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Zebrafish Vascular Development: General and Tissue-Specific Regulation
Nakajima Hiroyuki,Chiba Ayano,Fukumoto Moe,Morooka Nanami,Mochizuki Naoki 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.2
Circulation is required for the delivery of oxygen and nutrition to tissues and organs, as well as waste collection. Therefore, the heart and vessels develop first during embryogenesis. The circulatory system consists of the heart, blood vessels, and blood cells, which originate from the mesoderm. The gene expression pattern required for blood vessel development is predetermined by the hierarchical and sequential regulation of genes for the differentiation of mesodermal cells. Herein, we review how blood vessels form distinctly in different tissues or organs of zebrafish and how vessel formation is universally or tissue-specifically regulated by signal transduction pathways and blood flow. In addition, the unsolved issues of mutual contacts and interplay of circulatory organs during embryogenesis are discussed.
Influence of Cobalt Content on the Fatigue Strength of WC-Co Hardmetals
Nakajima Takeshi,Hosokawa Hiroyuki,Shimojima Koji 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The behavior of hardmetals under cyclic loads is investigated. Unnotched specimens were employed to obtain practical information regarding fatigue in hardmetals. All the tested hardmetals exhibit an increase in the number of cycles until failure with a decrease in the maximum stress, i.e., the hardmetals exhibit a high fatigue sensitivity. The fatigue strength increases with the cobalt content. Although distinct fatigue limits, as observed in metals, cannot be observed, the calculated fatigue limit stress at cycles is found to be approximately 70% of the flexural strength, and the stress value exhibits a linear relationship with the flexural stress.
Osamu Mikami,Hiroyuki Yamaguchi,Hideo Murata,Yasuyuki Nakajima,Shigeru Miyazaki 대한수의학회 2010 Journal of Veterinary Science Vol.11 No.2
Six 1-month-old piglets were intravenously injected with deoxynivalenol (DON) at the concentration of 1 mg/kg body weight, with three pigs each necropsied at 6 and 24 h post-injection (PI) for investigation of hepatotoxicity and immunotoxicity with special attention to apoptotic changes and cytokine mRNA expression. Histopathological examination of the DON-injected pigs revealed systemic apoptosis of lymphocytes in lymphoid tissues and hepatocytes. Apoptosis of lymphocytes and hepatocytes was confirmed by the TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method and immunohistochemical staining against singlestranded DNA and cleaved caspase-3. The number of TUNELpositive cells in the thymus and Peyer’s patches of the ileum was increased at 24 h PI compared to 6 h PI, but the peak was at 6 h PI in the liver. The mRNA expression of interleukin (IL)-1β, IL-6, IL-18, and tumor necrosis factor (TNF)-α in the spleen, thymus and mesenteric lymph nodes were determined by semi-quantitative RT-PCR, and elevated expression of IL-1β mRNA at 6 h PI and a decrease of IL-18 mRNA at 24 h PI were observed in the spleen. IL-1β and IL-6 mRNA expressions increased significantly at 6 h PI in the thymus, but TNF-α decreased at 6 h PI in the mesenteric lymph nodes. These results show the apoptosis of hepatocytes suggesting the hepatotoxic potential of DON, in addition to an immunotoxic effect on the modulation of proinflammatory cytokine genes in lymphoid organs with extensive apoptosis of lymphocytes induced by acute exposure to DON in pigs.
Factor Structure of the Targeted Inventory on Problems in Schizophrenia
Shoji Tanaka,Takanori Nagase,Takefumi Suzuki,Kensuke Nomura,Hiroyoshi Takeuchi,Shinichiro Nakajima,Hiroyuki Uchida,Gohei Yagi,Koichiro Watanabe,Masaru Mimura 대한정신약물학회 2013 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.11 No.1
Objective: The aim of this study was to explore the factor structure of a novel, 10-item rating scale, the Targeted Inventory on Problems in Schizophrenia (TIP-Sz). Determining the factor structure will be useful in the brief evaluation of medication and non-medication treatment of the disease. Methods: An exploratory factor analysis was performed on TIP-Sz scores obtained from 100 patients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for schizophrenia. Results: The factor analysis extracted four factors that were deemed clinically pertinent, which we labeled: disorganization, social cooperativeness, functional capacity, and emotional state. The items exhibited cross-loadings on the first three factors (i.e.,some items loaded on more than one factor). In particular, the ‘behavioral dyscontrol and disorganization,’ ‘insight and reality testing,’ and ‘overall prognostic impression’ items had comparable cross-loadings on all of the first three factors. The emotional state factor was distinct from the other factors in that the items loading on it did not cross-load on other factors. Conclusion: The TIP-Sz scale comprises factors that are associated with the psychosocial functioning and emotional state of patients, which are important outcome parameters for successful treatment of the disease.
