Adsorption and Desorption Analysis of Plasma Proteins by QCM

Yuki Sato,Takahiro Ishizaki,Nagahiro Saito,Osamu Takai 한국표면공학회 2008 한국표면공학회 학술발표회 초록집 Vol.2008 No.-

日本史の時代区分に関する覚書:「中世」について

佐藤雄基(Sato, Yuki) 동북아시아문화학회 2020 동북아시아문화학회 국제학술대회 발표자료집 Vol.2020 No.10

The aim of this paper is to rethink the periodization of "medieval" in Japanese history. There are two main ways to classify periods. One is the method of naming the periods based on the location of the government (the emperor or the warrior government). The second method is based on the Three or Four Periods of Ancient, Medieval, (Early Modern), or Modern.

朝河貫一とマルクブロックの交流について : ?米の?史?における日本中世史と封建制論の再?討

佐藤雄基(SATO Yuki) 동북아시아문화학회 2009 동북아시아문화학회 국제학술대회 발표자료집 Vol.2009 No.10월

Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)

Inoue Yuki,Wada Yuko,Sato Makoto,Sato Seiji,Okamoto Takashi,Kanemoto Naohide 한국독성학회 2023 Toxicological Research Vol.39 No.4

FCCP (carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone) is known to inhibit oxidative phosphorylation as a protonophore, dissipating the proton gradient across the inner mitochondrial membrane. To understand the toxicity of FCCP, 3-day, 2- and 4-week repeated oral dose studies were performed in male rats. In the 3-day and 2-week repeated dose toxicity studies, observations included salivation, increased body temperature, and dead and moribund animals. Increased liver weight was observed in conjunction with hydropic degeneration and centrilobular necrosis of hepatocytes. In addition, pathological changes were observed in the pancreas, testis, epididymal duct, stomach and parotid gland. Electron microscopic examination revealed mitochondrial pleomorphism in the hepatocytes. Swelling of mitochondria was observed in the alpha cells and beta cells of the pancreas. Dilatation of rough endoplasmic reticulum, Golgi bodies and loss of secretory granules were also noted in the beta cells of the pancreas. FCCP was also compared with three other mUncouplers (DNP, OPC-163493 and tolcapone) with regard to in vitro mitochondrial uncoupling (mUncoupling) activities. FCCP produced the peak ΔOCR (oxygen consumption rate) at the lowest concentration (0.4 μM), followed by OPC-163493, tolcapone, and DNP, based on peak values in ascending order of concentration (2.5, 10, and 50 μM, respectively). Considering the relationship between the mUncoupling activity and toxicity profile of the four mUncouplers, there is no parallel relationship between the in vitro mUncoupling activity and the degree of in vivo toxicity. These findings may contribute to the efficient development of new mitochondrial uncoupler candidates.

Vol.- No.- [2008] : 9ㆍ10世紀において

佐藤雄基(SATO Yuki) 동북아시아문화학회 2008 동북아시아문화학회 국제학술대회 발표자료집 Vol.- No.-

The two representative styles of documents in medieval Japan are "Kudashibumi," an edict with the force of law, and "Migyosho," a letter of instruction. Regarding the formation of these, there is the opinion that hypothesizes the era of retired emperors (Insei-ki), due to the handed down situation of existing documents, and recently there is the opinion that finds the origin of medieval document styles in the ancient writing of the Nara period. Regarding the "Migyosho", some argue for the existence of this in the Nara period, according to the definition by style of the Hosho-style, a document that a trusted vassal created in place of a noble master. However, the research terminology of "Migyosho" in ancient writing includes "Rokuhara Migyosho" and "Cohan Migyosho," which are not the Hosho-style, thus this opinion is influenced by the expression of historical archives and is not a refined opinion. "Migyosho," as it is found in historical archives, was called this to show respect due to the social relation between the giver and receiver, and as the names of these documents reflect the actual function of the document, they can be thought to be more fundamental than a definition by style. The name "Migyosho" goes back to the early 10<SUP>th</SUP> century, and appears together with the "Kokusho" as a document of the period of regents and advisers, corresponding to the ancient documents "Fu" and "Cho" in the Law on Official Communication of the Ritsuryo Codes. The "Kokusho" style document was used as an ordering document different from "Fu," from the 10<SUP>th</SUP> century to the 11<SUP>th</SUP> century. The names "Kokusho" and "Migyosho" were borrowed from the names and knowledge of Chinese official documents. Documents in styles similar to Kokusho did exist before the 9<SUP>th</SUP> century, but there was no clear distinction between "Fu", and the style and function did not always correspond. From the late 9<SUP>th</SUP> century to the 10<SUP>th</SUP> century, document styles were organized according to Chinese culture, and function and style began to correspond. By absorbing the function of the "Kokusho", which was established in this way, the medieval document "Kudashibumi" appears in the 11<SUP>th</SUP> century. It is true that there are document styles of the Nara period that can be connected to medieval document styles. However, when considering the corresponding of function and style, the function and style of medieval documents were formed between the late 9<SUP>th</SUP> century and 10<SUP>th</SUP> century.

