내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

韓醫學에서의 病態模型 歷史에 관한 小考

金楨氾,申尙玗 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.2

한의학에서 실험연구의 가능성과 실용성을 확보하기 위해서는 보다 한의학적 이론과 임상실제에 부합하는 병태모형의 개발이 수반되어야 한다. 한의학의 실험연구가 시작된 지 근 한 세대가 지난 시점에서 동물체에 인위적으로 유발하는 병태모형에 대하여 중국, 한국, 일본의 경우고 나누어 주로 증후병태모형을 중심으로 그 개발응용의 역사를 살펴보았다. 중국의 경우 증 개념의 병태모형이 도입된 실험연구는 1960년에 시작되어 1976년부터 본격화하였으며, 1984∼1988년의 결산기를 거쳐 다양한 증의 병태모형을 개발하여 실용기에 접어들고 있다. 한국의 경우 한의학의 실험연구는 1968년부터 본격적으로 시작되었고, 80년대에 들면서 양적으로 괄목할 만한 성장을 하였고 보다 다양한 병태모형이 도입되었으며 양허, 혈허, 어혈 관련 증 모형들이 개발되었고, 90년대에는 실험연구의 측정지표들이 보다 다양해지고 실험연구에 대한 고찰이 엄밀해졌으나, 병태모형에 대한 전문적인 연구가 부족한 편이다. In order to secure the purpose of both possibility and practicality on experimental research in oriental medicine, necessary to develop experimental models that coincide with oriental medical theories and clinical practice. We examined the history of development in experimental models dividing into China, Korea and Japan. In China, the experimental research introduced pattern(證)concept in it was begun in 1960 and get into stride from 1976. From 1984 to 1988, this study had passed through an accounting p pattern(證) has entered into a practical period. In Korea, the real experimental research of oriental medicine was begun in 1968. Entering into 80's, this study had taken gigantic expansion in volume and more variable models such as yang-deficiency-pattern(陽虛證), blood-deficiency-pattern(血虛證), blood-stasis-pattern(瘀血證). In 90's the method of measurement has been more variable and the consideration of experimental research has been more exact. But, on the other hand, the professional study of experimental models was deficient.

Interleukin-1β에 의한 사람 정상 코점막 상피세포의 분비기능 및 형태 변화

김경수,윤주헌,최진우,이정권,문형진,박준호,전희선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.11

