공동주택내 이산화질소(NO2) 및 휘발성유기화합물(VOCs) 노출에 따른 건강 위해성 평가

Jung,Soon-Won,Yang,Won-Ho,Son,Bu-Soon 한국환경보건학회 2007 한국환경보건학회지 Vol.33 No.4

Indoor air quality has become a topic of interest and concern. Especially changes in construction design and the increased use of synthetic products may result in an increasing of complaints and health effects about the quality of indoor air at home. In this study, nitrogen dioxide(NO2) and volatile organic compounds(VOCs) within new and established apartments on the basis of 4 years of building year were measured every 3 days consecutively during 60 days. We selected each 10 house in Seoul, Asan and Daegu, respectively, and produced risk numbers for hazard quotients, and predicted increases in incidence of cancer. The calculations were made for the adult with default exposure values and also made for a worst case scenario using Monte-Carlo simulation as describing the reasonable exposure(RME). Mean of Monte carlo analysis by benzene, in the construction under 4 years (male: 9.2105, female: 1.0×104) and over 4years (male: 6.8×105, female: 8.3×105) exceeded 106 of permitted standards in US EPA, RME of Monte carlo analysis. In construction under 4 years (male: 9.9×103, female: 9.6×103) and over 4years (male: 9.8×103, female: 7.8×103) exceeded 104 of maximum permitted standards in US EPA. The hazard index of non-carcinogenic pollutants by nitrogen dioxide, toluene, m,p-xylene and o-xylene, both male and female in apartment constructed under 4 years and over 4 years was found less than the permitted standards of hazardous health effects in CTE. Significant cancer risks and non-cancer hazard quotients were predicted in under 4 years of building year.

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

갑상샘 유두암과 혼재하여 발견된 편평세포암 1예

김호수,정태식,정정화,김수경,이상민,정순일,함종렬 영남대학교 의과대학 2011 Yeungnam University Journal of Medicine Vol.28 No.2

The occurrence of a mixed tumor containing papillary thyroid carcinoma (PTC) and primary squamous-cell carcinoma (SCC) is rare because there is no squamous epithelium in the thyroid gland. Reported herein is a 30-year-old female with mixed PTC and primary SCC of the thyroid presented as thyroid incidentaloma. Fine-needle aspiration biopsy of the thyroid nodule revealed the presence of malignant thyroid cells. The histopathological examination following total thyroidectomy yielded two mixed, morphologically distinct histotypes that included PTC and SCC. After total thyroidectomy, the patient underwent radioactive iodine therapy. No recurrence or metastasis occurred during the 20-month follow-up period after the operation.

Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis

Jung Kyung Hee,Kim Sang Eun,Go Han Gyeol,Lee Yun Ji,Park Min Seok,Ko Soyeon,Han Beom Seok,Yoon Young-Chan,Cho Ye Jin,Lee Pureunchowon,Lee Sang-Ho,Kim Kipyo,Hong Soon-Sun 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.6

According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney ferroptosis remain limited. In this study, we assessed the renoprotective effects of melatonin and zileuton as a novel therapeutic strategy against ferroptosis-mediated kidney injury and fibrosis. First, we identified RSL3-induced ferroptosis in renal tubular epithelial HK-2 and HKC-8 cells. Lipid peroxidation and cell death induced by RSL3 were synergistically mitigated by the combination of melatonin and zileuton. Combination treatment significantly downregulated the expression of ferroptosis-associated proteins, 4-HNE and HO-1, and upregulated the expression of GPX4. The expression levels of p-AKT and p-mTOR also increased, in addition to that of NRF2 in renal tubular epithelial cells. When melatonin (20 mg/kg) and zileuton (20 mg/kg) were administered to a unilateral ureteral obstruction (UUO) mouse model, the combination significantly reduced tubular injury and fibrosis by decreasing the expression of profibrotic markers, such as α-SMA and fibronectin. More importantly, the combination ameliorated the increase in 4-HNE levels and decreased GPX4 expression in UUO mice. Overall, the combination of melatonin and zileuton was found to effectively ameliorate ferroptosis-related kidney injury by upregulating the AKT/mTOR/ NRF2 signaling pathway, suggesting a promising therapeutic strategy for protection against ferroptosis-mediated kidney injury and fibrosis.

제올라이트(NaA형, NaX형)의 이온교환성에 관한 연구

정순희,김복련,금경호,서양곤,안주현 경상대학교 환경보전연구소 2001 環境保全硏究所報 Vol.9 No.-

A study has been made of the exchange of Ag^+, Li^+, and Ba^++, Ca^++, Sr^++ ion by using synthetic zeolite-13X and zeolite-NaA. The zeolite used in this work was supplied as beads by Aldrich Chemical Company, Inc., and the formula of unit cell is M_x/n[AlO₂)_x(SiO₂)_y]zH₂O. X-ray diffraction analysis and Fourier transform infrared spectroscopy indicated that the crystallinity of zeolites was retained though sodium ion in zeolite exchanged with the cation. The amount of ion exchanged was measured by the determining of the amount of cation remained in solution by Inductively coupled plasma, and surface area, adsorption isotherm, Ion exchange kinetics. The selectivity of ions was in the order Ag^+>Li^+>Sr^++>Ca^++>Ba^++.

