, it is expected to help secure a baseline.

Single-Dose Intramuscular Toxicity of Mahwangcheonoh Pharmacopuncture in a Rat Model - Toxicity of Mahwangcheonoh Pharmacopuncture in SD Rats -

성희진,이은용 대한약침학회 2016 Journal of pharmacopuncture Vol.19 No.4

Objectives: This study was conducted to analyze the single-dose toxicity and the safety of Mahwangcheonoh pharmacopuncture extracts. Methods: Six-week-old Sprague-Dawley rats were used for this study. Doses of Mahwangcheonoh pharmacopuncture extracts were set at 0.25 mL (low-dose), 0.5 mL (medium-dose) and 1.0 mL (high-dose) for the test groups. A dose of 1.0 mL of normal saline solution was set for the control group. During 14 days, general symptoms, mortalities, and changes in hematology, blood biochemistry and histopathology of all rats were observed. Results: No death was observed in all test groups. Any abnormal symptom was not observed in all of the groups. No significant changes in weight between the control group and the test groups were observed. In addition, no significant differences in the hematology signs, the blood biochemistry levels and the histopathological signs related to the Mahwangcheonoh pharmacopuncture extracts injection were observed. Conclusion: The findings of this study indicate that Mahwangcheonoh pharmacopuncture at doses of 1.0 mL or less may be consider safe and non-toxic. So, it can be used for therapy of obesity sufficiently. But further studies on this subject must be performed to confirm and verify this conclusion.

실사용데이터/실사용근거를 활용한 FDA와 EMA의 규제적 의사결정 사례 분석

성희진(Hi Gin Sung),박한희(Han-Heui Park),정규원(Gyu-Won Jung),신주영(Ju-Young Shin) 대한약학회 2020 약학회지 Vol.64 No.2

Lately, the use of Real-World Data (RWD)/Real-World Evidence (RWE) have been actively expanded in regulatory decisions. We aimed to investigate how RWD/RWE were used in pursuit of supporting regulatory actions of FDA and EMA. We selected 9 examples of regulatory decision making with the support of RWD/RWE. To identify information included in RWE submission, we referred to the official website of US FDA or EMA. In addition, we used ClinicalTrials.gov and Medline database to collect information on study design using RWE and RWD source used to generate RWE. Our study drugs were classified into 3 parts according to regulatory context; primary approval, label expansion, and regulatory response to safety signal after marketing. Among these examples, 5 biologic products including 1 vaccine had gone through accelerated review supported by RWE. To summarize, we investigated several examples where RWD/RWE has already been used in the process of making regulatory decisions for assessing the safety of drugs as well as their effectiveness. We recommend further discussions on advancing the use of RWD/RWE in regulatory context to improve patient access to novel rare disease treatments and provide more efficient safety assessment.

원발성 자궁경부 소세포암 1예

성희진 ( Hee Jin Seong ),김주연 ( Ju Youn Kim ),이상민 ( Sang Min Lee ),도영록 ( Young Rok Do ),송홍석 ( Hong Suk Song ) 대한내과학회 2008 대한내과학회지 Vol.74 No.2

저자들은 32세 여자가 성교 후 질출혈을 주소로 내원하여 자궁경부에 종물이 발견되었고, 수술 후 조직검사상 소세포암으로 판명된 원발성 자궁경부 소세포암 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Small cell carcinoma of the uterine cervix is a rare malignancy representing less than 5% of all cases of cervical carcinoma. It is clinically characterized by frequent early nodal and distant metastasis. Survival is relatively poor with hysterectomy alone. Currently, there is no consensus for the optimal management of small cell carcinoma of the uterine cervix. Most patients are treated with a multimodality approach, using chemotherapy and radiotherapy. We treated a 32-year-old woman with primary small cell carcinoma of the uterine cervix. The pelvic MR imaging showed a 3 cm mass in the uterine cervix and no evidence of other abnormalities in the adnexa. The patient treated with a radical hysterectomy alone and adjuvant therapy was not provided. Five months later, the patient had recurrent disease with multiple bone and liver metastases. We treated the patient with cisplatin and etoposide combination chemotherapy. Here we report the case of a primary small cell carcinoma of the uterine cervix with rapid progression after surgical treatment alone and review the medical literature. (Korean J Med 74:208-212, 2008)

투사형 전조등의 광학적 분석

성희진,홍사용,류지욱 公州大學校 基礎科學硏究所 1999 自然科學硏究 Vol.8 No.-

투사형 전도등의 특성을 조사하기 위해 광선 추적법으로 광학계를 분석하고 그 결과를 포물경 전도등과 비교하였다. 포물경 전도등의 경우 광학계가 단순한 장점이 있지만 광원의 일부분 만을 반사하며 실제 광원의 크기와 위치를 고려할 때 높은 수차가 불가피 했다. 투사형 전도등은 여러개의 광학부품 사용하는 복잡함과 전체적 길이가 길어지는 단점이 있지만 포물경 전도등 보다 40%이상의 빛을 더 활용하며 전체적인 수차도 상당히 줄일 수 있었다. 그러나 투사형 전도등 광학계의 성능은 비구면 렌즈의 형태에 매우 민감한 것으로 나타났다. To investigate characteristics of the projection type headlights for automobiles, we used ray tracing methods and compared the results with those from parabolic type headlights. The parabolic type headlights are simple but have two limits: first, they require large apertures. To reflect 50% of a source light, the aperture must be 4 times of focal length and to have more reflected light, apertures must grow geometrically. second, a parabolic mirror have large aberration when a source is away from a focus, since output of a headlight cannot be divergent, a source should locate far side from a mirror and moreover a light source has a finite size, large aberration is unavoidable. The projection type headlights have many optical components and longer depth compared with parabolic types, but their apertures can be made small. Advantage of using a ellipsoidal mirror is to reduce beam divergence by half and displace a focal position to another focal point, so that spherical aberration free and short focal length aspherical lens can be placed in proper position. In our study, we adopt a commercially available aspheric lens and the results were quite good compared with those from parabolic types but not optimal since output experienced total reflection at an aspheric lens. We found to improve performance of headlights, proper design of an aspheric lens was crucial.