민주적 사회의 실현과 “부정의의 감각(sense of injustice)” : 한일 비교를 통한 ‘민주시민교육’에 있어서의 젠더 교육의 가능성

사토 유키에(Yukie Sato) 동서대학교(동아시아연구원) 2022 동아시아와 시민 Vol.1 No.-

본 논문은 근년 활발히 논의되고 있는 ‘민주시민교육’이란 무엇이며, ‘민주시민교육’으로 어떤 교육이 필요한지를 한일 비교를 통해 밝히는 것을 목적으로 하는 것이다. 특히 한일에서 필요한 교육에 관해서는 젠더 측면에 주목하여 검토한다. 이 목적을 달성하기 위해 본 논문은 다음 세 가지 과제를 해명한다. 첫째로, ‘민주시민교육’의 특징에 관한 것이다. 본 논문에서는 ‘민주시민교육’과 ‘시민교육’을 비교하여, ‘시민교육’이 국민국가를 전제로 ‘주권자’로서의 ‘시민’을 양성하는 교육인 한편, ‘민주시민교육’은 글로벌한 ‘시민’을 양성하는 교육이라는 것을 지적한다. 또한, 한국에서는 이 두 가지 교육을 모두 ‘민주시민교육’이라 부르는 경향이 있음을 밝힌다. 둘째로, ‘민주시민교육’으로 지향해야 할 ‘민주주의’에 관한 것이다. 본 논문에서는 숙의민주주의가 가지는 장점과 한계를 검토하여, 모든 소수자가 “부정의의 감각”을 표출할 수 있는 사회를 민주적 사회라고 정의한다. 셋째로, “부정의의 감각”이 표출 가능한 사회를 실현하기 위해 필요한 교육에 관한 것이다. 본 논문에서는 한일에서 활발해진 #MeToo운동을 “부정의의 감각”이 표출된 사례로 분석함으로써, 민주적 사회를 실현하기 위해 세대를 막론한 젠더 교육의 실시가 중요함을 지적한다. 이상과 같은 본 논문은 ‘민주시민’의 양성을 위해 젠더 교육이 중요하고 현실적인 교육임을 제시하는 동시에, 한일에서 ‘시민’의 정의를 ‘주권자’에서 ‘동아시아 시민’으로 확장하기 위한 중요한 단서를 제공하는 것이다. This study aims to examine the kind of education required for the Education for Democratic Citizenship (EDC) and the potential of gender education for EDC by comparing cases between South Korea and Japan. Toward this end, it intends to answer the following questions. First, which characteristics of EDC distinguish it from citizenship/civic education? Second, what form of democracy should EDC endeavor to achieve? Third, what type of education is required to make society more democratic? In response to these questions, this study provides the following clarifications. First, citizenship/civic education aims to nurture citizens as sovereigns, whereas EDC endeavors to nurture them as global citizens; in South Korea, these two concepts are frequently referred using the same term. Second, the democratic society that EDC should works toward achieving is one wherein the “sense of injustice” of minorities is widely expressed. Third, to realize such a democratic society, education that can reduce existing inequality and discrimination is required, and gender education must be the core of such an education. This study provides a significant clue for expanding the definition of citizens in South Korea and Japan from being components of a nation-state to East Asian citizens.

Clinical Value of CT-Guided Needle Biopsy for Retroperitoneal Lesions

Yuki Tomozawa,Yoshitaka Inaba,Hidekazu Yamaura,Yozo Sato,Mina Kato,Takaaki Kanamoto,Makoto Sakane 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.3