수종 Laminate Veneer용 도재간의 색차 비교

정유경,홍순호 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.2

The shade of prosthetic materials is very important for a successful restoration esthetically harmonized with the natural tooth. the purposes of this study were to evaluate the color differences that can exist between different brands of procelain laminate veneer systems with identical shade designations and to evaluate the color variations after luting with resin cement. For this purpose, the following experiments were done:4 kinds of porcelain laminate veneer specimens were fired to the same thickness and a resin cement of the same shade was luted to each porcelain laminate veneer specimen. Afterwards, the color of each specimen was determined and analysed by the colorimeter. The results were as follows: Corresponding shades of different brands of porcelain laminate veneer systems produced significantly different colors(p<.05). Color variations were found after luting with resin cement to the porcelain laminate veneer specimens(p<.05).

급성 복증 소견을 보인 신증후출혈열 1예

신호식,정연순,임학 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Hemorrhagic fever with renal syndrome (HFRS) frequently cause abdominal pain with tenderness; therefore this is occasionally misdiagnosed as surgical abdomen. A 20-year-old male presented with abdominal pain for 2 days. He also had suffered from fever since 7 days ago. Abdominal computed tomography showed ascites along both paracolic gutters, mesentery and paravesical spaces. Hantaan virus infection was demonstrated by serology. After conservative treatment, the patient with HFRS spontaneously improved. We report a case of HFRS presented acute focal abdominal pain of acute abdomen.

혈청 Cystatin C와 크레아티닌에 근거한 사구체 여과율의 비교

신호식,정연순,임학 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : In recent years, cystatin C (CysC) was proposed as a new marker for the glomerular filtration rate (GFR) due to a constant serum level. The present study analyzes whether creatinine based GFR prediction equations might be replaced by simple prediction equations based on serum concentrations of CysC in healthy young Korean men. Methods : We studied 145 apparently healthy young Korean men aged 19-29 years who visited The Armed Forces Yangju Hospital (Gyeonggi Province, Repulic of Korea) for health check from November 2008 to January 2009. Creatinine-based GFR was estimated by the formula of modified MDRD, Crockcroft Gault (CG). CysC-based GFR was estimated by the formula of Larsson, Hoek, Filler, Grubb, Le Bricon, Orebro-cyst (DAKO), Orebro-cyst (Gentian). Linear regression analysis was performed to evaluated correlations between GFR estimating formulae based upon serum CysC and serum creatinine. Results : Among CysC based GFR, Hoek's GFR is most similar with CG GFR and abbreviated MDRD GFR. Significant correlations were noted between CysC based GFR and creatinine based GFR. Conclusion : Creatinine based GFR prediction equations for healthy young Korean men might be replaced by simple prediction equations based on serum concentrations of CysC (especially Hoek' equation). 배경 : 혈청 cystatin C는 외부 요인에 영향을 받지 않고 일정한 값을 유지하므로 사구체 여과율에 대한 새로운 표지자로 제시되고 있다. 본 연구는 젊은 성인 남성에서 cystatin C에 근거한 사구체 여과율이 혈청 크레아티닌에 의한 사구체 여과율을 대체할 수 있는지 조사하였다. 방법 : 2008년11월부터 2009년1월까지 병원을 방문한 평균 연령 21세의 젊은 성인남성 145명을 대상으로 하였다. Cystatin C에 근거한 사구체 여과율은 Larsson, Hoek, Filler, Grubb, Le Bricon, Orebro-cyst (DAKO), Orebro-cyst (Gentian) 공식을 이용하였고 혈청 크레아티닌에 근거한 사구체 여과율은 변형된 MDRD, Crockcroft Gault 공식을 이용하여 산출하였다. Cystatin C에 근거한 사구체 여과율과 혈청 크레아티닌에 근거한 사구체 여과율은 선형 회귀분석을 통해서 연관 관계를 확인하였다 결과 : Cystatin C에 근거한 사구체 여과율 산출 공식중에서 Hoek 공식에 의한 사구체 여과율이 혈청 크레아티닌에 근거한 사구체 여과율과 의미있는 상관관계를 보였다. 결론 : 젊은 성인 남성에서 Cystatin C에 근거한 사구체 여과율은 혈청 크레아티닌에 의한 사구체 여과율을 대체할 수 있을 것으로 생각된다.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

콩 생산의 효율성 요인분석과 벤치마킹

이순석,조성주,정호근 한국농업정책학회, 한국축산경영학회 2003 농업경영정책연구 Vol.30 No.3

This study aims to estimate the efficiency of soybean production using Data Envelopment Analysis, analyze the characteristics of efficient soybean agriculture using Tobit model, and calculate the efficient input-output levels of inefficient farmers using a frontier isoquant curve on the technical efficiency measures. The main results of this study are as follows: first, the technical and scale efficiency measures of the soybean farming were 0.832, 0.919, respectively; second, the average excessive levels of input cost are 9.1 hundred thousand won in 25 inefficient farmers.