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Application of fracture mechanical assessment to in-wall shield ribs in ITER vacuum vessel
Kim, Yu-Gyeong,Kim, Hyun-Soo,Park, Chul-Kyu,Kim, Gwang-Ho,Moon, Ho-Kyu,Hong, Kwen-Hee,Chung, Woo-Ho,Lee, Hyeon-Gon,Sa, Jeong-Woo,Choi, Chang-Ho,Sim, Jae-Min,Chang, Yoon-Suk North-Holland 2017 Fusion engineering and design Vol.124 No.-
<P><B>Abstract</B></P> <P>In-wall shield ribs are installed between double walls of vacuum vessel and their role is to hold neutron shielding blocks. Since one of key issues on these structures is to sustain integrity during entire ITER operation without any in-service inspection or maintenance, fracture behavior shall be evaluated in design stage. In the present study, a weight function method was employed for crack initiation assessment. The most critical structure was selected as a representative one and its structural integrity was evaluated. In order to check validity of this method, an extended finite element method was adopted for bounding cases. As a result, not only structural safety but also quite conservatism were observed comparing to those of extended finite element analysis with similar tendency. It means that the weight function method could be a conservatively practical approach for fracture mechanical assessment of in-wall shield ribs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Structural analysis of IWS rib assembly was performed and verified via RCC-MR. </LI> <LI> Systematic crack initiation assessment was conducted by using weight function method. </LI> <LI> Conservatism of the weight function method was verified by detailed X-FEM analyses. </LI> </UL> </P>
심방세동 환자에서 class Ic 항부정맥제 사용 중 발생한 wide QRS 빈맥 2예
심재광 ( Sim Jae Gwang ),이동일 ( Lee Dong Il ),장병일 ( Jang Byeong Il ),신현주 ( Sin Hyeon Ju ),변기현 ( Byeon Gi Hyeon ),김영우 ( Kim Yeong U ),김종현 ( Kim Jong Hyeon ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Wide QRS tachycardia may represent a rare proarrhythmic effect of some antiarrhythmic agents. Class Ic antiarrhythmic agents produce rate- dependent ventricular conduction slowing due to use-dependent sodium channel blockade, causing QRS prolongation in c
김광수,김삼식,김대한,황진석,심재철,이민석,이윤순,박일수 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2
목적 : 자궁경부의 선편평상피암은 원발성 자궁경부암의 약 2∼3%를 차지하며, 최근 편평상피암에 비해 그 상대적 빈도가 증가하는 추세이다. 그러나 우리나라에서는 자궁경부선암에 대한 몇 번의 통계적 조사외엔 구체적 임상적 연구가 드물다. 이에 선암 및 선편평상피암 환자들의 임상적 양상에 대한 분석을 시도하였다. 대상 및 방법 : 대상은 경북대학교 병원 및 동국대학교 경주병원 산부인과에서 자궁경부선암 및 선편평상피암으로 진단받은 환자들의 임상기록지를 통하여 연령별 분포, 임상병기별분포 및 이에 따른 치료, 증상 등의 임상적 양상을 분석하였다. 결과 : 1. 환자의 평균 연령은 49.5세로, 선암은 51.9세, 선편평상피암은 45세이다. 2. 임상병기별 분포는 1기가 22예(52.3%)로 가장 많았고, 2기 17예(40.5%), 3기 1예(2.4%), 4기 1예(2.4%)였다. 3. 분만 횟수는 1∼4회가 26예(61.9%)로 가장 많았다. 4. 가장 흔한 임상증상은 자궁출혈(비정기 출혈, 성교후 출혈, 폐경후 출혈)로 42예중 27예(64.3%)였으며, 그외 대하, 요통, 복통 등을 호소하였다. 5. 조직분화정도에 따른 분포는 well differentiated type이 15예(35.7%)로 가장 많았고, moderate differentiated type이 13예(30.9%), poorly differentiated type이 7예 (16.7%)였다. 6. class Ⅲ 이상의 비정형 질세포진 검사예는 20예(47.6%)였다. 7. 조직분화정도에 따른 임파절전이는 well differentiated type이 1예(14.3%), moderate differentiated type이 3예(27.3%), poorly differentiated type이 1예(33.3%)였다. 결론 : 임상적으로 잘 알려진 자궁경부 편평상피암과 선암의 임상적 고찰에는 별 특이한 차이가 없었으며, 자궁경부 선암의 치료에 있어서 병기에 따른 분류, 종양의 크기, 골반내 임파절 전이상태를 고려하여 치료 계획을 수립하여야 한다. There is increasing evidence that the prevalence of adenocarcinoma of the cervix has risen over the past two decades. Clinicopathological analysis was performed on 42 cases of adenocarcinoma and adenosqamous carcinoma of the uterine cervix. The adenosquamous patients were analysed on the basis of age, parity, stage, clinical symptom, histologic grading and pelvic lymph node metastasis. The mean age of the patient was 49.5 years old. The distribution by stage included FIGO stage Ⅰ, 22(52.3%); stage Ⅱ, 17(40.5%); stage Ⅲ, 1(2.4%); stage Ⅳ, 1(2.4%). The most frequent clinical symptom was uterine bleeding (intermenstrual, postcoital, postmenopausal) in 27 cases (64.3%). The histologic gradings were classified as follows: well differentiated type 15 cases(35.7%), moderate differentiated type 13 cases (30.9%) and poorly differentiated type 7 cases(16.7%). The rate of abnormal papanicolaou smear which obtained from patient were 40.7%. The frequency of lymph node metastasis was 14.3% in well differentiated type, 27.3% in moderate differentiated type and 33.3% in poorly differentiated type. There is no significant difference about clinicopathologic analysis between adenocarcinoma, adenosquamous carcinoma and squamous carcinoma of uterine cervix. There is considerable controversy about the most appropriate treatment of adenocarcinoma of the cervix. Treatment strategies should be based on the stage of disease, tumor size, lymph node metastasis status and recurrency.
