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( Jae Deog Jang ),( Hun Kim ),( Hyun Shin Park ),( Sang Hoon Woo ),( Jang Hoon Kim ),( Seon Ae Kim ),( Seok Jung Kim ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
The osteogenic potential of autologous bone marrow derived mononuclear cells(MNCs) mixed with atelocollagen and hydroxy apatite when transplanted to bone defects was evaluated. 15 mm defect on radius were made in 27 NZW rabbits. The rabbits were divided into control, MATREX-B(atelocollagen and hydroxyl apatite mixture) and ASTEM-B(MATREX-B and MNCs mixture) groups as treatments. Each group was scheduled to be sacrificed at 3, 6 or 9 weeks after the operation and took an x-ray for radiological evaluation and tissue staining with Masson`s trichrome. At 9 weeks after the operation, ASTEM-B and MATREX-B treated group showed an excellent bone healing results. At 6 weeks after the operation, ASTEM-B treated group showed that most of the injected collagen gel formulation was converted to bone like tissue in the defect area. At 6 weeks after the operation, MATREX-B treated group showed an initial step in bone remodeling process. In case of control group, bone healing effect in defect area at 6 or 9 weeks after the operation showed a slight bone formation, but symptom of bone remodeling was not observed. In this research, atelocollagen gel formulation with autologous bone marrow derived mononuclear cells showed an accelerated bone healing using the rabbit model with critical bone defect.
( Jae Yeol Kim ),( Jae-woo Jung ),( Min-jong Kang ),( Deog Kyeom Kim ),( Hayoung Choi ),( Young-jae Cho ),( Seung Hun Jang ),( Chang-hoon Lee ),( Yeon Mok Oh ),( Ji Sook Park ) 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5
Background/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of Streptococcus pneumoniae have not been evaluated in the post-era of pneumococcal vaccination in Korea. Methods: We conducted a prospective, multi-center, cohort study from seven University-affiliated hospitals. The primary objective was the identification of serotype-specific prevalence of pneumococcal pneumonia in COPD patients hospitalized for CAP. For the purpose, we conducted serotype-specific urine antigen detection (SS-UAD) assays for S. pneumoniae. The secondary objectives were other clinical characteristics of pneumonia including vaccination status. Results: The total number of participants was 349. Most of them were male (95.1%) with old ages (75.55 ± 8.59 y). The positive rate for S. pneumoniae was 9.2% with SS-UAD assay and the common serotypes were 22F, 6A, and 6B. In the sputum, Pseudomonas aeruginosa (5.0%) and Haemophilus influenzae (4.0%) were common pathogens. The vaccination rate was 78.8%, 53.0%, and 25.8% for influenza, pneumococcal polysaccharide vaccine 23 (PPV 23), and pneumococcal protein-conjugated vaccine 13 (PCV 13), respectively. Thirteen patients died during hospitalization (mortality rate; 3.7%). There was no difference in the respective rate of influenza vaccination (79.2% vs. 69.2%, p = 0.288) and PCV 13 vaccination (25.6% vs. 30.8%, p = 0.443) between survivors and the deceased. Conclusions: Serotypes 22F, 6A, and 6B, which are covered either by PPV 23 or by PCV 13, are still common pneumococcal serotypes in COPD pneumonia in the post-vaccination era in Korea.
Novel Repair Technique for Articular Cartilage Defect using a Fibrin and Hyaluronic acid Mixture
( Jae Deog Jang ),( Young Seok Moon ),( Yong Sik Kim ),( Nam Yong Choi ),( Hyun Su Mok1 ),( Young Ju Kim1 ),( Asode Ananthram Shetty ),( Seok Jung Kim ) 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.1
We evaluated the cartilage repair potential of a hyaluronic acid and fibrin mixture when transplanted into cartilage defects. Circular, articular, cartilage defects 4-mm in diameter were made in the trochlear region in 21 New Zealand white rabbits divided into three groups. The seven rabbits in the control group underwent microfracture (M group), the seven rabbits in the experimental group underwent microfracture with subsequent injection of hyaluronic acid mixed with fibrin (MH group), and seven rabbits in the other experimental group underwent microfracture followed by injection of bone marrow concentrate and hyaluronic acid mixed with fibrin (MBH group). At week 12 following surgery, the cartilage was observed and histologically compared in the three groups. The surface of the newly generated cartilage was very smooth and even, and we noticed that the entire area was completely regenerated in both experimental groups. The control group showed incomplete and irregular cartilage formation in the defect. In histologic scoring, comparison of the MBH group (M= 2.333) and the M group (M= 9.000) differed significantly (P= 0.046). Therefore, injection of a mixture of bone marrow concentrate, hyaluronic acid and fibrin to treat articular cartilage defects of the knee appears to be an effective method of cartilage regeneration.
