Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

S-528 : The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

특수 콘크리트를 이용한 공원시설 관련 제품에 관한 연구

박봉우,김진아,신애란,전병건 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

본 연구는 특수 콘크리트를 사용하여 공원시설 관련 제품을 생산하기 위한 기초 자료를 얻을 목적으로 수행하였다. 현재 국내에서 생산하여 사용되고 있는 공원 관련 시설물을 대상으로 소재에 대한 선호도와 소재의 특성을 우편을 통한 설문 조사를 하였다. 설문의 결과 가장 선호하는 소재는 목재, 인조목, 철금속, 비철금속, 석재 등의 순서로 나타났다. 재료 별 특성은 12개 공원 관련 시설과 7개 시멘트 콘크리트 제품을 대상으로 재료별로 10개 항목에 대한 특성을 조사하여 matrix로 나타내었다. 이렇게 조사된 결과를 토대로 하여 공원 관련 제품 생산을 위한 시험적인 모델로 특수 콘크리트를 사용한 블라드와 콘크리트 판넬의 모형을 제시하였다. The purpose of this study was to obtain basic information in order to produce of park facility products using by special concrete. This study made a survey of preference and character of the raw materials on park facility products throughout the country by mail questionnaire. As a result, the ranking of preference on raw materials were wood, imitation wood made from cement concrete, steel, and nonferrous metal. Also, the 10 characters of raw material on the 12 items of park facility products and 7 items of cement concrete products investigated and their results showed by matrix. Based on these results we suggest the pilot models of bollard and concrete panel for pedestrian using special concrete.

지연간격, 노출조건 및 인지발달수준에 따른 유아의 회상기억

박애경 中央大學校 韓國敎育問題硏究所 1998 韓國敎育問題硏究所論文集 Vol.- No.13

The purpose of present study was to test the children's recall memory by delayed interval (immediated vs. 1-wk vs. 2-wk vs 2-wk repetition exposure vs. 3-wk), the level of cognitive development age (4-, 6-years olds), and information type (consistent vs. inconsistent). In present study, four hypotheses were proposed. Hypothesis I was to testify the effect of delayed interval(1-wk, 2-wk, and 3-wk_ and the level of cognitive development on recall memory. Hypotheses 2, 3, and 4 were to testify the effect of delayed interval(zero, 1-wk, and 2-wk,) and repetition exposure on recall memory. That is, this hypotheses consisted of two step : first step have relevant to the simple delayed interval. second step have relevant to the variation of delayed interval and repetition exposure in detail. It used Welch-Ross, Diecidue and Miller's test tool in the collection of data. ANOVA, Scheffe test. and t-test, were used to analyze the data. Except for repetition exposure, the delayed interval, and the level of cognitive development exert clear effects on children's recall memory. The result of the present study are as follow : First, Children's recall memory was lower over the time " for 3-wk delayed recall than 1-wk delayed recall, and for 3-wk delayed recall than 2-wk delayed recall but there was no significant difference between 2-wk and 1-wk delayed recall. Second, Children's recall memory was higher for immediated recall after 1-wk repetition exposure in the 2-wk repetition exposure than 1-wk delayed condition. Third, Children's recall memory was higher for 2-wk repetition exposure delayed condition than 2-wk delayed recall. Fourth, Children's recall memory was higher for immediated recall after repetition exposure than immediate recall after first-exposure in 2-wk repetition exposure delayed condition. Fifth, Six-year-olds children in late preoperational period showed significantly more story recall memory than four-year-olds children in early preoperational period. Sixth, Type of information given had no an effect, : Inconsisting information not hindered their performance. This results can be applied to the instruction-learning method for young children.

