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둔상에 의한 흉부대동맥 손상에서 TEVAR에 관한 임상연구
구관우 ( Gwan Woo Ku ),최진호 ( Jin Ho Choi ),최민석 ( Min Suk Choi ),박상순 ( Sang Soon Park ),설영훈 ( Young Hoon Su ),고승제 ( Seung Je Go ),예진봉 ( Jin Bong Ye ),김중석 ( Joong Suck Kim ),김영철 ( Yeong Cheol Kim ),황정주 ( J 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.4
Purpose: Thoracic aortic injury is a life-threatening injury that has been traditionally treated by using surgical management. Recently, thoracic endovascular aortic repair (TEVAR) has been conducted pervasively as a better alternative treatment method. Therefore, this study will focus on analyzing the outcome of TEVAR in patients suffering from a blunt thoracic aortic injury. Methods: Of the blunt thoracic aortic injury patients admitted to Eulji University Hospital, this research focused on the 11 patients who had received TEVAR during the period from January 2008 to April 2014. Results: Seven of the 11 patients were male. At the time of admission, the mean systolic pressure was 105.64±24.60 mm Hg, and the mean heart rate was 103.64±20.02 per minute. The median interval from arrival to repair was 7 (4, 47) hours. The mean stay in the ICU was 21.82±16.37 hours. In three patients, a chimney graft technique was also performed to save the left subclavian artery. In one patient, a debranching of the aortic arch vessels was performed. In two patients, the left subclavian artery was totally covered. In one patient whose proximal aortic neck length was insufficient, the landing zone was extended by using a prophylactic left subclavian artery to left common carotid artery bypass before TEVAR. There were no operative mortalities, but a patient who was covered of left subclavian artery died from ischemic brain injury. Complications such as migration, endovascular leakage, collapse, infection and thrombus did not occur. Conclusion: Our short-term outcomes of TEVAR for blunt thoracic aorta injury was feasible. Left subclavian artery may be sacrificed if the proximal landing zone is short, but several methods to continue the perfusion should be considered. [ J Trauma Inj 2015; 28: 232-240 ]
Antigenicity of HM10760 in Guinea Pigs
Woo Hyuck Choi,Sung Hak Lee,Michael Lee,Moon-Ku Chung,Se Chang Kwon,Gwan Sun Lee,Jae Yong Han,Woo Suk Koh 한국독성학회 2005 Toxicological Research Vol.21 No.3
HM10760 is a recombinant human erythropoietin that has been developed as a drug for anemia. In this study, antigenic potential of HM10760 was examined by active systemic anaphylaxis in guinea pigs and passive cutaneous anaphylaxis in a guinea pig-guinea pig system. HM10760 was subcutaneously administered at 0, 2, and 20 ㎍/㎏ and also as a suspension with adjuvant (20 ㎍/㎏ + FCA). Ovalbumin as a suspension with adjuvant was administered to induce positive control responses. In the active systemic anaphylaxis test, no symptoms except rubbing or licking nose and urination that were considered as physiological phenomena were observed at 0 ㎍/㎏. Four of 5 animals at 2 ㎍/㎏ and all the 5 animals at 20 ㎍/㎏ showed cyanosis and lying on side. All animals in the adjuvant mixture group showed relatively mild symptoms such as rubbing or licking nose, urination, and evacuation. In the passive cutaneous anaphylaxis test, 0/5, 3/5, and 5/5 serum samples from the animals immunized with 0, 2, and 20 ㎍/㎏, respectively, showed positive reactions against HM10760. All 5 sera collected from the animals immunized with an adjuvant mixture contained HM10760-specific antibodies. These results suggest HM10760 have antigenicity in guinea pigs.
Antigenicity of HM10760 in Guinea Pigs
Choi, Woo-Hyuck,Lee, Sung-Hak,Lee, Mi-Chael,Chung, Moon-Ku,Kwon, Se-Chang,Lee, Gwan-Sun,Han, Jae-Yong,Koh, Woo-Suk Korean Society of ToxicologyKorea Environmental Mu 2005 Toxicological Research Vol.21 No.3
HM10760 is a recombinant human erythropoietin that has beer developed as a drug for anemia. In this study, antigenic potential of HM10760 was examined by active systemic anaphylaxis in guinea pigs and passive cutaneous anaphylaxis in a guinea pig-guinea pig system. HM10760 was subcutaneously administered at 0, 2, and $20{\mu}g/kg$ and also as a suspension with adjuvant ($20{\mu}g/kg$ + FCA). Ovalbumin as a suspension with adjuvant was administered to induce positive control responses. In the active systemic anaphylaxis test, no symptoms except rubbing or licking nose and urination that were considered as physiological phenomena were observed at $0{\mu}g/kg$. Four of 5 animals at $2{\mu}g/kg$ and all the 5 animals at $20{\mu}g/kg$ showed cyanosis and lying on side. All animals in the adjuvant mixture group showed relatively mild symptoms such as rubbing or licking nose, urination, and evacuation. In the passive cutaneous anaphylaxis test, 0/5, 3/5, and 5/5 serum samples from the animals immunized with 0, 2, and $20{\mu}g/kg$, respectively, showed positive reactions against HM10760. All 5 sera collected from the animals immunized with an adjuvant mixture contained HM10760-specific antibodies. These results suggest HM10760 have antigenicity in guinea pigs.