( Jae Deog Jang ),( Seok Jung Kim ),( Hyung Moon Yoon ),( Dong Cheul Shin ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.4
The development of applicable cells and of bio-matrices are currently important topics in the field of regenerative medicine. The harvested cell viabilities or proliferabilities of each person differ and sometimes show low viability or proliferability. Mesenchymal stem cells (MSCs), even those with decreased proliferability after sub-culturing to obtain a high cell number, may be a good candidate for tissue engineering. The differentiation potentials of MSCs showing no apparent population doubling in vitro were evaluated in a three-dimensional atelocollagen encapsulation culture system. The results showed considerable osteogenic potential but little adipogenic or chondro-genic potential. This study shows that stem cells, even with little proliferability, embedded in collagen gel beads pro-vide a good source for bone regeneration.
Acute Oral Toxicity of Extract Derived from Fruiting Body of Phellinus gilvus in Rats
Jae-Sung Bae,Kwang-Ho Jang,Sung-Guk Choi,Woo-Sik Jo,Man-Hee Rhee,Oh-Deog Kwon,Young-Hoan Kim,Eun-Young Kim,Seung-Chun Park 한국독성학회 2003 Toxicological Research Vol.19 No.3
This study was carried out to investigate the acute oral toxicity of a crude extract derived from fruiting body of Phellinus gilvus (PGE) using male and female SD rats. Groups consisted of five male and female rats were treated with a single dose of the test substance intragastrically at 0, 500, 1,000, 2,000, and 5,000 mg/kg, respectively. Clinical signs, body weight change, and food and water consumption change were observed for 14 days after administration. No mortality or abnormal clinical signs in animals were shown during the observation period at the dose used in this study. Also there was no difference in net body weight gain, water and food consumption or gross pathological findings at terminal sacrifice among the groups of rat treated with different doses<br/> of the test substance. The results suggested that acute oral toxicity of PGE in rats is very low at the conditions employed in this study and LD50 of PGE was estimated to be over 5,000 mg/ml in<br/> both sexes of rats.
Acute Oral Toxicity of Extract Derived from Fruiting Body of Phellinus gilvus in Rats
Bae, Jae-Sung,Jang, Kwang-Ho,Park, Sung-Guk,Jo, Woo-Sik,Rhee, Man-Hee,Kwon, Oh-Deog,Kim, Young-Hoan,Kim, Eun-Young,Park, Seung-Chun Korean Society of ToxicologyKorea Environmental Mu 2003 Toxicological Research Vol.19 No.3
This study was carried out to investigate the acute oral toxicity of a crude extract derived from fruiting body of Phellinus gilvus (PGE) using male and female SD rats. Groups consisted of five male and female rats were treated with a single dose of the test substance intragastrically at 0, 500, 1,000, 2,000, and 5,000 mg/kgaj, respectively. Clinical signs, body weight change, and food and water consumption change were observed for 14 days after administration. No mortality or abnormal clinical signs in animals were shown during the observation period at the dose used in this study. Also there was no difference in net body weight gain, water and food consumption or gross pathological findings at terminal sacrifice among the groups of rat treated with different doses of the test substance. The results suggested that acute oral toxicity of PGE in rats is very low at the conditions employed in this study and $LD_{50}$ of PGE was estimated to be over 5,000 mg/$\textrm{m}{\ell}$ in both sexes of rats.
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 전시 ; 간의 염증성 가성 종양 1예
장재영 ( Jang Jae Yeong ),김연수 ( Kim Yeon Su ),천영국 ( Cheon Yeong Gug ),김영석 ( Kim Yeong Seog ),김정훈 ( Kim Jeong Hun ),문종호 ( Mun Jong Ho ),조영덕 ( Jo Yeong Deog ),진소영 ( Jin So Yeong ),심찬섭 ( Sim Chan Seob ),김부성 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)