중증 화상 환자에서 영양지원

박지영,목혜숙,신현선,노순예,김애심,백금선,김도헌,허준,전욱 대한화상학회 2003 대한화상학회지 Vol.6 No.2

잡가 연구의 현황과 과제 : 국문학계의 연구를 중심으로

박애경 洌上古典硏究會 2003 열상고전연구 Vol.17 No.-

국문학계에서 잡가 연구는 가장 혼란스러운 분야라 할 수 있다. 연구 성과가 쌓일수록 잡가의 정체성과 존속 시기에 대한 합의가 이루어지기 보다는 이견이 속속 노출되고 있기 때문이다. 잡가는 19세기 중반 이후 도시 유흥의 장에 등장한 순간부터 1920년대 전성기를 맞을 때까지 상당한 수준의 대중적 파급력을 드러낸 바 있다. 뿐만아니라 잡가는 중세 해체기의 문화적 역동성을 자양분으로 하여 자기부상한 후, 근대 전화기를 거치며 전성기를 맞이 했다는 점에서 중세의 끝에 성장한 서민 예술이 근대라는 시기와 만나며 겪는 변화와 생존 방식을 선명하게 보여주고 있다. 요컨대 잡가는 19세기 문화사와 근대 전환기 예술의 운명과 존재 방식을 가늠하는 척도이며 관문이라 할 수 있다. 따라서 잡가 연구는 그 특수한 위상을 밝히는 방향으로 진행되어야 한다. 이를 구체적으로 지적하면 다음과 같다. 첫째, 문집, 가집, 고악보에 분산되어 있는 잡가 관련 기록을 수집하고, 해석할 필요가 있다. 둘째, 잡가의 존재양상과 방식을 객관적으로 살핌으로써 잡가의 개념과 범주에 대한 이견을 좁힐 필요가 있다. 셋째, 조선 후기에 형성되어 근대전환기를 거치고 일제 강점기까지 존속한 잡가를 통해 '통속예술에서 대중예술로의 상승'이라는 예술사의 발전 과정을 진단하고, 19세기 도시문화의 역동성을 밝혀낼 필요가 있다. 넷째, 전통적 장르에서 근대 대중예술로 순조롭게 발전한 잡가를 통해 시가에서 근대성이 실현되는 방식을 추적해볼 수 있다. 마지막으로 잡가를 고려가요, 사설시조 등 하위문화의 속성을 지니면서 잡종 장르의 면모를 지녔던 장르 간의 계보 속에서 파악함으로써 시가에서 장르 복합적인 현상을 해명하는 이론적 틀을 마련해볼 필요가 있다. Study on Jabka is taken as the most chaotic area in Korean literature academics. This is because different views are being raised rather than aligning on identity of Jabka and its duration as study results build up. From the moment of Jabka's introduction to urban entertainment stage in mid 19 century to height of prosperity in 1920s', Jabka demonstrated great deal of public spreading capability. Also, viewed in light of its emergence utilizing cultural dynamics during break down of middle age and having its peak passing through tansit period into modern age, Jabka demonstrates clearly as to how mass art that's developed at the end of middle age went through changes and survival measures by encounter with modern age. Jabka can be standard and gateway to discern 19 century cultural history and art's destiny and existence method during transit period into modern age. Therefore, Jabka studies need to direct towards period its unique phase. This can be illustrated in detail as follows. First, we need to collect and analyze Jabka related records scattered in various collections and music books. Second, we need toi narrow different views on Jabka's concept and criteria reviewing existence appearance and method of Jabka objectively. Third, we need to review development process of art history and to investigate dynamics of 19c urban culture through Jabka that was created at the end of Chosun dynasty and existed through modern transit period and Japanese occupation, that's summed up as rising from popular art to mass art. Forth, we can track its path in which modernity is materialized through Jabka that's developed from traditional gentr to one of modern mass art. Finally, we need to set theoretical frame that explains Jabka's hybrid genre complexity reviewing from genealogy between genres in which shows mixed gentr while maintaining character of sub culture such as Koryo Gayo and Sasulshizo.