Objective: The purpose of this study was to investigate retrospectively the clinical procedural performance of CT-guided needle biopsy for retroperitoneal lesions. Materials and Methods: CT-guided needle biopsy was performed in 74 consecutive patients (M:F = 44:30; mean age, 59.7 years) with retroperitoneal lesions between April 1998 and June 2009. The target lesion ranged from 1.5 to 12.5 cm in size. The biopsy access path ranged from 3.5 to 11.5 cm in depth. A biopsy specimen was obtained using an 18-gauge core needle under a CT or CT-fluoroscopy guidance and with the patient under local anesthesia. The histopathological diagnoses from the biopsies were obtained. The diagnostic confirmation of the subtype of lymphoma was evaluated. Results: Satisfactory biopsy samples were obtained in 73 (99%) of 74 patients and a pathological diagnosis was made in 70 (95%) of 74 patients. Sixty three lesions were malignant (45 lymphomas, nine primary tumors, nine lymph node metastases) and seven were benign. The subtype of lymphoma was specified in 43 (96%) of 45 patients who were diagnosed with lymphoma. Analysis of the value of CT-guided biopsy in this series indicated 63 true positives, zero false positive, six true negatives and five false negatives. This test had a sensitivity of 93%, a specificity of 100% and an accuracy of 93%. No major complications were seen and minor complications were noted in seven patients (five with local hematomas, two with transient pain at the puncture site). Conclusion: CT-guided needle biopsy for retroperitoneal lesions is highly practical and useful, and particularly for determining the subtypes in patients with lymphoma. Objective: The purpose of this study was to investigate retrospectively the clinical procedural performance of CT-guided needle biopsy for retroperitoneal lesions. Materials and Methods: CT-guided needle biopsy was performed in 74 consecutive patients (M:F = 44:30; mean age, 59.7 years) with retroperitoneal lesions between April 1998 and June 2009. The target lesion ranged from 1.5 to 12.5 cm in size. The biopsy access path ranged from 3.5 to 11.5 cm in depth. A biopsy specimen was obtained using an 18-gauge core needle under a CT or CT-fluoroscopy guidance and with the patient under local anesthesia. The histopathological diagnoses from the biopsies were obtained. The diagnostic confirmation of the subtype of lymphoma was evaluated. Results: Satisfactory biopsy samples were obtained in 73 (99%) of 74 patients and a pathological diagnosis was made in 70 (95%) of 74 patients. Sixty three lesions were malignant (45 lymphomas, nine primary tumors, nine lymph node metastases) and seven were benign. The subtype of lymphoma was specified in 43 (96%) of 45 patients who were diagnosed with lymphoma. Analysis of the value of CT-guided biopsy in this series indicated 63 true positives, zero false positive, six true negatives and five false negatives. This test had a sensitivity of 93%, a specificity of 100% and an accuracy of 93%. No major complications were seen and minor complications were noted in seven patients (five with local hematomas, two with transient pain at the puncture site). Conclusion: CT-guided needle biopsy for retroperitoneal lesions is highly practical and useful, and particularly for determining the subtypes in patients with lymphoma.

전시-P-120 : Hydrogen bondings of aged wood analyzed by infrared spectroscopy under tension

( Yukie Saito ),( Hanae Morinobu ),( Masatoshi Sato ),( Hirokazu Yamamoto ),( Tadatsugu Tai ) 韓國木材工學會 2013 한국목재공학회 학술발표논문집 Vol.2013 No.-

Long-term outcome after surgery in a patient with intestinal Behçet’s disease complicated by myelodysplastic syndrome and trisomy 8

( Yuki Mori ),( Fumihiko Iwamoto ),( Yasuaki Ishida ),( Toru Kuno ),( Shoji Kobayashi ),( Takashi Yoshida ),( Tatsuya Yamaguchi ),( Tadashi Sato ),( Makoto Sudo ),( Daisuke Ichikawa ),( Nobuyuki Enomo 대한장연구학회 2020 Intestinal Research Vol.18 No.4

Behçet’s disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but that the etiology of intestinal BD is at least partly derived from MDS itself. Furthermore, there is a relationship between MDS in patients with intestinal BD and trisomy 8. Immunosuppressive agents alone are insufficient to control MDS-associated BD, and many of these patients die of infection or hemorrhage. Surgery is considered for intestinal BD patients who are unresponsive to medical treatment or those with bowel complications such as perforation or persistent bleeding. We report a case of intestinal BD associated with MDS and trisomy 8. The patient was unresponsive to oral steroids and immunosuppressive treatment; the patient improved by surgical repair of a bowel perforation. Five years after the surgery, the patient is free of recurrence and not on medication. Our experience suggests that surgery may provide an effective therapeutic option for the treatment of MDS-related BD. (Intest Res 2020;18:469-475)

Endoscopic necrosectomy through a self-expandable metallic stent placed percutaneously for walled-off pancreatic necrosis

Yozo Sato,Kazuo Hara,Nozomi Okuno,Shinichi Murata,Takaaki Hasegawa,Hiroyuki Morinaga,Yuki Kimbara,Yugo Imai,Hidekazu Yamaura,Yoshitaka Inaba 소화기인터벤션의학회 2020 International journal of gastrointestinal interven Vol.9 No.3

Walled-off pancreatic necrosis (WOPN) is defined as encapsulated necrotic tissue after severe acute pancreatitis. Treatment strategies for WOPN can be challenging. Although open surgical necrosectomy is the standard treatment for WOPN, it is associated with high rates of morbidity and mortality. Endoscopic necrosectomy, introduced recently, is a treatment option that produces lower rates of morbidity than does open surgery. We report a case of severe WOPN that could not be treated with the usual procedures. Although endoscopic necrosectomy of the left subphrenic and prepancreatic spaces was technically impossible, these spaces could be percutaneously drained. Finally, sufficient drainage of these spaces was achieved with endoscopic necrosectomy through the internal lumen of the self-expandable metallic stent placed percutaneously. This procedure was performed by an endoscopist and an interventional radiologist, and the multidisciplinary approach was useful.