만성기침 환자의 기관지과만성 예측인자

( Hyun Hye Chu ),신경철(공동저자1) ( Kyeong Cheol Shin ),이경수(교신저자) ( Kyeong Soo Lee ) 대한임상병리사협회 2014 임상생리검사학회 발표자료집 Vol.2014 No.-

배경(Background): This study was conducted to analyze association between airway hyperresponsiveness and clinical asthma symptoms in patients using survey with targets of patients who underwent medical treatment for cough in the primary care clinic but visited the general hospital because the symptoms were not improved. The purpose of this study was to analyze the association between result of clinical examination for airway hyperresponsiveness which was gold standard and questionnaires about asthma symptoms and determine the availability in the diagnosis of asthma. Thus, this is to help the technician to check progress. 방법(Methods): Examination for airway hyperresponsiveness and clinical test were performed with targets of 311 patients who were between 18 years old and 70 years old and visited a university hospital located in Daegu metropolitancity from March 2011 to June 2012 because of chronic cough. 결과 (Results): There were significant associations between airway hyperresponsiveness and family medical history. There was no significant association between clinical symptom and survey for cough, but there was significant association with wheezing. There were significant associations with sleeping difficulty, difficulty in breathing at dawn, atopy symptoms and nasal symptoms. According to the results of non parametric statistics, it was found that the proportion of positive group for airway hyperresponsiveniss was higher with more numbers of significant symptoms used in this study. 결론(Conclusion): It is considered to be helpful to find potential asthma patients using useful related symptom questionnaires which were used in this study. It is possible to be used as basic information to develop the questionnaires to identify hypersensitivity of airway. It is also considered to be a great help to process of examinations. It is also considered to be a great help to process of examinations.

S-259 : A case of lung, pleura, and lymph nodes metastases from basal cell carcinoma

( Kyu Hyun Han ),( Jung Hyun Kim ),( Hye Cheol Jeong ),( Sun Young Shin ),( Hye Yun Jeon ),( Ji Min Chu ),( Eun Kyung Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Introduction: Basal cell carcinoma (BCC) is the most common cutaneous malignancies. However, metastasis form this tumor is extremely rare and estimated to range from 0.003 to 0.05% of cases. The criteria for the diagnosis of metastatic basal cell carcinoma (MBCC) is that the primary tumor is from skin and not of mucosal or glandular tissue; metastasis must be at a distant site and cannot be a result of direct extension; the primary and metastatic tumor must share the same histologic subtype. To our knowledge, only a few cases of MBCC have been reported in Korea. We report a case of BCC metastasizing to the lung, pleura, and lymph nodes. Case Report: A 69-year-old man was referred to our hospital with left pleuritic chest pain for 3 months. The patient had a history of basal cell carcinoma involving right upper arm that was diagnosed 20 years earlier. He underwent excision of the primary tumor and reconstruction with split-thickness skin graft. The tumor had three local recurrences that required excisions and radiation treatment. He had no evidence of recurrence for 5 years before this presentation. A chest computed tomographic (CT) scan showed multiple nodules in the right middle lobe and both lower lobes and small amount of pleural effusion with pleural thickening in left hemithorax. Fluorine 18-labeled fluorodeoxyglucose (FDG)-positron emission tomography-CT scan revealed abnormal FDG uptake in the lung nodules and the subaortic and left retrocrural lymph nodes. He underwent video-assisted thoracoscopic surgical biopsy for lung nodule and pleural nodule. This biopsy specimens of the lung nodule and pleural nodule revealed basal cell carcinoma. He was transferred another hospital and received chemotherapy.