An integrated approach to tropical and subtropical island conservation
Yamano, Hiroya,Satake, Kiyoshi,Inoue, Tomomi,Kadoya, Taku,Hayashi, Seiji,Kinjo, Koichi,Nakajima, Daisuke,Oguma, Hiroyuki,Ishiguro, Satoshi,Okagawa, Azusa,Suga, Shinsuke,Horie, Tetsuya,Nohara, Katsuhit The Ecological Society of Korea 2015 Journal of Ecology and Environment Vol.38 No.2
After the reversion of Okinawa (Ryukyu Islands) to Japan in 1972, extensive urban and agricultural development resulted in a significant increase in sediment discharge to coastal waters. The release of sediment has caused the degradation of freshwater and coastal ecosystems and biodiversity. A consideration for catchment-to-reef continua, as well as agricultural (socioeconomic) factors is necessary to establish proper land-based management plans for the conservation of the island environment. We have set up a framework to integrate biophysics and socioeconomics: 1) setting a conservation target and threshold, 2) identifying the sources and processes, and 3) examining cost-effectiveness and management priorities. The framework may be applicable to other tropical and subtropical islands with similar characteristics.
Performance Analysis of Ubiquitous Power Systems under Coordinated Control of System Elements
Liyanage, Kithsiri M.,Masuta, Taisuke,Shimizu, Koichiro,Kihara, Hiroyuki,Yokoyama, Akihiko,Ota, Yutaka,Nakajima, Tatsuhito,Taniguchi, Haruhito The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.1
The trend of integrating renewable energy sources into power networks is becoming common in practice, making power systems to be more ubiquitous in nature. The connection of renewable sources in large numbers at distribution level could cause adverse power fluctuations. By employing battery energy storage systems, these fluctuations can be reduced. However economic constraints imposed by high battery cost may not justify liberal use of battery storage to control power fluctuations. The authors have previously shown the possibility of reducing battery energy storage systems' capacity without degrading the performance in terms of energy capturing efficiency and arresting power fluctuations of a ubiquitous power network through coordinated control of elements. Meantime there are attempts to make use the battery energy storage available in electric vehicles to provide a cushion against power and frequency fluctuations caused by renewable generation. In this paper authors presents a comparison between the effectiveness of conventional battery energy storage system and that of battery energy storage available in electric vehicles to improve the performance of ubiquitous power network under coordinated control. This study has shown that energy storage from electric vehicles can outperform conventional battery energy storage systems of similar capacity range under certain conditions.
Tadayuki Takagi,Mitsuru Sugimoto,Hidemichi Imamura,Yosuke Takahata,Yuki Nakajima,Rei Suzuki,Naoki Konno,Hiroyuki Asama,Yuki Sato,Hiroki Irie,Jun Nakamura,Mika Takasumi,Minami Hashimoto,Tsunetaka Kato 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.1
high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needlefor MSI evaluation in patients with UR-PC. Methods: A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) orEUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33)were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patientswho underwent EUS-FNB and those who underwent EUS-FNA. Results: No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwentEUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained usingEUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariateanalysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. Conclusions: EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.
An integrated approach to tropical and subtropical island conservation
Hiroya Yamano,Kiyoshi Satake,Tomomi Inoue,Taku Kadoya,Seiji Hayashi,Koichi Kinjo,Daisuke Nakajima,Hiroyuki Oguma,Satoshi Ishiguro,Azusa Okagawa,Shinsuke Suga,Tetsuya Horie,Katsuhito Nohara,Naoko Fukay 한국생태학회 2015 Journal of Ecology and Environment Vol.38 No.2
After the reversion of Okinawa (Ryukyu Islands) to Japan in 1972, extensive urban and agricultural development resulted in a significant increase in sediment discharge to coastal waters. The release of sediment has caused the degradation of freshwater and coastal ecosystems and biodiversity. A consideration for catchment-to-reef continua, as well as agricul¬tural (socioeconomic) factors is necessary to establish proper land-based management plans for the conservation of the island environment. We have set up a framework to integrate biophysics and socioeconomics: 1) setting a conservation target and threshold, 2) identifying the sources and processes, and 3) examining cost-effectiveness and management pri¬orities. The framework may be applicable to other tropical and subtropical islands with similar characteristics.