단순 비만 지표로서의 목둘레의 분별점

강지현,유병연,서희선,심경원 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2

연구배경 : 목둘레는 인슐린저항성과 관련된 여러 질환과 연관되어 있으며 인슐린저항성의 위험이 증가되어 있는 환자들에서 목둘레가 임상적인 선별검사로 유용하게 쓰일 수 있으리라고 제시되어진 바 있다. 따라서 본 연구에서는 목둘레와 비만 관련 지표 및 인슐린저항성의 지표로서의 HOMA score 와의 상관관계를 알아보고, 비만 환자를 예측할 수 있는 최적의 목둘레 분별점을 알아보고자 하였다. 대상 및 방법 : 건양대학병원 종합검진센터에 내원하여 건강검진을 받은 성인 남녀 대상자 364명 (남자 199명, 여자 165명) 중 249명 (남자 136명, 여자 113명) 실험군(test group)로 하여 receiver output curve (ROC) 분석을 통해 체질량지수 25 kg/㎡에 대한 최적의 (optimal) 민감도와 특이도를 가지는 목둘레 분별점을 구하였으며, 나머지 115명 (남자 63명, 여자 52명)을 유효군 (validation group)으로 하여 실험군에서 얻어진 목둘레 분별점을 적용하여 그 유효성을 알아보았다. 또한 묵둘레와 비만 관련 지표 및 인슐린저항성의 지표로서의 HOMA score와의 상관관계를 알아보았다. 결과 : 목둘레는 남녀 대상군 모두에서 허리둘레, 엉덩이 둘레, 엉덩이허리둘레비, 체질량지수, 체지방률, 공복시 혈중 인슐린, HOMA score와 강한 양의 상관관계를 보였으며 실험군에서 비만 환자를 예측할 수 있는 최적의 목둘레의 분별점은 남자에서는 36.6 cm 여자에서는 32.3 cm 였다. 이때의 민감도는 남자 81.92%, 여자 91.5%, 특이도는 남자 77.4%, 여자 69.7%, 정확도는 남자 80.2%, 여자 85%였다. 또한 실험군에서 얻어진 목둘레의 분별점을 유효군에 적용한 결과 남자에서는 민감도 91.9%, 특이도 53.9%, 정확도 76.1%로 나타났으며 여자에서는 민감도 81.25%, 특이도 85%, 정확도 82.69%로 나타났다. 결론 : 본 연구는 측정이 간편한 단순 비만 지표로서의 목둘레와 흔히 사용되는 비만 관련 지표 및 인슐린저항성과의 관련성을 밝혔으며 비만환자를 예측하기 위한 방법으로서 남자 36.6 cm, 여자 32.3 cm라는 목둘레의 분별점을 제시하였다. 향후 보다 일반화할 수 있는 보완 연구가 이루어져야 할 것으로 생각된다. Background : Neck circumference has been reported to be related to the other anthropometric measures of obesity and also associated with the metabolic disorders related to insulin resistance. The measurement of neck circumference could be useful in clinical screening for persons at an enhanced risk for insulin resistance. The aim of this study was to determine whether a single measure of neck circumference might be correlated with other obesity indices and HOMA score and to define neck circumference cutoff levels for obesity. Methods : We examined 364 consecutive persons (199 men and 165 women), who visited konyang university hospital health examination center during August, 2002. To find the optimal, maximal sensitivity and specificity for neck circumference, the receiver output curve (ROC) analysis of cutoff points against BMI (25 kg/㎡) was performed using the test group (136 men and 113 women). We validated the cutoff level using validation group (63 men and 52 women). Other obesity indices and fasting glucose and insulin were measured to find the correlation between neck circumference. Results : Neck circumference was significantly correlated with waist circumference, hip circumference, waist hip ratio, BMI, total body fat percent, fasting insulin and HOMA score. Neck circumference 36.6 cm for men and 32.3 cm for women was the best cutoff levels for determining the subjects with BMI over 25 kg/㎡. In the validation unrelated group, the test characteristics were acceptable with 91.9% sensitivity, 53.9% specificity, and 76.1% accuracy for men, and 81.25% sensitivity, 85% specificity, and 82.69% accuracy for women. Conclusion : Neck circumference as a simple and easy screening method for obesity was strongly correlated with the other conventional obesity indices and HOMA score as a index of insulin resistance and we defined neck circumference cutoff level for obesity according existing BMI cutoff levels.