S-261 : A Case of Invasive Pulmonary Aspergillosis with Direct Invasion of Heart in Immunocompetent Patient

( Kyu Hyun Han ),( Jung Hyun Kim ),( Hye Cheol Jeong ),( Sun Young Shin ),( Hye Yun Jeon ),( Ji Min Chu ),( Eun Kyung Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Although an invasive pulmonary aspergillosis is not rare in an immunocompromised patients, it is very rare in an immunocompetent patients. We report a case of invasive pulmonary aspergillosis, which invaded the mediastinum and the left atrium. A 70-year-old female admitted for dyspnea. She had been well controlled for diabetes mellitus and hypertension. she had no past history of immunosuppression or underlying malignancy. A chest X-ray showed mediastinal widening and computed tomography (CT) scan of the chest revealed a large mediastinal mass and the lesion extended into the left atrium and right bronchus. A cardiac echocardiography showed a hyperechoic polypoid lesion in the left atrium and a huge mediastinal cystic mass compressed the right atrium and invaded the right pulmonary vein. The huge mediastinal cystic mass was connected to the right hilar mass. Fiberoptic bronchoscopic biopsy and CT-guided percutaneous needle aspiration biopsy (PCNA) of the right mediastinal mass were performed. The pathology from the bronchoscopic biopsy showed abundant fungal hyphaes. The result of stains with periodic acid-Schiff (PAS) and Gomori`s methenamine silver (GMS) for fungi was positive for fungal hyphae. The pathology of mediastinal mass revealed necrotic tissues. Despite of treatment with antifungal agents, she died from cardiac tamponade three months later. Invasive pulmonary aspergillosis, which involves the mediastinum and the heart, is very rare in immunocompetent patients. So, we report the case and reviewed the literatures.

Ginsenoside Rg3 activates Human KCNQ1 K+ Channel Currents through Interacting with the K318 and V319 residues : A Role of KCNE1 Subunit

Sun-Hye Choi(최선혜),Tae-Joon Shin,Byung-Hwan Lee,Mi-Kyung Pyo,Sung-Hee Hwang,Bo-Ra Kim,Sang-Mok Lee,Dae-hyun Chu,Han Choe,Jun-Ho Lee,Dong-Hyun Kim,Hyoung-Chun Kim,Hye-whon Rhim,Seung-Yeol Nah 고려인삼학회 2009 고려인삼학회 학술대회 Vol.2009 No.12

Impedance Spectroscopy of p-Conjugated Organic Materials

Seong Hyun Kim,양용석,정태형,Hye Yong Chu 한국전자통신연구원 2004 ETRI Journal Vol.26 No.2

AC electrical properties of organic light-emitting diodes with poly(2-methoxy-5-(2'-ethyl-hexyloxy)-1,4-phenylenevinylene) (MEH-PPV), poly[2,5-bia(dimethyloctylsilyl)-1,4-phenylenevinylene] (BDMOS-PPV), and tris-(8-hydroxyquinolate)- aluminum (AlQ3) as light-emitting materials are studied. The frequency-dependent real and imaginary parts of impedance were fitted using an equivalent circuit. We found that the conduction mechanism is a space-charge limited current with exponential trap distribution.

Ginsenoside Rg₃ activates human KCNQ1 K⁺ channel currents through interacting with the K318 and V319 residues: A role of KCNE1 subunit

Choi, Sun-Hye,Shin, Tae-Joon,Lee, Byung-Hwan,Chu, Dae-hyun,Choe, Han,Pyo, Mi-Kyung,Hwang, Sung-Hee,Kim, Bo-Ra,Lee, Sang-Mok,Lee, Jun-Ho,Kim, Dong-Hyun,Kim, Hyoung-Chun,Rhim, Hye-whon,Nah, Seung-Yeol Elsevier 2010 european journal of pharmacology Vol.637 No.1