Sim, Woo-Cheol,Han, Inhoi,Lee, Wonseok,Choi, You-Jin,Lee, Kang-Yo,Kim, Dong Gwang,Jung, Seung-Hwan,Oh, Seon-Hee,Lee, Byung-Hoon Elsevier 2016 Toxicology in vitro Vol.34 No.-
<P><B>Abstract</B></P> <P>Hyperhomocysteinemia is an independent risk factor for several cardiovascular diseases. The use of vitamins to modulate homocysteine metabolism substantially lowers the risk by reducing plasma homocysteine levels. In this study, we evaluated the effects of <SMALL>L</SMALL>-serine and related amino acids on homocysteine-induced endoplasmic reticulum (ER) stress and endothelial cell damage using EA.hy926 human endothelial cells. Homocysteine treatment decreased cell viability and increased apoptosis, which were reversed by cotreatment with <SMALL>L</SMALL>-serine. <SMALL>L</SMALL>-Serine inhibited homocysteine-induced ER stress as verified by decreased glucose-regulated protein 78kDa (GRP78) and C/EBP homologous protein (CHOP) expression as well as <I>X-box binding protein 1</I> (<I>xbp1</I>) mRNA splicing. The effects of <SMALL>L</SMALL>-serine on homocysteine-induced ER stress are not attributed to intracellular homocysteine metabolism, but instead to decreased homocysteine uptake. Glycine exerted effects on homocysteine-induced ER stress, apoptosis, and cell viability that were comparable to those of <SMALL>L</SMALL>-serine. Although glycine did not affect homocysteine uptake or export, coincubation of homocysteine with glycine for 24h reduced the intracellular concentration of homocysteine. Taken together, <SMALL>L</SMALL>-serine and glycine cause homocysteine-induced endothelial cell damage by reducing the level of intracellular homocysteine. <SMALL>L</SMALL>-Serine acts by competitively inhibiting homocysteine uptake in the cells. However, the mechanism(s) by which glycine lowers homocysteine levels are unclear.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <SMALL>L</SMALL>-Serine and glycine ameliorated cell viability and apoptosis induced by homocysteine. </LI> <LI> <SMALL>L</SMALL>-Serine reduced homocysteine-induced ER stress by inhibiting homocysteine uptake. </LI> <LI> Glycine decreased intracellular homocysteine level and attenuated homocysteine-induced ER stress. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
심영보,임재현,한연석,이우진,이준성,백현욱,전영빈,이정환,김유선,우광훈,문정섭 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2
Mesenteric venous thrombosis is an rare type of intestinal ischemia associated with significant mortality and morbidity because of its delay in diagnosis. Mesenteric vasculitis associated with allergic vasculitis can also produce an acute intestinal ischemia. We recently experienced a case of mesenteric venous thrombosis associated with allergic vasculitis, successfully treated with segmental bowel resection and anticoagulant therapy, we report this case with a brief review of the literatures. A 30-year-old man was admitted to our hospital because of severe abdominal pain and hematochezia. Abdominal CT scan showed superior mesenteric venous thrombosis extending into main portal vein. There were large amounts of ascites and the wall of the jejunum was markedly thickened. On the 5th hospital day, his abdomen was tense and diffusely tender: bowel sounds were absent. Exploratory laparotomy was performed under the impression of intestinal infarction. At laparotomy thrombosis of the mesenteric vein and gangrene of the jejunum were found. A small bowel resection with an end-to-end anastomosis was done. Histopathological examination confirmed venous bowel gangrene and showed leukocytoclastic vasculitis, the hallmark of allergic vasculitis. The patient recovered fully and was discharged on anticoagulant therapy. At follow-up after 6 months, the patient was well with no gastrointestinal symptoms.
다중회귀분석을 이용한 DEA-AR 모형 개발 및 국내 지방공사의 효율성 평가
심광식(Gwang Sic Sim),김재윤(Jae Yun Kim) 한국경영과학회 2012 韓國經營科學會誌 Vol.37 No.1
We design a DEA-AR model using multiple regression analysis with new methods which limit weights. When there are multiple input and single output variables, our model can be used, and the weights of input variables use the regression coefficient and coefficient of determination. To verify the effectiveness of the new model, we evaluate the efficiency of the Regional Corporations in Korea. Accordance with statistical analysis, it proved that there is no difference between the efficiency value of the DEA-AR using AHP and our DEA-AR model. Our model can be applied to a lot of research by substituting DEA-AR model relying on AHP in the future.