Angiolymphoid hyperplasia with eosinophilia associated with arteriovenous malformation

Seong Min Kang,Woo Jin Lee,Myoung Shin Kim,Chong Hyun Won,Sung Eun Chang,Ho Seok Suh1,Mi Woo Lee,Jee Ho Choi,Kee Chan Moon 대한피부과학회 2009 대한피부과학회 학술발표대회집 Vol.61 No.1

Diverse Non-fatal Immune-Related Adverse Events Following COVID-19 Vaccination in South Korea Using the National Health Insurance Service Database from 2020 to 2021

( Jee Hyun Suh ),( Hong Jin Kim ),( Min-ho Kim ),( Myeong Geun Choi ),( Eun Mi Chun ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0

Probability of ongoing pregnancy in women undergoing IVF using human chorionic gonadotropin(HCG) and progesterone levels

( Jee Hyun Kim ),( Byung Chul Jee ),( Jung Ryeol Lee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

목적: This study was performed to assess the probability of ongoing pregnancy using serum human chorionic gonadotropin(HCG) and progesterone levels measured at 11 days post-ET. Between May 2011 and June 2012, sera were prospectively obtained from 96 infertile women who underwent IVF-ET at 11 days post-ET. HCG and progesterone levels were measured by commercial enzyme-linked immunosorbent assay kits. Probability of ongoing pregnancy was estimated using HCG and progesterone levels. Pregnancy outcomes were followed. Initial serum hCG titer was elevated in 44 women, but 8 women ended in chemical pregnancy and 4 women were detected ectopic pregnancy. Twenty-eight women were identified ongoing (OG) pregnancy. Probability of ongoing pregnancy was higher in women with hCG>100IU/L. Among them, rate of OG pregnancy was 100% (8/8) when the progesterone levels were above 80ng/mL, 78.9% (15/19) when the progesterone levels between 30 and 80ng/mL, and 50% (2/4) when the levels were below 30 ng/mL. However, 3 women were identified OG pregnancy when the hCG levels were below the 100IU/L. Probability of OG pregnancy is estimated using hCG and progesterone levels in IVF-ET patients.

Dose-dependent embryotrophic effect of recombinant granulocyte-macrophage colony-stimulating factor and brain-derived neurotrophic factor in culture medium for mouse preimplantation embryo

( Jee Hyun Kim ),( Hyun Ju Lee ),( Eun Jeong Yu ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.5

Objective To evaluate the dose effect of recombinant mouse granulocyte-macrophage colony-stimulating factor (rmGM-CSF) or brain-derived neurotrophic factor (BDNF) in culture medium on the development of in vitro fertilized mouse embryos. Methods Mature oocytes were retrieved from superovulated female BDF1 mice and inseminated by sperm from male BDF1 mice. On day 1, two-cell stage embryos were divided and cultured until day 5 in the embryo maintenance medium supplemented with 0, 1, 2, 5, or 10 ng/mL of rmGM-CSF or supplemented with 0, 5, 10, or 20 ng/mL of BDNF. Blastocyst formation rate and their cell numbers were assessed. Results The blastocyst formation rate and the total cell count in blastocyst was similar in all the rmGM-CSF treatment groups when compared with the control. However, the blastocyst formation rate and the total cell count was significantly higher in the group supplemented with 10 ng/mL of BDNF compared with the control (63.9%, 45.8±11.5 vs. 52.3%, 38.0±6.8; P<0.05, respectively). Conclusion Supplementation of 10 ng/mL of BDNF enhanced the developmental potential of mouse preimplantation embryos, but supplementation of rmGM-CSF did not.

In vitro growth of mouse preantral follicles: effect of animal age and stem cell factor/insulin-like growth factor supplementation

Jee, Byung Chul,Kim, Jee Hyun,Park, Da Hyun,Youm, Hyewon,Suh, Chang Suk,Kim, Seok Hyun The Korean Society for Reproductive Medicine 2012 Clinical and Experimental Reproductive Medicine Vol.39 No.3

Objective: To determine whether animal age impacts in vitro preantral follicle growth. Effects of hCG, stem cell factor (SCF), and/or insulin-like growth factor (IGF) supplementation in growth medium were also investigated. Methods: Intact preantral follicles were mechanically isolated from fresh ovaries of BDF1 mice and cultured in growth medium for 9 to 11 days. Surviving follicles with antrum formation were transferred to maturation medium for 14 to 18 hours. Follicle survival, antrum formation, and retrieval of metaphase II (MII) oocytes were compared among three age categories (4-5, 7-8, and 10-11 week-old). By using 7- to 8-week-old mice, preantral follicles were cultured in growth medium supplemented with hCG (0, 5, or 10 mIU/mL), SCF (50 ng/mL), IGF-1 (50 ng/mL), and SCF+IGF-1. Results: Seven- to eight-week-old mice showed a higher follicle survival and antrum formation and produced more MII oocytes compared to other groups. In the 7- to 8-week-old mice, supplementation of 5 mIU/mL hCG significantly enhanced the antrum formation but the percentage of MII oocytes was similar to that of the control. Supplementation of SCF+IGF-1 did not enhance follicle survival or antrum formation but the percentage of MII oocytes increased modestly (39.1%) than in the control (28.6%, p>0.05, statistically not significant). Conclusion: Seven- to eight-week-old mice showed better outcomes in growth of preantral follicles in vitro than 4- to 5- or 10- to 11-week-old mice. Supplementation of hCG enhanced antrum formation and supplementation of SCF+IGF-1 yielded more mature oocytes; hence, these should be considered in the growth of preantral follicles in vitro.

