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Trisomy 9 Mosaicism in an Extremely Low Birth Weight Infant
( Hannah Cho ),( Ju Sun Heo ),( Ki Hoon Ahn ),( Soon-cheol Hong ) 대한주산의학회 2021 Perinatology Vol.32 No.2
Trisomy 9 mosaicism is a rare chromosomal abnormality with distinct and recognizable clinical features. In this report, we present an extremely low birth weight (ELBW) infant with trisomy 9 mosaicism. A male preterm infant born at 31+3 weeks of gestation, weighing 922 g, was delivered by cesarean section. Prenatal findings revealed severe intrauterine growth restriction and oligohydramnios. The result of non-invasive prenatal test was a low risk for chromosomal anomalies including trisomy 9. After birth, dysmorphic features were present, such as microcephaly, palpebral fissure, low set ears, a bulbous nose, micrognathia, and a high-arched palate. He also had a single umbilical artery, bilateral inguinal hernia, and cryptorchidism. Intra-organ evaluation revealed ventriculomegaly, mesocardia, absent right brachiocephalic trunk with double superior vena cava, and bilateral renal hypoplasia. He needed the respiratory support of a humidified high-flow nasal cannula until 4 months of corrected age. He had feeding difficulties requiring tube feeding because of poor oral sucking. The result of a postnatal chromosome study confirmed trisomy 9 mosaicism. To the best of our knowledge, this is the first case of an ELBW infant with trisomy 9 mosaicism in South Korea.
Hannah Kim(김한나),Hyun A Kim(김현아),Tae-guen Son(손태근),Hyunchul Cho(조현철),Jerome Charton(샤통 제롬),Woo Shik Jeong(정우식),Jong Woo Choi(최종우),Youngjun Kim(김영준) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11
Orbital wall is the thinnest bone that surrounds eyeballs. When there is an external force to mid-upper face, it is blown out to protect the eye from the pressure. Orbital fracture is a common traumatic deformity, but it can cause not only functional problems, but also esthetical problems such as exophthalmos or enophthalmus, and diplopia. The surgeon corrects eyeball position by placing plates to the fractured sites, but limited intra-operative view and complex anatomy make it difficult. 3D surgical software systems have been used for seeming the patient safety and getting reliable outcomes. However, these are not specialized for the surgery and time-consuming manual works are needed frequently. Thus, we propose a virtual surgical planning and implant design system. We focus on increasing usability by automated functions and minimized user interaction. There are four main modules in the proposed system. First, 3D patient’s model is automatically reconstructed from CT data, and the next, the fractured region is detected and visualized by registration of both orbits. Based on the detected area, patient-specific implant is designed using template models. After the surgery, pre-and post-operative 3D models can be compared and analyzed by using synchronized dual view, measurement tools and visualization of the difference of both models. We performed visual inspection for 3D modeling and fractured detection. As a result, the orbital wall of 3D facial model is properly reconstructed without unnecessary holes and the detected regions include real fractured sites properly. The average processing time takes about 4 minutes. In comparison with conventional systems, ours covers most functions and has strengths for automated functions such as orbital wall segmentation and fracture detection. We expect that the automated and optimized functions can reduce pre-operation time and improved surgical outcomes can be derived by using patient-specific 3D printed implant.
( Hannah Kim ),( Woon Jung Cho ),( Kwang Hee Han ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
Active or adaptive camouflage refers to rapid concealment of the self by changing color to match that of the background. Especially in today`s combats in which situation evolves second by second, rapid adjustment to blend into the surroundings is critical for survival. In order to meet such demands, the authors have developed CamouLED, a system that allows real-time adaptation to background. It consists of three major parts: a CMOS camera that reads background scenes, a patterning algorithm that processes the received image and generates a camouflage pattern and an 8 x 8 LED array that displays the generated camouflage pattern. The patterning algorithm contains three color combination strategies (Average, Main, Mosaic) and two pattern arrangement strategies (Arranged, Random). Combination of the two strategies allows generation of total six types of patterns. This study attempted to assess effectiveness of CamouLED as a means of camouflage in real environment. Photo simulation experiment previously conducted by the authors identified Average Random (AR) as the best strategy in the woodland background. In line with this, it was hypothesized that AR would also be a more effective camouflage strategy for CamouLED, compared to Average or Main. The LED array was placed among the bushes. Participants were asked to walk slowly towards the camouflaged target and try to locate it. The starting distance between the target and the participant was 50 meters.
( Hannah Jo ),( Young Woo Eom ),( Hyun-soo Kim ),( Hong Jun Park ),( Hee Man Kim ),( Mee-yon Cho ) 대한소화기학회 2018 Gut and Liver Vol.12 No.6
Background/Aims: Regulatory dendritic cells (rDCs), which can be induced by mesenchymal stem cells (MSCs), play an important role in inducing and maintaining homeostasis of regulatory T cells and exhibit anti-inflammatory functions. In this study, we investigated whether MSCs could differentiate DCs into rDCs and compared the therapeutic effects of rDCs and MSCs on dextran sodium sulfate (DSS)-induced chronic colitis mice. Methods: Immature DCs (imDCs) and lipopolysaccharide (LPS)-treated mature DCs (mDCs) were co-cultured with MSCs for 48 hours, and then the profiles of surface markers and cytokines and regulatory roles of these DCs for primary splenocytes were analyzed. In addition, the therapeutic effects of MSCs and DCs co-cultured with MSCs were compared in chronic colitis mice. Results: After co-culture of imDCs (MSC-DCs) or LPS-treated mDCs (LPS+MSCDCs) with MSCs, the expression of CD11c, CD80, CD86, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), was decreased, but that of CD11b, IL-10, and transforming growth factor-β (TGF-β) was increased. Furthermore, MSC-DCs and LPS+MSC-DCs induced the expression of CD4, CD25, and Foxp3 in primary splenocytes isolated from mice. In DSS-induced colitis mice, MSCs and MSC-DCs increased colon length, body weight, and survival rate and induced histological improvement. Moreover, in the colon tissues, the expression of IL-6, TNF-α, and IFN-γ decreased, but that of IL-10, TGF-β, and Foxp3 increased in the MSC- and MSC-DC-injected groups. Conclusions: Our data suggest that MSCs differentiate DCs into rDCs, which ameliorate chronic colitis. Thus, rDCs stimulated by MSCs may be therapeutically useful for the treatment of chronic inflammatory diseases. (Gut Liver 2018;12:664-673)