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삼성서울병원에서 HMG-CoA Reductase Inhibitors의 약물 사용 평가
황혜숙,민경아,김정미,손기호,최경업,서옥경 한국병원약사회 2001 병원약사회지 Vol.18 No.1
HMG-CoA reductase inhibitors (statins), as effective antilipidemic agents for lowering LDL-C concentrations, are commonly used in clinical practice to treat most of the major types of hyperlipidemia. The objectives of this study were to evaluate appropriateness of using lovastatin, pravastatin and simvastatin in Samsung Medical Center and to find out ways to improve further their use. A total of 154 outpatients on one of the statins were finally selected and their medical records were retrospectively reviewed. The criteria of DUE (Drug Use Evaluation), based on the standards by the American Society of Health-System Pharmacists, were modified appropriately according to our hospital settings. Using of statins were justified appropriately in 80.5% of patients. However, dietary therapy which should be done before statins treatment was rarely performed. The complications with statin use included minor symptoms such as GI problems and headache, but any convincing causal relationship to drug use was not detected. It was found that there has been a lack of constructive monitoring on hyperlipidemic patients from the initiation of stain therapy, strongly suggesting that there is a necessity to establish a standard treatment protocol for providing better systematic pharmaceutical service by hospital pharmacists on the bass of this standard.
최길성,정혜경,신재룡,곽윤식,조기형 충북대학교 컴퓨터 정보통신 연구소 1997 컴퓨터정보통신연구 Vol.5 No.1
In the GIS(Geographic Information System), the construction of a map-database requires vast expense and efforts. The manual and semi-automatic digitizing techniques which are generally used to make a digital map nowadays have limit to productivity, even to experts. Also, the existing methods have problems in maintaining consistent data precision by individual character of operators. In this thesis, we propose a new technique that automatically constructs a map-database by using a domain segmentation algorithm. The proposed technique minimizes the problems of the existing techniques. The reason is that it separates text and pictures domain automatically for coverages and the constructs data for each coverage.
한국 소아 기관지 천식 환아에서 연령에 따른 Theophylline 의 대사 변화에 관한 연구
이희정(Hee Jeong Lee),조혜영(Hye Young Cho),윤운기(Un Ki Youn),오지섭(Ji Sub Oh),류환선(Hwan Seon Ryu),손기호(Kie Ho Sohn),(Charles D . Sands) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 소아알레르기 및 호흡기학회지 Vol.5 No.1
N/A Theophylline is widely used in Korean pediatric patients in the treatment of asthma. To achieve adequate bronchodilation and avoid side effects , it is generally accepted that the serum theophylline concentration should be maintained between 10 and 20mcg/ml . Concentrations greater than 20mcg/ml are associated with an increased incidence of toxicity . Clinical effectiveness and toxicity are clearly related to understand factors which might altel theophylline pharmacokinetics . Age has been reported as a factor which might alter theophylline clearance. Thus we studied 287 asthmatic children who were admitted to our hospital and received intravenous aminophylline and oral theophylline. The average total clearance of theophylline was 30.00ml/kg/h in the infants under 6 months old and 53.14ml/kg/h in the infants between the age of 6 and 12 months . The average total clearance of theophylline was significantly increased in infants above 6 months old(p<0.001) . The average total clearance of theophylline of the children aged between 1 to 12 years was 65.77ml/kg/h and no significant difference according to age was noticed in this group . These suggest that age may be a factor which affects clearance of theophylline under 12 months old .
안현민(Hyun Min Ahn),기정혜(Jeong Hae Kie),김혜영(Hye Young Kim) 대한안과학회 2017 대한안과학회지 Vol.58 No.7
목적: 안과 영역에서 결핵은 결막결절이나 포도막염 형태로 흔히 나타나며 안와의 감염은 매우 드물다. 저자들은 양측 안와에 발생한 종괴에서 결핵을 진단하여 이를 보고하고자 한다. 증례요약: 64세 남성이 복시를 주소로 내원하였다. 과거력상 당뇨와 고혈압, 만성폐쇄성폐질환의 병력이 있었다. 양안의 교정시력은 1.0, 안압은 16 mmHg였으며, 양안에 안구돌출이 있었고, 양안 모두 하측 안와에서 종괴가 촉진되었다. 안와 컴퓨터단층촬영상, 근원추 바깥쪽에서 안구를 전체적으로 불규칙하게 둘러싸는 경계가 불명확한 종괴가 양안 모두에서 관찰되었다. 국소마취하에 양안에서 종양의 절개생검을 시행하였으며 병리조직검사상 건락괴사가 동반된 만성 육아종성 염증이 관찰되어 양안 안와 결핵으로 진단하였다. 호흡기내과에 전원하여 Isonizid, Rifampin, Ethambutol 3제 요법으로 치료를 12개월간 유지하여 종괴는 완전히 소실되었으며 치료 종료 12개월 후까지 재발이나 합병증은 없었다. 결론: 양안 안와에 발생한 종괴에서 결핵을 진단하고 치료하였으며 안와 결핵은 국내에 보고된 바 없기에 이를 보고하는 바이다. <대한안과학회지 2017;58(7):862-865> Purpose: Periocular tuberculosis is common in the form of conjunctival tuberculosis or uveitis; however, orbital tuberculosis is very rare. We report a case of tuberculosis diagnosed based on bilateral orbital masses. Case summary: A 64-year-old male with a history of diabetes, hypertension, and chronic obstructive pulmonary disease presented with diplopia. His best-corrected visual acuity was 1.0, and intraocular pressure was 16 mmHg in both eyes. Bilateral proptosis was noted, and inferior orbital masses were palpated in both eyes. On orbital computed tomography, irregular masses were surrounding both globes in the extraconal space. Incisional biopsy of the bilateral orbital masses was performed under local anesthesia. Pathologic examination revealed chronic granulomatous inflammation accompanied by caseous necrosis. The patient was diagnosed with bilateral orbital tuberculosis and underwent triple therapy with isoniazid, rifampin, and ethambutol for 12 months. The orbital masses completely resolved, and there was no recurrence or complication through 12 months after treatment. Conclusions: To our knowledge, bilateral orbital tuberculosis has not been reported yet. Herein, we report a case of orbital tuberculosis presenting as bilateral orbital masses. J Korean Ophthalmol Soc 2017;58(7):862-865