Efficacy of Random-start Controlled Ovarian Stimulation in Cancer Patients

Kim, Jee Hyun,Kim, Seul Ki,Lee, Hee Jun,Lee, Jung Ryeol,Jee, Byung Chul,Suh, Chang Suk,Kim, Seok Hyun The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.3

Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

Kim, Jee-Hyun,Shin, Mi-Sun,Yi, Gwang,Jee, Byung-Chul,Lee, Jung-Ryeol,Suh, Chang-Suk,Kim, Seok-Hyun The Korean Society for Reproductive Medicine 2012 Clinical and Experimental Reproductive Medicine Vol.39 No.1

Objective: This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF. Methods: Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis. Results: For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010). Conclusion: A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.

글로벌 시대의 기술혁신과 리스크 거버넌스를 위한 의사결정구조의 변화

서지현(Suh Jee-Hyun),원동규(Won Dong-kyu) 한국콘텐츠학회 2007 한국콘텐츠학회 종합학술대회 논문집 Vol.5 No.2_1

고도의 지식 기반사회인 현대사회에서 과학적 지식과 기술 혁신은 개인과 사회, 그리고 국가의 경제 발전과 경쟁력을 위한 필수적 요소로서 자리매김해 왔다. 그러나 이와 동시에 줄기세포연구, 유전자조작기술 등 기술혁신에 따른 잠재적 위험성은 사회적 불안 및 갈등요소로도 작용하고 있다. 기술에 대한 불확실성이 증가하고 사회가 다원화하면서 과학기술정책의 의사결정과정도 기존의 톱다운 방식인 ‘거버먼트(Government)’에서 점차적으로 ‘거버넌스(Governance)로 옮겨가고 있다. 다양한 사회 구성원의 참여로 의사결정이 이루어지는 거버넌스는 복잡한 사회 현상들에 대한 다원적 접근을 가능하게 한다. 본고에서는 거버넌스, 특히 기술혁신과 관련된 리스크 거버넌스를 중심으로 과학기술지식을 기반으로 한 의사결정모델을 살펴보고, 글로벌 시대에 과학기술과 사회의 지속가능한 발전을 위한 거버넌스 체계를 모색해보고자 한다. During the recent decades in democratic and industrialized countries, government policies for governing technological innovation and risks to environment and human health have undergone significant changes. The shift from a top-down legislative approach to a more inclusive and deliberative atmosphere is, putatively the most prominent change. Such a move is often described as a move from government to governance. In the governance of technology and risk, public engagement has been a major strategy in technology decision-making process. This article aims to look into the changes in the procedural modes of technology decision-making process. It discusses the main viewpoints that have been placed on the basis of such a move. Also, it further relates the changes in local decision-making process to science and technology decision-making at global level. It argues that the democratic and reflexive trends in local science and technology decision-making will be the basis upon which to shape and respond to global governance system: while international decision-making process would require accountability in integrating different values and rationalities, such accountability may be sustained and reinforced depending on the robustness of the local decisions and social choices.

부모의 과보호와 아동의 사회불안

서경현(Kyung-Hyun Suh),신현진(Hyun-Jin Sin),문지영(Jee-Young Moon) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.1

본 연구에서는 부모의 과보호가 남녀 아동의 사회불안에 어떤 영향을 미치는지를 탐색하였다. 본 연구의 참여자는 4∼6학년 초등학생 515명(남: 261, 여: 254)이었으며, 연령 분포는 만 9세에서 13세(M=10.86, SD=1.20) 사이였다. 본 연구에서 사용된 심리검사는 한국판 부모-자녀 결합형태 검사, LaGreca의 사회불안 척도와 한국판 아동용 사회불안 척도이다. 본 연구의 목적을 성취하기 위해 사회불안의 요인인 대인불안과 수행불안에 대한 2 (성별)×4 (부모의 과보호) 이원변량분석을 하였다. 분석 결과, 부모의 과잉간섭 수준이 높으면 대인불안과 수행불안 수준이 높았다. 그런데 부모의 과잉간섭의 영향은 남아는 아버지로부터 여아는 어머니로부터 받는 것으로 나타났다. 그리고 부모가 자녀의 자율성을 많이 존중하면 그렇지 않은 것보다 수행불안 수준이 낮았다. 본 연구의 결과를 선행연구들과 부모로부터의 탈동일시 욕구나 사회화 과정을 바탕으로 논의하였다. Researchers investigated how parent’s over protection influences social anxiety of their children. Participants were 515 students (261 males and 254 females) from 4th, 5th, and 6th grade of elementary school, whose ages ranged from 9 to 13 (M=10.86, SD=1.20). The psychological tests used in this research included the following: the Korean version of Parker’s Parental Bonding Instrument, LaGreca’s Social Anxiety Scale, and the Korean version of Social Anxiety Scale. To achieve the purpose of this study, 2 (gender)×4 (parent’s over protection) 2-way MANOVAs for interpersonal anxiety and performance anxiety were performed. Results revealed that children with higher parent’s intrusion showed more interpersonal anxiety and performance anxiety than children with lower parent’s intrusion. However, the influence of father’s intrusion was only effective for son, whereas the influence of mother’s intrusion was only effective for daughter. And, children with higher parent’s autonomy respect showed less performance anxiety than children with lower parent’s autonomy respect. It was discussed results of this study with previous studies, de-identification from parents, and socialization process. (Korean J Str Res 2010;18:19∼27)