Sung-Ho Cho,Hui-Ryong Yoo,Dong-Ku Kim,Dae-Jin Park,Yong-Woo Rho,Kang Seo,Gwan Soo Park,Doo-Hyun Choi,Sung-Jin Song 한국자기학회 2010 Journal of Magnetics Vol.15 No.4
This paper discusses the effectiveness of high magnetization saturation in ILI (In-Line Inspection) using an MFL (Magnetic Flux Leakage) tool, and introduces a practical method for improving the magnetization level together with the piggability. Thin steel plates, replacing the conventional wire brushes were used as conductors to transfer the magnetic flux to the pipe wall. The newly designed MFL tool was compared with the conventional version by means of FEM (Finite Element Method) analysis and full-scale experiments. In the results, the newly developed magnetization system obtained a stronger MFL signal amplitude, specially 2.7 times stronger, than that obtained by the conventional magnetization system for the same defect dimensions.
( Ki Hong Lee ),( Hyung Wook Park ),( Jeong Nam Eun ),( Jeong Gwan Cho ),( Nam Sik Yoon ),( Mi Ran Kim ),( Yo Han Ku ),( Hyukjin Park ),( Seung Hun Lee ),( Jeong Han Kim ),( Min Chul Kim ),( Woo Jin K 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5
Background/Aims: Coronary vasospasms are one of the important causes of sudden cardiac death (SCD). Provocation of coronary vasospasms can be useful, though some results may lead to false positives, with patients potentially experi-encing recurrent SCD despite appropriate medical treatments. We hypothesized that it is not coronary vasospasms but inherited primary arrhythmia syndromes (IPAS) that underlie the development of SCD. Methods: We analyzed 74 consecutive patients (3.8%) who survived out-of-hospital cardiac arrest among 1,986 patients who had angiographically proven coronary va-sospasms. Electrical abnormalities were evaluated in serial follow-up electrocardio-grams (ECGs) during and after the index event for a 3.9 years median follow-up. Ma-jor clinical events were defined as the composite of death and recurrent SCD events. Results: Forty five patients (60.8%) displayed electrocardiographic abnormali-ties suggesting IPAS: Brugada type patterns in six (8.2%), arrhythmogenic right ventricular dysplasia patterns in three (4.1%), long QT syndrome pattern in one (2.2%), and early repolarization in 38 (51.4%). Patients having major clinical events showed more frequent Brugada type patterns, early repolarization, and more dif-fuse multivessel coronary vasospasms. Brugada type pattern ECGs (adjusted haz-ard ratio [HR], 4.22; 95% confidence interval [CI], 1.16 to 15.99; p = 0.034), and early repolarization (HR, 2.97; 95% CI, 1.09 to 8.10; p = 0.034) were ultimately associated with an increased risk of mortality. Conclusions: Even though a number of aborted SCD survivors have coronary va-sospasms, some also have IPAS, which has the potential to cause SCD. Therefore, meticulous evaluations and follow-ups for IPAS are required in those patients.