《傷寒雜病論》의 診斷體系에 關한 硏究

申尙玗,金楨氾 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.1

《傷寒雜病論》의 診斷體系를 파악하기 위하여 《傷寒論》과 《금궤要略》을 합쳐 仲景의 醫案으로 상정하고, '辨病', '辨證', '辨症徵'의 각도에서 조사하고 살펴보았다. 《傷寒論》과 《금궤要略》의 관계는 外感 傷寒病 전문서와 內傷 雜病 전문서라기 보다는 두 책이 모두 外感 病因을 중시하되 《傷寒論》은 三陰三陽의 定性, 定位적 요소에 맞고 그 傳變규율을 가지는 병을 위주로한 반면, 《금궤要略》은 三陰三陽辨病, 病因辨病, 臨床特徵辨病으로 구분할 수 있고, 辨證방법으로는 六經辨證, 臟腑辨證, 八綱辨證, 病因辨證, 方劑辨證으로 구분할 수 있으며, 病證結合의 유형으로는 제반 辨病과 方劑辨證의 결합, 病因辨病과 六經辨證의 결합, 三陰三陽辨病과 八綱辨證의 결합, 三陰三陽辨病과 臟腑辨證의 결합, 臨床特徵辨病과 八綱辨證의 결합, 辨病위주로 辨證결합, 辨證위주로 辨病결합 등을 들 수 있다. 《傷寒雜病論》의 症徵을 이용한 변치로는 特徵症狀辨證法, 排除辨證法, 對比鑑別法 등을 위주로 하고, 脈診, 舌診, 腹診 모두 病證確診, 病因病耭, 病位病性의 변별에 기여하고 있었다. 《傷寒雜病論》의 진단체계는 辨病과 辨證 및 辨症徵의 다양한 辨治體系들이 유기적으로 연계되어 있으며, 仲景은 이를통해 발전변화하는 병태를 신속하고 정확하게 파악하여 治療하였음을 알 수 있었다. In order to find out the diagnostic system of 《Shang Han Za Bing Lun(傷寒雜病論)》, we combine 《Shang Han Lun(傷寒論)》 with 《Jin Kui Yao Lue(금궤要略)》 and assume it to be clinical charts of Zhang Zhongjing(張仲景). Later, we investigate and consider 《Shang Han Za Bing Lun》 in views of syndrome differentiation(辨證), disease differentiation(辨病) and differentiation of symptoms and signs(辨症徵). The conclusions obtained were summarized as follows. 1. The relation between 《Shang Han Lun》 and 《Jin Kui Yao Lue》 is not special books about febrile disease due to exogenous pathogenic factors and miscellaneous internal diseases due to internal injury. 《Shang Han Lun》 give the first consideration to diseases coming within the category of the triple Yin and triple Yang diseases(三陰三陽病). 《Jin Kui Yao Lue》 put first diseases coming within the unique category. 2. The types of differentiation of diseases(辨病) in 《Shang Han Za Bing Lun》 are divided up differentiation of diseases in accordance with the triple Yin and triple Yang(三陰三陽辨病), etiological differentiation of diseases(病因辨病) and differentiation of diseases according to clinical features(臨床特徵辨病). 3. The types of differentiation of syndromes(辨證) in 《Shang Han Za Bing Lun》 are divided up differentiation of syndromes in accordance with the theory of the six meridians(六經辨證), differentiation of syndromes according to pathological changes of Jang-Bu organs(臟腑辨證), differentiation of pathological conditions in accordance with the eight principal syndromes(八綱辨證), etiological differentiation of syndromes(病因辨證) and differentiation of syndromes according to prescriptions and herbs(方劑辨證). 4. The types of combinations of disease with syndrome(病證結合) in 《Shang Han Za Bing Lun》 are divided up 1) the combination of all disease differentiation with syndrome differentiation according to prescriptions, 2) the combination of etiological disease differentiation with syndrome differentiation in accordance with the theory of the six meridians, 3) the combination of disease differentiation in accordance with the triple Yin and triple Yang with differentiation of pathological conditions in accordance with the eight principal syndromes, 4) the combination of disease differentiation in accordance with the triple Yin and triple Yang with syndrome differentiation according to pathological changes of Jang-Bu organs, 5) the combination of disease differentiation according to clinical features with differentiation of pathological conditions in accordance with the eight principal syndromes, 6) putting first disease differentiation combined with syndrome differentiation, and 7) putting first syndrome differentiation combined with disease differentiation. 5. The types of differentiation of symptoms and signs(辨症徵) in 《Shang Han Za Bing Lun》 are syndrome differentiation according to special symptoms(特徵症狀辨證法), exclusive syndrome differentiation(排除辨證法), and comparative discrimination(對比鑑別法). The Pulse feeling(脈診), the Inspection of the tongue(舌診), the Diagnosis of the abdomen(腹診) all contribute to confirmation of disease/syndrome and discrimination of cause of disease(病因), pathological mechanism(病機), pathological position(病位), pathological characteristics(病性). Based on the above conclusions, the diagnostic system of 《Shang Han Za Bing Lun》 included manifold disease differentiations, syndrome differentiations, differentiations of symptoms and signs, and through these Zhang Zhongjing understanded the growing and changing pathological state of patient very quickly and exactly.