動物組織中의 脂質定量에 對하여

朴愛卿 이화화학회 1968 梨花化學會誌 Vol.- No.7

쥐의 뇌, 심장, 허파 등을 試料로 取하여 Thin layer chromatography에 依하여 脂質을 定量한 結果 cholesterol는 특히 뇌신경 조직과 부신에 많이 存在하며 Total cholesterol 含量은 뇌에 17.6㎎/g로 가장 많았고 심장에 3.2㎎/g로 가장 적었다. Free cholesterol 역시 뇌에 가장 많이 있고 심장에 가장 적었다. Glyceride는 Brain에 가장 많았고 大體로 Triglyceride가 많았다. Lipid is accumlated at adipose tissue, Adipose tissue consists of more than 90% triglyceride. Lipid is main energy source in the animal body as you know. In this experiment, we used brain, heart and lug from rat as samples. We tried to investigate the constituents of neutral lipid, and phospholipids. As a resalt, we separated six different material from nuetral lipid and four from the phospholipid. They were monoglyceride, diglyceride, triglyceride, free cholesterol esterified cholesterol fatty acids and phosphatidyl ethanol amine, phosphatidyl choline, phosphatidyl inositol, and one unknown lipid, respectively. Brain had the highest glyceride content and also highest cholesterol content which was about 4 times as high as that in the heart and lug. Phosphatidyl ethanol amine had the highest phospholipid and total cholesterol amount was the highest at the Brain.

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

日本 紀行歌辭의 계보와 日本觀의 변모양상

박애경 열상고전연구회 2006 열상고전연구 Vol.23 No.-

이 글의 목적은 조선 후기부터 일제 강점기에 사이에 씌여진 세 편의 일본 기행가사를 통해 일본관의 변화를 살피려는 것이다. 이를 위해 18세기 저작인 <일동장유가>, 한말 저작인 <유일록>, 일제 강점기에 나온 「東遊感興錄」을 대상으로 삼았다. 일본 기행가사에 나타난 일본관의 의미를 당대 문화적 환경과 관련하여 살피기 위해 먼저 공식적 여행의 체험을 그린 사행가사가 나오게 된 배경을 가사 장르 자체의 변화와 관련하여 살펴보았다. 또한 사행가사가 유학자이자 관료인 작가의 공적 여행의 기록인 동시에 조선 지식층의 내면의식을 보여주는 통로라는 것을 확인하였다. 3편의 일본 기행가사는 주권 왕조에서 식민지로 급전직하한 국가 운명만큼이나 달라진 대일관을 보여주고 있다. <일동장유가>가 화이관의 지속을 보여준다면, <유일록>은 화이관의 지속과 균열을 보여주는 동시에 일본에 대한 양가적 시선을 드러내고 있다. 일제 강점기 통치정책의 하나로 시행된 내지 시찰의 경험을 담은 「동유감흥록」은 말할 것도 없이, 식민지 담당자의 의도에 포섭된 자의 시선이 두드러지게 나타난다. 이렇듯 일본 기행가사에는 조선 후기 이후 달라진 대일 관계와 양국의 지위, 한학과 유학을 하던 조선의 전통적 지식층들이 시대의 변화를 바라보는 관점이 유장한 호흡 속에 나타나 있다. 따라서 일본 기행가사는 일본관 형성의 기저, 조선 지식층들의 대외 인식의 일단을 살피는 시대적 기록으로서의 가치가 크다고 할 수 있다. The purpose of this study is to inguire the change of an awareness of Japan through 3 works of Ilbon Kihaeng Kasa (Kasa which discribes the experience of a travel in Japan) written in the late of Chosun Dynasty and in the colonial period. For this purpose, this study deals 'Ildongjangyuga(日東壯遊歌)' written in the 18C, 'Yuilrok(游日錄)' written in the late of 19C and 'Dongyugamheungrok(東遊感興錄)‘ written in the colonial period. For analizing the meaning of an awareness of Japan in relation to the cultrural circumstance at that time, this styudy observes the condition for forming Sahaeng Kasa, as the records of the experience of official trip to other contries with a focus on the transformation of Kasa. In addition, this study tries to verificate the fact that Sahaeng Kasa was not only the records of official trip to other contries by the Confucian bureaucrats but also the path to come out their inner consciousness. Each work represents different view of Japan as a consequence of the change of the nation status from a sovereign dynasty to a colony. The meaning of Ilbon Kihaeng Kasa can be summarized as the records of an age which present the origin of a view of Japan as much as the understanding other contries of the intellectuals in Chosun Dynasty.

한방 다이어트 식품 HBM(Healthy Body Maker)의 체중감소 및 혈청 콜레스테롤 저하 효과

박재상,김애정,김선여 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.4

This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200±5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks, body weight of 5% HBM group was significantly lower than that of control group. respectively (p<0.05, p<0.01). 3. At 4 weeks, the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01). And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05). 4. At 6 weeks, the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group, It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.