<P><B>Abstract</B></P><P>The slowly activating delayed rectifier K<SUP>+</SUP> channels (<I>I</I><SUB><I>Ks</I></SUB>) are one of the main pharmacological targets for development of drugs against cardiovascular diseases. Cardiac <I>I</I><SUB><I>Ks</I></SUB> consists of KCNQ1 plus KCNE1 subunits. Ginsenoside, one of the active ingredient of <I>Panax ginseng</I>, enhances cardiac <I>I</I><SUB><I>Ks</I></SUB> currents. However, little is known about the molecular mechanisms of how ginsenoside interacts with channel proteins to enhance cardiac <I>I</I><SUB><I>Ks</I></SUB>. In the present study, we investigated ginsenoside Rg<SUB>3</SUB> (Rg<SUB>3</SUB>) effects on human <I>I</I><SUB><I>Ks</I></SUB> by co-expressing human KCNQ1 plus KCNE1 subunits in <I>Xenopus</I> oocytes. Rg<SUB>3</SUB> enhanced <I>I</I><SUB><I>Ks</I></SUB> currents in concentration- and voltage-dependent manners. The EC<SUB>50</SUB> was 15.2±8.7µM. However, in oocytes expressing KCNQ1 alone, Rg<SUB>3</SUB> inhibited the currents with concentration- and voltage-dependent manners. The IC<SUB>50</SUB> was 4.8±0.6µM. Since Rg<SUB>3</SUB> acts opposite ways in oocytes expressing KCNQ1 alone or KCNQ1 plus KCNE1 subunits, we examined Rg<SUB>3</SUB> effects after co-expression of different ratios of KCNE1 and KCNQ1. The increase of KCNE1/KCNQ1 ratio converted <I>I</I><SUB><I>Ks</I></SUB> inhibition to <I>I</I><SUB><I>Ks</I></SUB> activations. One to ten ratio of KCNE1 and KCNQ1 subunit is required for Rg<SUB>3</SUB> activation of <I>I</I><SUB><I>Ks</I></SUB>. Mutations of K318 and V319 into K318Y and V319Y of KCNQ1 channel abolished Rg<SUB>3</SUB> effects on KCNQ1 or KCNQ1 plus KCNE1 channel currents. The docked modeling revealed that K318 residue plays a key role in stabilization between Rg<SUB>3</SUB> and KCNQ1 plus KCNE1 or KCNQ1 subunit. These results indicate that Rg<SUB>3</SUB>-induced activation of <I>I</I><SUB><I>Ks</I></SUB> requires co-assembly of KCNQ1 and KCNE1 subunits and achieves this through interaction with residues K318 and V319 of KCNQ1 subunit.</P>

유,초등교사를 위한 다문화 연수 프로그램 개발 및 효과 분석

추병완 ( Beong Wan Chu ),양정혜 ( Jeong Hye Yang ),윤지현 ( Ji Hyun Yoon ),곽현규 ( Hyun Gyu Kwak ),황혜경 ( Hye Kyoung Hwang ) 서울敎育大學校 初等敎育硏究所 2011 한국초등교육 Vol.22 No.3