( Minhyeok Lee ),( Ji Woong Son ),( Chang Ryul Park ),( Daeun Kang ),( Su Yel Lee ),( Se Jin Park ),( Wan Jin Hwang ),( Gwan Woo Ku ),( Seong Lan Yu ),( In Beom Jeong ),( Sun Jung Kwon ),( Jaeku Kang 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Cancer stem cells (CSCs) identified in lung cancer exhibit resistance to chemotherapy, radiotherapy, and targeted therapy. Therefore, a technology to control of CSCs is needed to overcome such resistance to cancer therapy. Various evidences about the association between epithelial-mesenchymal transition related transcriptomic alteration and acquisition of CSC phenotype have been proposed recently. In our previous research, down-regulated miR-26a-5p is closely related to mesenchymal-like lung cancer cell lines. These findings suggest that miR-26a-5p might be involved in lung cancer stemness. Methods RNA polymerase III subunit G (POLR3G) was selected as a candidate target of miR-26a-5p related to cancer stemness. its quantitative relationship was investigated by polymerase chain reaction, western blot after transfection of miR-26a-5p. luciferase assay were done for investigating the direct regulation of miR-26a-5p on POLR3G expression. After transfection of miR-26a-5p, colony formation assay and sphere formation assay were performed to evaluate the effect on cancer stemness. By treating cancer cell by miR-26a-5p and paclitaxel, cell viability was checked by 3-(4,5-dimethylthiazol-2-yl)-5-(3- carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay and Muse cell analyzer. Expression level of each gene and its impact on survival were revealed by the cancer genome atlas pancancer database. Results miR-26a-5p regulated the expression of POLR3G directly. Overexpression of miR-26a-5p induced down regulation of POLR3G and a marked reduction of colony formation and sphere formation. Co-treatment of miR-26a-5p with paclitaxel decreased cell growth, suggesting that miR-26a-5p might play a role as a chemotherapy sensitizer. In the cancer genome atlas data, downregulated miR-26a-5p and up-regulated POLR3G were shown compared to adjacent normal tissue. High miR-26a-5p and low POLR3G expression were also related to higher survival rate of patients with lung adenocarcinoma. Conclusions Overexpression of miR-26a-5p can suppress lung cancer stemness and make cancer cell become sensitive to chemotherapy. This finding provides a novel insight into a potential lung cancer treatment by regulating stemness.
예진봉 ( Jin Bong Ye ),설영훈 ( Young Hoon Sul ),고승제 ( Seung Je Go ),권오상 ( Oh Sang Kwon ),김중석 ( Joong Suck Kim ),박상순 ( Sang Soon Park ),구관우 ( Gwan Woo Ku ),이민구 ( Min Koo Lee ),김영철 ( Yeong Cheol Kim ) 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.3
The primary and secondary survey was designed to identify all of a patient’s injuries and prioritize their management. However 15 to 22.3% of patient with missed injuries had clinically significant missed injuries. To reduce missed injury, special attention should be focused on patients with severe anatomical injury or obtunded. Victims of blunt trauma commonly had multiple system involvement. Some reports indicate that inexperience, breakdown of estalished protocol, clinical error, and restriction of imaging studies may be responsible for presence of missed injury. The best way of reducing clinical significant of missed injuries was repeated clinical assessment. Here we report a case of severe blunt hepatic injury patient and pericardial injury that was missed in primary and secondary survey. After damage control surgery of hepatic injury, she remained hemodynamically unstable. Further investigation found cardiac tamponade during intensive care. This was managed by pericardial window operation through previous abdominal incision and abdominal wound closure was performed. [ J Trauma Inj 2015; 28: 211-214 ]
김중석 ( Joong Suck Kim ),고승제 ( Seung Je Go ),김지대 ( Ji Dae Kim ),설영훈 ( Young Hoon Sul ),예진봉 ( Jin Bong Ye ),박상순 ( Sang Soon Park ),구관우 ( Gwan Woo Ku ),김영철 ( Yeong Cheol Kim ) 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.4
An arteriovenous fistula (AVF) from the renal artery following a penetrating abdominal trauma is not common. We report the case of a 19-year-old male who presented with a knife stab wound in the right upper quadrant. Due to unstable vital signs and to the protrusion of the mesentery through the stab wound, providing definite evidence of peritoneal violation, an emergent exploratory laparotomy was carried out. There were injuries at the proximal transverse mesocolon and the second portion of the duodenum, with bile leakage. There was also a mild amount of retroperitoneal hematoma near the right kidney, without signs of expansion or pulsation. The mesocolon and the duodenum were repaired. After the operation, abdominal computerized tomography (CT) was performed, which revealed contrast from the right renal artery shunting directly into the vena cava. Transcatheter arterial embolization with a coil and vascular plug was performed, and the fistula was repaired. The patient recovered completely and was discharged without complication. For further and thorough evaluation of an abdominal trauma, especially one involving the retroperitoneum, a CT scan is recommended, when possible, either prior to surgery or after surgery when the patient is stabile. Furthermore, a lateral retroperitoneal hematoma and an AVF after a penetrating trauma may not always require exploration. Sometimes, it may be safely treated non-operatively or with embolization. [ J Trauma Inj 2015; 28: 262-265 ]