안면비대칭을 동반한 Angle Ⅲ급 부정교합자의 안모형태에 관한 두부방사선계측학적 연구

손우성,강정숙,김미경,김종렬 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.4

The purpose of this was three-fold: i) to investigate the degree of asymmetry in Angle's Class Ⅲ malocclusion patients and normal adults; ⅱ) to determine the nature of difference existed between two groups; and ⅲ) to investigate the correlationship between the degree of asymmetry and ANB and overbite in Angle's Class Ⅲ malocclusion patients. The subjects consisted of 25 Angle's Class Ⅲ malocclusion patients and 25 normal adults and the mean ages were 22.0 and 24.5 years, respectively. Their posteroanterior and lateral cephalograms were traced and analysed with three-dimensional approach. The results were as follows: 1. Asymmetry of Angle's Class Ⅲ malocclusion group was significant in all regions except cranial base. Their horizontal asymmetry was seen in mandibular angle, maxillary and mandibular midline and menton. Vertical asymmetry was observed in maxillary lst molar and mandibular shape and anteroposterior asymmetry in mandibular angle. 2. Nine variables indicating asymmetry were selected and each variable had similar discriminant score. 3. There was a little correlationship between ANB and asymmetric variable(MSR-B6) and its correlation coefficients was 0.3564. 4. There was no significant correlationship between overbite and asymmetric variables.

완선에 대한 항진균제(clotrimazole) 단독 및 스테로이드가 첨가된 복합체(Triamcinolone acetonide and Hydrocortisone)의 치료효과에 관한 비교 연구

이증훈,서우영,김기홍,최종수 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

Although the combination products of antifungal agents and corticosteroids are often used in the treatment of superficial fungal infections, their usefulness is not settled. The combined corticosteroids may promote the spread of fungi. On the other hand, they can bring rapid relief from signs and symptoms and increase the local concentrations of the antifungal agents in the skin due to the vasoconstrictive effect. This study was performed to compare an antifungal agent with its combination products with corticosteroids in the treatment of tinea cruris. Seventy-four patients with tinea cruris, aged 18-26 years, were admitted to the study. All ere soldiers living in the same conditions. Sixty patients completed 2 weeks of therapy : clotrimazole, 19 ; combination with trimacinolone acetonide, 28; combination with hydrocortisone, 13. All treatments almost completely improved the lesions at the end of 2-week period. No specific treatment was significantly better. After 4 weeks the relapse rate was highest in the group treated with clotrimazole combined with triamcinolone acetonide (75%), compared with clotrimazone alone (47%) or its combination with hydrocortisone (50%), but not significant statistically (p<0.05).

癩菌 및 其他 9腫의 Mycobacteria 細胞壁抗原에 對한 癩患者의 皮內反應 比較硏究

愼鏞雨,李增壎,李惟信,張友鉉,金道一 大韓癩學會 1982 癩學 會誌 Vol.15 No.1

해수유동모델 결과의 3차원 가시화를 위한 GUI 구현

최우정,박성은,이원찬,구준호,서영상,김태현 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

해수유동모델 결과를 3차원적으로 가시화하기 위한 그래픽 유저 인터페이스를 구축하는 과정에서 지리정보시스템(GIS) 기술을 활용하였다. 연안역 관리에서 GIS 기법은 산재되어 있는 방대한 자료들을 저장하고 이를 3차원으로 가시화하는 기능을 제공하며 해석적, 통계적, 모델링 도구로써 주어진 상황에 적합한 데이터 변환이 가능하도록 해준다. 해수유동모델은 개방경계에서 조석, 바람, 수온, 염분, 강물 유입 및 태양복사 등과 같은 모델입력값을 부여함으로써 구동되며 대상해역은 진해만으로 하였다. 녈 연구에서는 국산 GIS 소프트웨어인 GeoMania (v2.5)를 사용하여 진해만을 대상으로 시뮬레이션된 해수유동모델 결과의 3차원 가시화 모듈을 구축하였다. This study presents an application of GIS technologies to construct the graphic user interface for 3-dimensional exhibition of the results obtained by ocean hydrodynamic model. In coastal management studies, GIS provide a receptacle for scattered data from diverse sources and an improvement of the 3D visualization of such data. Within the frame of a GIS a variety of analytical, statistical and modeling tools can be applied to transform data and make them suitable for a given application. A 3D hydrodynamic model was driven by time-dependent external forcing such as tide, wind velocity, temperature, salinity, river discharge, and solar radiation under the open boundary condition. The Jinhae bay was selected as a case study. Here, we have used GeoMania v2. 5 GIS software and its 3D Analyst extension module to visualize hydrodynamic model result that were simulated around the Jinhae bay.