2010년 11월 교육과학기술부에서 공시한 통계자료에 의하면 국내에 거주하는 국제결혼가정자녀(30,040명, ``09년 대비 21.4% 증가)와 외국인 근로자 자녀(1,748명,``09년 대비 37.6% 증가)의 수가 기하급수적으로 늘어나고 있기 때문에 다문화 교육과 다문화 연수에 대한 관심과 노력이 증가하고 있는 추세이다. 따라서 본 연구는 강원도 지역 유치원 교사 30명과 초등학교 교사90명을 대상으로 한 다문화 연수프로그램의 개발과정과, 운영 후 프로그램 효과를 파악하고자연수에 참여한 교사들의 효능감 향상 정도를 설문을 통해 분석하였다. 개발한 다문화 연수 프로그램은 문헌 분석과 기존 연구를 토대로 프로그램의 내용을 3개 영역, 16∼17개 주제, 총 30시간의 강좌로 구성하였다. 프로그램은 특강과 이론 및 워크샵, 문화체험 등으로 운영하였는데 이는 최근 교사 연수 프로그램의 효과를 극대화시키기 위해 강의식연수에서 탈피하여 다양한 연수 방법을 도입하고 있음을 반영한 것이다. 또한 개발한 프로그램이 교사의 다문화 역량 증진에 기여하는지 분석하고자 다문화 효능감에 관한 사전-사후 검사와연수운영 및 프로그램에 대한 만족도 조사를 실시하였다. 그 결과, 연수 프로그램 적용 후 교사들의 다문화 교수 효능감이 매우 향상되었으며, 만족도가 높게 나타나 본 연구에서 계획하였던 연수 프로그램의 목적을 대체적으로 달성하였음을 알 수 있었다. 추후 연구에는 교사들이 지속적으로 지원받을 수 있는 환경과 낮은 교육 경력과 연령, 다문화연수 경험 유무 등을 고려하여 다양한 트랙을 마련, 학습자 중심의 질적으로 향상된 연수 프로그램을 개발하는 노력이 요구된다. According to the statistical data announced by the Ministry of Education, Science and Technology in November 2010, there is a geometrical growth recently in the number of children of international marriage (30,040, increased by 21.4% over 2009) and children of foreign workers (1,748, increased by 37.6% over 2009). Accordingly, there were also a tremendous interested in multicultural training and education to raised multicultural sensitivity and teaching capacity by directed experience of various cultures beyond class boundary. This study aims to make a suggestion for program development and progress direction after analyzing efficacy of teachers who participated in the program development process and operation of multicultural training program to 30 nursery school teachers and 90 elementary school teachers in Gangwon-do. The multicultural training program consisted of 3 sections, 16∼17 themes and 30 hours class based on literature analysis and existing researches. The program included special lecture, theoretical lesson, workshop and cultural experience which reflected various training methods beyond lecture-based training to maximize its effectiveness. Pre-test and post-test of multicultural efficacy were carried out to analyze multicultural capacity of the program. As a result, it showed the program was effective to develop teachers`` multicultural teaching efficacy after the application of training program. And the satisfaction research of the program was performed to improve quality after reviewing needs and reaction of teachers. It showed overall high satisfaction in achieving the aim of training program

Research Trends in Sustainable Manufacturing: A Review and Future Perspective based on Research Databases

Hyun-Taek Lee,송지현,Soo-Hong Min,Hye-Sung Lee,Ki Young Song,Chong Nam Chu,Sung-Hoon Ahn 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.4

Sustainable manufacturing has become of great importance in various fields include manufacturing, mechanical engineering, materials science, environmental science, and energy science. In this paper, we analyzed and reviewed the research trends of sustainable manufacturing technologies and suggested future perspective. Specifically, the state-of-the-art and historical trajectory of sustainable manufacturing are analyzed using data obtained from the Web of Science library and the Journal Citation Reports (JCR). Selected journals and research categories are evaluated by the number of publications, the number of citations, impact factor (IF), and H-indices. To suggest future perspectives on sustainable manufacturing research, growth rate of each research objects are evaluated and historically followed. Sustainable manufacturing is likely to be change in its nature in the era of digital transformation. It is expected to provide the status and future of research trends of sustainable manufacturing to the both manufacturing researchers and journal publishers.

간세포암의 간동맥 화학색전술 후 합병된 간농양 1예

추현광,김주현,오세진,박혜영,박현철,전형식 대한감염학회 1995 감염 Vol.27 No.1

저자들은 간세포암 환자에서 간동맥 화학색전술 시행 후 합병된 Enterobacter cloacae 에 의한 간농양 1예를 경험하였기에 문헌고찰과 함께 보고한다. Transcatheter arterial chemoembolizaion(TACE) is a useful alternative to surgery and systemic chemotherapy for inoperable hepatocellular carcinoma. The common adverse reaction observed following TACE is a postembolization syndrome which consists of abdominal pain, fever, nausea, vomiting and leukocytosis. Heapatic abscess and septicemia have been reported to be rare complications. We experienced a case of hepatic abscess following TACE for a huge hepatocellular carcinoma. Enterobacter cloacae was isolated from drainage of the abscess and the patient was recovered with antimicrobial therapy and percutaneous drainage of abscess.

생활 스트레스가 경미한 일반 성인에서의 신체적 및 정신적 증상 : 종합병원 건강증진센터 내원자들을 대상으로

주상희,하은혜,이병욱,전덕인,김영현,송동호 한국정신신체의학회 2002 정신신체의학 Vol.10 No.1